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Sickle cell disease: The Lebanese experience

Show simple item record Inati A. Jradi O. Tarabay H. Moallem H. Rachkidi Y. El Accaoui R. Isma'eel H. Wehbe R. Mfarrej B.G. Dabbous I. Taher A.
dc.contributor.editor Dec-2007 2017-10-05T16:01:30Z 2017-10-05T16:01:30Z 2007
dc.identifier 10.1111/j.1751-553X.2007.00964.x
dc.identifier.issn 17515521
dc.description.abstract Sickle cell disease (SCD), the commonest single gene disorder worldwide, is an inherited disease that has different clinical and hematological manifestations in different populations. The objective of this study is to describe the characteristics of the Lebanese SCD population. This was a retrospective study that included information on 387 patients with either sickle cell anemia (SS) or sickle beta-thalassemia (ST). The mean (±SD) age was 17.9 years (±12.5), and the mean (±SD) follow-up was 9.3 ± 6.9 years. Fifty percent of the patients were males and SS-ST distribution was 3 : 1. The disease was clustered in two geographic areas in North and South Lebanon. Nearly, all patients were Muslims and 56percent were the offspring of consanguineous parents. The prevalence of splenomegaly beyond 6 years of age among SS patients was 28.9percent. The prevalence rates of stroke, leg ulcers and priapism were 4.1percent, 1.4percent, and 0.8percent, respectively. Comparing the SS and the ST patients, there were no statistically significant differences in the prevalence of all clinical manifestations except for splenomegaly (SS: 28.9percent, ST: 54.9percent, P-value 0.001) and splenectomy (SS: 16.1percent, ST: 35.7percent, P-value 0.001). In contrast to Northern American populations and similar to some Mediterranean populations, Lebanese SCD patients have a higher prevalence of persistent splenomegaly. The relatively low incidence of thrombotic complications deserves further investigation. The study's limitations include those of any other retrospective study and the fact that not all Lebanese centers caring for inherited hemoglobin disorders were included. However, the results of this first large scale national survey indicate that preventive efforts should target the Northern and Southern regions of Lebanon to decrease the number of new off springs afflicted with this disease similar to what has been successfully achieved with Thalassemia, another hemoglobinopathy that is highly prevalent in the country. © 2007 The Authors.
dc.format.extent Pages: (399-408)
dc.language English
dc.publisher OXFORD
dc.relation.ispartof Publication Name: International Journal of Laboratory Hematology; Publication Year: 2007; Volume: 29; no. 6; Pages: (399-408);
dc.source Scopus
dc.title Sickle cell disease: The Lebanese experience
dc.type Article
dc.contributor.affiliation Inati, A., Division of Pediatric Hematology - Oncology, Rafic Hariri University Hospital, Beirut, Lebanon, Chronic Care Center, Baabda, Lebanon, Balamand University, Faculty of Medicine, Koura, Lebanon
dc.contributor.affiliation Jradi, O., Labib Medical Center, Sidon, Lebanon
dc.contributor.affiliation Tarabay, H., Nini Hospital, Tripoli, Lebanon
dc.contributor.affiliation Moallem, H., Lebanese American University, School of Pharmacy, Byblos, Lebanon
dc.contributor.affiliation Rachkidi, Y., Nini Hospital, Tripoli, Lebanon
dc.contributor.affiliation El Accaoui, R., Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Isma'eel, H., Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Wehbe, R., Nini Hospital, Tripoli, Lebanon
dc.contributor.affiliation Mfarrej, B.G., Lebanese American University, School of Pharmacy, Byblos, Lebanon
dc.contributor.affiliation Dabbous, I., Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Taher, A., Chronic Care Center, Baabda, Lebanon, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.authorAddress Inati, A.; Division of Pediatric Hematology - Oncology, Rafic Hariri University Hospital, Beirut, Lebanon; email:
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Pediatrics and Adolescent Medicine;
dc.contributor.authorDepartment Pediatrics and Adolescent Medicine
dc.contributor.faculty Faculty of Medicine
dc.contributor.authorInitials Inati, A
dc.contributor.authorInitials Jradi, O
dc.contributor.authorInitials Tarabay, H
dc.contributor.authorInitials Moallem, H
dc.contributor.authorInitials Rachkidi, Y
dc.contributor.authorInitials El Accaoui, R
dc.contributor.authorInitials Isma'eel, H
dc.contributor.authorInitials Wehbe, R
dc.contributor.authorInitials Mfarrej, BG
dc.contributor.authorInitials Dabbous, I
dc.contributor.authorInitials Taher, A
dc.contributor.authorReprintAddress Inati, A (reprint author), Rafik Hariri Univ Hosp, Div Pediat Hematol Oncol, Beirut, Lebanon.
