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Consanguineous marriage and congenital heart defects: A case-control study in the neonatal period

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dc.contributor.author Khalid Y.
dc.contributor.author Ghina M.
dc.contributor.author Fadi B.
dc.contributor.author Fadi C.
dc.contributor.author May K.
dc.contributor.author Joseph R.
dc.contributor.author Makhoul G.
dc.contributor.author Hala T.
dc.contributor.editor
dc.date Jul-2006
dc.date.accessioned 2017-10-05T16:01:26Z
dc.date.available 2017-10-05T16:01:26Z
dc.date.issued 2006
dc.identifier 10.1002/ajmg.a.31309
dc.identifier.isbn
dc.identifier.issn 15524825
dc.identifier.uri http://hdl.handle.net/10938/19508
dc.description.abstract The independent effect of consanguinity on the prevalence of congenital heart defects (CHDs), all and specific types, was investigated in newborns admitted to nine hospitals located in Beirut, Lebanon and members of the National Collaborative Perinatal Neonatal Network (NCPNN). Cases were 173 newborns admitted to the Neonatal Intensive Care Units (NICU) of participating hospitals during the 3-year period from January 1, 2000 to December 31, 2002 and diagnosed during their hospital stay as having one or more CHD. Cases with chromosomal abnormalities were excluded. Cases with more than one CHD were assigned one principal malformation. Controls consisted of a random sample of 865 newborns without a CHD admitted to the NICU during the same period. After controlling for confounders, first cousin consanguinity remained significantly associated with an increased risk of CHD: infants born to first cousin marriages had a 1.8 times higher risk of having a CHD diagnosed at birth compared to those born to unrelated parents (95percent CI: 1.1-3.1). In particular, first-cousin marriage was a significant risk factor for ventricular septal defect (VSD), atrial septal defect (ASD), hypoplastic left heart (HLH), and single ventricle (SV). No association was found with d-transposition of the great arteries, coarctation, pulmonary atresia (PA), atrioventricular septal defect (AVSD), and tetralogy of Fallot (TOF). The results of this study suggest a familial factor in the multifactorial etiology of CHDs. Additional epidemiologic and family-based genetic studies are needed to understand the complex cause of CHDs. © 2006 Wiley-Liss, Inc.
dc.format.extent
dc.format.extent Pages: (1524-1530)
dc.language English
dc.publisher HOBOKEN
dc.relation.ispartof Publication Name: American Journal of Medical Genetics, Part A; Publication Year: 2006; Volume: 140; no. 14; Pages: (1524-1530);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Consanguineous marriage and congenital heart defects: A case-control study in the neonatal period
dc.type Article
dc.contributor.affiliation Khalid, Y., Department of Pediatrics, Faculty of Medicine, American University of Beirut Medical Center, Beirut, Lebanon, Department of Pediatrics, American University of Beirut, P.O. Box 110236, Riad El Solh-Beirut, 11072020, Lebanon
dc.contributor.affiliation Ghina, M., Department of Pediatrics, Faculty of Medicine, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Fadi, B., Department of Pediatrics, Faculty of Medicine, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Fadi, C., Department of Pediatrics, Faculty of Medicine, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation May, K., Department of Pediatrics, Faculty of Medicine, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Joseph, R., Department of Pediatrics, Nini Hospital, Tripoli, Lebanon
dc.contributor.affiliation Makhoul, G., Department of Pediatrics, Notre Dame de la Paix Hospital, Akkar, Lebanon
dc.contributor.affiliation Hala, T., School of Kinesiology and Health Science, York University, Toronto, Ont., Canada
dc.contributor.authorAddress Khalid, Y.; Department of Pediatrics, American University of Beirut, P.O. Box 110236, Riad El Solh-Beirut, 11072020, Lebanon; email: kayunis@aub.edu.lb
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Pediatrics and Adolescent Medicine;
dc.contributor.authorDepartment Pediatrics and Adolescent Medicine
dc.contributor.authorDivision
dc.contributor.authorEmail kayunis@aub.edu.lb
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Khalid, Y
dc.contributor.authorInitials Ghina, M
dc.contributor.authorInitials Fadi, B
dc.contributor.authorInitials Fadi, C
dc.contributor.authorInitials May, K
dc.contributor.authorInitials Joseph, R
dc.contributor.authorInitials Makhoul, G
dc.contributor.authorInitials Hala, T
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Khalid, Y (reprint author), Amer Univ Beirut, Dept Pediat, Fac Med, Med Ctr, POB 110236 Riad El Solh, Beirut 11072020, Lebanon.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
