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Thyroid cancer in Lebanese children and adolescents: A 15-year experience at a single institution

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dc.contributor.author Dardas M.
dc.contributor.author Abboud M.
dc.contributor.author Salti I.
dc.contributor.author Sabri A.
dc.contributor.author Shoucair M.
dc.contributor.author Saleh M.
dc.contributor.author Azar S.
dc.contributor.author Rodriguez-Galindo C.
dc.contributor.author Muwakkit S.
dc.contributor.editor
dc.date Aug-2009
dc.date.accessioned 2017-10-05T16:01:04Z
dc.date.available 2017-10-05T16:01:04Z
dc.date.issued 2009
dc.identifier 10.1080/08880010903091806
dc.identifier.isbn
dc.identifier.issn 08880018
dc.identifier.uri http://hdl.handle.net/10938/19302
dc.description.abstract Background and Aim: Thyroid carcinomas are rare in childhood and adolescence. Management of this entity remains controversial. The aim of this study is to review our experience with multidisciplinary management of papillary thyroid cancer in the pediatric population at a tertiary care specialized medical center in Lebanon. Procedure: The medical records of all patients with thyroid cancer younger than 20 years who presented to our center between January 1991 and January 2006 were reviewed. Results: Thirteen patients with papillary thyroid carcinoma (PTC) were identified. No patient had previous exposure to ionizing radiation. The mean age at diagnosis was 14.5 years. There were 8 females; all patients presented with a cervical mass. Ten patients underwent total thyroidectomy and three subtotal thyroidectomy. Eight patients (61.5percent) had regional lymph node metastases, only one of whom (7.6percent) had lung metastases. All received radioactive 131I ablation postsurgical excision. Five (38.5percent) had recurrences and needed multiple surgeries and-or 131I ablation. At a median follow-up time of 8.3 years all patients are disease free. Conclusion: Pediatric thyroid cancer in Lebanon is a rare tumor that presents mainly as a primary malignancy. The main clinical presentation is a cervical mass with locoregional lymph nodes metastasis. The mainstay of therapy is total thyroidectomy with lymph node dissection when indicated and radioactive 131I ablation. Despite recurrences the prognosis is excellent. Copyright © Informa Healthcare USA, Inc.
dc.format.extent
dc.format.extent Pages: (439-447)
dc.language English
dc.publisher PHILADELPHIA
dc.relation.ispartof Publication Name: Pediatric Hematology and Oncology; Publication Year: 2009; Volume: 26; no. 6; Pages: (439-447);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Thyroid cancer in Lebanese children and adolescents: A 15-year experience at a single institution
dc.type Article
dc.contributor.affiliation Dardas, M., Department of Pediatric Hematology Oncology, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Abboud, M., Department of Pediatric Hematology Oncology, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Salti, I., Division of Endocrinology, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Sabri, A., Department of Otolaryngology, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Shoucair, M., Division of Endocrinology, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Saleh, M., Division of Endocrinology, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Azar, S., Division of Endocrinology, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Rodriguez-Galindo, C., Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, United States
dc.contributor.affiliation Muwakkit, S., Department of Pediatric Hematology Oncology, American University of Beirut Medical Center, Beirut, Lebanon, Children Cancer Center of Lebanon, American University of Beirut Medical Center, Clemenceau Street. BLD 56, 11-0236, Beirut, Lebanon
dc.contributor.authorAddress Muwakkit, S.; Children Cancer Center of Lebanon, American University of Beirut Medical Center, Clemenceau Street. BLD 56, 11-0236, Beirut, Lebanon; email: samar.muwakkit@aub.edu.lb
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Pediatrics and Adolescent Medicine;
dc.contributor.authorDepartment Pediatrics and Adolescent Medicine
dc.contributor.authorDivision
dc.contributor.authorEmail samar.muwakkit@aub.edu.lb
