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Nationwide study of drug resistance among acid-fast bacilli positive pulmonary tuberculosis cases in Lebanon

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dc.contributor.author Araj G.F.
dc.contributor.author Saade M.
dc.contributor.author Itani L.Y.
dc.contributor.editor
dc.date Jan-2006
dc.date.accessioned 2017-10-05T15:59:42Z
dc.date.available 2017-10-05T15:59:42Z
dc.date.issued 2006
dc.identifier
dc.identifier.isbn
dc.identifier.issn 10273719
dc.identifier.uri http://hdl.handle.net/10938/19177
dc.description.abstract OBJECTIVE: To assess the prevalence of drug resistance among smear-positive sputum specimens from pulmonary tuberculosis (TB) cases in Lebanon. DESIGN: Between July 2002 and April 2004, 224 newly diagnosed TB cases and 21 previously treated TB cases were collected nationwide. Mycobacterium tuberculosis isolates were tested against isoniazid (INH), rifampicin (RMP), streptomycin (SM) and ethambutol (EMB) using the BACTEC-TB system. RESULTS: M. tuberculosis and non-tuberculous mycobacteria (NTM) isolates were recovered from 190 and 15 new cases, respectively, and from 16 and 1 previously treated cases, respectively. Overall drug resistance among new TB vs. previously treated TB cases was 19.5percent and 75percent, and for single drugs it was INH (12percent vs. 63percent), RMP (3percent vs. 56percent), SM (12percent vs. 44percent) and EMB (3percent vs. 44percent). The overall rate of multidrug resistance (MDR) was 5.8percent (1percent vs. 62.5percent). The male: female ratio was 1.3:1; most were young adults. CONCLUSION: Relatively moderate single drug resistance and very low MDR rates were found among new TB cases, while among previously treated TB cases very high resistance and MDR resistance rates were detected. Such findings underline the need for ongoing stringent control measures to curb the spread of M. tuberculosis and its deleterious effects. © 2006 The Union.
dc.format.extent
dc.format.extent Pages: (63-67)
dc.language English
dc.publisher PARIS
dc.relation.ispartof Publication Name: International Journal of Tuberculosis and Lung Disease; Publication Year: 2006; Volume: 10; no. 1; Pages: (63-67);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Nationwide study of drug resistance among acid-fast bacilli positive pulmonary tuberculosis cases in Lebanon
dc.type Article
dc.contributor.affiliation Araj, G.F., Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Beirut, Lebanon, Department of Pathology, American University of Beirut Medical Center, Beirut, Lebanon, P O Box 113-6044, Beirut, Lebanon
dc.contributor.affiliation Saade, M., National Tuberculosis Programme, Ministry of Public Health, Beirut, Lebanon
dc.contributor.affiliation Itani, L.Y., Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.authorAddress Araj, G.F.; Department of Pathology, American University of Beirut Medical Center, Beirut, Lebanon; email: garaj@aub.edu.lb
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Pathology and Laboratory Medicine;
dc.contributor.authorDepartment Pathology and Laboratory Medicine
dc.contributor.authorDivision
dc.contributor.authorEmail garaj@aub.edu.lb
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Araj, GF
dc.contributor.authorInitials Saade, M
dc.contributor.authorInitials Itani, LY
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Araj, GF (reprint author), Amer Univ Beirut, Med Ctr, Dept Pathol, POB 113-6044, Beirut, Lebanon.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
dc.description.cited ABER VR, 1980, TUBERCLE, V61, P123, DOI 10.1016-0041-3879(80)90001-X; Abu-Amero KK, 2002, ANN SAUDI MED, V22, P236; Al-Hajoj SA, 2004, SAUDI MED J, V25, P1545; Al-Marri MRHA, 2001, INT J TUBERC LUNG D, V5, P1116; ARAJ GE, 1994, LEBAN MED J, V42, P126; ARAJ GF, 2000, LEBAN MED J, V48, P18; AZIZ MA, 2003, WHOTB2003320; AZIZ MA, 2004, WHOHTMTB2004343; BASS JB, 1994, AM J RESP CRIT CARE, V149, P1359; BEHER MA, 1999, LANCET, V353, P444; Cegielski JP, 2002, INFECT DIS CLIN N AM, V16, P1, DOI 10.1016-S0891-5520(03)00045-X; Enarson Donald A, 2004, Paediatr Respir Rev, V5 Suppl A, pS143, DOI 10.1016-S1526-0542(04)90027-9; Hamze MM, 1997, INT J TUBERC LUNG D, V1, P314; HEIFETS L, 2002, CHEST, V118, P4; KARTALOGLU Z, 2002, MED PRIN PRACT, V11, P20; Metchock B, 1999, MANUAL CLIN MICROBIO, P399; Migliori GB, 2003, EUR RESPIR J, V21, P129, DOI 10.1183-09031936.03.00047402; Siddiqi K, 2003, LANCET INFECT DIS, V3, P288, DOI 10.1016-S1473-3099(03)00609-1; Siddiqi S, 1995, BACTEC TB System. Product and procedure manual; Trebucq A, 1999, INT J TUBERC LUNG D, V3, P466; Willcox P A, 2001, Curr Opin Pulm Med, V7, P148, DOI 10.1097-00063198-200105000-00006; 1997, WHOTB96210, P1; 2003, MWWR, V52, P217
dc.description.citedCount 5
dc.description.citedTotWOSCount 5
dc.description.citedWOSCount 4
dc.format.extentCount 5
dc.identifier.articleNo
dc.identifier.coden IJTDF
dc.identifier.pubmedID 16466039
dc.identifier.scopusID 33144482512
dc.identifier.url
dc.publisher.address 68 BOULEVARD SAINT-MICHEL,, 75006 PARIS, FRANCE
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dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
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dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr Int. J. Tuberc. Lung Dis.
