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Nationwide study of drug resistance among acid-fast bacilli positive pulmonary tuberculosis cases in Lebanon

Show simple item record Araj G.F. Saade M. Itani L.Y.
dc.contributor.editor Jan-2006 2017-10-05T15:59:42Z 2017-10-05T15:59:42Z 2006
dc.identifier.issn 10273719
dc.description.abstract OBJECTIVE: To assess the prevalence of drug resistance among smear-positive sputum specimens from pulmonary tuberculosis (TB) cases in Lebanon. DESIGN: Between July 2002 and April 2004, 224 newly diagnosed TB cases and 21 previously treated TB cases were collected nationwide. Mycobacterium tuberculosis isolates were tested against isoniazid (INH), rifampicin (RMP), streptomycin (SM) and ethambutol (EMB) using the BACTEC-TB system. RESULTS: M. tuberculosis and non-tuberculous mycobacteria (NTM) isolates were recovered from 190 and 15 new cases, respectively, and from 16 and 1 previously treated cases, respectively. Overall drug resistance among new TB vs. previously treated TB cases was 19.5percent and 75percent, and for single drugs it was INH (12percent vs. 63percent), RMP (3percent vs. 56percent), SM (12percent vs. 44percent) and EMB (3percent vs. 44percent). The overall rate of multidrug resistance (MDR) was 5.8percent (1percent vs. 62.5percent). The male: female ratio was 1.3:1; most were young adults. CONCLUSION: Relatively moderate single drug resistance and very low MDR rates were found among new TB cases, while among previously treated TB cases very high resistance and MDR resistance rates were detected. Such findings underline the need for ongoing stringent control measures to curb the spread of M. tuberculosis and its deleterious effects. © 2006 The Union.
dc.format.extent Pages: (63-67)
dc.language English
dc.publisher PARIS
dc.relation.ispartof Publication Name: International Journal of Tuberculosis and Lung Disease; Publication Year: 2006; Volume: 10; no. 1; Pages: (63-67);
dc.source Scopus
dc.title Nationwide study of drug resistance among acid-fast bacilli positive pulmonary tuberculosis cases in Lebanon
dc.type Article
dc.contributor.affiliation Araj, G.F., Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Beirut, Lebanon, Department of Pathology, American University of Beirut Medical Center, Beirut, Lebanon, P O Box 113-6044, Beirut, Lebanon
dc.contributor.affiliation Saade, M., National Tuberculosis Programme, Ministry of Public Health, Beirut, Lebanon
dc.contributor.affiliation Itani, L.Y., Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.authorAddress Araj, G.F.; Department of Pathology, American University of Beirut Medical Center, Beirut, Lebanon; email:
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Pathology and Laboratory Medicine;
dc.contributor.authorDepartment Pathology and Laboratory Medicine
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Araj, GF
dc.contributor.authorInitials Saade, M
dc.contributor.authorInitials Itani, LY
dc.contributor.authorReprintAddress Araj, GF (reprint author), Amer Univ Beirut, Med Ctr, Dept Pathol, POB 113-6044, Beirut, Lebanon.
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedCount 5
dc.description.citedTotWOSCount 5
dc.description.citedWOSCount 4
dc.format.extentCount 5
dc.identifier.coden IJTDF
dc.identifier.pubmedID 16466039
dc.identifier.scopusID 33144482512
dc.publisher.address 68 BOULEVARD SAINT-MICHEL,, 75006 PARIS, FRANCE
dc.relation.ispartOfISOAbbr Int. J. Tuberc. Lung Dis.
dc.relation.ispartOfIssue 1
dc.relation.ispartofPubTitle International Journal of Tuberculosis and Lung Disease
dc.relation.ispartofPubTitleAbbr Int. J. Tuberc. Lung Dis.
dc.relation.ispartOfVolume 10
dc.source.ID WOS:000234981500011
dc.type.publication Journal
dc.subject.otherAuthKeyword Drugs
dc.subject.otherAuthKeyword Mycobacterium tuberculosis
dc.subject.otherAuthKeyword New TB cases
dc.subject.otherAuthKeyword Resistance
dc.subject.otherAuthKeyword Tuberculosis
dc.subject.otherChemCAS ethambutol, 10054-05-4, 1070-11-7, 3577-94-4, 74-55-5
dc.subject.otherChemCAS isoniazid, 54-85-3, 62229-51-0, 65979-32-0
dc.subject.otherChemCAS rifampicin, 13292-46-1
dc.subject.otherChemCAS streptomycin, 57-92-1
dc.subject.otherIndex ethambutol
dc.subject.otherIndex isoniazid
dc.subject.otherIndex rifampicin
dc.subject.otherIndex streptomycin
dc.subject.otherIndex tuberculostatic agent
dc.subject.otherIndex acid fast bacterium
dc.subject.otherIndex adolescent
dc.subject.otherIndex adult
dc.subject.otherIndex aged
dc.subject.otherIndex antibiotic resistance
dc.subject.otherIndex article
dc.subject.otherIndex controlled study
dc.subject.otherIndex drug sensitivity
dc.subject.otherIndex female
dc.subject.otherIndex human
dc.subject.otherIndex Lebanon
dc.subject.otherIndex lung tuberculosis
dc.subject.otherIndex major clinical study
dc.subject.otherIndex male
dc.subject.otherIndex Mycobacterium
dc.subject.otherIndex Mycobacterium tuberculosis
dc.subject.otherIndex priority journal
dc.subject.otherIndex sputum culture
dc.subject.otherIndex sputum smear
dc.subject.otherIndex tuberculosis
dc.subject.otherIndex Adult
dc.subject.otherIndex Aged
dc.subject.otherIndex Drug Resistance, Bacterial
dc.subject.otherIndex Female
dc.subject.otherIndex Humans
dc.subject.otherIndex Incidence
dc.subject.otherIndex Lebanon
dc.subject.otherIndex Male
dc.subject.otherIndex Microbial Sensitivity Tests
dc.subject.otherIndex Middle Aged
dc.subject.otherIndex Mycobacterium tuberculosis
dc.subject.otherIndex Tuberculosis, Multidrug-Resistant
dc.subject.otherIndex Tuberculosis, Pulmonary
dc.subject.otherKeywordPlus ANTITUBERCULOSIS DRUGS
dc.subject.otherKeywordPlus MYCOBACTERIUM-TUBERCULOSIS
dc.subject.otherKeywordPlus SAUDI-ARABIA
dc.subject.otherKeywordPlus LABORATORIES
dc.subject.otherKeywordPlus PREVALENCE
dc.subject.otherKeywordPlus QUALITY
dc.subject.otherWOS Infectious Diseases
dc.subject.otherWOS Respiratory System

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