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Dardas, M
dc.contributor.authorInitials Abboud, M
dc.contributor.authorInitials Salti, I
dc.contributor.authorInitials Sabri, A
dc.contributor.authorInitials Shoucair, M
dc.contributor.authorInitials Saleh, M
dc.contributor.authorInitials Azar, S
dc.contributor.authorInitials Rodriguez-Galindo, C
dc.contributor.authorInitials Muwakkit, S
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Muwakkit, S (reprint author), Amer Univ Beirut, Children Canc Ctr Lebanon, Med Ctr, Dept Pediat Hematol Oncol, Clemenceau St BLD 56,1st Floor,POB 11-0236, Beirut, Lebanon.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
dc.description.cited Alessandri AJ, 2000, MED PEDIATR ONCOL, V35, P41; Borson-Chazot F, 2004, WORLD J SURG, V28, P1088, DOI 10.1007-s00268-004-7630-y; Collini P, 2006, PEDIATR BLOOD CANCER, V46, P300, DOI 10.1002-pbc.20474; Dackiw APB, 2004, SURG CLIN N AM, V84, P817, DOI 10.1016-j.suc.2004.03.001; Gow KW, 2003, J PEDIATR SURG, V38, P1574, DOI 10.1016-S0022-3468(03)00563-3; GREENE FL, 2002, THYROID AJCC CANC ST, P77; Hameed R, 2005, J PAEDIATR CHILD H, V41, P572, DOI 10.1111-j.1440-1754.2005.00724.x; Haveman JW, 2003, ANN SURG ONCOL, V10, P15, DOI 10.1245-ASO.2003.03.002; Jarzab B, 2005, ENDOCR-RELAT CANCER, V12, P773, DOI 10.1677-erc.1.00880; Massimino M, 2006, PEDIATR BLOOD CANCER, V46, P307, DOI 10.1002-pbc.20438; Metzger ML, 2006, PEDIATR BLOOD CANCER, V46, P314, DOI 10.1002-pbc.20541; Palmer BA, 2005, J PEDIATR SURG, V40, P1284, DOI 10.1016-j.jpedsurg.2005.05.012; Shapiro NL, 2005, LARYNGOSCOPE, V115, P337, DOI 10.1097-01.mlg.0000154743.71184.09; Thompson GB, 2004, WORLD J SURG, V28, P1187, DOI 10.1007-s00268-004-7605-z; ZIMMERMAN D, 1988, SURGERY, V104, P1157
dc.description.citedCount 1
dc.description.citedTotWOSCount 1
dc.description.citedWOSCount 1
dc.format.extentCount 9
dc.identifier.articleNo
dc.identifier.coden PHONE
dc.identifier.pubmedID 19657994
dc.identifier.scopusID 68649114581
dc.identifier.url
dc.publisher.address 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA
dc.relation.ispartofConference
dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr Pediatr. Hematol. Oncol.
dc.relation.ispartOfIssue 6
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Pediatric Hematology and Oncology
dc.relation.ispartofPubTitleAbbr Pediatr. Hematol. Oncol.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 26
dc.source.ID WOS:000268708600007
dc.type.publication Journal
dc.subject.otherAuthKeyword Children
dc.subject.otherAuthKeyword Lebanon
dc.subject.otherAuthKeyword Primary
dc.subject.otherAuthKeyword Thyroid cancer
dc.subject.otherChemCAS iodine 131, 10043-66-0, 15124-39-7
dc.subject.otherChemCAS Iodine Radioisotopes
dc.subject.otherIndex iodine 131
dc.subject.otherIndex adolescent
dc.subject.otherIndex article
dc.subject.otherIndex cancer recurrence
dc.subject.otherIndex child
dc.subject.otherIndex clinical article
dc.subject.otherIndex female
dc.subject.otherIndex human
dc.subject.otherIndex Lebanon
dc.subject.otherIndex lung metastasis
dc.subject.otherIndex lymph node metastasis
dc.subject.otherIndex male
dc.subject.otherIndex medical record review
dc.subject.otherIndex papillary carcinoma
dc.subject.otherIndex radioisotope therapy
dc.subject.otherIndex subtotal thyroidectomy
dc.subject.otherIndex thyroid papillary carcinoma
dc.subject.otherIndex thyroidectomy
dc.subject.otherIndex Adenocarcinoma, Follicular
dc.subject.otherIndex Adolescent
dc.subject.otherIndex Carcinoma, Papillary
dc.subject.otherIndex Child
dc.subject.otherIndex Child, Preschool
dc.subject.otherIndex Female
dc.subject.otherIndex Humans
dc.subject.otherIndex Iodine Radioisotopes
dc.subject.otherIndex Lebanon
dc.subject.otherIndex Lung Neoplasms
dc.subject.otherIndex Lymphatic Metastasis
dc.subject.otherIndex Male
dc.subject.otherIndex Neoplasm Recurrence, Local
dc.subject.otherIndex Prognosis
dc.subject.otherIndex Risk Factors
dc.subject.otherIndex Thyroid Neoplasms
dc.subject.otherIndex Thyroidectomy
dc.subject.otherKeywordPlus CARCINOMA
dc.subject.otherKeywordPlus CHILDHOOD
dc.subject.otherKeywordPlus RECURRENCE
dc.subject.otherWOS Oncology
dc.subject.otherWOS Hematology
dc.subject.otherWOS Pediatrics


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