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Halzoun, an allergic pharyngitis syndrome in Lebanon: The trematode Dicrocoelium dendriticum as an additional cause

Show simple item record Khalil G. Haddad C. Otrock Z.K. Jaber F. Farra A.
dc.contributor.editor 2013 2017-10-05T15:59:36Z 2017-10-05T15:59:36Z 2013
dc.identifier 10.1016/j.actatropica.2012.09.013
dc.description.abstract Halzoun syndrome typically manifests in the form of an allergic pharyngitis following the consumption of raw or undercooked ovine liver. First described in Lebanon in 1905, it was initially attributed to Fasciola hepatica, while later publications have attributed it to other pathogens. There has been no definitive documentation of the pathogen causing the Lebanese Halzoun syndrome. The aim of our study was to identify the parasite responsible for the pathogenesis of the Lebanese Halzoun syndrome. 32 patients with typical clinical symptoms of Halzoun syndrome were recruited in the emergency room at our hospital from 2005 to 2007. One parasite was isolated from a patient's expectorations, and two others were isolated from pieces of a raw sheep liver retrieved from the patients' dishes. A piece of infected goat liver intended for consumption was also collected from a local butcher. All parasites were examined microscopically for identification. All patients presented with immune allergic-like symptoms of the eyes, ears, nose, or throat. All collected parasites were identified as Dicrocoelium dendriticum. Our study has identified D. dendriticum, rather than Linguatula serrata or F. hepatica, as the prime suspect in the pathogenesis of the Lebanese Halzoun syndrome. © 2012 Elsevier B.V.
dc.format.extent Pages: (115-118)
dc.language English
dc.publisher AMSTERDAM
dc.relation.ispartof Publication Name: Acta Tropica; Publication Year: 2013; Volume: 125; no. 1; Pages: (115-118);
dc.source Scopus
dc.title Halzoun, an allergic pharyngitis syndrome in Lebanon: The trematode Dicrocoelium dendriticum as an additional cause
dc.type Article
dc.contributor.affiliation Khalil, G., Medical Microbiology Department, School of Medicine, Saint-Joseph University of Beirut, Lebanon
dc.contributor.affiliation Haddad, C., Service de Gastro-Enterologie, Centre Hospitalier de Tonnerre 89700, Yonne, France
dc.contributor.affiliation Otrock, Z.K., Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Jaber, F., Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Farra, A., University Medical Center Rizk Hospital, Lebanese American University, P.O. Box: 36, Byblos, Lebanon
dc.contributor.authorAddress Khalil, G.; Division of Infectious Diseases, Department of Internal Medicine, Hôpital Saint Georges Ajaltoun, Hôpital Saint Joseph Centre Médical Raymond et Aida Najjar Beirut, P.O. Box 954, Jounieh, Lebanon; email:
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Pathology and Laboratory Medicine;
dc.contributor.authorDepartment Pathology and Laboratory Medicine
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Khalil, G
dc.contributor.authorInitials Haddad, C
dc.contributor.authorInitials Otrock, ZK
dc.contributor.authorInitials Jaber, F
dc.contributor.authorInitials Farra, A
dc.contributor.authorReprintAddress Khalil, G (reprint author), Hop St Joseph, Ctr Med Raymond and Aida Najjar Beirut, Dept Internal Med, Div Infect Dis, POB 954, Jounieh, Lebanon.
dc.contributor.authorUniversity American University of Beirut Medical Center
dc.description.cited Andrews SJ, 1999, FASCIOLOSIS, P1; Brumpt E., 1936, PRECIS PARASITOLOGIE, P572; Camara L, 1996, VET RES, V27, P87; DRABICK JJ, 1987, REV INFECT DIS, V9, P1087; Dreyfuss G, 2005, PARASITOL RES, V95, P278, DOI 10.1007-s00436-004-1269-3; DUCOMMUN D, 1991, PARASITOL RES, V77, P364, DOI 10.1007-BF00930918; Golvan Y.J., 1990, NOUVELLES TECHNIQUES, P98; KHALIL GM, 1965, AM J TROP MED HYG, V14, P736; Khoury A., 1905, ARCH PARASITOLOGIE, V9, P78; Koehsler M, 2011, EMERG INFECT DIS, V17, P870, DOI 10.3201-eid1705.100790; LE CORROLLER Y., 1959, BULL SOC PATHOL EXOT, V52, P730; Maleky F, 2001, Indian J Med Sci, V55, P439; Manet L., 1971, COLLECTION FLAMMARIO, P60; Manga-Gonzalez MY, 2001, PARASITOLOGY, V123, pS91, DOI 10.1017-S0031182001008204; Mas-Coma S., 1997, Research and Reviews in Parasitology, V57, P145; Morsy Tosson A., 1999, Journal of the Egyptian Society of Parasitology, V29, P787; Otranto D, 2003, TRENDS PARASITOL, V19, P12, DOI 10.1016-S1471-4922(02)00009-0; PAPADAKIS A. M., 1958, TRANS ROY SOC TROP MED AND HYG, V52, P454, DOI 10.1016-0035-9203(58)90132-9; SCHACHER JF, 1969, T ROY SOC TROP MED H, V63, P854, DOI 10.1016-0035-9203(69)90131-X; SCHACHER JF, 1965, J TROP MED HYG, V68, P226; Siavashi MR, 2002, IRANIAN J MED SCI, V27, P191; Unat E.K., 1999, CERRAHPASA J MED, V30, P45; Watson J. M., 1956, Journal of Tropical Medicine and Hygiene, V59, P147; Witenberg G, 1944, ACTA MED ORIENT, V3, P191; Yagi H, 1996, ACTA TROP, V62, P127, DOI 10.1016-S0001-706X(96)00017-4
dc.description.citedTotWOSCount 0
dc.description.citedWOSCount 0
dc.format.extentCount 4
dc.identifier.coden ACTRA
dc.identifier.pubmedID 23022355
dc.identifier.scopusID 84868698993
dc.publisher.address PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
dc.relation.ispartOfISOAbbr Acta Trop.
