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Short- and long-term safety of weekly high-dose vitamin D3 supplementation in school children

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dc.contributor.author Maalouf J.
dc.contributor.author Nabulsi M.
dc.contributor.author Vieth R.
dc.contributor.author Kimball S.
dc.contributor.author El-Rassi R.
dc.contributor.author Mahfoud Z.
dc.contributor.author Fuleihan G.E.-H.
dc.contributor.editor
dc.date Jul-2008
dc.date.accessioned 2017-10-05T16:01:01Z
dc.date.available 2017-10-05T16:01:01Z
dc.date.issued 2008
dc.identifier 10.1210/jc.2007-2530
dc.identifier.isbn
dc.identifier.issn
dc.identifier.uri http://hdl.handle.net/10938/19264
dc.description.abstract Background: Hypovitaminosis D is prevalent in youth worldwide, but the safety of vitamin D at doses exceeding 200 IU-d is unknown in this age group. We assessed the safety of high doses of vitamin D3 administered to apparently healthy schoolchildren. Methods: To assess short-term safety, 25 subjects randomly received placebo or vitamin D3 at doses of 14,000 IU-wk for 8 wk. To assess long-term safety, 340 subjects randomly received placebo, vitamin D3 as 1,400 IU-wk or 14,000 IU-wk for 1 yr. Biochemical variables were monitored at 0, 2, 4, 6, and 8 wk and 8 wk off therapy in the short-term study and at 0, 6, and 12 months in the long-term study. Results: In both the short- and long-term studies, mean serum calcium and 1,25-hydroxyvitamin levels did not change in any group. In the short-term study, mean 25-hydroxyvitamin concentrations increased from 44 (± 11) to 54 (± 19) ng-ml in the treated groups (P = 0.033). In the long-term study, mean 25-hydroxyvitamin D levels increased from 15 ± 8 to 19 ± 7 ng-ml (P andlt; 0.0001) in subjects receiving 1,400 IU-wk and from 15 ± 7 to 36 ± 22 ng-ml (P andlt; 0.0001) in the group receiving 14,000 IU-wk. No subject developed vitamin D intoxication. Conclusion: Vitamin D 3 at doses equivalent to 2000 IU-d for 1 yr is safe in adolescents and results in desirable vitamin D levels. Copyright © 2008 by The Endocrine Society.
dc.format.extent
dc.format.extent Pages: (2693-2701)
dc.language English
dc.publisher CHEVY CHASE
dc.relation.ispartof Publication Name: Journal of Clinical Endocrinology and Metabolism; Publication Year: 2008; Volume: 93; no. 7; Pages: (2693-2701);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Short- and long-term safety of weekly high-dose vitamin D3 supplementation in school children
dc.type Article
dc.contributor.affiliation Maalouf, J., Calcium Metabolism and Osteoporosis Program, Department of Internal Medicine, American University of Beirut, Beirut, 113-6044, Lebanon
dc.contributor.affiliation Nabulsi, M., Department of Pediatrics, School of Medicine, American University of Beirut, Beirut, 113-6044, Lebanon
dc.contributor.affiliation Vieth, R., Department of Nutritional Sciences, University of Toronto, Toronto, ON M5S 3E2, Canada, Department of Laboratory Medicine, University of Toronto, Toronto, ON M5S 3E2, Canada
dc.contributor.affiliation Kimball, S., Department of Nutritional Sciences, University of Toronto, Toronto, ON M5S 3E2, Canada
dc.contributor.affiliation El-Rassi, R., Calcium Metabolism and Osteoporosis Program, Department of Internal Medicine, American University of Beirut, Beirut, 113-6044, Lebanon
dc.contributor.affiliation Mahfoud, Z., Department of Epidemiology and Population Health, School of Health Sciences, American University of Beirut, Beirut, 113-6044, Lebanon
dc.contributor.affiliation Fuleihan, G.E.-H., Calcium Metabolism and Osteoporosis Program, Department of Internal Medicine, American University of Beirut, Beirut, 113-6044, Lebanon, Calcium Metabolism and Osteoporosis Program, American University of Beirut-Medical Center, Bliss Street, Beirut, 113-6044, Lebanon
dc.contributor.authorAddress Fuleihan, G. E.-H.; Calcium Metabolism and Osteoporosis Program, American University of Beirut-Medical Center, Bliss Street, Beirut, 113-6044, Lebanon; email: gf01@aub.edu.lb
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Pediatrics and Adolescent Medicine;
dc.contributor.authorDepartment Pediatrics and Adolescent Medicine
dc.contributor.authorDivision
dc.contributor.authorEmail gf01@aub.edu.lb
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Maalouf, J
dc.contributor.authorInitials Nabulsi, M
dc.contributor.authorInitials Vieth, R
dc.contributor.authorInitials Kimball, S
dc.contributor.authorInitials El-Rassi, R
dc.contributor.authorInitials Mahfoud, Z
dc.contributor.authorInitials Fuleihan, GEH
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Fuleihan, GEH (reprint author), Amer Univ Beirut, Med Ctr, Calcium Metab and Osteoporosis Program, Dept Internal Med, Bliss St, Beirut 1136044, Lebanon.