dc.description.cited Abdulrazzaq YM, 1997, CLIN GENET, V51, P167; Badaruddoza Afzal M, 1994, CLIN GENET, V45, P288; Bassili A, 2000, EUR J EPIDEMIOL, V16, P805, DOI 10.1023-A:1007601919164; Becker SM, 2001, AM J MED GENET, V99, P8, DOI 10.1002-1096-8628(20010215)99:18::AID-AJMG11163.0.CO;2-U; Bitar Fadi F., 1999, Middle East Journal of Anesthesiology, V15, P159; Botto LD, 2001, PEDIATRICS, V107, pE32, DOI 10.1542-peds.107.3.e32; *CENTR ADM STAT, 2000, STAT CHILDR LEB; CLARK EB, 2001, MOSS ADAMS HEART DIS, P74; Dorsten LE, 1999, DEMOGRAPHY, V36, P263, DOI 10.2307-2648113; FERENCZ C, 1997, PERSPECTIVES PEDAIT, V5; Ferencz C, 1993, PERSPECTIVES PEDIAT, V4; Fyler DC, 1980, PEDIATRICS S, V65, P376; GEV D, 1986, HUM HERED, V36, P213, DOI 10.1159-000153628; Gnanalingham MG, 1999, ACTA PAEDIATR, V88, P473, DOI 10.1080-08035259950169936; Grant JC, 1997, ANN HUM GENET, V61, P143; Hijazi Z, 2001, J TROP PEDIATRICS, V47, P13, DOI 10.1093-tropej-47.1.13; Hussain R, 1998, PAEDIATR PERINAT EP, V12, P370; JABER L, 1992, AM J MED GENET, V44, P1, DOI 10.1002-ajmg.1320440102; KHLAT M, 1988, SOC BIOL, V35, P324; Khoury SA, 2000, SAUDI MED J, V21, P150; Mokhtar MM, 2001, EUR J EPIDEMIOL, V17, P559, DOI 10.1023-A:1014567800950; MORTON NE, 1958, AM J HUM GENET, V10, P344; Nabulsi MM, 2003, AM J MED GENET A, V116A, P342, DOI 10.1002-ajmg.a.10020; PRADAT P, 1992, J EPIDEMIOL COMMUN H, V46, P211, DOI 10.1136-jech.46.3.211; Rittler M, 2001, AM J MED GENET, V102, P36, DOI 10.1002-1096-8628(20010722)102:136::AID-AJMG13943.0.CO;2-M; Roodpeyma S, 2002, CLIN PEDIATR, V41, P653, DOI 10.1177-000992280204100903; STOLL C, 1994, AM J MED GENET, V49, P114, DOI 10.1002-ajmg.1320490123; Stoltenberg C, 1997, AM J EPIDEMIOL, V145, P439; Zlotogora J, 1997, AM J MED GENET, V68, P472, DOI 10.1002-(SICI)1096-8628(19970211)68:4472::AID-AJMG203.0.CO;2-O
dc.description.citedCount 31
dc.description.citedTotWOSCount 8
dc.description.citedWOSCount 8
dc.format.extentCount 7
dc.identifier.articleNo
dc.identifier.coden AJMGD
dc.identifier.pubmedID 16763961
dc.identifier.scopusID 33745610099
dc.identifier.url
dc.publisher.address DIV JOHN WILEY and SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
dc.relation.ispartofConference
dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr Am. J. Med. Genet. A
dc.relation.ispartOfIssue 14
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle American Journal of Medical Genetics, Part A
dc.relation.ispartofPubTitleAbbr Am. J. Med. Genet. Part A
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 140
dc.source.ID WOS:000238799900006
dc.type.publication Journal
dc.subject.otherAuthKeyword Birth prevalence
dc.subject.otherAuthKeyword Congenital heart defects
dc.subject.otherAuthKeyword Consanguinity
dc.subject.otherChemCAS
dc.subject.otherIndex aorta coarctation
dc.subject.otherIndex article
dc.subject.otherIndex case control study
dc.subject.otherIndex congenital heart disease
dc.subject.otherIndex congenital malformation
dc.subject.otherIndex consanguineous marriage
dc.subject.otherIndex controlled study
dc.subject.otherIndex Fallot tetralogy
dc.subject.otherIndex female
dc.subject.otherIndex great vessels transposition
dc.subject.otherIndex heart atrium septum defect
dc.subject.otherIndex heart septum defect
dc.subject.otherIndex heart single ventricle
dc.subject.otherIndex heart ventricle septum defect
dc.subject.otherIndex hospital admission
dc.subject.otherIndex human
dc.subject.otherIndex hypoplastic left heart syndrome
dc.subject.otherIndex Lebanon
dc.subject.otherIndex lung atresia
dc.subject.otherIndex major clinical study
dc.subject.otherIndex male
dc.subject.otherIndex newborn
dc.subject.otherIndex newborn intensive care
dc.subject.otherIndex newborn period
dc.subject.otherIndex prevalence
dc.subject.otherIndex priority journal
dc.subject.otherIndex risk assessment
dc.subject.otherIndex risk factor
dc.subject.otherIndex Adult
dc.subject.otherIndex Case-Control Studies
dc.subject.otherIndex Consanguinity
dc.subject.otherIndex Female
dc.subject.otherIndex Heart Defects, Congenital
dc.subject.otherIndex Heart Septal Defects, Atrial
dc.subject.otherIndex Heart Septal Defects, Ventricular
dc.subject.otherIndex Heart Ventricles
dc.subject.otherIndex Humans
dc.subject.otherIndex Hypoplastic Left Heart Syndrome
dc.subject.otherIndex Infant, Newborn
dc.subject.otherIndex Lebanon
dc.subject.otherIndex Male
dc.subject.otherIndex Pregnancy
dc.subject.otherIndex Risk Factors
dc.subject.otherKeywordPlus PARENTAL CONSANGUINITY
dc.subject.otherKeywordPlus RISK-FACTORS
dc.subject.otherKeywordPlus CHILDHOOD MORTALITY
dc.subject.otherKeywordPlus BIRTH-DEFECTS
dc.subject.otherKeywordPlus DISEASE
dc.subject.otherKeywordPlus MALFORMATIONS
dc.subject.otherKeywordPlus ALEXANDRIA
dc.subject.otherKeywordPlus PAKISTAN
dc.subject.otherKeywordPlus INFANT
dc.subject.otherKeywordPlus EGYPT
dc.subject.otherWOS Genetics and Heredity


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