AUB ScholarWorks

Split daily recombinant human LH dose in hypogonadotrophic hypogonadism: A nonrandomized controlled pilot study

Show simple item record

dc.contributor.author Awwad J.T.
dc.contributor.author Farra C.
dc.contributor.author Mitri F.
dc.contributor.author Abdallah M.A.
dc.contributor.author Jaoudeh M.A.
dc.contributor.author Ghazeeri G.
dc.contributor.editor
dc.date Jan-2013
dc.date.accessioned 2017-10-05T15:59:36Z
dc.date.available 2017-10-05T15:59:36Z
dc.date.issued 2013
dc.identifier 10.1016/j.rbmo.2012.09.016
dc.identifier.isbn
dc.identifier.issn 14726483
dc.identifier.uri http://hdl.handle.net/10938/19106
dc.description.abstract This prospective controlled nonrandomized pilot study was conducted to investigate whether split daily doses of recombinant human LH (rHLH) is more efficacious than the single daily dose in supporting follicular development and ovulation in primary hypogonadotrophic hypogonadism (HH). Twenty-seven women with HH received a 150 IU fixed daily subcutaneous dose of recombinant human FSH, supplemented by 75 IU daily dose of rHLH given either as a single dose (n = 9; single-dose group) or four equally divided doses (n = 18; split-dose group). Ovulation was defined by three efficacy end points: at least one follicle 17 mm in diameter, pre-ovulatory serum oestradiol ≥400 pmol-l and a midluteal progesterone ≥25 nmol-l. Although lacking statistical significance, the proportion of women in the rHLH split-dose group who fulfilled all three end points was higher than the single-dose group (72.2percent versus 55.6percent). Women in the split-dose group achieved higher serum oestradiol concentrations per follicle, endometrial thickness measurements and numbers of follicles than in the single-dose group (not statistically significant). The odds ratio for ovulation rate was 2.08 (not statistically significant). There were no serious untoward side effects. Administering rHLH in split daily doses could provide superior results compared with the traditional single daily dose. © 2012, Reproductive Healthcare Ltd.
dc.format.extent
dc.format.extent Pages: (88-92)
dc.language English
dc.publisher OXFORD
dc.relation.ispartof Publication Name: Reproductive BioMedicine Online; Publication Year: 2013; Volume: 26; no. 1; Pages: (88-92);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Split daily recombinant human LH dose in hypogonadotrophic hypogonadism: A nonrandomized controlled pilot study
dc.type Article
dc.contributor.affiliation Awwad, J.T., Department of Obstetrics and Gynecology, American University of Beirut, Medical Center, Beirut, Lebanon
dc.contributor.affiliation Farra, C., Department of Pathology, American University of Beirut, Medical Center, Beirut, Lebanon
dc.contributor.affiliation Mitri, F., Department of Obstetrics and Gynecology, American University of Beirut, Medical Center, Beirut, Lebanon, Department of Pathology, American University of Beirut, Medical Center, Beirut, Lebanon
dc.contributor.affiliation Abdallah, M.A., Department of Obstetrics and Gynecology, American University of Beirut, Medical Center, Beirut, Lebanon
dc.contributor.affiliation Jaoudeh, M.A., Department of Pathology, American University of Beirut, Medical Center, Beirut, Lebanon, Division of Endocrinology, Rizk Hospital, Beirut, Lebanon
dc.contributor.affiliation Ghazeeri, G., Department of Obstetrics and Gynecology, American University of Beirut, Medical Center, Beirut, Lebanon
dc.contributor.authorAddress Ghazeeri, G.; Department of Obstetrics and Gynecology, American University of Beirut, Medical Center, Beirut, Lebanon; email: gg02@aub.edu.lb
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Pathology and Laboratory Medicine;
dc.contributor.authorDepartment Pathology and Laboratory Medicine
dc.contributor.authorDivision
dc.contributor.authorEmail gg02@aub.edu.lb
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Awwad, JT
dc.contributor.authorInitials Farra, C
dc.contributor.authorInitials Mitri, F
dc.contributor.authorInitials Abou Abdallah, M
dc.contributor.authorInitials Abou Jaoudeh, M
dc.contributor.authorInitials Ghazeeri, G
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Ghazeeri, G (reprint author), Amer Univ Beirut, Med Ctr, Dept Obstet and Gynecol, Beirut, Lebanon.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
