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Magnetic resonance angiography in children with sickle cell disease and abnormal transcranial Doppler ultrasonography findings enrolled in the STOP study

Show simple item record Abboud M.R. Cure J. Granger S. Gallagher D. Hsu L. Wang W. Woods G. Berman B. Brambilla D. Pegelow C. Lewin J. Zimmermann R.A. Adams R.J.
dc.contributor.editor Apr-2004 2017-10-05T16:01:02Z 2017-10-05T16:01:02Z 2004
dc.identifier 10.1182/blood-2003-06-1972
dc.identifier.issn 00064971
dc.description.abstract The stroke prevention study in sickle cell disease (STOP) demonstrated a 90percent reduction in stroke risk with transfusion among patients with time-averaged mean cerebral blood velocity (TAMV) of 200 cm-s or more as measured by transcranial Doppler (TCD). In STOP, 232 brain magnetic resonance angiograms (MRAs) were performed on 100 patients, 47 in the transfusion arm and 53 in the standard care arm. Baseline MRA findings were interpreted as normal in 75 patients and as indicating mild stenosis in 4 patients and severe stenosis in 21 patients. Among 35 patients who underwent magnetic resonance angiography within 30 days of random assignment, the TAMV was significantly higher in 7 patients with severe stenosis compared with 28 patients with normal MRA findings or mild stenosis (276.7 ± 34 vs 215 ± 15.6 cm-s; P .001). In the standard care arm, 4 of 13 patients with abnormal MRA findings had strokes compared with 5 of 40 patients with normal MRA findings (P= .03). In this arm, TAMV became normal (less than 170 cm-s) or conditional (170-199 cm-s) in 26 of 38 patients with normal or mildly abnormal baseline MRA but remained abnormal in 8 of 10 patients with severely abnormal baseline MRA. These results suggest that TCD often detects flow abnormalities indicative of stroke risk before MRA lesions become evident. Furthermore, patients with abnormal MRA findings and higher TCD velocities are at higher risk for stroke, and their cerebral TAMVs are unlikely to decrease without transfusion. © 2004 by The American Society of Hematology.
dc.format.extent Pages: (2822-2826)
dc.language English
dc.publisher WASHINGTON
dc.relation.ispartof Publication Name: Blood; Publication Year: 2004; Volume: 103; no. 7; Pages: (2822-2826);
dc.source Scopus
dc.title Magnetic resonance angiography in children with sickle cell disease and abnormal transcranial Doppler ultrasonography findings enrolled in the STOP study
dc.type Article
dc.contributor.affiliation Abboud, M.R., Children's Cancer Center of Lebanon, Amer. Univ. of Beirut Medical Center, PO Box 11-0236, Riad El-Solh, Beirut 1107-2020, Lebanon
dc.contributor.affiliation Cure, J.
dc.contributor.affiliation Granger, S.
dc.contributor.affiliation Gallagher, D.
dc.contributor.affiliation Hsu, L.
dc.contributor.affiliation Wang, W.
dc.contributor.affiliation Woods, G.
dc.contributor.affiliation Berman, B.
dc.contributor.affiliation Brambilla, D.
dc.contributor.affiliation Pegelow, C.
dc.contributor.affiliation Lewin, J.
dc.contributor.affiliation Zimmermann, R.A.
dc.contributor.affiliation Adams, R.J.
dc.contributor.authorAddress Abboud, M.R.; Children's Cancer Center of Lebanon, Amer. Univ. of Beirut Medical Center, PO Box 11-0236, Riad El-Solh, Beirut 1107-2020, Lebanon; email:
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Pediatrics and Adolescent Medicine;
dc.contributor.authorDepartment Pediatrics and Adolescent Medicine
dc.contributor.faculty Faculty of Medicine
dc.contributor.authorInitials Abboud, MR
dc.contributor.authorInitials Cure, J
dc.contributor.authorInitials Granger, S
dc.contributor.authorInitials Gallagher, D
dc.contributor.authorInitials Hsu, L
dc.contributor.authorInitials Wang, W
dc.contributor.authorInitials Woods, G
dc.contributor.authorInitials Berman, B
dc.contributor.authorInitials Brambilla, D
dc.contributor.authorInitials Pegelow, C
dc.contributor.authorInitials Lewin, J
dc.contributor.authorInitials Zimmermann, RA
dc.contributor.authorInitials Adams, RJ
dc.contributor.authorReprintAddress Abboud, MR (reprint author), American Univ, Beirut Med Ctr, Childrens Canc Ctr Lebanon, POB 11-0236, Beirut 11072020, Lebanon.
