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Chronic dizocilpine or apomorphine and development of neuropathy in two rat models I: Behavioral effects and role of nucleus accumbens

Show simple item record Sarkis R. Saade N. Atweh S. Jabbur S. Al-Amin H.
dc.contributor.editor Mar-2011 2017-10-05T16:04:42Z 2017-10-05T16:04:42Z 2011
dc.identifier 10.1016/j.expneurol.2010.12.004
dc.identifier.issn 00144886
dc.description.abstract Dopaminergic and glutamatergic inputs converge on nucleus accumbens (NAC) and affect the neuropathic pain. We tested the effects of daily systemic administration of dizocilpine (MK-801), a N-methyl- d-Aspartate (NMDA) noncompetitive receptor antagonist, or apomorphine (APO), a dopamine (DA) D1 and D2 receptor agonist, on neuropathic manifestations in the chronic constriction injury (CCI) and the spared nerve injury (SNI) models of mononeuropathy in rats. Six groups of rats were subjected to CCI or SNI neuropathy and 5-7 days later received daily intraperitoneal (ip) injections of saline, MK-801, or APO for two weeks. Tests for nociception and motor behaviors were performed at regular intervals. Tactile and cold allodynia were assessed using von Frey hairs or acetone drops, respectively. Heat hyperalgesia was assessed by the paw withdrawal test. Tests were performed before administering the daily injections. Another four groups of rats were subjected to SNI surgery, and then had their NAC (contralateral to the lesioned paw) perfused for two weeks with MK-801, saline, APO. +. ascorbic acid, or ascorbic acid alone using mini-osmotic pumps. Behavioral manifestations were assessed as above. Systemic daily injections of MK-801 and APO markedly attenuated the neuropathic manifestations in the CCI and SNI models with a minimal effect on cold allodynia. The same results were seen in the SNI model with chronic perfusion of NAC. Our results suggest that daily systemic administration of DA agonists and NMDA antagonists can attenuate neuropathic pain manifestations and that the NAC is involved in the modulation of neuropathic-like behaviors. © 2010 Elsevier Inc.
dc.format.extent Pages: (19-29)
dc.language English
dc.publisher SAN DIEGO
dc.relation.ispartof Publication Name: Experimental Neurology; Publication Year: 2011; Volume: 228; no. 1; Pages: (19-29);
dc.source Scopus
dc.title Chronic dizocilpine or apomorphine and development of neuropathy in two rat models I: Behavioral effects and role of nucleus accumbens
dc.type Article
dc.contributor.affiliation Sarkis, R., Department of Psychiatry, Faculty of Medicine, American University of Beirut, Beirut, Lebanon
dc.contributor.affiliation Saadé, N., Department of Physiology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon, Department of Human Morphology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon
dc.contributor.affiliation Atweh, S., Department of Internal Medicine, Faculty of Medicine, American University of Beirut, Beirut, Lebanon
dc.contributor.affiliation Jabbur, S., Department of Physiology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon
dc.contributor.affiliation Al-Amin, H., Department of Psychiatry, Faculty of Medicine, American University of Beirut, Beirut, Lebanon, Weill Cornell Medical College in Qatar, Qatar Foundation-Education City, Al Rayyan St. P.O. Box 24144, Doha, Qatar
dc.contributor.authorAddress Al-Amin, H.; Department of Psychiatry, American University of Beirut-Medical Center, Box 16A, Beirut, Lebanon; email:
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Psychiatry;
dc.contributor.authorDepartment Psychiatry
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Sarkis, R
dc.contributor.authorInitials Saade, N
dc.contributor.authorInitials Atweh, S
dc.contributor.authorInitials Jabbur, S
dc.contributor.authorInitials Al-Amin, H
dc.contributor.authorReprintAddress Al-Amin, H (reprint author), Amer Univ Beirut, Dept Psychiat, Med Ctr, Fac Med, Box 16A, Beirut, Lebanon.
