AUB ScholarWorks

Effect of consanguinity on birth weight for gestational age in a developing country

Show simple item record Mumtaz G. Tamim H. Kanaan M. Khawaja M. Khogali M. Wakim G. Yunis K.A.
dc.contributor.editor Apr-2007 2017-10-05T16:01:28Z 2017-10-05T16:01:28Z 2007
dc.identifier 10.1093/aje/kwk108
dc.identifier.issn 00029262
dc.description.abstract Consanguinity, the marriage between relatives, has been associated with adverse child health outcomes because it increases homozygosity of recessive alleles. The objective of this study was to assess the effect of consanguinity on the birth weight of newborns in Greater Beirut, Lebanon. Cross-sectional data were collected on 10,289 consecutive liveborn singleton newborns admitted to eight hospitals belonging to the National Collaborative Perinatal Neonatal Network during the years 2000 and 2001. Birth weight was modeled by use of the fetal growth ratio, defined as the ratio of the observed birth weight to the median birth weight for gestational age. A mixed-effect multiple linear regression model was used to predict the net effect of first- and second-cousin marriage on the birth weight for gestational age, accounting for within-hospital clustering of data. After controlling for medical and sociodemographic covariates, the authors found a statistically significant negative association between consanguinity and birth weight at each gestational age. No significant difference was observed in the decrease in birth weight between the first- and second-cousin marriages. Overall, consanguinity was associated with a decrease in birth weight for gestational age by 1.8percent (ß = -0.018, 95percent confidence interval: -0.027, -0.008). The largest effects on fetal growth were seen with lower parity and smoking during pregnancy. Copyright © 2007 by the Johns Hopkins Bloomberg School of Public Health All rights reserved.
dc.format.extent Pages: (742-752)
dc.language English
dc.publisher CARY
dc.relation.ispartof Publication Name: American Journal of Epidemiology; Publication Year: 2007; Volume: 165; no. 7; Pages: (742-752);
dc.source Scopus
dc.title Effect of consanguinity on birth weight for gestational age in a developing country
dc.type Article
dc.contributor.affiliation Mumtaz, G., Department of Pediatrics, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Tamim, H., School of Kinesiology and Health Science, York University, Toronto, Ont., Canada
dc.contributor.affiliation Kanaan, M., Department of Epidemiology and Population Health, Faculty of Health Sciences, American University of Beirut, Beirut, Lebanon
dc.contributor.affiliation Khawaja, M., Department of Epidemiology and Population Health, Faculty of Health Sciences, American University of Beirut, Beirut, Lebanon
dc.contributor.affiliation Khogali, M., Department of Family Medicine, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Wakim, G., Department of Pediatrics, Rizk Hospital, Beirut, Lebanon
dc.contributor.affiliation Yunis, K.A., Department of Pediatrics, American University of Beirut Medical Center, Beirut, Lebanon, Pediatrics Department, Faculty of Medicine, American University of Beirut, P.O. Box 11-0236, Riad El-Solh, Beirut 1107 2020, Lebanon
dc.contributor.authorAddress Yunis, K.A.; Pediatrics Department, Faculty of Medicine, American University of Beirut, P.O. Box 11-0236, Riad El-Solh, Beirut 1107 2020, Lebanon; email:
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Pediatrics and Adolescent Medicine;
dc.contributor.authorDepartment Pediatrics and Adolescent Medicine
dc.contributor.faculty Faculty of Medicine
dc.contributor.authorInitials Mumtaz, G
dc.contributor.authorInitials Tamim, H
dc.contributor.authorInitials Kanaan, M
dc.contributor.authorInitials Khawaja, M
dc.contributor.authorInitials Khogali, M
dc.contributor.authorInitials Wakim, G
dc.contributor.authorInitials Yunis, KA
dc.contributor.authorReprintAddress Yunis, KA (reprint author), Amer Univ Beirut, Fac Med, Dept Pediat, Ctr Med, POB 110236, Beirut 11072020, Lebanon.