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedCount 10
dc.description.citedTotWOSCount 10
dc.description.citedWOSCount 10
dc.format.extentCount 10
dc.identifier.pubmedID 17988293
dc.identifier.scopusID 35848944433
dc.publisher.address 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND
dc.relation.ispartOfISOAbbr Int. J. Lab. Hematol.
dc.relation.ispartOfIssue 6
dc.relation.ispartofPubTitle International Journal of Laboratory Hematology
dc.relation.ispartofPubTitleAbbr Int. J. Lab. Hematol.
dc.relation.ispartOfVolume 29
dc.source.ID WOS:000250727100001
dc.type.publication Journal
dc.subject.otherAuthKeyword Complications
dc.subject.otherAuthKeyword Lebanon
dc.subject.otherAuthKeyword Sickle cell disease
dc.subject.otherChemCAS hydroxyurea, 127-07-1
dc.subject.otherIndex hydroxyurea
dc.subject.otherIndex adolescent
dc.subject.otherIndex adult
dc.subject.otherIndex article
dc.subject.otherIndex beta thalassemia
dc.subject.otherIndex child
dc.subject.otherIndex clinical feature
dc.subject.otherIndex controlled study
dc.subject.otherIndex female
dc.subject.otherIndex human
dc.subject.otherIndex infant
dc.subject.otherIndex Lebanon
dc.subject.otherIndex leg ulcer
dc.subject.otherIndex major clinical study
dc.subject.otherIndex male
dc.subject.otherIndex morbidity
dc.subject.otherIndex prevalence
dc.subject.otherIndex priapism
dc.subject.otherIndex priority journal
dc.subject.otherIndex sickle cell anemia
dc.subject.otherIndex splenomegaly
dc.subject.otherIndex stroke
dc.subject.otherIndex Adolescent
dc.subject.otherIndex Adult
dc.subject.otherIndex Anemia, Sickle Cell
dc.subject.otherIndex beta-Thalassemia
dc.subject.otherIndex Child
dc.subject.otherIndex Child, Preschool
dc.subject.otherIndex Consanguinity
dc.subject.otherIndex Female
dc.subject.otherIndex Humans
dc.subject.otherIndex Infant
dc.subject.otherIndex Infant, Newborn
dc.subject.otherIndex Islam
dc.subject.otherIndex Lebanon
dc.subject.otherIndex Male
dc.subject.otherIndex Middle Aged
dc.subject.otherIndex Prevalence
dc.subject.otherIndex Retrospective Studies
dc.subject.otherIndex Splenectomy
dc.subject.otherIndex Splenomegaly
dc.subject.otherKeywordPlus HEPATITIS-C-VIRUS
dc.subject.otherKeywordPlus ACUTE SPLENIC SEQUESTRATION
dc.subject.otherKeywordPlus B SURFACE-ANTIGEN
dc.subject.otherKeywordPlus BRAZILIAN POPULATION
dc.subject.otherKeywordPlus BACTERIAL-INFECTION
dc.subject.otherKeywordPlus NIGERIAN CHILDREN
dc.subject.otherKeywordPlus LEG ULCERATION
dc.subject.otherKeywordPlus RISK-FACTORS
dc.subject.otherKeywordPlus ANEMIA
dc.subject.otherKeywordPlus MORTALITY
dc.subject.otherWOS Hematology

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