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Glomerular hyperfiltration and proteinuria in transfusion-independent patients with β-thalassemia intermedia

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dc.contributor.author Ziyadeh F.N.
dc.contributor.author Musallam K.M.
dc.contributor.author Mallat N.S.
dc.contributor.author Mallat S.
dc.contributor.author Jaber F.
dc.contributor.author Mohamed A.A.
dc.contributor.author Koussa S.
dc.contributor.author Taher A.T.
dc.contributor.editor
dc.date Feb-2013
dc.date.accessioned 2017-10-05T15:59:36Z
dc.date.available 2017-10-05T15:59:36Z
dc.date.issued 2013
dc.identifier 10.1159/000339787
dc.identifier.isbn
dc.identifier.issn 16602110
dc.identifier.uri http://hdl.handle.net/10938/19105
dc.description.abstract Background-Aims: Renal manifestations have been described in β-thalassemia major and were attributed to transfusional iron overload and chelation therapy. Patients with the milder phenotype, β-thalassemia intermedia (TI), remain largely transfusion and iron chelation independent while enduring a chronic hemolytic anemia and primary iron overload. Data on renal function in patients with TI is lacking. Methods: In this cross-sectional study of 50 TI patients, we evaluated the association of estimated glomerular filtration rate (eGFR) and urinary protein to creatinine (UPr-UCr) ratio with relevant patient, disease and laboratory indices. Results: The median age of patients was 28 years (44percent males). The eGFR was andgt;90 ml-min-1.73 m2 in all patients, with a median value of 142.3 ml-min-1.73 m2. The median UPr-UCr ratio was 213.2 mg-g. There was a negative correlation between age and eGFR, while the UPr-UCr ratio correlated positively with markers of anemia, hemolysis and iron overload. A total of 24 (48percent) patients had evidence of glomerular hyperfiltration, while 7 (14percent) had proteinuria (UPr-UCr ratio andgt;500 mg-g). Patients with proteinuria were characterized by elevated liver iron concentration (andgt;7 mg Fe-g dry weight), non-transferrin-bound iron levels and nucleated red blood cell counts. Conclusions: A considerable proportion of TI patients show evidence of abnormally elevated eGFR, with a declining trend towards advancing age. The occurrence of proteinuria is associated with anemia, hemolysis and iron toxicity. © 2012 S. Karger AG, Basel.
dc.format.extent
dc.language English
dc.publisher BASEL
dc.relation.ispartof Publication Name: Nephron - Clinical Practice; Publication Year: 2013; Volume: 121; no. 41702;
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Glomerular hyperfiltration and proteinuria in transfusion-independent patients with β-thalassemia intermedia
dc.type Article
dc.contributor.affiliation Ziyadeh, F.N., Department of Internal Medicine, American University of Beirut Medical Center, PO Box 11-0236, Riad El-Solh 1107 2020, Beirut, Lebanon
dc.contributor.affiliation Musallam, K.M., Department of Medicine and Medical Specialties, IRCCS Ca' Granda Foundation Maggiore Policlinico Hospital, Milan, Italy
dc.contributor.affiliation Mallat, N.S., Department of Internal Medicine, American University of Beirut Medical Center, PO Box 11-0236, Riad El-Solh 1107 2020, Beirut, Lebanon
dc.contributor.affiliation Mallat, S., Department of Internal Medicine, American University of Beirut Medical Center, PO Box 11-0236, Riad El-Solh 1107 2020, Beirut, Lebanon
dc.contributor.affiliation Jaber, F., Department of Pathology and Laboratory Medicine, American University of Beirut, Beirut, Lebanon
dc.contributor.affiliation Mohamed, A.A., Department of Internal Medicine, American University of Beirut Medical Center, PO Box 11-0236, Riad El-Solh 1107 2020, Beirut, Lebanon
dc.contributor.affiliation Koussa, S., Chronic Care Center, Hazmieh, Lebanon
dc.contributor.affiliation Taher, A.T., Department of Internal Medicine, American University of Beirut Medical Center, PO Box 11-0236, Riad El-Solh 1107 2020, Beirut, Lebanon, Chronic Care Center, Hazmieh, Lebanon
dc.contributor.authorAddress Ziyadeh, F.N.; Department of Internal Medicine, American University of Beirut Medical Center, PO Box 11-0236, Riad El-Solh 1107 2020, Beirut, Lebanon
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Pathology and Laboratory Medicine;
dc.contributor.authorDepartment Pathology and Laboratory Medicine
dc.contributor.authorDivision
dc.contributor.authorEmail ataher@aub.edu.lb
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Ziyadeh, FN
dc.contributor.authorInitials Musallam, KM
dc.contributor.authorInitials Mallat, NS
dc.contributor.authorInitials Mallat, S
dc.contributor.authorInitials Jaber, F
dc.contributor.authorInitials Mohamed, AA
dc.contributor.authorInitials Koussa, S
dc.contributor.authorInitials Taher, AT
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Taher, AT (reprint author), Amer Univ Beirut, Med Ctr, Dept Internal Med, POB 11-0236, Beirut 11072020, Lebanon.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedCount 4
dc.description.citedTotWOSCount 4
dc.description.citedWOSCount 4
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dc.identifier.articleNo
dc.identifier.coden NCPEC
dc.identifier.pubmedID 23235469
dc.identifier.scopusID 84870729584
dc.identifier.url
dc.publisher.address ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
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dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr Nephron. Clin. Pract.
