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ASPL-TFE3 translocation in vulvovaginal alveolar soft part sarcoma

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dc.contributor.author Jabbour M.N.
dc.contributor.author Seoud M.
dc.contributor.author Al-Ahmadie H.
dc.contributor.author Abdul-Karim F.W.
dc.contributor.author Zaatari G.S.
dc.contributor.editor
dc.date 2014
dc.date.accessioned 2017-10-05T15:59:39Z
dc.date.available 2017-10-05T15:59:39Z
dc.date.issued 2014
dc.identifier 10.1097/PGP.0b013e318290407c
dc.identifier.isbn
dc.identifier.issn 02771691
dc.identifier.uri http://hdl.handle.net/10938/19149
dc.description.abstract Alveolar soft part sarcoma of the vulvovaginal region is limited to only 8 reported vaginal cases and 1 vulvar case in the English literature. The histogenesis of the tumor remains intriguing with postulates favoring a myogenic versus nonmyogenic origin. A reciprocal translocation for ASPL-TFE3 gene fusion, frequently detected in ∼90percent of cases, combined with TFE3 protein immunoexpression are highly sensitive and specific methods for diagnostic confirmation. The current report describes a unique case of vulvovaginal alveolar soft part sarcoma showing the classic morphologic features with documentation of TFE3 protein expression and the ASPL-TFE3 gene rearrangement. Furthermore, a brief review of the literature of vulvar and vaginal alveolar soft part sarcoma cases with the various treatment modalities is outlined. © 2014 International Society of Gynecological Pathologists.
dc.format.extent
dc.format.extent Pages: (263-267)
dc.language English
dc.publisher Lippincott Williams and Wilkins; PHILADELPHIA
dc.relation.ispartof Publication Name: International Journal of Gynecological Pathology; Publication Year: 2014; Volume: 33; no. 3; Pages: (263-267);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title ASPL-TFE3 translocation in vulvovaginal alveolar soft part sarcoma
dc.type Article
dc.contributor.affiliation Jabbour, M.N., Departments of Pathology and Laboratory Medicine, American University of Beirut Medical Center, P.O. Box: 11-0236, Beirut 1107 2020, Lebanon
dc.contributor.affiliation Seoud, M., Departments of Obstetrics and Gynecology, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Al-Ahmadie, H., Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY, United States
dc.contributor.affiliation Abdul-Karim, F.W., Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH, United States
dc.contributor.affiliation Zaatari, G.S., Departments of Pathology and Laboratory Medicine, American University of Beirut Medical Center, P.O. Box: 11-0236, Beirut 1107 2020, Lebanon
dc.contributor.authorAddress Zaatari, G.S.; Departments of Pathology and Laboratory Medicine, American University of Beirut Medical Center, P.O. Box: 11-0236, Beirut 1107 2020, Lebanon; email: zaatari@aub.edu.lb
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Pathology and Laboratory Medicine;
dc.contributor.authorDepartment Pathology and Laboratory Medicine
dc.contributor.authorDivision
dc.contributor.authorEmail zaatari@aub.edu.lb
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Jabbour, MN
dc.contributor.authorInitials Seoud, M
dc.contributor.authorInitials Al-Ahmadie, H
dc.contributor.authorInitials Abdul-Karim, FW
dc.contributor.authorInitials Zaatari, GS
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Zaatari, GS (reprint author), Amer Univ Beirut Med Ctr, Dept Pathol and Lab Med, POB 11-0236, Beirut 11072020, Lebanon.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedCount
dc.description.citedTotWOSCount 1
dc.description.citedWOSCount 1
dc.format.extentCount 5
dc.identifier.articleNo
dc.identifier.coden IJGPD
dc.identifier.pubmedID
dc.identifier.scopusID 84898599018
dc.identifier.url
dc.publisher.address 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
dc.relation.ispartofConference
dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr Int. J. Gynecol. Pathol.
dc.relation.ispartOfIssue 3
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle International Journal of Gynecological Pathology
dc.relation.ispartofPubTitleAbbr Int. J. Gynecol. Pathol.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 33
dc.source.ID WOS:000334474200009
dc.type.publication Journal
dc.subject.otherAuthKeyword Alveolar soft part sarcoma
dc.subject.otherAuthKeyword ASPL-TFE3 gene fusion
dc.subject.otherAuthKeyword TFE3 protein
dc.subject.otherAuthKeyword Vagina
dc.subject.otherAuthKeyword Vulva
dc.subject.otherChemCAS
dc.subject.otherIndex membrane protein
dc.subject.otherIndex protein TFE3
dc.subject.otherIndex unclassified drug
dc.subject.otherIndex adult
dc.subject.otherIndex alveolar soft part sarcoma
dc.subject.otherIndex article
dc.subject.otherIndex ASPL TFE3 gene
dc.subject.otherIndex cancer radiotherapy
dc.subject.otherIndex case report
dc.subject.otherIndex cesarean section
dc.subject.otherIndex computer assisted tomography
dc.subject.otherIndex female
dc.subject.otherIndex fusion gene
dc.subject.otherIndex gene rearrangement
dc.subject.otherIndex gene translocation
dc.subject.otherIndex histopathology
dc.subject.otherIndex human
dc.subject.otherIndex human tissue
dc.subject.otherIndex immunohistochemistry
dc.subject.otherIndex local excision
dc.subject.otherIndex postoperative period
dc.subject.otherIndex priority journal
dc.subject.otherIndex protein expression
dc.subject.otherIndex third trimester pregnancy
dc.subject.otherIndex vulvovaginal alveolar soft part sarcoma
dc.subject.otherKeywordPlus FEMALE GENITAL-TRACT
dc.subject.otherKeywordPlus TFE3 GENE FUSIONS
dc.subject.otherKeywordPlus TUMORS
dc.subject.otherKeywordPlus IMMUNOHISTOCHEMISTRY
dc.subject.otherKeywordPlus IMMUNOREACTIVITY
dc.subject.otherKeywordPlus EXPRESSION
dc.subject.otherKeywordPlus STRATEGY
dc.subject.otherWOS Obstetrics and Gynecology
dc.subject.otherWOS Pathology


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