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Extended use of serum free light chain as a biomarker in lymphoproliferative disorders: A comprehensive review

Show simple item record Charafeddine K.M. Jabbour M.N. Kadi R.H. Daher R.T.
dc.contributor.editor Jun-2012 2017-10-05T15:59:34Z 2017-10-05T15:59:34Z 2012
dc.identifier 10.1309/AJCP4INKZ6LYAQXW
dc.identifier.issn 00029173
dc.description.abstract Serum free light chain (sFLC) assays were shown to improve detection, management, and prognostication in plasma cell disorders. Recently, sFLC assays improved detection of M proteins when combined with standard methods of protein electrophoresis-immunofixation in patients with non-Hodgkin lymphoma-chronic lymphocytic leukemia (NHL-CLL). Incidence of abnormal sFLC ratio (sFLCr) varied from 0percent to 36percent and 29.7percent to 59percent in NHL and CLL, respectively. Increased sFLC levels or abnormal sFLCr predict shorter overall survival in early-stage CLL. Furthermore, abnormal sFLCr correlated with advanced disease stage and poorer outcome. In diffuse large B-cell lymphomas, increased sFLC was demonstrated as an independent, adverse prognostic factor for overall-event-free survival. Moreover, abnormal sFLCr can be a diagnostic tool in central nervous system lymphomas. Finally, the quantitative FLC assay has the potential to become a new, easily measured biomarker for predicting prognosis and enhanced detection in NHL-CLL. It may be used serially at follow-up evaluations to provide clues to relapse. © American Society for Clinical Pathology.
dc.format.extent Pages: (890-897)
dc.language English
dc.publisher CHICAGO
dc.relation.ispartof Publication Name: American Journal of Clinical Pathology; Publication Year: 2012; Volume: 137; no. 6; Pages: (890-897);
dc.source Scopus
dc.title Extended use of serum free light chain as a biomarker in lymphoproliferative disorders: A comprehensive review
dc.type Article
dc.contributor.affiliation Charafeddine, K.M., Department of Pathology, Laboratory Medicine, American University of Beirut Medical Center, PO Box 11-0236, Beirut 1107-2020, Lebanon
dc.contributor.affiliation Jabbour, M.N., Department of Pathology, Laboratory Medicine, American University of Beirut Medical Center, PO Box 11-0236, Beirut 1107-2020, Lebanon
dc.contributor.affiliation Kadi, R.H., Department of Pathology, Laboratory Medicine, American University of Beirut Medical Center, PO Box 11-0236, Beirut 1107-2020, Lebanon
dc.contributor.affiliation Daher, R.T., Department of Pathology, Laboratory Medicine, American University of Beirut Medical Center, PO Box 11-0236, Beirut 1107-2020, Lebanon
dc.contributor.authorAddress Daher, R.T.; Department of Pathology, Laboratory Medicine, American University of Beirut Medical Center, PO Box 11-0236, Beirut 1107-2020, Lebanon; email:
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Pathology and Laboratory Medicine;
dc.contributor.authorDepartment Pathology and Laboratory Medicine
dc.contributor.faculty Faculty of Medicine
dc.contributor.authorInitials Charafeddine, KM
dc.contributor.authorInitials Jabbour, MN
dc.contributor.authorInitials Kadi, RH
dc.contributor.authorInitials Daher, RT
dc.contributor.authorReprintAddress Daher, RT (reprint author), Amer Univ Beirut, Dept Pathol and Lab Med, Med Ctr, POB 11-0236, Beirut 11072020, Lebanon.
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedCount 9
dc.description.citedTotWOSCount 8
dc.description.citedWOSCount 8
dc.format.extentCount 8
dc.identifier.coden AJCPA
dc.identifier.pubmedID 22586047
dc.identifier.scopusID 84863755369
dc.publisher.address 2100 W HARRISON ST, CHICAGO, IL 60612 USA
dc.relation.ispartOfISOAbbr Am. J. Clin. Pathol.
dc.relation.ispartOfIssue 6
dc.relation.ispartofPubTitle American Journal of Clinical Pathology
dc.relation.ispartofPubTitleAbbr Am. J. Clin. Pathol.
dc.relation.ispartOfVolume 137
dc.source.ID WOS:000304575700005
dc.type.publication Journal
dc.subject.otherAuthKeyword Chronic lymphocytic leukemia
dc.subject.otherAuthKeyword Non-Hodgkin lymphoma
dc.subject.otherAuthKeyword Prognosis
dc.subject.otherAuthKeyword Serum free light chain
dc.subject.otherAuthKeyword Serum free light chain ratio
dc.subject.otherChemCAS Biological Markers
dc.subject.otherChemCAS Immunoglobulin Light Chains
dc.subject.otherIndex biological marker
dc.subject.otherIndex M protein
dc.subject.otherIndex serum free light chain
dc.subject.otherIndex unclassified drug
dc.subject.otherIndex biological marker
dc.subject.otherIndex immunoglobulin light chain
dc.subject.otherIndex article
dc.subject.otherIndex blood level
dc.subject.otherIndex Burkitt lymphoma
dc.subject.otherIndex cerebrospinal fluid analysis
dc.subject.otherIndex chronic lymphatic leukemia
dc.subject.otherIndex disease severity
dc.subject.otherIndex event free survival
dc.subject.otherIndex follow up
dc.subject.otherIndex human
dc.subject.otherIndex large cell lymphoma
dc.subject.otherIndex lymphoproliferative disease
dc.subject.otherIndex nonhodgkin lymphoma
dc.subject.otherIndex overall survival
dc.subject.otherIndex prediction
dc.subject.otherIndex priority journal
dc.subject.otherIndex prognosis
dc.subject.otherIndex protein analysis
dc.subject.otherIndex protein electrophoresis
dc.subject.otherIndex quantitative analysis
dc.subject.otherIndex relapse
dc.subject.otherIndex B cell lymphoma
dc.subject.otherIndex blood
dc.subject.otherIndex cerebrospinal fluid
dc.subject.otherIndex chronic lymphatic leukemia
dc.subject.otherIndex disease course
dc.subject.otherIndex female
dc.subject.otherIndex immunology
dc.subject.otherIndex male
dc.subject.otherIndex paraproteinemia
dc.subject.otherIndex review
dc.subject.otherIndex Biological Markers
dc.subject.otherIndex Disease Progression
dc.subject.otherIndex Female
dc.subject.otherIndex Humans
dc.subject.otherIndex Immunoglobulin Light Chains
dc.subject.otherIndex Leukemia, Lymphocytic, Chronic, B-Cell
dc.subject.otherIndex Lymphoma, AIDS-Related
dc.subject.otherIndex Lymphoproliferative Disorders
dc.subject.otherIndex Male
dc.subject.otherIndex Paraproteinemias
dc.subject.otherIndex Prognosis
dc.subject.otherKeywordPlus CHRONIC LYMPHOCYTIC-LEUKEMIA
dc.subject.otherKeywordPlus INDEPENDENT RISK-FACTOR
dc.subject.otherKeywordPlus MONOCLONAL GAMMOPATHY
dc.subject.otherKeywordPlus MULTIPLE-MYELOMA
dc.subject.otherKeywordPlus CD38 EXPRESSION
dc.subject.otherKeywordPlus UNDETERMINED SIGNIFICANCE
dc.subject.otherKeywordPlus DIAGNOSTIC PERFORMANCE
dc.subject.otherKeywordPlus GENOMIC ABERRATIONS
dc.subject.otherKeywordPlus RATIO
dc.subject.otherKeywordPlus LYMPHOMA
dc.subject.otherWOS Pathology

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