Successful pregnancy involving a man with chronic myeloid leukemia on dasatinib

Oweini H.; Otrock Z.K.; Mahfouz R.A.R.; Bazarbachi A.

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dc.contributor.author	Oweini H.
dc.contributor.author	Otrock Z.K.
dc.contributor.author	Mahfouz R.A.R.
dc.contributor.author	Bazarbachi A.
dc.contributor.editor
dc.date	Jan-2011
dc.date.accessioned	2017-10-05T15:59:29Z
dc.date.available	2017-10-05T15:59:29Z
dc.date.issued	2011
dc.identifier	10.1007/s00404-010-1501-6
dc.identifier.isbn
dc.identifier.issn	09320067
dc.identifier.uri	http://hdl.handle.net/10938/19045
dc.description.abstract	Dasatinib is a highly potent Bcr-Abl inhibitor that is approved for the treatment of imatinib-resistant or -intolerant chronic myeloid leukemia (CML). The potential effects of dasatinib on sperm counts, sperm function, and fertility have not been studied yet. There is only one report in the medical literature of successful pregnancies while patients were taking dasatinib, thus making our case the second report. Here, we present the case of a 38-year-old man who conceived a healthy baby while on dasatinib therapy. © 2010 Springer-Verlag.
dc.format.extent
dc.format.extent	Pages: (133-134)
dc.language	English
dc.publisher	HEIDELBERG
dc.relation.ispartof	Publication Name: Archives of Gynecology and Obstetrics; Publication Year: 2011; Volume: 283; no. 1; Pages: (133-134);
dc.relation.ispartofseries
dc.relation.uri
dc.source	Scopus
dc.subject.other
dc.title	Successful pregnancy involving a man with chronic myeloid leukemia on dasatinib
dc.type	Article
dc.contributor.affiliation	Oweini, H., Department of Internal Medicine, American University, Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation	Otrock, Z.K., Department of Pathology and Laboratory Medicine, American University, Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation	Mahfouz, R.A.R., Department of Pathology and Laboratory Medicine, American University, Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation	Bazarbachi, A., Department of Internal Medicine, American University, Beirut Medical Center, Beirut, Lebanon
dc.contributor.authorAddress	Bazarbachi, A.; Bone Marrow Transplantation Program, Department of Medicine, American University of Beirut Medical Center, P.O. Box 113-6044, Beirut, Lebanon; email: bazarbac@aub.edu.lb
dc.contributor.authorCorporate	University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Pathology and Laboratory Medicine;
dc.contributor.authorDepartment	Pathology and Laboratory Medicine
dc.contributor.authorDivision
dc.contributor.authorEmail	bazarbac@aub.edu.lb
dc.contributor.faculty	Faculty of Medicine
dc.contributor.authorInitials	Oweini, H
dc.contributor.authorInitials	Otrock, ZK
dc.contributor.authorInitials	Mahfouz, RAR
dc.contributor.authorInitials	Bazarbachi, A
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress	Bazarbachi, A (reprint author), Amer Univ Beirut, Med Ctr, Bone Marrow Transplantat Program, Dept Med, POB 113-6044, Beirut, Lebanon.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity	American University of Beirut Medical Center
dc.description.cited	[Anonymous], 2012, HIGHLIGHTS PRESCRIBI, V26; Ault P, 2006, J CLIN ONCOL, V24, P1204, DOI 10.1200-JCO.2005.04.6557; Cortes J, 2008, BLOOD, V112; Deininger Michael W, 2008, Hematology Am Soc Hematol Educ Program, P419, DOI 10.1182-asheducation-2008.1.419; Lichtman MA, 2001, WILLIAMS HEMATOLOGY, P1047; Sawyers CL, 1999, NEW ENGL J MED, V340, P1330, DOI 10.1056-NEJM199904293401706
dc.description.citedCount	9
dc.description.citedTotWOSCount	12
dc.description.citedWOSCount	8
dc.format.extentCount	2
dc.identifier.articleNo
dc.identifier.coden	AGOBE
dc.identifier.pubmedID	20473616
dc.identifier.scopusID	78751591628
dc.identifier.url
dc.publisher.address	TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
dc.relation.ispartofConference
dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr	Arch. Gynecol. Obstet.
dc.relation.ispartOfIssue	1
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle	Archives of Gynecology and Obstetrics
dc.relation.ispartofPubTitleAbbr	Arch. Gynecol. Obstet.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume	283
dc.source.ID	WOS:000285784000023
dc.type.publication	Journal
dc.subject.otherAuthKeyword	Chronic myeloid leukemia
dc.subject.otherAuthKeyword	Dasatinib
dc.subject.otherAuthKeyword	Pregnancy
dc.subject.otherChemCAS	dasatinib, 302962-49-8
dc.subject.otherChemCAS	hydroxyurea, 127-07-1
dc.subject.otherChemCAS	imatinib, 152459-95-5, 220127-57-1
dc.subject.otherChemCAS	nilotinib, 641571-10-0
dc.subject.otherChemCAS	Antineoplastic Agents
dc.subject.otherChemCAS	Protein Kinase Inhibitors
dc.subject.otherChemCAS	Pyrimidines
dc.subject.otherChemCAS	Thiazoles
dc.subject.otherChemCAS	dasatinib, 302962-49-8
dc.subject.otherIndex	dasatinib
dc.subject.otherIndex	hydroxyurea
dc.subject.otherIndex	imatinib
dc.subject.otherIndex	interferon
dc.subject.otherIndex	nilotinib
dc.subject.otherIndex	adult
dc.subject.otherIndex	article
dc.subject.otherIndex	ascites
dc.subject.otherIndex	cancer resistance
dc.subject.otherIndex	case report
dc.subject.otherIndex	chronic myeloid leukemia
dc.subject.otherIndex	conception
dc.subject.otherIndex	cytogenetics
dc.subject.otherIndex	drug withdrawal
dc.subject.otherIndex	hepatosplenomegaly
dc.subject.otherIndex	human
dc.subject.otherIndex	human cell
dc.subject.otherIndex	leukocyte count
dc.subject.otherIndex	maintenance therapy
dc.subject.otherIndex	male
dc.subject.otherIndex	pericardial effusion
dc.subject.otherIndex	Philadelphia chromosome positive cell
dc.subject.otherIndex	pleura effusion
dc.subject.otherIndex	pregnancy outcome
dc.subject.otherIndex	treatment duration
dc.subject.otherIndex	treatment response
dc.subject.otherIndex	Adult
dc.subject.otherIndex	Antineoplastic Agents
dc.subject.otherIndex	Female
dc.subject.otherIndex	Fertilization
dc.subject.otherIndex	Humans
dc.subject.otherIndex	Infant
dc.subject.otherIndex	Leukemia, Myelogenous, Chronic, BCR-ABL Positive
dc.subject.otherIndex	Male
dc.subject.otherIndex	Pregnancy
dc.subject.otherIndex	Protein Kinase Inhibitors
dc.subject.otherIndex	Pyrimidines
dc.subject.otherIndex	Thiazoles
dc.subject.otherKeywordPlus
dc.subject.otherWOS	Obstetrics and Gynecology

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