Distribution of killer cell immunoglobulin-like receptors genotypes in the Lebanese population

Mahfouz R.; Rayes R.; Mahfoud Z.; Bazarbachi A.; Zaatari G.

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dc.contributor.author	Mahfouz R.
dc.contributor.author	Rayes R.
dc.contributor.author	Mahfoud Z.
dc.contributor.author	Bazarbachi A.
dc.contributor.author	Zaatari G.
dc.contributor.editor
dc.date	Jul-2006
dc.date.accessioned	2017-10-05T15:59:42Z
dc.date.available	2017-10-05T15:59:42Z
dc.date.issued	2006
dc.identifier	10.1111/j.1399-0039.2006.00605.x
dc.identifier.isbn
dc.identifier.issn	00012815
dc.identifier.uri	http://hdl.handle.net/10938/19184
dc.description.abstract	This study represents the first report on the distribution of 16 Killer cell Immunoglobulin-like Receptors (KIR) genes in 120 unrelated healthy Lebanese individuals. We observed that 2DL2 frequency (61percent) comes second highest after South Asians (64percent) and 2DL5 frequency (58.3percent) is the second highest reported so far after the South Asians (74percent). Interestingly, a large number of AA1 genotype individuals with no loci for activating KIR and three completely new BB profiles not previously reported were found in our population with a group A : group B haplotypes ratio of 1.3:1. The frequency of the KIR loci suggests that the Lebanese population shares common general features with the Caucasoid populations studied before, but still has its own unique decreased or increased frequencies of several loci. © 2006 The Authors.
dc.format.extent
dc.format.extent	Pages: (66-71)
dc.language	English
dc.publisher	OXFORD
dc.relation.ispartof	Publication Name: Tissue Antigens; Publication Year: 2006; Volume: 68; no. 1; Pages: (66-71);
dc.relation.ispartofseries
dc.relation.uri
dc.source	Scopus
dc.subject.other
dc.title	Distribution of killer cell immunoglobulin-like receptors genotypes in the Lebanese population
dc.type	Article
dc.contributor.affiliation	Mahfouz, R., Department of Pathology and Laboratory Medicine, AUBMC, Lebanon, Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center (AUBMC), PO Box 11-0236, Riad El Solh 1107,2020 Beirut, Lebanon
dc.contributor.affiliation	Rayes, R., Department of Pathology and Laboratory Medicine, AUBMC, Lebanon
dc.contributor.affiliation	Mahfoud, Z., Department of Epidemiology and Population Health, AUB
dc.contributor.affiliation	Bazarbachi, A., Department of Internal Medicine, AUBMC
dc.contributor.affiliation	Zaatari, G., Department of Pathology and Laboratory Medicine, AUBMC, Lebanon
dc.contributor.authorAddress	Mahfouz, R.; Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center (AUBMC), PO Box 11-0236, Riad El Solh 1107,2020 Beirut, Lebanon; email: rm11@aub.edu.lb
dc.contributor.authorCorporate	University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Pathology and Laboratory Medicine;
dc.contributor.authorDepartment	Pathology and Laboratory Medicine
dc.contributor.authorDivision
dc.contributor.authorEmail	rm11@aub.edu.lb
dc.contributor.faculty	Faculty of Medicine
dc.contributor.authorInitials	Mahfouz, R
dc.contributor.authorInitials	Rayes, R
dc.contributor.authorInitials	Mahfoud, Z
dc.contributor.authorInitials	Bazarbachi, A
dc.contributor.authorInitials	Zaatari, G
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress	Mahfouz, R (reprint author), Amer Univ Beirut, Med Ctr, Dept Pathol and Lab Med, POB 11-0236,Riad El Solh 1107, Beirut 2020, Lebanon.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity	American University of Beirut Medical Center