dc.relation.ispartOfIssue 1
dc.relation.ispartofPubTitle Acta Tropica
dc.relation.ispartofPubTitleAbbr Acta Trop.
dc.relation.ispartOfVolume 125
dc.source.ID WOS:000312417200017
dc.type.publication Journal
dc.subject.otherAuthKeyword Dicrocoelium dendriticum
dc.subject.otherAuthKeyword Fasciola hepatica
dc.subject.otherAuthKeyword Food-borne parasites
dc.subject.otherAuthKeyword Halzoun
dc.subject.otherAuthKeyword Pharyngitis
dc.subject.otherAuthKeyword Trematodiases
dc.subject.otherChemCAS methylprednisolone, 6923-42-8, 83-43-2
dc.subject.otherIndex methylprednisolone
dc.subject.otherIndex disease
dc.subject.otherIndex flatworm
dc.subject.otherIndex food intake
dc.subject.otherIndex health risk
dc.subject.otherIndex infectious disease
dc.subject.otherIndex parasite
dc.subject.otherIndex pathogen
dc.subject.otherIndex adolescent
dc.subject.otherIndex adult
dc.subject.otherIndex allergic pharyngitis
dc.subject.otherIndex article
dc.subject.otherIndex clinical article
dc.subject.otherIndex Dicrocoelium
dc.subject.otherIndex dicrocoelium dendriticum
dc.subject.otherIndex emergency ward
dc.subject.otherIndex Fasciola hepatica
dc.subject.otherIndex female
dc.subject.otherIndex food contamination
dc.subject.otherIndex human
dc.subject.otherIndex Lebanon
dc.subject.otherIndex Linguatula
dc.subject.otherIndex liver
dc.subject.otherIndex male
dc.subject.otherIndex nonhuman
dc.subject.otherIndex parasite identification
dc.subject.otherIndex parasite isolation
dc.subject.otherIndex pathogenesis
dc.subject.otherIndex pentastomiasis
dc.subject.otherIndex pharyngitis
dc.subject.otherIndex respiratory tract allergy
dc.subject.otherIndex sheep
dc.subject.otherIndex sputum
dc.subject.otherIndex Adolescent
dc.subject.otherIndex Adult
dc.subject.otherIndex Animals
dc.subject.otherIndex Dicrocoeliasis
dc.subject.otherIndex Dicrocoelium
dc.subject.otherIndex Female
dc.subject.otherIndex Food Microbiology
dc.subject.otherIndex Foodborne Diseases
dc.subject.otherIndex Humans
dc.subject.otherIndex Hypersensitivity
dc.subject.otherIndex Lebanon
dc.subject.otherIndex Liver
dc.subject.otherIndex Male
dc.subject.otherIndex Microscopy
dc.subject.otherIndex Middle Aged
dc.subject.otherIndex Pharyngitis
dc.subject.otherIndex Young Adult
dc.subject.otherIndex Lebanon
dc.subject.otherIndex Capra hircus
dc.subject.otherIndex Dicrocoelium dendriticum
dc.subject.otherIndex Fasciola hepatica
dc.subject.otherIndex Ovis
dc.subject.otherIndex Ovis aries
dc.subject.otherIndex Trematoda
dc.subject.otherKeywordPlus LINGUATULA-SERRATA
dc.subject.otherKeywordPlus FASCIOLA-HEPATICA
dc.subject.otherKeywordPlus MARRARA-SYNDROME
dc.subject.otherKeywordPlus NYMPHS
dc.subject.otherWOS Parasitology
dc.subject.otherWOS Tropical Medicine

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