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Cutaneous leishmaniasis mimicking inflammatory and neoplastic processes: A clinical, histopathological and molecular study of 57 cases

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dc.contributor.author Saab J.
dc.contributor.author Fedda F.
dc.contributor.author Khattab R.
dc.contributor.author Yahya L.
dc.contributor.author Loya A.
dc.contributor.author Satti M.
dc.contributor.author Kibbi A.-G.
dc.contributor.author Houreih M.A.
dc.contributor.author Raslan W.
dc.contributor.author El-Sabban M.
dc.contributor.author Khalifeh I.
dc.contributor.editor
dc.date Feb-2012
dc.date.accessioned 2017-10-05T15:59:34Z
dc.date.available 2017-10-05T15:59:34Z
dc.date.issued 2012
dc.identifier 10.1111/j.1600-0560.2011.01844.x
dc.identifier.isbn
dc.identifier.issn 03036987
dc.identifier.uri http://hdl.handle.net/10938/19077
dc.description.abstract Background: Cutaneous leishmaniasis displays considerable variation in its histopathological and clinical presentation. Clinically, it progresses from a papule into a painless ulcerated and crusted nodule-papule. Microscopically, it progresses from sheets of amastigote-filled histiocytes to granulomatous inflammation. Methods: The study was conducted on 145 skin biopsies from untreated patients with histopathological and-or clinical suspicion of cutaneous leishmaniasis in Lebanon, Syria and Saudi Arabia (1992-2010). The pre-biopsy clinical diagnosis and demographic data were collected. Biopsies were evaluated for the major microscopic pattern, and the parasitic index (PI) was also determined. Diagnosis was confirmed by polymerase chain reaction (PCR) followed by molecular sub-speciation. Results: Of the 145 patients, 125 were confirmed as cutaneous leishmaniasis by PCR. Eighteen cases presented with a pre-biopsy clinical diagnosis other than cutaneous leishmaniasis that ranged from dermatitis to neoplasm. Of the 125 cases, 57 showed a major histopathological pattern other than cutaneous leishmaniasis. Identification of amastigotes was equivocal (PI ≤ 1) in 38 of the 57 cases. Of interest, all the 18 cases with a pre-biopsy clinical diagnosis other than cutaneous leishmaniasis also showed atypical histopathology for cutaneous leishmaniasis. Conclusions: The manifestations of cutaneous leishmaniasis are broad and may mimic other inflammatory and neoplastic diseases. Pathologists and dermatologists should be aware of such pitfalls and can utilize PCR to confirm the diagnosis of leishmaniasis. Copyright © 2012 John Wiley and Sons A-S.
dc.format.extent
dc.format.extent Pages: (251-262)
dc.language English
dc.publisher MALDEN
dc.relation.ispartof Publication Name: Journal of Cutaneous Pathology; Publication Year: 2012; Volume: 39; no. 2; Pages: (251-262);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Cutaneous leishmaniasis mimicking inflammatory and neoplastic processes: A clinical, histopathological and molecular study of 57 cases
dc.type Article
dc.contributor.affiliation Saab, J., Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Hamra, Beirut, 1107 2020, Lebanon
dc.contributor.affiliation Fedda, F., Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Hamra, Beirut, 1107 2020, Lebanon
dc.contributor.affiliation Khattab, R., Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Hamra, Beirut, 1107 2020, Lebanon
dc.contributor.affiliation Yahya, L., Department of Human Morphology, American University of Beirut, Beirut, Lebanon
dc.contributor.affiliation Loya, A., Department of Pathology, Shaukat Khanum Memorial Cancer Hospital and Research Center, Lahore, Pakistan
dc.contributor.affiliation Satti, M., Department of Pathology, King Abdulaziz Medical City, Jeddah, Saudi Arabia
dc.contributor.affiliation Kibbi, A.-G., Department of Dermatology, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Houreih, M.A., Department of Pathology, Tishreen University, Lattakia, Syrian Arab Republic
