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Is Helicobacter pylori really present in the adenoids of children?

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dc.contributor.author Bitar M.A.
dc.contributor.author Soweid A.
dc.contributor.author Mahfouz R.
dc.contributor.author Zaatari G.
dc.contributor.author Fuleihan N.
dc.contributor.editor
dc.date Dec-2005
dc.date.accessioned 2017-10-05T15:59:37Z
dc.date.available 2017-10-05T15:59:37Z
dc.date.issued 2005
dc.identifier 10.1007/s00405-005-0926-1
dc.identifier.isbn
dc.identifier.issn 09374477
dc.identifier.uri http://hdl.handle.net/10938/19122
dc.description.abstract Adenoid hyperplasia is a common cause of nasal obstruction in the pediatric age group. Recently, the adenoids were shown to harbor Helicobacter pylori (HP) based only on the rapid urease test (RUT). We conducted this pilot study to identify the presence of HP in the adenoids histologically and assess the reliability of both the RUT and histology in detecting HP in an extragastric location, using nested (two-steps) polymerase chain reaction (nPCR). Consecutive patients undergoing adenoidectomy for obstructive adenoid hyperplasia were enrolled. Adenoid specimens were subjected to the RUT. Histological sections stained with hematoxylin and eosin, Giemsa and Warthin-Starry were examined. We then used nPCR to detect the presence of HP in the studied specimens. Twenty-five patients (3-10 years; mean of 5.5 years) were enrolled. Twenty-one (84percent) adenoids were positive by the RUT. Seventeen (68percent) had bacteria on histological sections; four (16percent) contained HP-like organisms. However, all specimens were negative by nPCR. No patient had a history of symptoms suggestive of laryngopharyngeal reflux within 6 months of the study. In conclusion, the children enrolled in this study did not have HP in their adenoids. High false positive results can occur with the RUT when used on adenoid tissues. It is not possible to rely solely on morphology to detect HP in an extragastric location. The nPCR remains the best way to identify HP accurately, but does not imply its presence in an active role. © Springer-Verlag 2005.
dc.format.extent
dc.format.extent Pages: (987-992)
dc.language English
dc.publisher NEW YORK
dc.relation.ispartof Publication Name: European Archives of Oto-Rhino-Laryngology; Publication Year: 2005; Volume: 262; no. 12; Pages: (987-992);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Is Helicobacter pylori really present in the adenoids of children?
dc.type Article
dc.contributor.affiliation Bitar, M.A., Department of Otolaryngology and Head and Neck Surgery, American University, Beirut Medical Center, P.O. Box: 11-0236-A52, 1107-2020 Beirut, Lebanon
dc.contributor.affiliation Soweid, A., Department of Internal Medicine, American University, Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Mahfouz, R., Department of Pathology and Laboratory Medicine, American University, Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Zaatari, G., Department of Pathology and Laboratory Medicine, American University, Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Fuleihan, N., Department of Otolaryngology and Head and Neck Surgery, American University, Beirut Medical Center, Beirut, Lebanon
dc.contributor.authorAddress Bitar, M.A.; Department of Otolaryngology and Head and Neck Surgery, American University, Beirut Medical Center, P.O. Box: 11-0236-A52, 1107-2020 Beirut, Lebanon; email: mb36@aub.edu.lb
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Pathology and Laboratory Medicine;
dc.contributor.authorDepartment Pathology and Laboratory Medicine
dc.contributor.authorDivision