dc.contributor.authorUniversity American University of Beirut Medical Center
dc.description.cited Al-Abdulkareem AA, 1998, J COMMUN HEALTH, V23, P75, DOI 10.1023-A:1018727005707; ALGHAZALI LI, 1997, J BIOSOC SCI, V29, P491; Arnold AM, 2003, AM J EPIDEMIOL, V157, P74, DOI 10.1093-aje-kwf156; BAI PVA, 1982, TROP GEOGR MED, V34, P225; Barzi F, 2004, AM J EPIDEMIOL, V160, P34, DOI 10.1093-aje-kwh175; BASARAN N, 1994, CLIN GENET, V45, P208; BASSON PM, 1979, J BIOSOC SCI, V11, P201; Clausson B, 2000, BRIT J OBSTET GYNAEC, V107, P375, DOI 10.1111-j.1471-0528.2000.tb13234.x; Clausson B, 1998, BRIT J OBSTET GYNAEC, V105, P1011, DOI 10.1111-j.1471-0528.1998.tb10266.x; Durkin MS, 2000, AM J EPIDEMIOL, V152, P1024, DOI 10.1093-aje-152.11.1024; FRIED K, 1974, AM J HUM GENET, V76, P65; GOLDING J, 1990, SOC SCI MED, V30, P497, DOI 10.1016-0277-9536(90)90352-S; Hamed RMA, 2002, J NEPHROL, V15, P130; Hijazi Z, 2001, J TROP PEDIATRICS, V47, P13, DOI 10.1093-tropej-47.1.13; HONEYMAN MM, 1987, ARCH DIS CHILD, V62, P231; Jaber L, 1997, J MED GENET, V34, P1000, DOI 10.1136-jmg.34.12.1000; KHLAT M, 1989, AM J PHYS ANTHROPOL, V80, P481, DOI 10.1002-ajpa.1330800407; Khlat M, 1984, J BIOSOC SCI, V16, P369; KHOURY SA, 1992, AM J MED GENET, V43, P769, DOI 10.1002-ajmg.1320430502; KRAMER MS, 1990, PEDIATRICS, V86, P18; KULKARNI ML, 1990, J MED GENET, V27, P348, DOI 10.1136-jmg.27.6.348; Mohsin M, 2003, J BIOSOC SCI, V35, P161, DOI 10.1017-S0021932003000014; Mokhtar MM, 2001, EUR J EPIDEMIOL, V17, P559, DOI 10.1023-A:1014567800950; MORTON NE, 1958, AM J HUM GENET, V10, P344; Pinheiro J. C., 2000, MIXED EFFECTS MODELS; RAO PSS, 1980, J MED GENET, V17, P27, DOI 10.1136-jmg.17.1.27; Raundenbush S. W., 2002, HIERARCHICAL LINEAR; *REP LEB MIN ENV, 2001, LEB STAT ENV REP; *REP LEB MIN PUBL, 1998, LEB MAT CHILD HLTH S; RITTLER M, 2001, AM J MED GENET, V22, P36; RUBIN DB, 1991, STAT MED, V10, P585, DOI 10.1002-sim.4780100410; Schafer J. L., 2002, J COMPUT GRAPH STAT, V11, P421; Schafer JL, 1998, MULTIVAR BEHAV RES, V33, P545, DOI 10.1207-s15327906mbr3304_5; SIBERT JR, 1979, ARCH DIS CHILD, V54, P317; Soliman Ashraf T., 1999, Indian Journal of Pediatrics, V66, P363, DOI 10.1007-BF02845526; Spencer N, 2002, J EPIDEMIOL COMMUN H, V56, P326, DOI 10.1136-jech.56.5.326; STOLL C, 1994, AM J MED GENET, V49, P114, DOI 10.1002-ajmg.1320490123; Stoltenberg C, 1998, AM J EPIDEMIOL, V148, P452; *UN CHILDR FUND, 2000, STAT CHILDR LEB 2000; Van Buuren S, 1999, STAT MED, V18, P681, DOI 10.1002-(SICI)1097-0258(19990330)18:6681::AID-SIM713.0.CO;2-R; WEN SW, 1995, AM J EPIDEMIOL, V141, P1177; WEN SW, 1990, AM J OBSTET GYNECOL, V162, P213; WILCOX MA, 1995, BRIT J OBSTET GYNAEC, V102, P918, DOI 10.1111-j.1471-0528.1995.tb10882.x; Yuan Y. C., 2000, P 25 ANN SAS US GROU; YUNIS KA, IN PRESS PAEDIAT PER; Zlotogora J, 1997, AM J MED GENET, V68, P472, DOI 10.1002-(SICI)1096-8628(19970211)68:4472::AID-AJMG203.0.CO;2-O
dc.description.citedCount 22
dc.description.citedTotWOSCount 18
dc.description.citedWOSCount 18
dc.format.extentCount 11
dc.identifier.coden AJEPA
dc.identifier.pubmedID 17311799
dc.identifier.scopusID 33947205714
dc.publisher.address JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
dc.relation.ispartOfISOAbbr Am. J. Epidemiol.
