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Nontransferrin-bound iron in transfused patients with sickle cell disease

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dc.contributor.author Inati A.
dc.contributor.author Musallam K.M.
dc.contributor.author Cappellini M.D.
dc.contributor.author Duca L.
dc.contributor.author Taher A.T.
dc.contributor.editor
dc.date Apr-2011
dc.date.accessioned 2017-10-05T16:01:09Z
dc.date.available 2017-10-05T16:01:09Z
dc.date.issued 2011
dc.identifier 10.1111/j.1751-553X.2010.01224.x
dc.identifier.isbn
dc.identifier.issn 17515521
dc.identifier.uri http://hdl.handle.net/10938/19362
dc.description.abstract The value of nontransferrin-bound iron (NTBI) as an index of iron overload in patients with thalassemia has been evaluated; however, data in patients with sickle cell disease (SCD) is limited. NTBI levels were evaluated in a cross-sectional study of 43 transfused patients with SCD. Patient charts were reviewed for demographics, status of the spleen, and total number of lifetime transfusions. All patients were chelation naïve and none of the patients had evidence of hepatitis B or C infection. Blood samples were taken for assessment of NTBI and serum ferritin (SF); liver iron concentration (LIC) was determined by R2 magnetic resonance imaging. NTBI levels were generally low with a median of -0.01μm (range -2.56 to 6.37μm). Among study variables, NTBI levels were only significantly correlated to age and total number of lifetime transfusions, whereas LIC and SF only significantly correlated with total number of lifetime transfusions. On multivariate analysis, only total number of lifetime transfusions remained independently correlated with NTBI (P=0.001), SF (P0.001), and LIC (P0.001). On multivariate stepwise linear regression analysis, SF was a better predictor of LIC than NTBI. In transfused patients with SCD, NTBI levels are low yet correlate significantly with transfusion burden. However, they offer poor predictability of LIC when compared with SF. © 2010 Blackwell Publishing Ltd.
dc.format.extent
dc.format.extent Pages: (133-137)
dc.language English
dc.publisher MALDEN
dc.relation.ispartof Publication Name: International Journal of Laboratory Hematology; Publication Year: 2011; Volume: 33; no. 2; Pages: (133-137);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Nontransferrin-bound iron in transfused patients with sickle cell disease
dc.type Article
dc.contributor.affiliation Inati, A., Division of Pediatric Hematology and Oncology, Children's Center for Cancer and Blood Diseases, Rafik Hariri University Hospital, Beirut, Lebanon, Nini Hospital, Tripoli, Lebanon, Balamand University, Balamand, Lebanon
dc.contributor.affiliation Musallam, K.M., Department of Internal Medicine, Hematology-Oncology Division, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Cappellini, M.D., Universitá di Milano, Policlinico Foundation IRCCS, Milan, Italy
dc.contributor.affiliation Duca, L., Universitá di Milano, Policlinico Foundation IRCCS, Milan, Italy
dc.contributor.affiliation Taher, A.T., Department of Internal Medicine, Hematology-Oncology Division, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.authorAddress Inati, A.; Division of Pediatric Hematology and Oncology, Children's Center for Cancer and Blood Diseases, Rafik Hariri University Hospital, Bir Hasan, Beirut, Lebanon; email: adlette.inati@lau.edu.lb
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Pediatrics and Adolescent Medicine;
dc.contributor.authorDepartment Pediatrics and Adolescent Medicine
dc.contributor.authorDivision
dc.contributor.authorEmail adlette.inati@lau.edu.lb
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Inati, A
dc.contributor.authorInitials Musallam, KM
dc.contributor.authorInitials Cappellini, MD
dc.contributor.authorInitials Duca, L
dc.contributor.authorInitials Taher, AT
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Inati, A (reprint author), Rafik Hariri Univ Hosp, Div Pediat Hematol and Oncol, Childrens Ctr Canc and Blood Dis, Beirut, Lebanon.
dc.contributor.authorResearcherID Duca, Lorena-K-6909-2012
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedCount 4
dc.description.citedTotWOSCount 5
dc.description.citedWOSCount 4
dc.format.extentCount 5
dc.identifier.articleNo
dc.identifier.coden
dc.identifier.pubmedID 21382180
dc.identifier.scopusID 79952470934
dc.identifier.url
dc.publisher.address COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
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dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr Int. J. Lab. Hematol.
dc.relation.ispartOfIssue 2
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle International Journal of Laboratory Hematology
dc.relation.ispartofPubTitleAbbr Int. J. Lab. Hematol.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 33
dc.source.ID WOS:000288127900005
dc.type.publication Journal
dc.subject.otherAuthKeyword Iron overload
dc.subject.otherAuthKeyword Nontransferrin-bound iron
dc.subject.otherAuthKeyword Serum marker
dc.subject.otherAuthKeyword Sickle cell disease
dc.subject.otherAuthKeyword Transfusion
dc.subject.otherChemCAS iron, 14093-02-8, 53858-86-9, 7439-89-6
dc.subject.otherChemCAS transferrin, 82030-93-1
dc.subject.otherChemCAS Ferritins, 9007-73-2
dc.subject.otherChemCAS Iron, 7439-89-6
dc.subject.otherIndex iron
dc.subject.otherIndex transferrin
dc.subject.otherIndex adolescent
dc.subject.otherIndex adult
dc.subject.otherIndex article
dc.subject.otherIndex blood sampling
dc.subject.otherIndex blood transfusion
dc.subject.otherIndex child
dc.subject.otherIndex clinical article
dc.subject.otherIndex female
dc.subject.otherIndex human
dc.subject.otherIndex iron overload
dc.subject.otherIndex male
dc.subject.otherIndex nuclear magnetic resonance imaging
dc.subject.otherIndex priority journal
dc.subject.otherIndex sickle cell anemia
dc.subject.otherIndex transferrin blood level
dc.subject.otherIndex Adolescent
dc.subject.otherIndex Adult
dc.subject.otherIndex Anemia, Sickle Cell
dc.subject.otherIndex Blood Transfusion
dc.subject.otherIndex Child
dc.subject.otherIndex Child, Preschool
dc.subject.otherIndex Cross-Sectional Studies
dc.subject.otherIndex Female
dc.subject.otherIndex Ferritins
dc.subject.otherIndex Humans
dc.subject.otherIndex Iron
dc.subject.otherIndex Iron Overload
dc.subject.otherIndex Liver
dc.subject.otherIndex Male
dc.subject.otherIndex Middle Aged
dc.subject.otherIndex Young Adult
dc.subject.otherKeywordPlus BETA-THALASSEMIA
dc.subject.otherKeywordPlus MAGNETIC-RESONANCE
dc.subject.otherKeywordPlus TRANSFERRIN
dc.subject.otherKeywordPlus OVERLOAD
dc.subject.otherKeywordPlus INTERMEDIA
dc.subject.otherKeywordPlus THERAPY
dc.subject.otherKeywordPlus PLASMA
dc.subject.otherWOS Hematology


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