dc.description.cited Balasch J, 2009, J CLIN ENDOCR METAB, V94, P2367, DOI 10.1210-jc.2009-0262; BALEN AH, 1994, HUM REPROD, V9, P1563; Burgues S, 2001, HUM REPROD, V16, P2525, DOI 10.1093-humrep-16.12.2525; DAYA S, 1995, FERTIL STERIL, V64, P347; De Leo V, 2012, CURR PHARM BIOTECHNO, V13, P379; European Recombinant Human LH Group S, 1998, J CLIN ENDOCR METAB, V83, P1507, DOI DOI 10.1210-JC.83.5.1507; Franco JG, 2009, REPROD BIOL ENDOCRIN, V7, DOI 10.1186-1477-7827-7-58; Gibreel Ahmed, 2010, Biologics, V4, P5; Gordon UD, 2001, FERTIL STERIL, V75, P324, DOI 10.1016-S0015-0282(00)01701-5; Howles CM, 2000, MOL CELL ENDOCRINOL, V161, P25, DOI 10.1016-S0303-7207(99)00219-1; Kaufmann R, 2007, CLIN ENDOCRINOL, V67, P563, DOI 10.1111-j.1365-2265.2007.02925.x; Krause Bernd Th, 2009, Biologics, V3, P337; le Cotonnec JY, 1998, FERTIL STERIL, V69, P201, DOI 10.1016-S0015-0282(97)00503-7; MARTIN KA, 1993, J CLIN ENDOCR METAB, V77, P125, DOI 10.1210-jc.77.1.125; SCHOOT DC, 1994, HUM REPROD, V9, P1237; SHAPIRO H, 1993, FERTIL STERIL, V59, P1055; SHOHAM Z, 1991, FERTIL STERIL, V56, P1048; Shoham Z, 2008, CLIN ENDOCRINOL, V69, P471, DOI 10.1111-j.1365-2265.2008.03299.x; Tarlatzis B, 2006, HUM REPROD, V21, P90, DOI 10.1093-humrep-dei293; Weghofer A, 2008, HUM REPROD, V23, P499, DOI 10.1093-humrep-dem412
dc.description.citedCount 1
dc.description.citedTotWOSCount 1
dc.description.citedWOSCount 1
dc.format.extentCount 5
dc.identifier.articleNo
dc.identifier.coden RBOEA
dc.identifier.pubmedID 23177418
dc.identifier.scopusID 84874118421
dc.identifier.url
dc.publisher.address THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
dc.relation.ispartofConference
dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr Reprod. Biomed. Online
dc.relation.ispartOfIssue 1
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Reproductive BioMedicine Online
dc.relation.ispartofPubTitleAbbr Reprod. BioMed. Online
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 26
dc.source.ID WOS:000313562900013
dc.type.publication Journal
dc.subject.otherAuthKeyword Follicles
dc.subject.otherAuthKeyword Gonadotrophins
dc.subject.otherAuthKeyword Hypogonadotrophic hypogonadism
dc.subject.otherAuthKeyword Ovulation
dc.subject.otherAuthKeyword Recombinant human LH
dc.subject.otherAuthKeyword Split dose
dc.subject.otherChemCAS estradiol, 50-28-2
dc.subject.otherChemCAS progesterone, 57-83-0
dc.subject.otherChemCAS recombinant follitropin, 1219693-73-8
dc.subject.otherChemCAS Estradiol, 50-28-2
dc.subject.otherChemCAS Luteinizing Hormone, 9002-67-9
dc.subject.otherChemCAS Recombinant Proteins
dc.subject.otherIndex estradiol
dc.subject.otherIndex progesterone
dc.subject.otherIndex recombinant follitropin
dc.subject.otherIndex recombinant luteinizing hormone
dc.subject.otherIndex adult
dc.subject.otherIndex article
dc.subject.otherIndex clinical article
dc.subject.otherIndex controlled clinical trial
dc.subject.otherIndex controlled study
dc.subject.otherIndex drug efficacy
dc.subject.otherIndex drug mechanism
dc.subject.otherIndex endometrial thickness
dc.subject.otherIndex estradiol blood level
dc.subject.otherIndex female
dc.subject.otherIndex human
dc.subject.otherIndex hypogonadotropic hypogonadism
dc.subject.otherIndex ovary follicle development
dc.subject.otherIndex ovary hyperstimulation
dc.subject.otherIndex ovulation
dc.subject.otherIndex progesterone blood level
dc.subject.otherIndex single drug dose
dc.subject.otherIndex treatment outcome
dc.subject.otherIndex Adolescent
dc.subject.otherIndex Adult
dc.subject.otherIndex Endometrium
dc.subject.otherIndex Estradiol
dc.subject.otherIndex Female
dc.subject.otherIndex Humans
dc.subject.otherIndex Hypogonadism
dc.subject.otherIndex Injections, Subcutaneous
dc.subject.otherIndex Luteinizing Hormone
dc.subject.otherIndex Odds Ratio
dc.subject.otherIndex Ovarian Follicle
dc.subject.otherIndex Ovulation
dc.subject.otherIndex Pilot Projects
dc.subject.otherIndex Prospective Studies
dc.subject.otherIndex Recombinant Proteins
dc.subject.otherKeywordPlus FOLLICLE-STIMULATING-HORMONE
dc.subject.otherKeywordPlus HUMAN MENOPAUSAL GONADOTROPIN
dc.subject.otherKeywordPlus HUMAN LUTEINIZING-HORMONE
dc.subject.otherKeywordPlus LUTROPIN-ALPHA
dc.subject.otherKeywordPlus OVULATION INDUCTION
dc.subject.otherKeywordPlus DEFICIENT WOMEN
dc.subject.otherKeywordPlus DOUBLE-BLIND
dc.subject.otherKeywordPlus FSH
dc.subject.otherKeywordPlus EFFICACY
dc.subject.otherKeywordPlus SAFETY
dc.subject.otherWOS Obstetrics and Gynecology
dc.subject.otherWOS Reproductive Biology


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search AUB ScholarWorks


Browse

My Account