dc.contributor.authorUniversity American University of Beirut Medical Center
dc.description.cited Al-Amin H, 2011, EXP NEUROL, V228, P30, DOI 10.1016-j.expneurol.2010.11.005; Al-Amin HA, 2003, BRAIN RES, V981, P99, DOI 10.1016-S0006-8993(03)02988-3; Altier N, 1999, LIFE SCI, V65, P2269, DOI 10.1016-S0024-3205(99)00298-2; Altier N, 1998, J PHARMACOL EXP THER, V285, P208; Ansah OB, 2007, EXP NEUROL, V205, P536, DOI 10.1016-j.expneurol.2007.03.010; BENNETT GJ, 1988, PAIN, V33, P87, DOI 10.1016-0304-3959(88)90209-6; Bennett GJ, 2000, J PAIN SYMPTOM MANAG, V19, pS2; Bleakman D, 2006, SEMIN CELL DEV BIOL, V17, P592, DOI 10.1016-j.semcdb.2006.10.008; Breese GR, 2002, NEUROSCI BIOBEHAV R, V26, P441, DOI 10.1016-S0149-7634(02)00011-8; Brefel-Courbon C, 2005, MOVEMENT DISORD, V20, P1557, DOI 10.1002-mds.20629; Chizh BA, 2005, CURR PHARM DESIGN, V11, P2977, DOI 10.2174-1381612054865082; CODERRE TJ, 1994, PAIN, V59, P345, DOI 10.1016-0304-3959(94)90020-5; DAVAR G, 1991, BRAIN RES, V553, P327, DOI 10.1016-0006-8993(91)90844-L; Decosterd I, 2004, ANESTH ANALG, V99, P457; Decosterd I, 2000, PAIN, V87, P149, DOI 10.1016-S0304-3959(00)00276-1; Erichsen HK, 2002, PAIN, V98, P151, DOI 10.1016-S0304-3959(02)00039-8; Fillingim RB, 2009, J PAIN, V10, P447, DOI 10.1016-j.jpain.2008.12.001; Fisher K, 2000, J PAIN SYMPTOM MANAG, V20, P358, DOI 10.1016-S0885-3924(00)00213-X; Fisher K, 1998, PAIN, V77, P59, DOI 10.1016-S0304-3959(98)00082-7; Hama AT, 2005, ANESTH ANALG, V101, P175, DOI 10.1213-01.ANE.0000155247.93604.62; Hamidi GA, 2006, PHYSIOL BEHAV, V88, P628, DOI 10.1016-j.physbeh.2006.05.017; HARGREAVES K, 1988, PAIN, V32, P77, DOI 10.1016-0304-3959(88)90026-7; Holtman JR, 2008, PHARMACOL BIOCHEM BE, V90, P676, DOI 10.1016-j.pbb.2008.05.011; Hudspith MJ, 1999, BRAIN RES, V822, P220, DOI 10.1016-S0006-8993(99)01161-0; Magnusson JE, 2000, BRAIN RES, V855, P260, DOI 10.1016-S0006-8993(99)02396-3; MAO J, 1992, BRAIN RES, V576, P254, DOI 10.1016-0006-8993(92)90688-6; MAO J, 1992, BRAIN RES, V598, P271, DOI 10.1016-0006-8993(92)90193-D; MAO JR, 1993, BRAIN RES, V605, P164, DOI 10.1016-0006-8993(93)91368-3; Medvedev IO, 2004, NEUROPHARMACOLOGY, V47, P175, DOI 10.1016-j.neuropharm.2004.01.019; Munro G, 2007, EUR J PHARMACOL, V575, P66, DOI 10.1016-j.ejphar.2007.07.062; Paxinos G, 1997, RAT BRAIN STEREOTAXI; Pelissier T, 2006, EUR J PHARMACOL, V546, P40, DOI 10.1016-j.ejphar.2006.06.081; Pertovaara A, 2008, PAIN, V137, P50, DOI 10.1016-j.pain.2007.08.009; Potvin S, 2009, SYNAPSE, V63, P390, DOI 10.1002-syn.20616; Potvin S, 2008, PAIN, V138, P70, DOI 10.1016-j.pain.2007.11.007; Saade NE, 1997, BRAIN RES, V751, P1, DOI 10.1016-S0006-8993(96)01164-X; Saade NE, 2002, NEUROSCIENCE, V115, P403, DOI 10.1016-S0306-4522(02)00417-7; Saade NE, 2008, PROG NEUROBIOL, V86, P22, DOI 10.1016-j.pneurobio.2008.06.002; Svensson TH, 2000, BRAIN RES REV, V31, P320, DOI 10.1016-S0165-0173(99)00048-X; Taylor BK, 2003, BRAIN RES, V987, P135, DOI 10.1016-S0006-8993(03)03318-3; Tinazzi M, 2008, PAIN, V136, P117, DOI 10.1016-j.pain.2007.06.022; Tseng KY, 2004, J NEUROSCI, V24, P5131, DOI 10.1523-JNEUROSCI.1021-04.2004; Vissers KC, 2005, LIFE SCI, V77, P414, DOI 10.1016-j.lfs.2004.10.068; WILCOX RE, 1980, J PHARM SCI, V69, P974, DOI 10.1002-jps.2600690830; Wood PB, 2006, PAIN, V120, P230, DOI 10.1016-j.pain.2005.12.014; Xie WR, 2005, PAIN, V116, P243, DOI 10.1016-j.pain.2005.04.017; YAMAMOTO T, 1992, PAIN, V51, P329, DOI 10.1016-0304-3959(92)90218-Z; YAMAMOTO T, 1992, NEUROSCI LETT, V135, P67, DOI 10.1016-0304-3940(92)90137-V; YAMAMOTO T, 1993, PAIN, V54, P79, DOI 10.1016-0304-3959(93)90102-U; Zhang Xiu-Juan, 2005, Shengli Xuebao, V57, P66; ZIMMERMANN M, 1983, PAIN, V16, P109, DOI 10.1016-0304-3959(83)90201-4
dc.description.citedCount 8
dc.description.citedTotWOSCount 8
dc.description.citedWOSCount 8
dc.format.extentCount 11
dc.identifier.coden EXNEA
dc.identifier.pubmedID 21146525
dc.identifier.scopusID 79851511592
dc.publisher.address 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
dc.relation.ispartOfISOAbbr Exp. Neurol.
