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Plasminogen Activator Inhibitor-1 (PAI-1) gene 4G-5G alleles frequency distribution in the Lebanese population

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dc.contributor.author Shammaa D.M.R.
dc.contributor.author Sabbagh A.S.
dc.contributor.author Taher A.T.
dc.contributor.author Zaatari G.S.
dc.contributor.author Mahfouz R.A.R.
dc.contributor.editor
dc.date Sep-2008
dc.date.accessioned 2017-10-05T15:59:47Z
dc.date.available 2017-10-05T15:59:47Z
dc.date.issued 2008
dc.identifier 10.1007/s11033-007-9106-2
dc.identifier.isbn
dc.identifier.issn 03014851
dc.identifier.uri http://hdl.handle.net/10938/19243
dc.description.abstract Plasminogen activator inhibitor-1 (PAI-1) is an inhibitor of fibrinolysis. Increased plasma PAI-1 levels play an essential role in the pathogenesis of cardiovascular risk and other diseases associated with thrombosis. The 4G-5G polymorphism of the PAI-1 promoter region has been extensively studied in different populations. We studied 160 healthy unrelated Lebanese individuals using a reverse hybridization PCR assay to detect the 5G-5G, 4G-5G and, 4G-4G genotypes of the PAI-1 gene and the frequencies of the 4G and 5G alleles. We found that 4G-5G genotype was the most prevalent (45.6percent) followed by 5G-5G (36.9percent) and 4G-4G (17.5percent). The frequencies of the 4G and 5G alleles were calculated to be 0.403 and 0.597, respectively. Compared to other ethnic communities, the Lebanese population was found to harbour a relatively high prevalence of the rare 4G allele. This, in turn, may predispose this population to develop cardiovascular diseases and other thrombotic clinical conditions. This study aids to enhance our understanding of the genetic features of the Lebanese population. © 2007 Springer Science+Business Media B.V.
dc.format.extent
dc.format.extent Pages: (453-457)
dc.language English
dc.publisher DORDRECHT
dc.relation.ispartof Publication Name: Molecular Biology Reports; Publication Year: 2008; Volume: 35; no. 3; Pages: (453-457);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Plasminogen Activator Inhibitor-1 (PAI-1) gene 4G-5G alleles frequency distribution in the Lebanese population
dc.type Article
dc.contributor.affiliation Shammaa, D.M.R., Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, P.O. Box 11-0236, Riad El Solh 1107 2020, Beirut, Lebanon
dc.contributor.affiliation Sabbagh, A.S., Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, P.O. Box 11-0236, Riad El Solh 1107 2020, Beirut, Lebanon
dc.contributor.affiliation Taher, A.T., Department of Internal Medicine, American University of Beirut Medical Center, P.O. Box 11-0236, Riad El Solh 1107 2020, Beirut, Lebanon
dc.contributor.affiliation Zaatari, G.S., Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, P.O. Box 11-0236, Riad El Solh 1107 2020, Beirut, Lebanon
dc.contributor.affiliation Mahfouz, R.A.R., Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, P.O. Box 11-0236, Riad El Solh 1107 2020, Beirut, Lebanon
dc.contributor.authorAddress Mahfouz, R. A. R.; Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, P.O. Box 11-0236, Riad El Solh 1107 2020, Beirut, Lebanon; email: rm11@aub.edu.lb
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Pathology and Laboratory Medicine;
dc.contributor.authorDepartment Pathology and Laboratory Medicine
dc.contributor.authorDivision
dc.contributor.authorEmail rm11@aub.edu.lb
dc.contributor.faculty Faculty of Medicine
dc.contributor.authorInitials Shammaa, DMR
dc.contributor.authorInitials Sabbagh, AS
dc.contributor.authorInitials Taher, AT
dc.contributor.authorInitials Zaatari, GS
dc.contributor.authorInitials Mahfouz, RAR
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Mahfouz, RAR (reprint author), Amer Univ Beirut, Med Ctr, Dept Pathol and Lab Med, POB 11-0236,Riad El Solh 1107 2020, Beirut, Lebanon.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedCount 3
dc.description.citedTotWOSCount 5
dc.description.citedWOSCount 4
dc.format.extentCount 5
dc.identifier.articleNo
dc.identifier.coden MLBRB
dc.identifier.pubmedID 17578681
dc.identifier.scopusID 48249102707
dc.identifier.url
dc.publisher.address VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
dc.relation.ispartofConference
dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr Mol. Biol. Rep.
dc.relation.ispartOfIssue 3
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Molecular Biology Reports
dc.relation.ispartofPubTitleAbbr Mol. Biol. Rep.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 35
dc.source.ID WOS:000257952900023
dc.type.publication Journal
dc.subject.otherAuthKeyword 4G
dc.subject.otherAuthKeyword 5G
dc.subject.otherAuthKeyword Alleles
dc.subject.otherAuthKeyword Frequency
dc.subject.otherAuthKeyword Lebanese
dc.subject.otherAuthKeyword PAI-1
dc.subject.otherChemCAS plasminogen activator inhibitor 1, 140208-23-7
dc.subject.otherChemCAS Plasminogen Activator Inhibitor 1
dc.subject.otherIndex plasminogen activator inhibitor 1
dc.subject.otherIndex article
dc.subject.otherIndex cardiovascular disease
dc.subject.otherIndex controlled study
dc.subject.otherIndex disease predisposition
dc.subject.otherIndex ethnic group
dc.subject.otherIndex female
dc.subject.otherIndex gene
dc.subject.otherIndex gene frequency
dc.subject.otherIndex genotype
dc.subject.otherIndex human
dc.subject.otherIndex human experiment
dc.subject.otherIndex hybridization
dc.subject.otherIndex Lebanon
dc.subject.otherIndex male
dc.subject.otherIndex normal human
dc.subject.otherIndex plasminogen activator inhibitor 1 gene
dc.subject.otherIndex polymerase chain reaction
dc.subject.otherIndex population genetics
dc.subject.otherIndex prevalence
dc.subject.otherIndex thrombosis
dc.subject.otherIndex Alleles
dc.subject.otherIndex Female
dc.subject.otherIndex Genotype
dc.subject.otherIndex Humans
dc.subject.otherIndex Lebanon
dc.subject.otherIndex Male
dc.subject.otherIndex Plasminogen Activator Inhibitor 1
dc.subject.otherKeywordPlus CORONARY-ARTERY-DISEASE
dc.subject.otherKeywordPlus DEEP-VEIN THROMBOSIS
dc.subject.otherKeywordPlus MYOCARDIAL-INFARCTION
dc.subject.otherKeywordPlus VENOUS THROMBOSIS
dc.subject.otherKeywordPlus TISSUE-TYPE
dc.subject.otherKeywordPlus RISK FACTOR
dc.subject.otherKeywordPlus POLYMORPHISM
dc.subject.otherKeywordPlus PROMOTER
dc.subject.otherKeywordPlus PREVALENCE
dc.subject.otherKeywordPlus GENOTYPE
dc.subject.otherWOS Biochemistry and Molecular Biology


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