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Review of meningococcal vaccines with updates on immunization in adults

Show simple item record Zahlanie Y.C. Hammadi M.M. Ghanem S.T. Dbaibo G.S.
dc.contributor.editor 2014 2017-10-05T16:01:24Z 2017-10-05T16:01:24Z 2014
dc.identifier 10.4161/hv.27739
dc.identifier.issn 21645515
dc.description.abstract Meningococcal disease is a serious and global life-threatening disease. Six serogroups (A, B, C, W-135, X, and Y) account for the majority of meningococcal disease worldwide. Meningococcal polysaccharide vaccines were introduced several decades ago and have led to the decline in the burden of disease. However, polysaccharide vaccines have several limitations, including poor immunogenicity in infants and toddlers, short-lived protection, lack of immunologic memory, negligible impact on nasopharyngeal carriage, and presence of hyporesponsiveness after repeated doses. The chemical conjugation of plain polysaccharide vaccines has the potential to overcome these drawbacks. Meningococcal conjugate vaccines include the quadrivalent vaccines (MenACWY-DT, Men-ACWY-CRM, and MenACWY-TT) as well as the monovalent A and C vaccines. These conjugate vaccines were shown to elicit strong immune response in adults. This review addresses the various aspects of meningococcal disease, the limitations posed by polysaccharide vaccines, the different conjugate vaccines with their immunogenicity and reactogenicity in adults, and the current recommendations in adults. © 2014 Landes Bioscience.
dc.format.extent Pages: (995-1007)
dc.language English
dc.publisher Landes Bioscience; AUSTIN
dc.relation.ispartof Publication Name: Human Vaccines and Immunotherapeutics; Publication Year: 2014; Volume: 10; no. 4; Pages: (995-1007);
dc.source Scopus
dc.title Review of meningococcal vaccines with updates on immunization in adults
dc.type Review
dc.contributor.affiliation Zahlanie, Y.C., Center for Infectious Diseases Research, Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Hammadi, M.M., Center for Infectious Diseases Research, Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Ghanem, S.T., Department of Pediatrics, Makassed General Hospital, Beirut, Lebanon
dc.contributor.affiliation Dbaibo, G.S., Center for Infectious Diseases Research, Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.authorAddress Dbaibo, G.S.; Center for Infectious Diseases Research, Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut, Lebanon; email:
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Pediatrics and Adolescent Medicine;
dc.contributor.authorDepartment Pediatrics and Adolescent Medicine
dc.contributor.faculty Faculty of Medicine
dc.contributor.authorInitials Zahlanie, YC
dc.contributor.authorInitials Hammadi, MM
dc.contributor.authorInitials Ghanem, ST
dc.contributor.authorInitials Dbaibo, GS
dc.contributor.authorReprintAddress Dbaibo, GS (reprint author), Amer Univ Beirut, Div Pediat Infect Dis, Ctr Infect Dis Res, Dept Pediat and Adolescent Med,Med Ctr, Beirut, Lebanon.
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedTotWOSCount 1
dc.description.citedWOSCount 1
dc.format.extentCount 13
dc.identifier.scopusID 84899825254
dc.publisher.address 1806 RIO GRANDE ST, AUSTIN, TX 78702 USA
dc.relation.ispartOfISOAbbr Human Vaccines Immunother.
dc.relation.ispartOfIssue 4
dc.relation.ispartofPubTitle Human Vaccines and Immunotherapeutics
dc.relation.ispartofPubTitleAbbr Hum. Vaccines Immunother.
dc.relation.ispartOfVolume 10
dc.source.ID WOS:000336655000029
dc.type.publication Journal
dc.subject.otherAuthKeyword Adults
dc.subject.otherAuthKeyword Meningococcal conjugate vaccine
dc.subject.otherAuthKeyword Meningococcal disease
dc.subject.otherAuthKeyword Meningococcal polysaccharide vaccine
dc.subject.otherAuthKeyword Neisseria meningitidis
dc.subject.otherAuthKeyword Recommendations
dc.subject.otherChemCAS ampicillin, 69-52-3, 69-53-4, 7177-48-2, 74083-13-9, 94586-58-0
dc.subject.otherIndex ampicillin
dc.subject.otherIndex chickenpox measles mumps rubella vaccine
dc.subject.otherIndex diphtheria pertussis poliomyelitis tetanus Haemophilus influenzae type b hepatitis B vaccine
dc.subject.otherIndex diphtheria toxoid
dc.subject.otherIndex hepatitis A hepatitis B vaccine
dc.subject.otherIndex host factor
dc.subject.otherIndex influenza vaccine
dc.subject.otherIndex measles mumps rubella vaccine
dc.subject.otherIndex meningococcal conjugate quadrivalent vaccine
dc.subject.otherIndex Meningococcus vaccine
dc.subject.otherIndex menjugate kit
dc.subject.otherIndex penicillin derivative
dc.subject.otherIndex Pneumococcus vaccine
dc.subject.otherIndex polysaccharide vaccine
dc.subject.otherIndex priorix tetra
dc.subject.otherIndex unclassified drug
dc.subject.otherIndex allergic reaction
dc.subject.otherIndex antibiotic prophylaxis
dc.subject.otherIndex antibody titer
dc.subject.otherIndex arthralgia
dc.subject.otherIndex bacterial colonization
dc.subject.otherIndex bacterium isolation
dc.subject.otherIndex drug efficacy
dc.subject.otherIndex drug safety
dc.subject.otherIndex fatigue
dc.subject.otherIndex fever
dc.subject.otherIndex gastrointestinal symptom
dc.subject.otherIndex geographic distribution
dc.subject.otherIndex headache
dc.subject.otherIndex human
dc.subject.otherIndex immune response
dc.subject.otherIndex immunization
dc.subject.otherIndex immunogenicity
dc.subject.otherIndex immunological memory
dc.subject.otherIndex incidence
dc.subject.otherIndex injection site erythema
dc.subject.otherIndex injection site pain
dc.subject.otherIndex injection site reaction
dc.subject.otherIndex malaise
dc.subject.otherIndex meningococcosis
dc.subject.otherIndex myalgia
dc.subject.otherIndex nausea
dc.subject.otherIndex Neisseria meningitidis
dc.subject.otherIndex opsonization
dc.subject.otherIndex pain
dc.subject.otherIndex paresthesia
dc.subject.otherIndex pathogenesis
dc.subject.otherIndex practice guideline
dc.subject.otherIndex review
dc.subject.otherIndex seasonal influenza
dc.subject.otherIndex seizure
dc.subject.otherIndex somnolence
dc.subject.otherIndex species invasion
dc.subject.otherIndex swelling
dc.subject.otherIndex virus strain
dc.subject.otherKeywordPlus TOXOID CONJUGATE VACCINE
dc.subject.otherKeywordPlus MENINGITIDIS SEROGROUP-C
dc.subject.otherKeywordPlus POLYSACCHARIDE VACCINE
dc.subject.otherKeywordPlus NEISSERIA-MENINGITIDIS
dc.subject.otherKeywordPlus UNITED-STATES
dc.subject.otherKeywordPlus GROUP-A
dc.subject.otherKeywordPlus MENACWY-TT
dc.subject.otherKeywordPlus BACTERIAL-MENINGITIS
dc.subject.otherKeywordPlus YOUNG-ADULTS
dc.subject.otherKeywordPlus CURRENT RECOMMENDATIONS
dc.subject.otherWOS Biotechnology and Applied Microbiology
dc.subject.otherWOS Immunology

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