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ASPL-TFE3 translocation in vulvovaginal alveolar soft part sarcoma

Show simple item record Jabbour M.N. Seoud M. Al-Ahmadie H. Abdul-Karim F.W. Zaatari G.S.
dc.contributor.editor 2014 2017-10-05T15:59:39Z 2017-10-05T15:59:39Z 2014
dc.identifier 10.1097/PGP.0b013e318290407c
dc.identifier.issn 02771691
dc.description.abstract Alveolar soft part sarcoma of the vulvovaginal region is limited to only 8 reported vaginal cases and 1 vulvar case in the English literature. The histogenesis of the tumor remains intriguing with postulates favoring a myogenic versus nonmyogenic origin. A reciprocal translocation for ASPL-TFE3 gene fusion, frequently detected in ∼90percent of cases, combined with TFE3 protein immunoexpression are highly sensitive and specific methods for diagnostic confirmation. The current report describes a unique case of vulvovaginal alveolar soft part sarcoma showing the classic morphologic features with documentation of TFE3 protein expression and the ASPL-TFE3 gene rearrangement. Furthermore, a brief review of the literature of vulvar and vaginal alveolar soft part sarcoma cases with the various treatment modalities is outlined. © 2014 International Society of Gynecological Pathologists.
dc.format.extent Pages: (263-267)
dc.language English
dc.publisher Lippincott Williams and Wilkins; PHILADELPHIA
dc.relation.ispartof Publication Name: International Journal of Gynecological Pathology; Publication Year: 2014; Volume: 33; no. 3; Pages: (263-267);
dc.source Scopus
dc.title ASPL-TFE3 translocation in vulvovaginal alveolar soft part sarcoma
dc.type Article
dc.contributor.affiliation Jabbour, M.N., Departments of Pathology and Laboratory Medicine, American University of Beirut Medical Center, P.O. Box: 11-0236, Beirut 1107 2020, Lebanon
dc.contributor.affiliation Seoud, M., Departments of Obstetrics and Gynecology, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Al-Ahmadie, H., Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY, United States
dc.contributor.affiliation Abdul-Karim, F.W., Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH, United States
dc.contributor.affiliation Zaatari, G.S., Departments of Pathology and Laboratory Medicine, American University of Beirut Medical Center, P.O. Box: 11-0236, Beirut 1107 2020, Lebanon
dc.contributor.authorAddress Zaatari, G.S.; Departments of Pathology and Laboratory Medicine, American University of Beirut Medical Center, P.O. Box: 11-0236, Beirut 1107 2020, Lebanon; email:
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Pathology and Laboratory Medicine;
dc.contributor.authorDepartment Pathology and Laboratory Medicine
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Jabbour, MN
dc.contributor.authorInitials Seoud, M
dc.contributor.authorInitials Al-Ahmadie, H
dc.contributor.authorInitials Abdul-Karim, FW
dc.contributor.authorInitials Zaatari, GS
dc.contributor.authorReprintAddress Zaatari, GS (reprint author), Amer Univ Beirut Med Ctr, Dept Pathol and Lab Med, POB 11-0236, Beirut 11072020, Lebanon.
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedTotWOSCount 1
dc.description.citedWOSCount 1
dc.format.extentCount 5
dc.identifier.coden IJGPD
dc.identifier.scopusID 84898599018
dc.publisher.address 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
dc.relation.ispartOfISOAbbr Int. J. Gynecol. Pathol.
dc.relation.ispartOfIssue 3
dc.relation.ispartofPubTitle International Journal of Gynecological Pathology
dc.relation.ispartofPubTitleAbbr Int. J. Gynecol. Pathol.
dc.relation.ispartOfVolume 33
dc.source.ID WOS:000334474200009
dc.type.publication Journal
dc.subject.otherAuthKeyword Alveolar soft part sarcoma
dc.subject.otherAuthKeyword ASPL-TFE3 gene fusion
dc.subject.otherAuthKeyword TFE3 protein
dc.subject.otherAuthKeyword Vagina
dc.subject.otherAuthKeyword Vulva
dc.subject.otherIndex membrane protein
dc.subject.otherIndex protein TFE3
dc.subject.otherIndex unclassified drug
dc.subject.otherIndex adult
dc.subject.otherIndex alveolar soft part sarcoma
dc.subject.otherIndex article
dc.subject.otherIndex ASPL TFE3 gene
dc.subject.otherIndex cancer radiotherapy
dc.subject.otherIndex case report
dc.subject.otherIndex cesarean section
dc.subject.otherIndex computer assisted tomography
dc.subject.otherIndex female
dc.subject.otherIndex fusion gene
dc.subject.otherIndex gene rearrangement
dc.subject.otherIndex gene translocation
dc.subject.otherIndex histopathology
dc.subject.otherIndex human
dc.subject.otherIndex human tissue
dc.subject.otherIndex immunohistochemistry
dc.subject.otherIndex local excision
dc.subject.otherIndex postoperative period
dc.subject.otherIndex priority journal
dc.subject.otherIndex protein expression
dc.subject.otherIndex third trimester pregnancy
dc.subject.otherIndex vulvovaginal alveolar soft part sarcoma
dc.subject.otherKeywordPlus FEMALE GENITAL-TRACT
dc.subject.otherKeywordPlus TFE3 GENE FUSIONS
dc.subject.otherKeywordPlus TUMORS
dc.subject.otherKeywordPlus IMMUNOHISTOCHEMISTRY
dc.subject.otherKeywordPlus IMMUNOREACTIVITY
dc.subject.otherKeywordPlus EXPRESSION
dc.subject.otherKeywordPlus STRATEGY
dc.subject.otherWOS Obstetrics and Gynecology
dc.subject.otherWOS Pathology

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