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Equal antipyretic effectiveness of oral and rectal acetaminophen: A randomized controlled trial [ISRCTNI 1886401]

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dc.contributor.author Nabulsi M.
dc.contributor.author Tamim H.
dc.contributor.author Sabra R.
dc.contributor.author Mahfoud Z.
dc.contributor.author Malaeb S.
dc.contributor.author Fakih H.
dc.contributor.author Mikati M.
dc.contributor.editor
dc.date Sep-2005
dc.date.accessioned 2017-10-05T16:02:41Z
dc.date.available 2017-10-05T16:02:41Z
dc.date.issued 2005
dc.identifier 10.1186/1471-2431-5-35
dc.identifier.isbn
dc.identifier.issn 14712431
dc.identifier.uri http://hdl.handle.net/10938/19571
dc.description.abstract Background: The antipyretic effectiveness of rectal versus oral acetaminophen is not well established. This study is designed to compare the antipyretic effectiveness of two rectal acetaminophen doses (15 mg-kg) and (35 mg-kg), to the standard oral dose of 15 mg-kg. Methods: This is a randomized, double-dummy, double-blind study of 51 febrile children, receiving one of three regimens of a single acetaminophen dose: 15 mg-kg orally, 15 mg-kg rectally, or 35 mg-kg rectally. Rectal temperature was monitored at baseline and hourly for a total of six hours. The primary outcome of the study, time to maximum antipyresis, and the secondary outcome of time to temperature reduction by at least 1°C were analyzed by one-way ANOVA. Two-way ANOVA with repeated measures over time was used to compare the secondary outcome: change in temperature from baseline at times1, 2, 3, 4, 5, and 6 hours among the three groups. Intent-to-treat analysis was planned. Results: No significant differences were found among the three groups in the time to maximum antipyresis (overall mean = 3.6 hours; 95percent CI: 3.2-4.0), time to fever reduction by 1°C or the mean hourly temperature from baseline to 6 hours following dose administration. Hypothermia (temperature 36.5°C) occurred in 11(21.6percent) subjects, with the highest proportion being in the rectal high-dose group. Conclusion: Standard (15 mg-kg) oral, (15 mg-kg) rectal, and high-dose (35 mg-kg) rectal acetaminophen have similar antipyretic effectiveness. © 2005 Nabulsi et al; licensee BioMed Central Ltd.
dc.format.extent
dc.language English
dc.relation.ispartof Publication Name: BMC Pediatrics; Publication Year: 2005; Volume: 5;
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Equal antipyretic effectiveness of oral and rectal acetaminophen: A randomized controlled trial [ISRCTNI 1886401]
dc.type Article
dc.contributor.affiliation Nabulsi, M., Department of Pediatrics, American University, Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Tamim, H., Department of Epidemiology and Population Health, Faculty of Health Sciences, American University of Beirut, Beirut, Lebanon
dc.contributor.affiliation Sabra, R., Department of Pharmacology and Therapeutics, Faculty of Medicine, American University of Beirut, Beirut, Lebanon
dc.contributor.affiliation Mahfoud, Z., Department of Epidemiology and Population Health, Faculty of Health Sciences, American University of Beirut, Beirut, Lebanon
dc.contributor.affiliation Malaeb, S., Department of Pediatrics, American University, Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Fakih, H., Department of Pediatrics, Middle East Hospital, Beirut, Lebanon
dc.contributor.affiliation Mikati, M., Department of Pediatrics, American University, Beirut Medical Center, Beirut, Lebanon
dc.contributor.authorAddress Nabulsi, M.; Department of Pediatrics, American University, Beirut Medical Center, Beirut, Lebanon; email: mn04@aub.edu.lb
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Pharmacology and Toxicology;
dc.contributor.authorDepartment Pharmacology and Toxicology
dc.contributor.authorDivision
dc.contributor.authorEmail
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials empty
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
dc.description.cited
dc.description.citedCount 11
dc.description.citedTotWOSCount
dc.description.citedWOSCount
dc.format.extentCount 1
dc.identifier.articleNo 35
dc.identifier.coden BPMEB
dc.identifier.pubmedID 16143048
dc.identifier.scopusID 26444565340
dc.identifier.url
dc.publisher.address
dc.relation.ispartofConference
dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr
dc.relation.ispartOfIssue
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle BMC Pediatrics
dc.relation.ispartofPubTitleAbbr BMC Pediatr.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 5
dc.source.ID
dc.type.publication Journal
dc.subject.otherAuthKeyword
dc.subject.otherChemCAS paracetamol, 103-90-2
dc.subject.otherChemCAS Acetaminophen, 103-90-2
dc.subject.otherChemCAS Analgesics, Non-Narcotic
dc.subject.otherIndex adol
dc.subject.otherIndex paracetamol
dc.subject.otherIndex placebo
dc.subject.otherIndex analgesic agent
dc.subject.otherIndex paracetamol
dc.subject.otherIndex adolescent
dc.subject.otherIndex analysis of variance
dc.subject.otherIndex antipyretic activity
dc.subject.otherIndex article
dc.subject.otherIndex child
dc.subject.otherIndex child care
dc.subject.otherIndex clinical trial
dc.subject.otherIndex controlled clinical trial
dc.subject.otherIndex controlled study
dc.subject.otherIndex double blind procedure
dc.subject.otherIndex drug administration route
dc.subject.otherIndex drug dose regimen
dc.subject.otherIndex drug efficacy
dc.subject.otherIndex drug mechanism
dc.subject.otherIndex fever
dc.subject.otherIndex human
dc.subject.otherIndex hypothermia
dc.subject.otherIndex infant
dc.subject.otherIndex randomized controlled trial
dc.subject.otherIndex rectum temperature
dc.subject.otherIndex temperature measurement
dc.subject.otherIndex treatment outcome
dc.subject.otherIndex body temperature
dc.subject.otherIndex chi square distribution
dc.subject.otherIndex comparative study
dc.subject.otherIndex drug effect
dc.subject.otherIndex female
dc.subject.otherIndex male
dc.subject.otherIndex oral drug administration
dc.subject.otherIndex preschool child
dc.subject.otherIndex rectal drug administration
dc.subject.otherIndex Acetaminophen
dc.subject.otherIndex Administration, Oral
dc.subject.otherIndex Administration, Rectal
dc.subject.otherIndex Adolescent
dc.subject.otherIndex Analgesics, Non-Narcotic
dc.subject.otherIndex Body Temperature
dc.subject.otherIndex Chi-Square Distribution
dc.subject.otherIndex Child
dc.subject.otherIndex Child, Preschool
dc.subject.otherIndex Double-Blind Method
dc.subject.otherIndex Female
dc.subject.otherIndex Fever
dc.subject.otherIndex Humans
dc.subject.otherIndex Infant
dc.subject.otherIndex Male
dc.subject.otherIndex Treatment Outcome
dc.subject.otherKeywordPlus
dc.subject.otherWOS


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