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Regression of skeletal manifestations of hyperparathyroidism with oral vitamin D

Show simple item record Arabi A. Khoury N. Zahed L. Birbari A. Fuleihan G.E.-H.
dc.contributor.editor Jul-2006 2017-10-05T15:59:43Z 2017-10-05T15:59:43Z 2006
dc.identifier 10.1210/jc.2005-2518
dc.description.abstract Context: Parathyroidectomy is the only effective therapy for osteitis fibrosa cystica in hyperparathyroidism. Objective: The objective of this study was to describe the changes of skeletal and nonskeletal manifestations in a patient with hyperparathyroidism and renal failure after oral vitamin D therapy. Design: This was a descriptive case report. Setting: The patient was followed up in a referral center. Patient: A 55-yr-old male patient with moderate renal failure was referred for expansile lytic lesions affecting several ribs and the spinous process of T12. His creatinine was 1.8 mg-dl; calcium, 8.9 mg-dl; PTH, 666 pg-ml; and 1,25 dihydroxy-vitamin D, 27 pg-ml. Bone mineral density (BMD) Z-scores by dual-energy x-ray absorptiometry were -4.1 at the spine, -1.7 at the hip, and -4.3 at the forearm. Main Outcome Measures: The main outcome measures were the skeletal manifestations of hyperparathyroidism. Results: At 10 months of therapy, calcium level was 10 mg-d, PTH level declined to 71 pg-ml, and BMD increased by 12percent at the spine and 18percent at the hip. Computerized tomography (CT) cuts revealed marked regression in the lytic lesions. At 2 yr, BMD increased by an additional 6percent at the spine, and there were no further changes in the lytic lesions by CT. The vitamin D receptor genotype using the restriction enzymes Bsm1, Taq1, and Apa1 was Bb, tt, and AA. Conclusions: We showed regression of severe skeletal abnormalities of hyperparathyroidism documented by serial CT images in response to oral vitamin D therapy. It is possible that the vitamin D receptor genotype of the patient modulated this response. Copyright © 2006 by The Endocrine Society.
dc.format.extent Pages: (2480-2483)
dc.language English
dc.publisher CHEVY CHASE
dc.relation.ispartof Publication Name: Journal of Clinical Endocrinology and Metabolism; Publication Year: 2006; Volume: 91; no. 7; Pages: (2480-2483);
dc.source Scopus
dc.title Regression of skeletal manifestations of hyperparathyroidism with oral vitamin D
dc.type Conference Paper
dc.contributor.affiliation Arabi, A., Calcium Metabolism and Osteoporosis Program, American University of Beirut-Medical Center, Beirut, 113-6044, Lebanon, Calcium Metabolism and Osteoporosis Program, American University of Beirut-Medical Center, Bliss Street, Beirut, 113-6044, Lebanon
dc.contributor.affiliation Khoury, N., Division of Endocrinology, Department of Diagnostic Radiology, American University of Beirut-Medical Center, Beirut, 113-6044, Lebanon
dc.contributor.affiliation Zahed, L., Department of Pathology and Laboratory Medicine, American University of Beirut-Medical Center, Beirut, 113-6044, Lebanon
dc.contributor.affiliation Birbari, A., Division of Nephrology, Hypertension and Vascular Medicine, American University of Beirut-Medical Center, Beirut, 113-6044, Lebanon
dc.contributor.affiliation Fuleihan, G.E.-H., Calcium Metabolism and Osteoporosis Program, American University of Beirut-Medical Center, Beirut, 113-6044, Lebanon
dc.contributor.authorAddress Arabi, A.; Calcium Metabolism and Osteoporosis Program, American University of Beirut-Medical Center, Bliss Street, Beirut, 113-6044, Lebanon; email:
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Pathology and Laboratory Medicine;
dc.contributor.authorDepartment Pathology and Laboratory Medicine
dc.contributor.faculty Faculty of Medicine
dc.contributor.authorInitials Arabi, A
dc.contributor.authorInitials Khoury, N
dc.contributor.authorInitials Zahed, L
dc.contributor.authorInitials Birbari, A
dc.contributor.authorInitials Fuleihan, GEH
dc.contributor.authorReprintAddress Arabi, A (reprint author), Amer Univ Beirut, Med Ctr, Calcium Metab and Osteoporosis Program, Bliss St, Beirut 1136044, Lebanon.