dc.description.cited	Artavanis-Tsakonas K, 2003, J IMMUNOL, V171, P5396; Denis L, 2005, TISSUE ANTIGENS, V66, P267, DOI 10.1111-j.1399-0039.2005.00473.x; Farag SS, 2002, BLOOD, V100, P1935, DOI 10.1182-blood-2002-02-0350; Gaudieri S, 2005, GENES IMMUN, V6, P683, DOI 10.1038-sj.gene.6364256; Hiby SE, 2004, J EXP MED, V200, P957, DOI 10.1084-jem.20041214; Hsu KC, 2002, IMMUNOL REV, V190, P40, DOI 10.1034-j.1600-065X.2002.19004.x; Hsu KC, 2005, BLOOD, V105, P4878, DOI 10.1182-blood-2004-12-4825; Hsu KC, 2002, J IMMUNOL, V169, P5118; Jiang K, 2005, TISSUE ANTIGENS, V65, P556, DOI 10.1111-j.1399-0039.2005.00412.x; Lanier LL, 2005, ANNU REV IMMUNOL, V23, P225, DOI 10.1146-annurev.immunol.23.021704.115526; LANIER LL, 1997, GENETIC DIVERSITY HL; Luszczek W, 2004, HUM IMMUNOL, V65, P758, DOI 10.1016-j.humimm.2004.05.008; Makrigiannis AP, 2003, CANCER BIOL THER, V2, P610; Martin MP, 2002, NAT GENET, V31, P429, DOI 10.1038-ng934; Maxwell LD, 2004, EXP GERONTOL, V39, P1223, DOI 10.1016-j.exger.2004.05.003; Moodie SJ, 2002, EUR J IMMUNOGENET, V29, P287, DOI 10.1046-j.1365-2370.2002.00313.x; Nelson GW, 2004, J IMMUNOL, V173, P4273; Niokou D, 2003, HUM IMMUNOL, V64, P1167, DOI 10.1016-j.humimm.2003.08.100; Norman PJ, 2002, GENES IMMUN, V3, P86, DOI 10.1038-sj-gene-6363836; Norman PJ, 2001, IMMUNOGENETICS, V52, P195; Norman PJ, 2004, IMMUNOGENETICS, V56, P225, DOI 10.1007-s00251-004-0674-1; Rajalingam R, 2002, IMMUNOGENETICS, V53, P1009, DOI 10.1007-s00251-001-0425-5; Shilling HG, 2003, BLOOD, V101, P3730, DOI 10.1182-blood-2002-08-2568; Shilling HG, 2002, J IMMUNOL, V168, P2307; Suzuki Y, 2004, J INVEST DERMATOL, V122, P1133, DOI 10.1111-j.0022-202X.2004.22517.x; Toneva M, 2001, TISSUE ANTIGENS, V57, P358, DOI 10.1034-j.1399-0039.2001.057004358.x; Uhrberg M, 1997, IMMUNITY, V7, P753, DOI 10.1016-S1074-7613(00)80394-5; Uhrberg M, 2002, IMMUNOGENETICS, V54, P221, DOI 10.1007-s00251-002-0463-7; Vilches C, 2002, ANNU REV IMMUNOL, V20, P217, DOI 10.1146-annurev.immunol.20.092501.134942; Whang DH, 2005, HUM IMMUNOL, V66, P146, DOI 10.1016-j.humimm.2004.10.013; Witt CS, 1999, TRANSPLANTATION, V68, P1784, DOI 10.1097-00007890-199912150-00024; Yawata M, 2002, IMMUNOGENETICS, V54, P543, DOI 10.1007-s00251-002-0497-x; Yawata M, 2002, CRIT REV IMMUNOL, V22, P463
dc.description.citedCount	19
dc.description.citedTotWOSCount	23
dc.description.citedWOSCount	20
dc.format.extentCount	6
dc.identifier.articleNo
dc.identifier.coden	TSANA
dc.identifier.pubmedID	16774542
dc.identifier.scopusID	33745125709
dc.identifier.url
dc.publisher.address	9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND
dc.relation.ispartofConference
dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr	Tissue Antigens
dc.relation.ispartOfIssue	1
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle	Tissue Antigens
dc.relation.ispartofPubTitleAbbr	Tissue Antigens
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume	68
dc.source.ID	WOS:000238186900009
dc.type.publication	Journal
dc.subject.otherAuthKeyword	Genotype
dc.subject.otherAuthKeyword	KIR
dc.subject.otherAuthKeyword	Lebanese
dc.subject.otherAuthKeyword	Prevalence
dc.subject.otherChemCAS	Receptors, Immunologic
dc.subject.otherChemCAS	killer cell immunoglobulin-like receptor
dc.subject.otherIndex	killer cell immunoglobulin like receptor
dc.subject.otherIndex	article
dc.subject.otherIndex	Asian
dc.subject.otherIndex	Caucasian
dc.subject.otherIndex	controlled study
dc.subject.otherIndex	gene frequency
dc.subject.otherIndex	gene locus
dc.subject.otherIndex	genotype
dc.subject.otherIndex	haplotype
dc.subject.otherIndex	human
dc.subject.otherIndex	Lebanon
dc.subject.otherIndex	priority journal
dc.subject.otherIndex	South Asia
dc.subject.otherIndex	Demography
dc.subject.otherIndex	Gene Frequency
dc.subject.otherIndex	Genotype
dc.subject.otherIndex	Haplotypes
dc.subject.otherIndex	Humans
dc.subject.otherIndex	Lebanon
dc.subject.otherIndex	Prevalence
dc.subject.otherIndex	Receptors, Immunologic
dc.subject.otherKeywordPlus	GENE CONTENT
dc.subject.otherKeywordPlus	ALLELIC POLYMORPHISM
dc.subject.otherKeywordPlus	PSORIASIS-VULGARIS
dc.subject.otherKeywordPlus	HAPLOTYPE ANALYSIS
dc.subject.otherKeywordPlus	GENOMIC DIVERSITY
dc.subject.otherKeywordPlus	KIR HAPLOTYPES
dc.subject.otherKeywordPlus	HLA
dc.subject.otherKeywordPlus	DISEASE
dc.subject.otherKeywordPlus	TRANSPLANTATION
dc.subject.otherKeywordPlus	SUSCEPTIBILITY
dc.subject.otherWOS	Cell Biology
dc.subject.otherWOS	Immunology
dc.subject.otherWOS	Pathology

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