dc.contributor.authorResearcherID Szaleniec, Maciej-A-1198-2013
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedCount 62
dc.description.citedTotWOSCount 54
dc.description.citedWOSCount 52
dc.format.extentCount 9
dc.identifier.articleNo
dc.identifier.coden JCEMA
dc.identifier.pubmedID 18445674
dc.identifier.scopusID 47549089512
dc.identifier.url
dc.publisher.address 8401 CONNECTICUT AVE, SUITE 900, CHEVY CHASE, MD 20815-5817 USA
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dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr J. Clin. Endocrinol. Metab.
dc.relation.ispartOfIssue 7
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Journal of Clinical Endocrinology and Metabolism
dc.relation.ispartofPubTitleAbbr J. Clin. Endocrinol. Metab.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 93
dc.source.ID WOS:000257513700042
dc.type.publication Journal
dc.subject.otherAuthKeyword
dc.subject.otherChemCAS 25 hydroxyvitamin D, 64719-49-9
dc.subject.otherChemCAS alkaline phosphatase, 9001-78-9
dc.subject.otherChemCAS calcitriol, 32222-06-3, 32511-63-0, 66772-14-3
dc.subject.otherChemCAS calcium, 7440-70-2
dc.subject.otherChemCAS colecalciferol, 1406-16-2, 67-97-0
dc.subject.otherChemCAS phosphorus, 7723-14-0
dc.subject.otherChemCAS 25-hydroxyvitamin D, 64719-49-9
dc.subject.otherChemCAS Calcium, 7440-70-2
dc.subject.otherChemCAS Cholecalciferol, 67-97-0
dc.subject.otherChemCAS Vitamin D, 1406-16-2
dc.subject.otherIndex 25 hydroxyvitamin D
dc.subject.otherIndex alkaline phosphatase
dc.subject.otherIndex calcitriol
dc.subject.otherIndex calcium
dc.subject.otherIndex colecalciferol
dc.subject.otherIndex phosphorus
dc.subject.otherIndex placebo
dc.subject.otherIndex adolescent
dc.subject.otherIndex alkaline phosphatase blood level
dc.subject.otherIndex article
dc.subject.otherIndex calcium blood level
dc.subject.otherIndex clinical article
dc.subject.otherIndex clinical trial
dc.subject.otherIndex controlled clinical trial
dc.subject.otherIndex controlled study
dc.subject.otherIndex dose response
dc.subject.otherIndex double blind procedure
dc.subject.otherIndex drug megadose
dc.subject.otherIndex drug safety
dc.subject.otherIndex drug withdrawal
dc.subject.otherIndex female
dc.subject.otherIndex glomerulonephritis
dc.subject.otherIndex human
dc.subject.otherIndex long term exposure
dc.subject.otherIndex low drug dose
dc.subject.otherIndex male
dc.subject.otherIndex patient compliance
dc.subject.otherIndex phosphate blood level
dc.subject.otherIndex priority journal
dc.subject.otherIndex randomized controlled trial
dc.subject.otherIndex risk assessment
dc.subject.otherIndex school child
dc.subject.otherIndex short course therapy
dc.subject.otherIndex single blind procedure
dc.subject.otherIndex vitamin blood level
dc.subject.otherIndex vitamin D intoxication
dc.subject.otherIndex vitamin supplementation
dc.subject.otherIndex Adolescent
dc.subject.otherIndex Calcium
dc.subject.otherIndex Child
dc.subject.otherIndex Cholecalciferol
dc.subject.otherIndex Dietary Supplements
dc.subject.otherIndex Double-Blind Method
dc.subject.otherIndex Female
dc.subject.otherIndex Humans
dc.subject.otherIndex Male
dc.subject.otherIndex Vitamin D
dc.subject.otherKeywordPlus SERUM 25-HYDROXYVITAMIN D
dc.subject.otherKeywordPlus D DEFICIENCY
dc.subject.otherKeywordPlus MALE-ADOLESCENTS
dc.subject.otherKeywordPlus CALCIUM
dc.subject.otherKeywordPlus PARAMETERS
dc.subject.otherKeywordPlus OSTEOPOROSIS
dc.subject.otherKeywordPlus PREVALENCE
dc.subject.otherKeywordPlus PREVENTION
dc.subject.otherKeywordPlus INTERVALS
dc.subject.otherKeywordPlus EFFICACY
dc.subject.otherWOS Endocrinology and Metabolism


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