dc.relation.ispartOfIssue 1
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle International Journal of Tuberculosis and Lung Disease
dc.relation.ispartofPubTitleAbbr Int. J. Tuberc. Lung Dis.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 10
dc.source.ID WOS:000234981500011
dc.type.publication Journal
dc.subject.otherAuthKeyword Drugs
dc.subject.otherAuthKeyword Mycobacterium tuberculosis
dc.subject.otherAuthKeyword New TB cases
dc.subject.otherAuthKeyword Resistance
dc.subject.otherAuthKeyword Tuberculosis
dc.subject.otherChemCAS ethambutol, 10054-05-4, 1070-11-7, 3577-94-4, 74-55-5
dc.subject.otherChemCAS isoniazid, 54-85-3, 62229-51-0, 65979-32-0
dc.subject.otherChemCAS rifampicin, 13292-46-1
dc.subject.otherChemCAS streptomycin, 57-92-1
dc.subject.otherIndex ethambutol
dc.subject.otherIndex isoniazid
dc.subject.otherIndex rifampicin
dc.subject.otherIndex streptomycin
dc.subject.otherIndex tuberculostatic agent
dc.subject.otherIndex acid fast bacterium
dc.subject.otherIndex adolescent
dc.subject.otherIndex adult
dc.subject.otherIndex aged
dc.subject.otherIndex antibiotic resistance
dc.subject.otherIndex article
dc.subject.otherIndex controlled study
dc.subject.otherIndex drug sensitivity
dc.subject.otherIndex female
dc.subject.otherIndex human
dc.subject.otherIndex Lebanon
dc.subject.otherIndex lung tuberculosis
dc.subject.otherIndex major clinical study
dc.subject.otherIndex male
dc.subject.otherIndex Mycobacterium
dc.subject.otherIndex Mycobacterium tuberculosis
dc.subject.otherIndex priority journal
dc.subject.otherIndex sputum culture
dc.subject.otherIndex sputum smear
dc.subject.otherIndex tuberculosis
dc.subject.otherIndex Adult
dc.subject.otherIndex Aged
dc.subject.otherIndex Drug Resistance, Bacterial
dc.subject.otherIndex Female
dc.subject.otherIndex Humans
dc.subject.otherIndex Incidence
dc.subject.otherIndex Lebanon
dc.subject.otherIndex Male
dc.subject.otherIndex Microbial Sensitivity Tests
dc.subject.otherIndex Middle Aged
dc.subject.otherIndex Mycobacterium tuberculosis
dc.subject.otherIndex Tuberculosis, Multidrug-Resistant
dc.subject.otherIndex Tuberculosis, Pulmonary
dc.subject.otherKeywordPlus ANTITUBERCULOSIS DRUGS
dc.subject.otherKeywordPlus MYCOBACTERIUM-TUBERCULOSIS
dc.subject.otherKeywordPlus SAUDI-ARABIA
dc.subject.otherKeywordPlus LABORATORIES
dc.subject.otherKeywordPlus PREVALENCE
dc.subject.otherKeywordPlus QUALITY
dc.subject.otherWOS Infectious Diseases
dc.subject.otherWOS Respiratory System


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