dc.contributor.authorEmail mb36@aub.edu.lb
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Bitar, MA
dc.contributor.authorInitials Soweid, A
dc.contributor.authorInitials Mahfouz, R
dc.contributor.authorInitials Zaatari, G
dc.contributor.authorInitials Fuleihan, N
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Bitar, MA (reprint author), Amer Univ Beirut, Med Ctr, Dept Otolaryngol Head and Neck Surg, POB 11-0236-A52, Beirut 11072020, Lebanon.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
dc.description.cited Berloco P, 2001, EUR J CLIN MICROBIOL, V20, P68, DOI 10.1007-s10096-001-8048-1; BRODSKY L, 1993, ARCH OTOLARYNGOL, V119, P821; Bulajic M, 2002, WORLD J GASTROENTERO, V8, P301; di Bonaventura G, 2001, J INFECTION, V42, P221, DOI 10.1053-jinf.2001.0815; Di Bonaventura G, 2000, New Microbiol, V23, P445; Ishihara K, 1997, FEMS MICROBIOL LETT, V152, P355, DOI 10.1016-S0378-1097(97)00227-9; Leung WK, 1999, AM J GASTROENTEROL, V94, P2881; MACKOWIAK PA, 1982, NEW ENGL J MED, V307, P83, DOI 10.1056-NEJM198207083070203; Skinner LJ, 2001, CLIN OTOLARYNGOL, V26, P505, DOI 10.1046-j.1365-2273.2001.00513.x; TORREY JC, 1945, AM J DIS CHILD, V69, P208; Unver S, 2001, LARYNGOSCOPE, V111, P2183, DOI 10.1097-00005537-200112000-00021; Yilmaz M, 2004, INT J PEDIATR OTORHI, V68, P307, DOI 10.1016-j.ijporl.2003.10.016; Young KA, 2000, J MED MICROBIOL, V49, P343
dc.description.citedCount 16
dc.description.citedTotWOSCount 13
dc.description.citedWOSCount 13
dc.format.extentCount 6
dc.identifier.articleNo
dc.identifier.coden EAOTE
dc.identifier.pubmedID 15924276
dc.identifier.scopusID 29144524591
dc.identifier.url
dc.publisher.address 233 SPRING STREET, NEW YORK, NY 10013 USA
dc.relation.ispartofConference
dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr Eur. Arch. Oto-Rhino-Laryn.
dc.relation.ispartOfIssue 12
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle European Archives of Oto-Rhino-Laryngology
dc.relation.ispartofPubTitleAbbr Eur. Arch. Oto-Rhino-Laryngol.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 262
dc.source.ID WOS:000233995700010
dc.type.publication Journal
dc.subject.otherAuthKeyword Adenoids
dc.subject.otherAuthKeyword Helicobacter pylori
dc.subject.otherAuthKeyword Polymerase chain reaction
dc.subject.otherAuthKeyword Rapid urease test
dc.subject.otherChemCAS eosin, 17372-87-1, 51395-88-1, 548-26-5
dc.subject.otherChemCAS hematoxylin, 517-28-2
dc.subject.otherChemCAS Urease, EC 3.5.1.5
dc.subject.otherIndex eosin
dc.subject.otherIndex hematoxylin
dc.subject.otherIndex adenoid
dc.subject.otherIndex adenoidectomy
dc.subject.otherIndex article
dc.subject.otherIndex child
dc.subject.otherIndex Giemsa stain
dc.subject.otherIndex Helicobacter pylori
dc.subject.otherIndex histology
dc.subject.otherIndex human
dc.subject.otherIndex human tissue
dc.subject.otherIndex hyperplasia
dc.subject.otherIndex laryngopharyngeal reflux
dc.subject.otherIndex nonhuman
dc.subject.otherIndex pilot study
dc.subject.otherIndex polymerase chain reaction
dc.subject.otherIndex priority journal
dc.subject.otherIndex time series analysis
dc.subject.otherIndex Adenoidectomy
dc.subject.otherIndex Adenoids
dc.subject.otherIndex Child
dc.subject.otherIndex Child, Preschool
dc.subject.otherIndex Helicobacter Infections
dc.subject.otherIndex Helicobacter pylori
dc.subject.otherIndex Humans
dc.subject.otherIndex Pilot Projects
dc.subject.otherIndex Polymerase Chain Reaction
dc.subject.otherIndex Urease
dc.subject.otherKeywordPlus INFECTION
dc.subject.otherKeywordPlus TRANSMISSION
dc.subject.otherKeywordPlus RESERVOIR
dc.subject.otherKeywordPlus TONSILS
dc.subject.otherWOS Otorhinolaryngology


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