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Apolipoprotein E gene polymorphism and allele frequencies in the Lebanese population

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dc.contributor.author Mahfouz R.A.R.
dc.contributor.author Sabbagh A.S.
dc.contributor.author Zahed L.F.
dc.contributor.author Mahfoud Z.R.
dc.contributor.author Kalmoni R.F.
dc.contributor.author Otrock Z.K.
dc.contributor.author Taher A.T.
dc.contributor.author Zaatari G.S.
dc.contributor.editor
dc.date Jun-2006
dc.date.accessioned 2017-10-05T15:59:42Z
dc.date.available 2017-10-05T15:59:42Z
dc.date.issued 2006
dc.identifier 10.1007/s11033-006-6260-x
dc.identifier.isbn
dc.identifier.issn 03014851
dc.identifier.uri http://hdl.handle.net/10938/19186
dc.description.abstract Apolipoprotein E (ApoE) genotypes were studied in order to determine the prevalence in the Lebanese population and compare it with other populations. DNA from 160 unrelated healthy donors from our HLA-bank was used. ApoE genotype was determined using the CardioVascular Disease (CVD) StripAssay (this assay is based on a Polymerase Chain Reaction-Reverse Hybridization technique). The prevalence of genotypes E3-3, E3-4, and E2-3 was found to be 69percent, 26percent, and 22percent, respectively, and 0.6percent for each of E2-4 and E4-4 genotypes. The Lebanese population tested showed similarities to earlier reported ApoE genotypic distributions (high E3 allele frequency) but also peculiar differences especially to some Arabic countries (total absence of E2 allele among Saudis) and other populations. This is the first report from Lebanon that will serve as a template for future investigations of the prevalence of ApoE alleles in association with various clinical entities. © Springer 2006.
dc.format.extent
dc.format.extent Pages: (145-149)
dc.language English
dc.publisher DORDRECHT
dc.relation.ispartof Publication Name: Molecular Biology Reports; Publication Year: 2006; Volume: 33; no. 2; Pages: (145-149);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Apolipoprotein E gene polymorphism and allele frequencies in the Lebanese population
dc.type Article
dc.contributor.affiliation Mahfouz, R.A.R., Department of Pathology and Laboratory Medicine, American University, Beirut Medical Center, P.O Box 11-0236, Riad El Solh, 1107 2020, Beirut, Lebanon
dc.contributor.affiliation Sabbagh, A.S., Department of Pathology and Laboratory Medicine, American University, Beirut Medical Center, P.O Box 11-0236, Riad El Solh, 1107 2020, Beirut, Lebanon
dc.contributor.affiliation Zahed, L.F., Department of Pathology and Laboratory Medicine, American University, Beirut Medical Center, P.O Box 11-0236, Riad El Solh, 1107 2020, Beirut, Lebanon
dc.contributor.affiliation Mahfoud, Z.R., Department of Public Health, AUBMC, Beirut, Lebanon
dc.contributor.affiliation Kalmoni, R.F., Department of Pathology and Laboratory Medicine, American University, Beirut Medical Center, P.O Box 11-0236, Riad El Solh, 1107 2020, Beirut, Lebanon
dc.contributor.affiliation Otrock, Z.K., Department of Internal Medicine, AUBMC, Beirut, Lebanon
dc.contributor.affiliation Taher, A.T., Department of Internal Medicine, AUBMC, Beirut, Lebanon
dc.contributor.affiliation Zaatari, G.S., Department of Pathology and Laboratory Medicine, American University, Beirut Medical Center, P.O Box 11-0236, Riad El Solh, 1107 2020, Beirut, Lebanon