dc.relation.ispartOfIssue 41702
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Nephron - Clinical Practice
dc.relation.ispartofPubTitleAbbr Nephron Clin. Pract.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 121
dc.source.ID WOS:000314239100007
dc.type.publication Journal
dc.subject.otherAuthKeyword Anemia
dc.subject.otherAuthKeyword Glomerular filtration rate
dc.subject.otherAuthKeyword Iron overload
dc.subject.otherAuthKeyword Proteinuria
dc.subject.otherAuthKeyword Thalassemia
dc.subject.otherAuthKeyword Tubule cells
dc.subject.otherChemCAS creatinine, 19230-81-0, 60-27-5
dc.subject.otherChemCAS iron, 14093-02-8, 53858-86-9, 7439-89-6
dc.subject.otherChemCAS protein, 67254-75-5
dc.subject.otherIndex creatinine
dc.subject.otherIndex iron
dc.subject.otherIndex protein
dc.subject.otherIndex adolescent
dc.subject.otherIndex adult
dc.subject.otherIndex anemia
dc.subject.otherIndex article
dc.subject.otherIndex beta thalassemia
dc.subject.otherIndex child
dc.subject.otherIndex clinical article
dc.subject.otherIndex comparative study
dc.subject.otherIndex creatinine blood level
dc.subject.otherIndex creatinine urine level
dc.subject.otherIndex cross-sectional study
dc.subject.otherIndex disease association
dc.subject.otherIndex erythrocyte count
dc.subject.otherIndex female
dc.subject.otherIndex glomerulus filtration
dc.subject.otherIndex glomerulus filtration rate
dc.subject.otherIndex hemolysis
dc.subject.otherIndex human
dc.subject.otherIndex iron overload
dc.subject.otherIndex male
dc.subject.otherIndex preschool child
dc.subject.otherIndex priority journal
dc.subject.otherIndex proteinuria
dc.subject.otherIndex school child
dc.subject.otherIndex Adolescent
dc.subject.otherIndex Adult
dc.subject.otherIndex beta-Thalassemia
dc.subject.otherIndex Comorbidity
dc.subject.otherIndex Cross-Sectional Studies
dc.subject.otherIndex Female
dc.subject.otherIndex Glomerular Filtration Rate
dc.subject.otherIndex Humans
dc.subject.otherIndex Iron Overload
dc.subject.otherIndex Kidney Diseases
dc.subject.otherIndex Lebanon
dc.subject.otherIndex Male
dc.subject.otherIndex Middle Aged
dc.subject.otherIndex Prevalence
dc.subject.otherIndex Proteinuria
dc.subject.otherIndex Risk Assessment
dc.subject.otherIndex Young Adult
dc.subject.otherKeywordPlus RENAL TUBULAR FUNCTION
dc.subject.otherKeywordPlus SICKLE-CELL-DISEASE
dc.subject.otherKeywordPlus MAGNETIC-RESONANCE
dc.subject.otherKeywordPlus IRON OVERLOAD
dc.subject.otherKeywordPlus LIPID-PEROXIDATION
dc.subject.otherKeywordPlus OXIDATIVE STRESS
dc.subject.otherKeywordPlus BOUND IRON
dc.subject.otherKeywordPlus ANEMIA
dc.subject.otherKeywordPlus FAILURE
dc.subject.otherKeywordPlus INJURY
dc.subject.otherWOS Urology and Nephrology


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