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Up-regulation of nerve growth factor and interleukin-10 in inflamed and non-inflamed intestinal segments in rats with experimental colitis

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dc.contributor.author Barada K.A.
dc.contributor.author Mourad F.H.
dc.contributor.author Sawah S.I.
dc.contributor.author Khoury C.
dc.contributor.author Safieh-Garabedian B.
dc.contributor.author Nassar C.F.
dc.contributor.author Tawil A.
dc.contributor.author Jurjus A.
dc.contributor.author Saade N.E.
dc.contributor.editor
dc.date Mar-2007
dc.date.accessioned 2017-10-05T15:59:45Z
dc.date.available 2017-10-05T15:59:45Z
dc.date.issued 2007
dc.identifier 10.1016/j.cyto.2007.04.005
dc.identifier.isbn
dc.identifier.issn 10434666
dc.identifier.uri http://hdl.handle.net/10938/19216
dc.description.abstract Inflammatory bowel diseases are characterized by dysregulated immune response to the normal microflora and structural and functional changes of the enteric nervous system which occur in inflamed as well as non-inflamed areas of the bowel. This study describes the changes in the expression of nerve growth factor (NGF) and interleukin-10 (IL-10) in the colon and in various segments of the small intestine in two rat models of experimental colitis induced by iodoacetamide or 2,4,6-trinitrobenzene sulfonic acid (TNBS). Levels of NGF and IL-10 were measured by ELISA in tissue homogenate sampled from duodenum, jejunum, ileum and colon at different time intervals. NGF and IL-10 increased significantly in homogenates of strips isolated from all small intestinal segments, 3-6 h after iodoacetamide or TNBS administration and remained elevated until the colonic inflammation subsided. Similar but more pronounced increase occurred in areas of the colon adjacent to the ulcer. Histologic examinations revealed inflammatory changes in the colon; however, examination of sections from the small intestines did not reveal significant differences between controls and rats with colitis. The marked up-regulation of nerve growth factor and interleukin-10 in colitis suggests that they play a role in limiting or resolving inflammation and in preventing it from becoming uncontrolled. It also suggests that experimental colitis may be associated with latent inflammation in the small bowel. © 2007 Elsevier Ltd. All rights reserved.
dc.format.extent
dc.format.extent Pages: (236-245)
dc.language English
dc.publisher LONDON
dc.relation.ispartof Publication Name: Cytokine; Publication Year: 2007; Volume: 37; no. 3; Pages: (236-245);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Up-regulation of nerve growth factor and interleukin-10 in inflamed and non-inflamed intestinal segments in rats with experimental colitis
dc.type Article
dc.contributor.affiliation Barada, K.A., Department of Internal Medicine, Faculty of Arts and Sciences, American University of Beirut, PO Box 11-0236, Riad El Solh, Beirut, Lebanon
dc.contributor.affiliation Mourad, F.H., Department of Internal Medicine, Faculty of Arts and Sciences, American University of Beirut, PO Box 11-0236, Riad El Solh, Beirut, Lebanon
dc.contributor.affiliation Sawah, S.I., Department of Human Morphology and Physiology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon
dc.contributor.affiliation Khoury, C., Faculty of Medicine and Medical Sciences, University of Balamand, Balamand, Lebanon
dc.contributor.affiliation Safieh-Garabedian, B., Faculty of Medicine, Department of Biology, Faculty of Arts and Sciences, Beirut, Lebanon
dc.contributor.affiliation Nassar, C.F., Faculty of Medicine and Medical Sciences, University of Balamand, Balamand, Lebanon
dc.contributor.affiliation Tawil, A., Department of Pathology, Laboratory Medicine, Faculty of Medicine, Beirut, Lebanon
dc.contributor.affiliation Jurjus, A., Department of Human Morphology and Physiology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon
dc.contributor.affiliation Saadé, N.E., Department of Human Morphology and Physiology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon
dc.contributor.authorAddress Barada, K.A.; Department of Internal Medicine, Faculty of Arts and Sciences, American University of Beirut, PO Box 11-0236, Riad El Solh, Beirut, Lebanon; email: kb02@aub.edu.lb
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Pathology and Laboratory Medicine;
dc.contributor.authorDepartment Pathology and Laboratory Medicine
dc.contributor.authorDivision
dc.contributor.authorEmail kb02@aub.edu.lb
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Barada, KA
dc.contributor.authorInitials Mourad, FH
dc.contributor.authorInitials Sawah, SI
dc.contributor.authorInitials Khoury, C
dc.contributor.authorInitials Safieh-Garabedian, B
dc.contributor.authorInitials Nassar, CF
dc.contributor.authorInitials Tawil, A
dc.contributor.authorInitials Jurjus, A
dc.contributor.authorInitials Saade, NE
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Barada, KA (reprint author), Amer Univ Beirut, Fac Arts and Sci, Dept Internal Med, POB 11-0236, Beirut, Lebanon.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedCount 24
dc.description.citedTotWOSCount 28
dc.description.citedWOSCount 24
dc.format.extentCount 10
dc.identifier.articleNo
dc.identifier.coden CYTIE
dc.identifier.pubmedID 17517520
dc.identifier.scopusID 34249946875
dc.identifier.url
dc.publisher.address 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
dc.relation.ispartofConference
dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr Cytokine
dc.relation.ispartOfIssue 3
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Cytokine
dc.relation.ispartofPubTitleAbbr Cytokine
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 37
dc.source.ID WOS:000247701300010
dc.type.publication Journal
dc.subject.otherAuthKeyword Chronic colitis
dc.subject.otherAuthKeyword Inflammation
dc.subject.otherAuthKeyword Interleukin-10
dc.subject.otherAuthKeyword Iodoacetamide
dc.subject.otherAuthKeyword Nerve growth factor
dc.subject.otherChemCAS iodoacetamide, 144-48-9
dc.subject.otherChemCAS nerve growth factor, 9061-61-4
dc.subject.otherChemCAS trinitrobenzenesulfonic acid, 16655-63-3, 2508-19-2
dc.subject.otherChemCAS Interleukin-10, 130068-27-8
dc.subject.otherChemCAS Iodoacetamide, 144-48-9
dc.subject.otherChemCAS Nerve Growth Factor, 9061-61-4
dc.subject.otherChemCAS Trinitrobenzenesulfonic Acid, 2508-19-2
dc.subject.otherIndex interleukin 10
dc.subject.otherIndex iodoacetamide
dc.subject.otherIndex nerve growth factor
dc.subject.otherIndex trinitrobenzenesulfonic acid
dc.subject.otherIndex animal experiment
dc.subject.otherIndex animal model
dc.subject.otherIndex animal tissue
dc.subject.otherIndex article
dc.subject.otherIndex colitis
dc.subject.otherIndex colon
dc.subject.otherIndex controlled study
dc.subject.otherIndex duodenum
dc.subject.otherIndex enzyme linked immunosorbent assay
dc.subject.otherIndex histology
dc.subject.otherIndex ileum
dc.subject.otherIndex jejunum
dc.subject.otherIndex nonhuman
dc.subject.otherIndex priority journal
dc.subject.otherIndex rat
dc.subject.otherIndex small intestine disease
dc.subject.otherIndex statistical significance
dc.subject.otherIndex tissue homogenate
dc.subject.otherIndex upregulation
dc.subject.otherIndex Animals
dc.subject.otherIndex Colitis
dc.subject.otherIndex Colon
dc.subject.otherIndex Inflammation
dc.subject.otherIndex Interleukin-10
dc.subject.otherIndex Intestine, Small
dc.subject.otherIndex Iodoacetamide
dc.subject.otherIndex Nerve Growth Factor
dc.subject.otherIndex Rats
dc.subject.otherIndex Rats, Sprague-Dawley
dc.subject.otherIndex Trinitrobenzenesulfonic Acid
dc.subject.otherIndex Up-Regulation
dc.subject.otherIndex Rattus
dc.subject.otherKeywordPlus INFLAMMATORY-BOWEL-DISEASE
dc.subject.otherKeywordPlus CROHNS-DISEASE
dc.subject.otherKeywordPlus ULCERATIVE-COLITIS
dc.subject.otherKeywordPlus MUCOSAL INFLAMMATION
dc.subject.otherKeywordPlus NEUROTROPHIC FACTORS
dc.subject.otherKeywordPlus EPITHELIAL-CELLS
dc.subject.otherKeywordPlus GUT INFLAMMATION
dc.subject.otherKeywordPlus IMMUNE-SYSTEM
dc.subject.otherKeywordPlus B-LYMPHOCYTES
dc.subject.otherKeywordPlus NITRIC-OXIDE
dc.subject.otherWOS Biochemistry and Molecular Biology
dc.subject.otherWOS Cell Biology
dc.subject.otherWOS Immunology


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