dc.contributor.authorAddress Mahfouz, R.A.R.; Department of Pathology and Laboratory Medicine, American University, Beirut Medical Center, P.O Box 11-0236, Riad El Solh, 1107 2020, Beirut, Lebanon; email: rm11@aub.edu.lb
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Pathology and Laboratory Medicine;
dc.contributor.authorDepartment Pathology and Laboratory Medicine
dc.contributor.authorDivision
dc.contributor.authorEmail rm11@aub.edu.lb
dc.contributor.faculty Faculty of Medicine
dc.contributor.authorInitials Mahfouz, RAR
dc.contributor.authorInitials Sabbagh, AS
dc.contributor.authorInitials Zahed, LF
dc.contributor.authorInitials Mahfoud, ZR
dc.contributor.authorInitials Kalmoni, RF
dc.contributor.authorInitials Otrock, ZK
dc.contributor.authorInitials Taher, AT
dc.contributor.authorInitials Zaatari, GS
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Mahfouz, RAR (reprint author), Amer Univ Beirut, Med Ctr, Dept Pathol and Lab Med, Riad El Solh,1107,POB 11-0236, Beirut 2020, Lebanon.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
dc.description.cited Al-Khedhairy AA, 2004, MOL BIOL REP, V31, P257; Al-Shammari S, 2004, ANN SAUDI MED, V24, P361; Al-Shammri S, 2005, CLIN CHIM ACTA, V351, P203, DOI 10.1016-j.cccn.2004.09.015; Bednarska-Makaruk M, 2005, ALCOHOL ALCOHOLISM, V40, P274, DOI 10.1093-alcalc-agh157; Benjamin R, 1996, NEURODEGENERATION, V5, P43; Bosco P, 2005, NEUROSCI LETT, V388, P168, DOI 10.1016-j.neulet.2005.06.056; Chang NW, 2005, BREAST CANCER RES TR, V90, P257, DOI 10.1007-s10549-004-4656-7; CHARTIERHARLIN MC, 1994, HUM MOL GENET, V3, P569, DOI 10.1093-hmg-3.4.569; Cocco E, 2005, NEUROLOGY, V64, P564; CORDER EH, 1993, SCIENCE, V261, P921, DOI 10.1126-science.8346443; Corder EH, 2005, J BIOMED BIOTECHNOL, P189, DOI 10.1155-JBB.2005.189; Corella D, 2001, AM J CLIN NUTR, V73, P736; Devanand DP, 2005, ARCH NEUROL-CHICAGO, V62, P975, DOI 10.1001-archneur.62.6.975; Dixit Manjusha, 2005, BMC Endocr Disord, V5, P7, DOI 10.1186-1472-6823-5-7; Fernandez-Mestre MT, 2005, DIS MARKERS, V21, P15; Gamboa R, 2000, HUM BIOL, V72, P975; Gerard HC, 2005, MICROB PATHOGENESIS, V39, P19, DOI 10.1016-j.micpath.2005.05.002; HARDY J, 1995, AM J MED GENET, V60, P456, DOI 10.1002-ajmg.1320600519; HOULDEN H, 1995, NEUROSCI LETT, V188, P202, DOI 10.1016-0304-3940(95)11422-S; Hsu CC, 2005, JAMA-J AM MED ASSOC, V293, P2892, DOI 10.1001-jama.293.23.2892; Janssen JC, 2003, NEUROLOGY, V60, P235; Johannsen P, 1997, Ugeskr Laeger, V159, P5658; Kohnke H, 2005, EUR J CLIN PHARMACOL, V61, P381, DOI 10.1007-s00228-005-0936-3; Kumar T, 2002, HUM BIOL, V74, P137, DOI 10.1353-hub.2002.0006; Lahoz C, 2001, ATHEROSCLEROSIS, V154, P529, DOI 10.1016-S0021-9150(00)00570-0; Lambert JC, 1997, HUM MOL GENET, V6, P2151, DOI 10.1093-hmg-6.12.2151; Lee Y, 2004, NEUROCHEM INT, V44, P107, DOI 10.1016-S0197-0186(03)00112-8; Malek G, 2005, P NATL ACAD SCI USA, V102, P11900, DOI 10.1073-pnas.0503015102; Margaglione M, 1998, STROKE, V29, P399; Muros M, 1996, ATHEROSCLEROSIS, V121, P13, DOI 10.1016-0021-9150(95)06643-8; Pertovaara M, 2004, RHEUMATOLOGY, V43, P1484, DOI 10.1093-rheumatology-keh383; Ramsaransing GSM, 2005, EUR J NEUROL, V12, P514, DOI 10.1111-j.1468-1331.2005.01009.x; ROSES AD, 1995, ARZNEIMITTEL-FORSCH, V45-1, P413; Senanarong Vorapun, 2001, Journal of the Medical Association of Thailand, V84, P182; Slattery ML, 