dc.relation.ispartOfIssue 1
dc.relation.ispartofPubTitle Experimental Neurology
dc.relation.ispartofPubTitleAbbr Exp. Neurol.
dc.relation.ispartOfVolume 228
dc.source.ID WOS:000287722200005
dc.type.publication Journal
dc.subject.otherAuthKeyword Dopamine
dc.subject.otherAuthKeyword Glutamate
dc.subject.otherAuthKeyword Neuropathic pain
dc.subject.otherAuthKeyword Neuropathy
dc.subject.otherAuthKeyword Nucleus accumbens
dc.subject.otherChemCAS acetone, 67-64-1
dc.subject.otherChemCAS apomorphine, 314-19-2, 58-00-4
dc.subject.otherChemCAS ascorbic acid, 134-03-2, 15421-15-5, 50-81-7
dc.subject.otherChemCAS dizocilpine, 77086-21-6
dc.subject.otherChemCAS sodium chloride, 7647-14-5
dc.subject.otherChemCAS Apomorphine, 58-00-4
dc.subject.otherChemCAS Dizocilpine Maleate, 77086-22-7
dc.subject.otherIndex acetone
dc.subject.otherIndex apomorphine
dc.subject.otherIndex ascorbic acid
dc.subject.otherIndex dizocilpine
dc.subject.otherIndex sodium chloride
dc.subject.otherIndex allodynia
dc.subject.otherIndex animal behavior
dc.subject.otherIndex animal experiment
dc.subject.otherIndex animal model
dc.subject.otherIndex antinociception
dc.subject.otherIndex article
dc.subject.otherIndex controlled study
dc.subject.otherIndex disease model
dc.subject.otherIndex female
dc.subject.otherIndex hot plate test
dc.subject.otherIndex hyperalgesia
dc.subject.otherIndex locomotion
dc.subject.otherIndex nerve compression
dc.subject.otherIndex nerve injury
dc.subject.otherIndex neuropathic pain
dc.subject.otherIndex nociception
dc.subject.otherIndex nonhuman
dc.subject.otherIndex nucleus accumbens
dc.subject.otherIndex osmotic minipump
dc.subject.otherIndex priority journal
dc.subject.otherIndex rat
dc.subject.otherIndex tactile stimulation
dc.subject.otherIndex treatment duration
dc.subject.otherIndex Animals
dc.subject.otherIndex Apomorphine
dc.subject.otherIndex Disease Models, Animal
dc.subject.otherIndex Dizocilpine Maleate
dc.subject.otherIndex Female
dc.subject.otherIndex Mononeuropathies
dc.subject.otherIndex Motor Activity
dc.subject.otherIndex Neuralgia
dc.subject.otherIndex Nucleus Accumbens
dc.subject.otherIndex Pain Measurement
dc.subject.otherIndex Random Allocation
dc.subject.otherIndex Rats
dc.subject.otherIndex Rats, Sprague-Dawley
dc.subject.otherKeywordPlus SPARED NERVE INJURY
dc.subject.otherKeywordPlus METHYL-D-ASPARTATE
dc.subject.otherKeywordPlus PERIPHERAL MONONEUROPATHY
dc.subject.otherKeywordPlus THERMAL HYPERALGESIA
dc.subject.otherKeywordPlus NMDA-RECEPTOR
dc.subject.otherKeywordPlus GLUTAMATE RECEPTORS
dc.subject.otherKeywordPlus ANTIPSYCHOTIC-DRUGS
dc.subject.otherKeywordPlus PARKINSONS-DISEASE
dc.subject.otherKeywordPlus SCIATIC-NERVE
dc.subject.otherKeywordPlus CHRONIC PAIN
dc.subject.otherWOS Neurosciences

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