dc.contributor.authorUniversity American University of Beirut Medical Center
dc.description.cited Agarwal G, 2002, SURGERY, V132, P1075, DOI 10.1067-msy.2002.128484; Alvarez-Hernandez D, 2003, KIDNEY INT S, V85, pS19; ANDRESS DL, 1989, NEW ENGL J MED, V321, P274, DOI 10.1056-NEJM198908033210502; Bilezikian J P, 2000, Rev Endocr Metab Disord, V1, P237, DOI 10.1023-A:1026508829397; BRANDT EH, 1989, J PHYS-CONDENS MAT, V1, P10003, DOI 10.1088-0953-8984-1-50-003; Carling T, 1998, WORLD J SURG, V22, P700; Carling T, 1997, J CLIN ENDOCR METAB, V82, P1772, DOI 10.1210-jc.82.6.1772; DENT C E, 1962, Br Med J, V2, P1419; FAJTOVA VT, 1995, CALCIFIED TISSUE INT, V57, P329, DOI 10.1007-BF00302067; Franco M, 2002, JOINT BONE SPINE, V69, P506, DOI 10.1016-S1297-319X(02)00439-6; Gago EV, 2005, J ENDOCRINOL INVEST, V28, P117; Khan A, 2000, CAN MED ASSOC J, V163, P184; Kulak CAM, 1998, J CLIN ENDOCR METAB, V83, P732, DOI 10.1210-jc.83.3.732; Levy AS, 2005, KIDNEY INT, V67, P2089; LUMB GA, 1974, AM J MED, V56, P833, DOI 10.1016-0002-9343(74)90812-2; Marco MP, 2001, CLIN NEPHROL, V56, P111; MORRISON NA, 1994, NATURE, V367, P284, DOI 10.1038-367284a0; MOURAD G, 1995, NEPHROL DIAL TRANSPL, V10, P552; Nordenstrom E, 2004, WORLD J SURG, V28, P502, DOI 10.1007-s00268-004-7274-y; RAEBURN C, 2002, SURGERY, V131, P896; RODRIGUEZ M, 1991, J AM SOC NEPHROL, V2, P1014; STANBURY SW, 1977, CLIN ENDOCRINOL, V7, pS25, DOI 10.1111-j.1365-2265.1977.tb03358.x; Yokoyama K, 1998, KIDNEY INT, V53, P454, DOI 10.1046-j.1523-1755.1998.00781.x
dc.description.citedCount 10
dc.description.citedTotWOSCount 10
dc.description.citedWOSCount 10
dc.format.extentCount 4
dc.identifier.coden JCEMA
dc.identifier.pubmedID 16608887
dc.identifier.scopusID 33745766895
dc.publisher.address 8401 CONNECTICUT AVE, SUITE 900, CHEVY CHASE, MD 20815-5817 USA
dc.relation.ispartOfISOAbbr J. Clin. Endocrinol. Metab.
dc.relation.ispartOfIssue 7
dc.relation.ispartofPubTitle Journal of Clinical Endocrinology and Metabolism
dc.relation.ispartofPubTitleAbbr J. Clin. Endocrinol. Metab.