dc.contributor.authorResearcherID Hsu, Lewis-A-3360-2008
dc.contributor.authorUniversity American University of Beirut Medical Center
dc.description.cited ADAMS R, 1992, NEW ENGL J MED, V326, P605, DOI 10.1056-NEJM199202273260905; ADAMS R, 1989, J CARDIOVASC TECHNOL, V8, pA216; Adams RJ, 1998, NEW ENGL J MED, V339, P5, DOI 10.1056-NEJM199807023390102; ADAMS RJ, 1992, STROKE, V23, P1073; BALKARAN B, 1992, J PEDIATR, V120, P360, DOI 10.1016-S0022-3476(05)80897-2; DEBAUN MR, 1995, J PEDIAT HEMATOL ONC, V17, P29, DOI 10.1097-00043426-199502000-00005; Gillams AR, 1998, PEDIATR RADIOL, V28, P283, DOI 10.1007-s002470050352; KANDEEL AY, 1996, DIAGN NEURORADIOL, V38, P406; KOSBY M, 1990, J ASS ACAD MINOR PHY, V1, P71; Ohene-Frempong K, 1998, BLOOD, V91, P288; PAGELOW CH, 1995, J PEDIATR, V126, P896; Pegelow CH, 2001, ARCH NEUROL-CHICAGO, V58, P2017, DOI 10.1001-archneur.58.12.2017; POWARS D, 1978, AM J MED, V65, P461, DOI 10.1016-0002-9343(78)90772-6; RUSSELL MO, 1984, BLOOD, V63, P162; Seibert JJ, 1998, PEDIATR RADIOL, V28, P138, DOI 10.1007-s002470050314; SEIBERT JJ, 1993, RADIOLOGY, V189, P457; STOCKMAN JA, 1972, NEW ENGL J MED, V287, P846, DOI 10.1056-NEJM197210262871703; Verlhac S, 1995, PEDIATR RADIOL, V25, pS14; WANG WC, 1991, J PEDIATR-US, V118, P377, DOI 10.1016-S0022-3476(05)82150-X; Wang WC, 2000, J PEDIAT HEMATOL ONC, V22, P335, DOI 10.1097-00043426-200007000-00010; WIZNITZER M, 1990, J PEDIATR, V117, P551, DOI 10.1016-S0022-3476(05)80687-0
dc.description.citedCount 58
dc.description.citedTotWOSCount 58
dc.description.citedWOSCount 58
dc.format.extentCount 5
dc.identifier.coden BLOOA
dc.identifier.pubmedID 14684415
dc.identifier.scopusID 12144290116
dc.publisher.address 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA
dc.relation.ispartOfISOAbbr Blood
dc.relation.ispartOfIssue 7
dc.relation.ispartofPubTitle Blood
dc.relation.ispartofPubTitleAbbr Blood
dc.relation.ispartOfVolume 103
dc.source.ID WOS:000222163200064
dc.type.publication Journal
dc.subject.otherIndex article
dc.subject.otherIndex blood flow velocity
dc.subject.otherIndex blood transfusion
dc.subject.otherIndex brain blood flow
dc.subject.otherIndex child
dc.subject.otherIndex controlled study
dc.subject.otherIndex disease severity
dc.subject.otherIndex Doppler flowmetry
dc.subject.otherIndex female
dc.subject.otherIndex high risk population
dc.subject.otherIndex human
dc.subject.otherIndex magnetic resonance angiography
dc.subject.otherIndex major clinical study
dc.subject.otherIndex male
dc.subject.otherIndex priority journal
dc.subject.otherIndex risk assessment
dc.subject.otherIndex sickle cell anemia
dc.subject.otherIndex stenosis
dc.subject.otherIndex stroke
dc.subject.otherIndex Anemia, Sickle Cell
dc.subject.otherIndex Blood Flow Velocity
dc.subject.otherIndex Blood Transfusion
dc.subject.otherIndex Brain
dc.subject.otherIndex Cerebrovascular Accident
dc.subject.otherIndex Cerebrovascular Circulation
dc.subject.otherIndex Child
dc.subject.otherIndex Female
dc.subject.otherIndex Humans
dc.subject.otherIndex Magnetic Resonance Angiography
dc.subject.otherIndex Male
dc.subject.otherIndex Ultrasonography, Doppler, Transcranial
dc.subject.otherKeywordPlus CENTRAL-NERVOUS-SYSTEM
dc.subject.otherKeywordPlus CEREBROVASCULAR-DISEASE
dc.subject.otherKeywordPlus ASYMPTOMATIC PATIENTS
dc.subject.otherKeywordPlus TRANSFUSION THERAPY
dc.subject.otherKeywordPlus ANEMIA
dc.subject.otherKeywordPlus STROKE
dc.subject.otherKeywordPlus MRA
dc.subject.otherKeywordPlus RISK
dc.subject.otherWOS Hematology

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