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Estrogen receptor α is not a candidate gene for metabolic syndrome in Caucasian elderly subjects

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dc.contributor.author Hoteit M.
dc.contributor.author Arabi A.
dc.contributor.author Habib R.
dc.contributor.author Mahfouz R.
dc.contributor.author Baddoura R.
dc.contributor.author Halaby G.
dc.contributor.author El-Hajj Fuleihan G.
dc.contributor.editor
dc.date Jan-2014
dc.date.accessioned 2017-10-05T15:59:40Z
dc.date.available 2017-10-05T15:59:40Z
dc.date.issued 2014
dc.identifier 10.1016/j.metabol.2013.08.004
dc.identifier.isbn
dc.identifier.issn 00260495
dc.identifier.uri http://hdl.handle.net/10938/19163
dc.description.abstract Objective Variants of estrogen receptor α (ERα) have been associated with obesity, dyslipidemia, diabetes and blood pressure. The Middle East registers some of the highest rate of metabolic syndrome worldwide. The aim of this study is to investigate the relationship between metabolic syndrome, a clustered combination of these metabolic factors, and polymorphisms PvuII and XbaI of ERα in Lebanese Caucasian elderly overweight subjects. Material-Methods 250 Caucasian Lebanese unrelated elderly men and women, median age 71 years, were studied. ERα intronic polymorphisms variants, PvuII and XbaI diplotypes and genotypes, were examined. Associations with metabolic syndrome, defined by the American Heart Association-National Heart, Lung, and Blood Institute (AHA-NHLBI), and its components, namely high density lipoprotein (HDL), fasting glucose levels, blood pressure, and waist circumference were evaluated in regression models. Results ER α diplotypes and genotypes distributions were similar between participants with and without metabolic syndrome, in the overall group of subjects, and by gender. No consistent associations between the diplotypes and genotypes tested and metabolic syndrome, or its components, could be detected. Conclusions Genetic variants in ERα were not associated with metabolic syndrome or its components, in a group of 250 Lebanese Caucasian elderly participants, a group with a high prevalence of metabolic syndrome. © 2014 Elsevier Inc.
dc.format.extent
dc.format.extent Pages: (50-60)
dc.language English
dc.relation.ispartof Publication Name: Metabolism: Clinical and Experimental; Publication Year: 2014; Volume: 63; no. 1; Pages: (50-60);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Estrogen receptor α is not a candidate gene for metabolic syndrome in Caucasian elderly subjects
dc.type Article
dc.contributor.affiliation Hoteit, M., Calcium Metabolism and Osteoporosis Program, WHO Collaborating Center for Metabolic Bone Disorders, American University of Beirut Medical Center, P.O. Box: 113-6044-C8, Beirut, Lebanon
dc.contributor.affiliation Arabi, A., Calcium Metabolism and Osteoporosis Program, WHO Collaborating Center for Metabolic Bone Disorders, American University of Beirut Medical Center, P.O. Box: 113-6044-C8, Beirut, Lebanon
dc.contributor.affiliation Habib, R., Outcomes Research Unit, Clinical Research Institute, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Mahfouz, R., Department of Pathology and Laboratory Medicine, Faculty of Medicine, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Baddoura, R., Division of Rheumatology, Saint Joseph University, Beirut, Lebanon, Department of Endocrinology, Saint Joseph University, Beirut, Lebanon
dc.contributor.affiliation Halaby, G., Division of Rheumatology, Saint Joseph University, Beirut, Lebanon, Department of Endocrinology, Saint Joseph University, Beirut, Lebanon
dc.contributor.affiliation El-Hajj Fuleihan, G., Calcium Metabolism and Osteoporosis Program, WHO Collaborating Center for Metabolic Bone Disorders, American University of Beirut Medical Center, P.O. Box: 113-6044-C8, Beirut, Lebanon
dc.contributor.authorAddress El-Hajj Fuleihan, G.; Calcium Metabolism and Osteoporosis Program, WHO Collaborating Center for Metabolic Bone Disorders, American University of Beirut Medical Center, P.O. Box: 113-6044-C8, Beirut, Lebanon; email: gf01@aub.edu.lb
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Pathology and Laboratory Medicine;