dc.relation.ispartOfVolume 91
dc.source.ID WOS:000238840600003
dc.type.publication Journal
dc.subject.otherChemCAS alendronic acid, 66376-36-1
dc.subject.otherChemCAS alfacalcidol, 41294-56-8
dc.subject.otherChemCAS calcitriol, 32222-06-3, 32511-63-0, 66772-14-3
dc.subject.otherChemCAS calcium carbonate, 13397-26-7, 13701-58-1, 14791-73-2, 471-34-1
dc.subject.otherChemCAS calcium, 7440-70-2
dc.subject.otherChemCAS creatinine, 19230-81-0, 60-27-5
dc.subject.otherChemCAS parathyroid hormone, 12584-96-2, 68893-82-3, 9002-64-6
dc.subject.otherChemCAS 1-hydroxycholecalciferol, 41294-56-8
dc.subject.otherChemCAS Calcium, 7440-70-2
dc.subject.otherChemCAS Cholecalciferol, 67-97-0
dc.subject.otherChemCAS Hydroxycholecalciferols
dc.subject.otherChemCAS Receptors, Calcitriol
dc.subject.otherChemCAS Vitamin D, 1406-16-2
dc.subject.otherIndex alendronic acid
dc.subject.otherIndex alfacalcidol
dc.subject.otherIndex calcitriol
dc.subject.otherIndex calcium
dc.subject.otherIndex calcium carbonate
dc.subject.otherIndex creatinine
dc.subject.otherIndex parathyroid hormone
dc.subject.otherIndex restriction endonuclease
dc.subject.otherIndex vitamin D
dc.subject.otherIndex vitamin D receptor
dc.subject.otherIndex adult
dc.subject.otherIndex Albright syndrome
dc.subject.otherIndex anamnesis
dc.subject.otherIndex bone density
dc.subject.otherIndex bone disease
dc.subject.otherIndex case report
dc.subject.otherIndex computer assisted tomography
dc.subject.otherIndex conference paper
dc.subject.otherIndex dual energy X ray absorptiometry
dc.subject.otherIndex forearm
dc.subject.otherIndex genotype
dc.subject.otherIndex hip
dc.subject.otherIndex human
dc.subject.otherIndex kidney failure
dc.subject.otherIndex laboratory test
dc.subject.otherIndex male
dc.subject.otherIndex osteolysis
dc.subject.otherIndex physical examination
dc.subject.otherIndex priority journal
dc.subject.otherIndex remission
dc.subject.otherIndex rib
dc.subject.otherIndex secondary hyperparathyroidism
dc.subject.otherIndex thoracic spine
dc.subject.otherIndex thorax radiography
dc.subject.otherIndex ultrasound
dc.subject.otherIndex Bone Density
dc.subject.otherIndex Bone Diseases
dc.subject.otherIndex Calcium
dc.subject.otherIndex Cholecalciferol
dc.subject.otherIndex Genotype
dc.subject.otherIndex Humans
dc.subject.otherIndex Hydroxycholecalciferols
dc.subject.otherIndex Hyperparathyroidism, Secondary
dc.subject.otherIndex Kidney Failure, Chronic
dc.subject.otherIndex Male
dc.subject.otherIndex Middle Aged
dc.subject.otherIndex Osteitis Fibrosa Cystica
dc.subject.otherIndex Osteoporosis
dc.subject.otherIndex Receptors, Calcitriol
dc.subject.otherIndex Thalassemia
dc.subject.otherIndex Tomography, X-Ray Computed
dc.subject.otherIndex Vitamin D
dc.subject.otherKeywordPlus D-RECEPTOR GENE
dc.subject.otherKeywordPlus OSTEITIS FIBROSA CYSTICA
dc.subject.otherKeywordPlus CHRONIC-RENAL-FAILURE
dc.subject.otherKeywordPlus INTRAVENOUS CALCITRIOL
dc.subject.otherKeywordPlus HEMODIALYSIS-PATIENTS
dc.subject.otherKeywordPlus PARATHYROID FUNCTION
dc.subject.otherKeywordPlus BROWN TUMOR
dc.subject.otherKeywordPlus BONE
dc.subject.otherKeywordPlus POLYMORPHISM
dc.subject.otherKeywordPlus RECOVERY
dc.subject.otherWOS Endocrinology and Metabolism

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