dc.relation.ispartOfIssue 7
dc.relation.ispartofPubTitle American Journal of Epidemiology
dc.relation.ispartofPubTitleAbbr Am. J. Epidemiol.
dc.relation.ispartOfVolume 165
dc.source.ID WOS:000244959600003
dc.type.publication Journal
dc.subject.otherAuthKeyword Birth weight
dc.subject.otherAuthKeyword Consanguinity
dc.subject.otherAuthKeyword Developing countries
dc.subject.otherAuthKeyword Gestational age
dc.subject.otherAuthKeyword Lebanon
dc.subject.otherIndex body mass
dc.subject.otherIndex embryonic development
dc.subject.otherIndex growth rate
dc.subject.otherIndex inbreeding depression
dc.subject.otherIndex marriage
dc.subject.otherIndex neonate
dc.subject.otherIndex pregnancy
dc.subject.otherIndex adult
dc.subject.otherIndex article
dc.subject.otherIndex birth weight
dc.subject.otherIndex cluster analysis
dc.subject.otherIndex consanguineous marriage
dc.subject.otherIndex consanguinity
dc.subject.otherIndex controlled study
dc.subject.otherIndex cross-sectional study
dc.subject.otherIndex data analysis
dc.subject.otherIndex demography
dc.subject.otherIndex developing country
dc.subject.otherIndex female
dc.subject.otherIndex fetus growth
dc.subject.otherIndex gestational age
dc.subject.otherIndex hospital admission
dc.subject.otherIndex human
dc.subject.otherIndex Lebanon
dc.subject.otherIndex low birth weight
dc.subject.otherIndex male
dc.subject.otherIndex maternal smoking
dc.subject.otherIndex mathematical model
dc.subject.otherIndex multiple linear regression analysis
dc.subject.otherIndex newborn
dc.subject.otherIndex parity
dc.subject.otherIndex prediction
dc.subject.otherIndex social aspect
dc.subject.otherIndex statistical significance
dc.subject.otherIndex Adult
dc.subject.otherIndex Birth Weight
dc.subject.otherIndex Chi-Square Distribution
dc.subject.otherIndex Consanguinity
dc.subject.otherIndex Cross-Sectional Studies
dc.subject.otherIndex Developing Countries
dc.subject.otherIndex Female
dc.subject.otherIndex Gestational Age
dc.subject.otherIndex Humans
dc.subject.otherIndex Infant, Newborn
dc.subject.otherIndex Lebanon
dc.subject.otherIndex Linear Models
dc.subject.otherIndex Male
dc.subject.otherIndex Maternal Age
dc.subject.otherIndex Asia
dc.subject.otherIndex Beirut
dc.subject.otherIndex Beyrouth
dc.subject.otherIndex Eurasia
dc.subject.otherIndex Lebanon
dc.subject.otherIndex Middle East
dc.subject.otherKeywordPlus FETAL GROWTH
dc.subject.otherKeywordPlus MULTIPLE IMPUTATION
dc.subject.otherKeywordPlus RISK-FACTORS
dc.subject.otherKeywordPlus PARENTAL CONSANGUINITY
dc.subject.otherKeywordPlus PRETERM DELIVERY
dc.subject.otherKeywordPlus INFANTS
dc.subject.otherKeywordPlus MARRIAGE
dc.subject.otherKeywordPlus CHILDREN
dc.subject.otherKeywordPlus HEALTH
dc.subject.otherKeywordPlus RETARDATION
dc.subject.otherWOS Public, Environmental and Occupational Health

Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search AUB ScholarWorks


My Account