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Hospital-based surveillance study of rotavirus gastroenteritis in children under 5 years of age in Lebanon

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dc.contributor.author Dbaibo G.
dc.contributor.author Rajab M.
dc.contributor.author Inati A.
dc.contributor.author Mikhael R.
dc.contributor.author Choueiry E.
dc.contributor.author Al-Tannir M.
dc.contributor.author Salam O.
dc.contributor.author Ramakrishnan G.
dc.contributor.author Deantonio R.
dc.contributor.editor
dc.date 2013
dc.date.accessioned 2017-10-05T16:01:21Z
dc.date.available 2017-10-05T16:01:21Z
dc.date.issued 2013
dc.identifier 10.1016/j.trivac.2013.08.002
dc.identifier.isbn
dc.identifier.issn 18794378
dc.identifier.uri http://hdl.handle.net/10938/19461
dc.description.abstract Background Rotavirus (RV) is a major cause of gastroenteritis (GE) in infants and young children globally, with rotavirus gastroenteritis (RVGE) causing dehydration due to diarrhea and frequently leading to hospitalization. Epidemiological data on RVGE in Lebanon are lacking, therefore this study aims to collect such baseline data. Methods We conducted multicenter, hospital-based surveillance across Lebanon to estimate the proportion of diarrheal hospitalizations attributable to RV in children under 5 years of age. Medical history, GE symptoms, treatment prior to hospitalization and demographics were obtained from medical records and parent-guardian interviews. The severity of GE episodes was determined using the 20-point Vesikari scale (score ≥11 was considered severe). Stool samples were analyzed for RV using an enzyme immunoassay and for strain prevalence using reverse transcriptase polymerase chain reaction. Results Between April 2007 and September 2008, a total of 534 subjects were enrolled, of whom 491 were included in the final analysis. GE attributable to RV was 27.7percent and nearly 75percent of the RVGE cases occurred in children under 2 years of age. No differences were observed between the severity of signs and symptoms in RV positive and negative subjects. Hospitalization occurred mainly between December-March and lasted for a median of 3 days. Treatment primarily consisted of intravenous rehydration and almost all subjects (96.1percent) had recovered by the time of discharge. Prevalent circulating G and P types were G4 (36.9percent), G1WT (29.2percent), P[8]WT (77.7percent) and P[4] (17.7percent); the most common circulating RV strain was G4P[8]WT (36.9percent). Conclusion RVGE hospitalizations are prevalent in children under 5 years of age in Lebanon. This baseline data might be useful for decision makers when initiating measures, such as vaccination, to prevent the disease. © 2013 The Authors.
dc.format.extent
dc.format.extent Pages: (25-30)
dc.language English
dc.relation.ispartof Publication Name: Trials in Vaccinology; Publication Year: 2013; Volume: 2; no. 1; Pages: (25-30);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Hospital-based surveillance study of rotavirus gastroenteritis in children under 5 years of age in Lebanon
dc.type Article
dc.contributor.affiliation Dbaibo, G., American University of Beirut, Pediatrics and Adolescent Medicine, Center for Infectious Diseases Research, PO Box 11-0236, Riad El-Solh, Beirut, Lebanon
dc.contributor.affiliation Rajab, M., Makassed General Hospital, Pediatrics, Pediatric Intensive Care Unit, Beirut, Lebanon
dc.contributor.affiliation Inati, A., Lebanese American University, Byblos, Lebanon, Lebanese American University, Beirut, Lebanon, Nini Hospital, Pediatrics Tripoli, Lebanon
dc.contributor.affiliation Mikhael, R., Hotel Dieu de France Hospital, Pediatrics, Pediatric Infectious and Immunology Unit, Beirut, Lebanon
dc.contributor.affiliation Choueiry, E., Hotel Dieu de France Hospital, Pediatrics, Pediatric Intensive Care Unit, Beirut, Lebanon
dc.contributor.affiliation Al-Tannir, M., King Fahad Medical, Research and Scientific Publication Center, Riyadh, Saudi Arabia
dc.contributor.affiliation Salam, O., American University of Beirut, Pediatrics and Adolescent Medicine, Center for Infectious Diseases Research, PO Box 11-0236, Riad El-Solh, Beirut, Lebanon, Riverside Regional Medical Center, OBGYN, Newport News, VA, United States
dc.contributor.affiliation Ramakrishnan, G., GlaxoSmithKline Pharmaceuticals, Bangalore, India
dc.contributor.affiliation Deantonio, R., GlaxoSmithKline Vaccines, Wavre, Belgium
dc.contributor.authorAddress Dbaibo, G.; American University of Beirut, Pediatrics and Adolescent Medicine, Center for Infectious Diseases Research, PO Box 11-0236, Riad El-Solh, Beirut, Lebanon; email: gdbaibo@aub.edu.lb
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Pediatrics and Adolescent Medicine;
dc.contributor.authorDepartment Pediatrics and Adolescent Medicine
dc.contributor.authorDivision
dc.contributor.authorEmail
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
dc.description.cited
dc.description.citedCount
dc.description.citedTotWOSCount
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dc.format.extentCount 6
dc.identifier.articleNo
dc.identifier.coden
dc.identifier.pubmedID
dc.identifier.scopusID 84890126865
dc.identifier.url
dc.publisher.address
dc.relation.ispartofConference
dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr
dc.relation.ispartOfIssue 1
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Trials in Vaccinology
dc.relation.ispartofPubTitleAbbr Trails Vaccinology
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 2
dc.source.ID
dc.type.publication Journal
dc.subject.otherAuthKeyword Epidemiology
dc.subject.otherAuthKeyword Gastroenteritis
dc.subject.otherAuthKeyword Lebanon
dc.subject.otherAuthKeyword Middle East
dc.subject.otherAuthKeyword Rotavirus
dc.subject.otherChemCAS
dc.subject.otherIndex antibiotic agent
dc.subject.otherIndex article
dc.subject.otherIndex child
dc.subject.otherIndex controlled study
dc.subject.otherIndex diarrhea
dc.subject.otherIndex disease duration
dc.subject.otherIndex disease severity
dc.subject.otherIndex disease surveillance
dc.subject.otherIndex enzyme immunoassay
dc.subject.otherIndex feces analysis
dc.subject.otherIndex female
dc.subject.otherIndex fever
dc.subject.otherIndex gastroenteritis
dc.subject.otherIndex hospitalization
dc.subject.otherIndex human
dc.subject.otherIndex infant
dc.subject.otherIndex interview
dc.subject.otherIndex Lebanon
dc.subject.otherIndex major clinical study
dc.subject.otherIndex male
dc.subject.otherIndex medical history
dc.subject.otherIndex medical record review
dc.subject.otherIndex named inventories, questionnaires and rating scales
dc.subject.otherIndex oral rehydration therapy
dc.subject.otherIndex parent
dc.subject.otherIndex preschool child
dc.subject.otherIndex prevalence
dc.subject.otherIndex priority journal
dc.subject.otherIndex rehydration
dc.subject.otherIndex reverse transcription polymerase chain reaction
dc.subject.otherIndex Rotavirus infection
dc.subject.otherIndex Vesikari scale
dc.subject.otherIndex virus strain
dc.subject.otherIndex vomiting
dc.subject.otherKeywordPlus
dc.subject.otherWOS


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