dc.contributor.authorDepartment Pathology and Laboratory Medicine
dc.contributor.authorDivision
dc.contributor.authorEmail
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials empty
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
dc.description.cited
dc.description.citedCount
dc.description.citedTotWOSCount
dc.description.citedWOSCount
dc.format.extentCount 11
dc.identifier.articleNo
dc.identifier.coden METAA
dc.identifier.pubmedID 24140101
dc.identifier.scopusID 84890126140
dc.identifier.url
dc.publisher.address
dc.relation.ispartofConference
dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr
dc.relation.ispartOfIssue 1
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Metabolism: Clinical and Experimental
dc.relation.ispartofPubTitleAbbr Metab. Clin. Exp.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 63
dc.source.ID
dc.type.publication Journal
dc.subject.otherAuthKeyword Components
dc.subject.otherAuthKeyword Diplotypes
dc.subject.otherAuthKeyword Estrogen Receptor α
dc.subject.otherAuthKeyword Genotypes
dc.subject.otherAuthKeyword Metabolic syndrome
dc.subject.otherChemCAS glucose, 50-99-7, 84778-64-3
dc.subject.otherChemCAS Biological Markers
dc.subject.otherChemCAS Estrogen Receptor alpha
dc.subject.otherIndex estrogen receptor alpha
dc.subject.otherIndex glucose
dc.subject.otherIndex high density lipoprotein
dc.subject.otherIndex triacylglycerol
dc.subject.otherIndex aged
dc.subject.otherIndex article
dc.subject.otherIndex blood pressure
dc.subject.otherIndex Caucasian
dc.subject.otherIndex DNA polymorphism
dc.subject.otherIndex female
dc.subject.otherIndex gene frequency
dc.subject.otherIndex genetic association
dc.subject.otherIndex genetic variability
dc.subject.otherIndex genotype
dc.subject.otherIndex geriatric patient
dc.subject.otherIndex glucose blood level
dc.subject.otherIndex hip circumference
dc.subject.otherIndex human
dc.subject.otherIndex hyperglycemia
dc.subject.otherIndex hypertriglyceridemia
dc.subject.otherIndex major clinical study
dc.subject.otherIndex male
dc.subject.otherIndex metabolic syndrome X
dc.subject.otherIndex priority journal
dc.subject.otherIndex triacylglycerol blood level
dc.subject.otherIndex waist circumference
dc.subject.otherIndex AHA-NHLBI
dc.subject.otherIndex Analysis of Variance
dc.subject.otherIndex ANOVA
dc.subject.otherIndex base pair (bp)
dc.subject.otherIndex BMI
dc.subject.otherIndex Body Mass Index
dc.subject.otherIndex Bp
dc.subject.otherIndex Components
dc.subject.otherIndex CS(MS)
dc.subject.otherIndex Cumulative metabolic syndrome components count
dc.subject.otherIndex Deoxyribonucleic acid
dc.subject.otherIndex Diplotypes
dc.subject.otherIndex DNA
dc.subject.otherIndex ER α
dc.subject.otherIndex Estrogen Receptor α
dc.subject.otherIndex Estrogen Receptor alpha
dc.subject.otherIndex Genotypes
dc.subject.otherIndex HDL
dc.subject.otherIndex High density lipoprotein
dc.subject.otherIndex MENA
dc.subject.otherIndex Metabolic syndrome
dc.subject.otherIndex Middle East and North Africa
dc.subject.otherIndex National Health and Nutrition Examination Survey
dc.subject.otherIndex NHANES
dc.subject.otherIndex Odd ratio [95percent Confidence Interval]
dc.subject.otherIndex OR [95percent CI]
dc.subject.otherIndex PCR
dc.subject.otherIndex Polymerase chain reaction
dc.subject.otherIndex Restriction fragment length polymorphism
dc.subject.otherIndex RFLP
dc.subject.otherIndex The American Heart Association-National Heart, Lung, and Blood Institute
dc.subject.otherIndex Aged
dc.subject.otherIndex Aged, 80 and over
dc.subject.otherIndex Biological Markers
dc.subject.otherIndex Estrogen Receptor alpha
dc.subject.otherIndex European Continental Ancestry Group
dc.subject.otherIndex Female
dc.subject.otherIndex Genotype
dc.subject.otherIndex Humans
dc.subject.otherIndex Lebanon
dc.subject.otherIndex Logistic Models
dc.subject.otherIndex Male
dc.subject.otherIndex Metabolic Syndrome X
dc.subject.otherIndex Obesity
dc.subject.otherIndex Overweight
dc.subject.otherIndex Polymerase Chain Reaction
dc.subject.otherIndex Polymorphism, Single Nucleotide
dc.subject.otherKeywordPlus
dc.subject.otherWOS


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