2005, CARCINOGENESIS, V26, P1422, DOI 10.1093-carcin-bgi088; [唐慧 Tang Hui], 2005, [中华医学遗传学杂志, Chinese Journal of Medical Genetics], V22, P224; Teasdale GM, 2005, BRAIN, V128, P2556, DOI 10.1093-brain-awh595; Um JY, 2005, INT J NEUROSCI, V115, P743, DOI 10.1080-00207450590524421; Visser LE, 2005, PHARMACOGENET GENOM, V15, P69, DOI 10.1097-01213011-200502000-00002; Wozniak MA, 2002, HEPATOLOGY, V36, P456, DOI 10.1053-jhep.2002.34745; Yang Sheng-li, 2004, Chinese Medical Sciences Journal, V19, P150; Yip AG, 2005, NEUROLOGY, V65, P259, DOI 10.1212-01.wnl.0000168863.49053.4d; Zhao JH, 2005, SOC PSYCH PSYCH EPID, V40, P557, DOI 10.1007-s00127-005-0925-y; Zhu Wenli, 2001, Zhonghua Yufang Yixue Zazhi, V35, P297; Zofkova I, 2002, EUR J ENDOCRINOL, V147, P503, DOI 10.1530-eje.0.1470503
dc.description.citedCount 26
dc.description.citedTotWOSCount 24
dc.description.citedWOSCount 23
dc.format.extentCount 5
dc.identifier.articleNo
dc.identifier.coden MLBRB
dc.identifier.pubmedID 16817024
dc.identifier.scopusID 33745621883
dc.identifier.url
dc.publisher.address VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
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dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr Mol. Biol. Rep.
dc.relation.ispartOfIssue 2
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Molecular Biology Reports
dc.relation.ispartofPubTitleAbbr Mol. Biol. Rep.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 33
dc.source.ID WOS:000238744000009
dc.type.publication Journal
dc.subject.otherAuthKeyword Apolipoprotein E
dc.subject.otherAuthKeyword Genotyping
dc.subject.otherAuthKeyword Lebanese population
dc.subject.otherAuthKeyword Polymorphism
dc.subject.otherAuthKeyword Prevalence
dc.subject.otherChemCAS DNA, 9007-49-2
dc.subject.otherChemCAS Apolipoproteins E
dc.subject.otherIndex apolipoprotein E
dc.subject.otherIndex DNA
dc.subject.otherIndex allele
dc.subject.otherIndex article
dc.subject.otherIndex DNA determination
dc.subject.otherIndex DNA extraction
dc.subject.otherIndex DNA polymorphism
dc.subject.otherIndex gene frequency
dc.subject.otherIndex genetic variability
dc.subject.otherIndex genotype
dc.subject.otherIndex HLA system
dc.subject.otherIndex human
dc.subject.otherIndex human tissue
dc.subject.otherIndex Lebanon
dc.subject.otherIndex polymerase chain reaction
dc.subject.otherIndex polymerase chain reaction reverse hybridization
dc.subject.otherIndex prevalence
dc.subject.otherIndex Apolipoproteins E
dc.subject.otherIndex Gene Frequency
dc.subject.otherIndex Genetic Predisposition to Disease
dc.subject.otherIndex Genetic Screening
dc.subject.otherIndex Genetic Testing
dc.subject.otherIndex Genotype
dc.subject.otherIndex Humans
dc.subject.otherIndex Lebanon
dc.subject.otherIndex Polymerase Chain Reaction
dc.subject.otherIndex Polymorphism, Genetic
dc.subject.otherIndex Population
dc.subject.otherKeywordPlus FAMILIAL ALZHEIMERS-DISEASE
dc.subject.otherKeywordPlus E GENOTYPE
dc.subject.otherKeywordPlus LATE-ONSET
dc.subject.otherKeywordPlus EPSILON-4 ALLELE
dc.subject.otherKeywordPlus APOE GENOTYPE
dc.subject.otherKeywordPlus MULTIPLE-SCLEROSIS
dc.subject.otherKeywordPlus RISK
dc.subject.otherKeywordPlus SUSCEPTIBILITY
dc.subject.otherKeywordPlus E-EPSILON-4
dc.subject.otherKeywordPlus DETERMINES
dc.subject.otherWOS Biochemistry and Molecular Biology


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