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Gene frequencies of the HPA-1 platelet antigen alleles in the Lebanese population

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dc.contributor.author Sabbagh A.S.
dc.contributor.author Taher A.T.
dc.contributor.author Zaatari G.S.
dc.contributor.author Mahfouz R.A.R.
dc.contributor.editor
dc.date Dec-2007
dc.date.accessioned 2017-10-05T15:59:45Z
dc.date.available 2017-10-05T15:59:45Z
dc.date.issued 2007
dc.identifier 10.1111/j.1365-3148.2007.00792.x
dc.identifier.isbn
dc.identifier.issn 09587578
dc.identifier.uri http://hdl.handle.net/10938/19224
dc.description.abstract The objective was to study the gene frequencies of HPA-1 in the Lebanese population for the first time. The aims of this study were to assess the prevalence of 1a and 1b HPA-1 alleles in healthy Lebanese individuals and compare with the international literature. Human platelet antigen (HPA) systems are involved in alloimmunization, organ transplantation rejection and the development of cardiovascular disease. Of several classified HPA systems, HPA-1 specifically has been considered to be the most important antigenic system implicated in the Caucasian population. This specific gene has never been investigated in our population. DNA was extracted from specimens collected from 205 healthy unrelated Lebanese individuals and tested, using a reverse hybridization polymerase chain reaction (PCR) assay, for the prevalence of 1a and 1b HPA-1 alleles. Genotypes 1a-1a, 1a-1b, and 1b-1b were assigned accordingly. We observed that the 1a-1a genotype was the most prevalent (65.85percent) followed by 1a-1b (30.24percent) and 1b-1b (3.91percent) with allelic frequencies for 1a and 1b of 0.81 and 0.19, respectively. As compared with other ethnic groups, the Lebanese population was found to have a relatively high prevalence of the HPA-1b, which may predispose to a higher risk of alloimmunization. This report is the first to study the prevalence of the HPA-1 system in the Lebanese population and serves as a template for future clinical research involving platelet disorders and cardiovascular diseases. © 2007 The Authors.
dc.format.extent
dc.format.extent Pages: (473-478)
dc.language English
dc.publisher OXFORD
dc.relation.ispartof Publication Name: Transfusion Medicine; Publication Year: 2007; Volume: 17; no. 6; Pages: (473-478);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Gene frequencies of the HPA-1 platelet antigen alleles in the Lebanese population
dc.type Article
dc.contributor.affiliation Sabbagh, A.S., Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Taher, A.T., Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Zaatari, G.S., Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Mahfouz, R.A.R., Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Beirut, Lebanon, Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center (AUBMC), PO BOX 11-0236, Riad El Solh, Beirut 1107 2020, Lebanon
dc.contributor.authorAddress Mahfouz, R.A.R.; Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center (AUBMC), PO BOX 11-0236, Riad El Solh, Beirut 1107 2020, Lebanon; email: rm11@aub.edu.lb
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Pathology and Laboratory Medicine;
dc.contributor.authorDepartment Pathology and Laboratory Medicine
dc.contributor.authorDivision
dc.contributor.authorEmail rm11@aub.edu.lb
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Sabbagh, AS
dc.contributor.authorInitials Taher, AT
dc.contributor.authorInitials Zaatari, GS
dc.contributor.authorInitials Mahfouz, RAR
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Mahfouz, RAR (reprint author), Amer Univ Beirut, Med Ctr, Dept Pathol and Lab Med, PO Box 11-0236, Beirut 11072020, Lebanon.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedCount 10
dc.description.citedTotWOSCount 10
dc.description.citedWOSCount 10
dc.format.extentCount 6
dc.identifier.articleNo
dc.identifier.coden TRMDE
dc.identifier.pubmedID 18067652
dc.identifier.scopusID 36649013239
dc.identifier.url
dc.publisher.address 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND
dc.relation.ispartofConference
dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr Transfus. Med.
dc.relation.ispartOfIssue 6
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Transfusion Medicine
dc.relation.ispartofPubTitleAbbr Transfus. Med.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 17
dc.source.ID WOS:000251330000007
dc.type.publication Journal
dc.subject.otherAuthKeyword 1a
dc.subject.otherAuthKeyword 1b
dc.subject.otherAuthKeyword Alleles
dc.subject.otherAuthKeyword Frequency
dc.subject.otherAuthKeyword HPA-1
dc.subject.otherAuthKeyword Lebanese
dc.subject.otherChemCAS 1a alloantigen, human
dc.subject.otherChemCAS Antigens, Human Platelet
dc.subject.otherChemCAS Integrin beta3
dc.subject.otherChemCAS human platelet antigen 1b
dc.subject.otherIndex platelet antigen 1
dc.subject.otherIndex thrombocyte antigen
dc.subject.otherIndex unclassified drug
dc.subject.otherIndex alloimmunization
dc.subject.otherIndex article
dc.subject.otherIndex DNA extraction
dc.subject.otherIndex ethnic group
dc.subject.otherIndex female
dc.subject.otherIndex gene frequency
dc.subject.otherIndex genotype
dc.subject.otherIndex graft rejection
dc.subject.otherIndex human
dc.subject.otherIndex Lebanon
dc.subject.otherIndex male
dc.subject.otherIndex normal human
dc.subject.otherIndex organ transplantation
dc.subject.otherIndex polymerase chain reaction
dc.subject.otherIndex prevalence
dc.subject.otherIndex Adult
dc.subject.otherIndex Alleles
dc.subject.otherIndex Antigens, Human Platelet
dc.subject.otherIndex Blood Donors
dc.subject.otherIndex Blood Platelet Disorders
dc.subject.otherIndex Cardiovascular Diseases
dc.subject.otherIndex Ethnic Groups
dc.subject.otherIndex Female
dc.subject.otherIndex Gene Frequency
dc.subject.otherIndex Genotype
dc.subject.otherIndex Humans
dc.subject.otherIndex Integrin beta3
dc.subject.otherIndex Lebanon
dc.subject.otherIndex Male
dc.subject.otherIndex Platelet Transfusion
dc.subject.otherIndex Risk
dc.subject.otherIndex Sampling Studies
dc.subject.otherKeywordPlus POLYMERASE CHAIN-REACTION
dc.subject.otherKeywordPlus CORONARY-ARTERY-DISEASE
dc.subject.otherKeywordPlus MEMBRANE GLYCOPROTEIN IIIA
dc.subject.otherKeywordPlus SEQUENCE-SPECIFIC PRIMERS
dc.subject.otherKeywordPlus INHERITED RISK-FACTOR
dc.subject.otherKeywordPlus MYOCARDIAL-INFARCTION
dc.subject.otherKeywordPlus BLOOD-DONORS
dc.subject.otherKeywordPlus POLYMORPHISM
dc.subject.otherKeywordPlus ALLOANTIGENS
dc.subject.otherKeywordPlus RECEPTOR
dc.subject.otherWOS Hematology


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