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Factor XIII gene V34L mutation in the Lebanese population: Another unique feature in this community?

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dc.contributor.author Mahfouz R.A.R.
dc.contributor.author Sabbagh A.S.
dc.contributor.author Shammaa D.M.R.
dc.contributor.author Otrock Z.K.
dc.contributor.author Zaatari G.S.
dc.contributor.author Taher A.T.
dc.contributor.editor
dc.date Sep-2008
dc.date.accessioned 2017-10-05T15:59:47Z
dc.date.available 2017-10-05T15:59:47Z
dc.date.issued 2008
dc.identifier 10.1007/s11033-007-9096-0
dc.identifier.isbn
dc.identifier.issn 03014851
dc.identifier.uri http://hdl.handle.net/10938/19244
dc.description.abstract We studied the distribution of the Factor XIII gene V34L polymorphism in a sample of healthy Lebanese individuals to assess its prevalence and compare it with other populations. Factor XIII genotypes were determined using the Cardiovascular Disease (CVD) StripAssay (ViennaLab, Austria), which is based on a Polymerase Chain Reaction-Reverse hybridization technique. DNA from 205 unrelated healthy donors from our HLA database was used. The prevalence of Wild type, heterozygous, and homozygous genotypes was found to be 74.2percent, 22.4percent, and 3.4percent respectively. The sampled Lebanese population showed that the prevalence of V34L carriers (25.8percent) was lower than Caucasians in general (44.3percent) and, interestingly, with a low allele frequency of 0.14 similar to that in Blacks and South Asians. This first report from Lebanon sheds light on an additional unique genetic feature of this population and will prospectively serve as a baseline statistical data for future investigations of the prevalence of Factor XIII V34L mutation in association with various clinical entities notably cardiovascular diseases. © 2007 Springer Science+Business Media B.V.
dc.format.extent
dc.format.extent Pages: (375-378)
dc.language English
dc.publisher DORDRECHT
dc.relation.ispartof Publication Name: Molecular Biology Reports; Publication Year: 2008; Volume: 35; no. 3; Pages: (375-378);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Factor XIII gene V34L mutation in the Lebanese population: Another unique feature in this community?
dc.type Article
dc.contributor.affiliation Mahfouz, R.A.R., American University of Beirut Medical Center, Department of Pathology, and Laboratory of Medicine, P.O. Box 11-0236, Riad El Sol, Beirut 1107 2020, Lebanon
dc.contributor.affiliation Sabbagh, A.S., American University of Beirut Medical Center, Department of Pathology, and Laboratory of Medicine, P.O. Box 11-0236, Riad El Sol, Beirut 1107 2020, Lebanon
dc.contributor.affiliation Shammaa, D.M.R., American University of Beirut Medical Center, Department of Pathology, and Laboratory of Medicine, P.O. Box 11-0236, Riad El Sol, Beirut 1107 2020, Lebanon
dc.contributor.affiliation Otrock, Z.K., Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Zaatari, G.S., American University of Beirut Medical Center, Department of Pathology, and Laboratory of Medicine, P.O. Box 11-0236, Riad El Sol, Beirut 1107 2020, Lebanon
dc.contributor.affiliation Taher, A.T., Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.authorAddress Mahfouz, R. A. R.; American University of Beirut Medical Center, Department of Pathology, and Laboratory of Medicine, P.O. Box 11-0236, Riad El Sol, Beirut 1107 2020, Lebanon; email: rm11@aub.edu.lb
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Pathology and Laboratory Medicine;
dc.contributor.authorDepartment Pathology and Laboratory Medicine
dc.contributor.authorDivision
dc.contributor.authorEmail rm11@aub.edu.lb
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Mahfouz, RAR
dc.contributor.authorInitials Sabbagh, AS
dc.contributor.authorInitials Shammaa, DMR
dc.contributor.authorInitials Otrock, ZK
dc.contributor.authorInitials Zaatari, GS
dc.contributor.authorInitials Taher, AT
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Mahfouz, RAR (reprint author), Amer Univ Beirut, Med Ctr, Dept Pathol and Lab Med, POB 11-0236, Beirut 11072020, Lebanon.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedCount 6
dc.description.citedTotWOSCount 7
dc.description.citedWOSCount 7
dc.format.extentCount 4
dc.identifier.articleNo
dc.identifier.coden MLBRB
dc.identifier.pubmedID 17516146
dc.identifier.scopusID 48249110354
dc.identifier.url
dc.publisher.address VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
dc.relation.ispartofConference
dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr Mol. Biol. Rep.
dc.relation.ispartOfIssue 3
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Molecular Biology Reports
dc.relation.ispartofPubTitleAbbr Mol. Biol. Rep.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 35
dc.source.ID WOS:000257952900013
dc.type.publication Journal
dc.subject.otherAuthKeyword Factor XIII
dc.subject.otherAuthKeyword Lebanese
dc.subject.otherAuthKeyword Population
dc.subject.otherAuthKeyword Prevalence
dc.subject.otherAuthKeyword V34L
dc.subject.otherChemCAS blood clotting factor 13, 9013-56-3
dc.subject.otherChemCAS DNA, 9007-49-2
dc.subject.otherChemCAS Factor XIII, 9013-56-3
dc.subject.otherChemCAS Leucine, 61-90-5
dc.subject.otherChemCAS Valine, 7004-03-7
dc.subject.otherIndex blood clotting factor 13
dc.subject.otherIndex DNA
dc.subject.otherIndex allele
dc.subject.otherIndex article
dc.subject.otherIndex cardiovascular disease
dc.subject.otherIndex female
dc.subject.otherIndex gene mutation
dc.subject.otherIndex genetic polymorphism
dc.subject.otherIndex genotype
dc.subject.otherIndex HLA system
dc.subject.otherIndex human
dc.subject.otherIndex Lebanon
dc.subject.otherIndex major clinical study
dc.subject.otherIndex male
dc.subject.otherIndex polymerase chain reaction
dc.subject.otherIndex prevalence
dc.subject.otherIndex prospective study
dc.subject.otherIndex wild type
dc.subject.otherIndex Factor XIII
dc.subject.otherIndex Female
dc.subject.otherIndex Genotype
dc.subject.otherIndex Health
dc.subject.otherIndex Humans
dc.subject.otherIndex Lebanon
dc.subject.otherIndex Leucine
dc.subject.otherIndex Male
dc.subject.otherIndex Mutation
dc.subject.otherIndex Valine
dc.subject.otherKeywordPlus COAGULATION-FACTOR-XIII
dc.subject.otherKeywordPlus PRIMARY INTRACEREBRAL HEMORRHAGE
dc.subject.otherKeywordPlus DEEP VENOUS THROMBOSIS
dc.subject.otherKeywordPlus PLASMA FACTOR-XIII
dc.subject.otherKeywordPlus FACTOR-V-LEIDEN
dc.subject.otherKeywordPlus VAL34LEU POLYMORPHISM
dc.subject.otherKeywordPlus MYOCARDIAL-INFARCTION
dc.subject.otherKeywordPlus A-SUBUNIT
dc.subject.otherKeywordPlus ARTERIAL THROMBOEMBOLISM
dc.subject.otherKeywordPlus COMMON POLYMORPHISM
dc.subject.otherWOS Biochemistry and Molecular Biology


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