dc.contributor.affiliation Raslan, W., Department of Pathology, Dhahran Health Center, Dhahran, Saudi Arabia
dc.contributor.affiliation El-Sabban, M., Department of Human Morphology, American University of Beirut, Beirut, Lebanon
dc.contributor.affiliation Khalifeh, I., Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Hamra, Beirut, 1107 2020, Lebanon
dc.contributor.authorAddress Khalifeh, I.; Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Hamra, Beirut, 1107 2020, Lebanon; email: ik08@aub.edu.lb
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Pathology and Laboratory Medicine;
dc.contributor.authorDepartment Pathology and Laboratory Medicine
dc.contributor.authorDivision
dc.contributor.authorEmail ik08@aub.edu.lb
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Saab, J
dc.contributor.authorInitials Fedda, F
dc.contributor.authorInitials Khattab, R
dc.contributor.authorInitials Yahya, L
dc.contributor.authorInitials Loya, A
dc.contributor.authorInitials Satti, M
dc.contributor.authorInitials Kibbi, AG
dc.contributor.authorInitials Houreih, MA
dc.contributor.authorInitials Raslan, W
dc.contributor.authorInitials El-Sabban, M
dc.contributor.authorInitials Khalifeh, I
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Khalifeh, I (reprint author), Amer Univ Beirut, Med Ctr, Dept Pathol and Lab Med, Beirut 11072020, Lebanon.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedCount 6
dc.description.citedTotWOSCount 7
dc.description.citedWOSCount 7
dc.format.extentCount 12
dc.identifier.articleNo
dc.identifier.coden JCUPB
dc.identifier.pubmedID 22168790
dc.identifier.scopusID 84859087894
dc.identifier.url
dc.publisher.address COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
dc.relation.ispartofConference
dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr J. Cutan. Pathol.
dc.relation.ispartOfIssue 2
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Journal of Cutaneous Pathology
dc.relation.ispartofPubTitleAbbr J. Cutaneous Pathol.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 39
dc.source.ID WOS:000299336800006
dc.type.publication Journal
dc.subject.otherAuthKeyword Cutaneous leishmaniasis
dc.subject.otherAuthKeyword Mimic
dc.subject.otherAuthKeyword Molecular sub-speciation
dc.subject.otherAuthKeyword Stimulant
dc.subject.otherChemCAS
dc.subject.otherIndex adolescent
dc.subject.otherIndex adult
dc.subject.otherIndex article
dc.subject.otherIndex biopsy
dc.subject.otherIndex clinical trial
dc.subject.otherIndex dermatitis
dc.subject.otherIndex differential diagnosis
dc.subject.otherIndex female
dc.subject.otherIndex genetics
dc.subject.otherIndex human
dc.subject.otherIndex male
dc.subject.otherIndex methodology
dc.subject.otherIndex middle aged
dc.subject.otherIndex multicenter study
dc.subject.otherIndex parasitology
dc.subject.otherIndex pathology
dc.subject.otherIndex polymerase chain reaction
dc.subject.otherIndex skin leishmaniasis
dc.subject.otherIndex skin tumor
dc.subject.otherIndex Adolescent
dc.subject.otherIndex Adult
dc.subject.otherIndex Biopsy
dc.subject.otherIndex Dermatitis
dc.subject.otherIndex Diagnosis, Differential
dc.subject.otherIndex Female
dc.subject.otherIndex Humans
dc.subject.otherIndex Leishmaniasis, Cutaneous
dc.subject.otherIndex Male
dc.subject.otherIndex Middle Aged
dc.subject.otherIndex Polymerase Chain Reaction
dc.subject.otherIndex Skin Neoplasms
dc.subject.otherKeywordPlus POLYMERASE-CHAIN-REACTION
dc.subject.otherKeywordPlus SQUAMOUS-CELL CARCINOMA
dc.subject.otherKeywordPlus ATYPICAL PRESENTATION
dc.subject.otherKeywordPlus SKIN BIOPSIES
dc.subject.otherKeywordPlus DIAGNOSIS
dc.subject.otherKeywordPlus FEATURES
dc.subject.otherKeywordPlus PCR
dc.subject.otherWOS Dermatology
dc.subject.otherWOS Pathology


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