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Treatment-resistant depression in adolescents: Review and updates on clinical management

Show simple item record Maalouf F.T. Atwi M. Brent D.A.
dc.contributor.editor Nov-2011 2017-10-05T16:04:43Z 2017-10-05T16:04:43Z 2011
dc.identifier 10.1002/da.20884
dc.identifier.issn 10914269
dc.description.abstract Treatment-resistant depression (TRD) in adolescents is prevalent and impairing. We here review the definition, prevalence, clinical significance, risk factors, and management of TRD in adolescents. Risk factors associated with TRD include characteristics of depression (severity, level of hopelessness, and suicidal ideation), psychiatric and medical comorbidities, environmental factors (family conflict, maternal depression, and history of abuse), and pharmacokinetics and other biomarkers. Management options include review of the adequacy of the initial treatment, re-assessment for the above-noted factors that might predispose to treatment resistance, switching antidepressants, and augmentation with medication or psychotherapy. Other modalities, such as electroconvulsive therapy, vagal nerve stimulation, and repetitive transcranial magnetic stimulation, are also reviewed. Depression and Anxiety, 2011. © 2011 Wiley Periodicals, Inc. © 2011 Wiley Periodicals, Inc.
dc.format.extent Pages: (946-954)
dc.language English
dc.publisher MALDEN
dc.relation.ispartof Publication Name: Depression and Anxiety; Publication Year: 2011; Volume: 28; no. 11; Pages: (946-954);
dc.source Scopus
dc.title Treatment-resistant depression in adolescents: Review and updates on clinical management
dc.type Review
dc.contributor.affiliation Maalouf, F.T., Department of Psychiatry, American University, Beirut Medical Center, Riad el Solh Street, Beirut, Lebanon, Western Psychiatric Institute and Clinic, University of Pittsburgh, School of Medicine, PA, United States
dc.contributor.affiliation Atwi, M., Department of Psychiatry, American University, Beirut Medical Center, Riad el Solh Street, Beirut, Lebanon
dc.contributor.affiliation Brent, D.A., Western Psychiatric Institute and Clinic, University of Pittsburgh, School of Medicine, PA, United States
dc.contributor.authorAddress Maalouf, F.T.; Department of Psychiatry, American University, Beirut Medical Center, Riad el Solh Street, Beirut, Lebanon; email:
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Psychiatry;
dc.contributor.authorDepartment Psychiatry
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Maalouf, FT
dc.contributor.authorInitials Atwi, M
dc.contributor.authorInitials Brent, DA
dc.contributor.authorReprintAddress Maalouf, FT (reprint author), Amer Univ Beirut, Med Ctr, Dept Psychiat, Riad el Solh St, Beirut, Lebanon.
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedCount 17
dc.description.citedTotWOSCount 15
dc.description.citedWOSCount 15
dc.format.extentCount 9
dc.identifier.coden DEANF
dc.identifier.pubmedID 21898710
dc.identifier.scopusID 81255179223
dc.publisher.address COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
dc.relation.ispartOfISOAbbr Depress. Anxiety
dc.relation.ispartOfIssue 11
dc.relation.ispartofPubTitle Depression and Anxiety
dc.relation.ispartofPubTitleAbbr Depression Anxiety
dc.relation.ispartOfVolume 28
dc.source.ID WOS:000297221800002
dc.type.publication Journal
dc.subject.otherAuthKeyword adolescent
dc.subject.otherAuthKeyword antidepressant
dc.subject.otherAuthKeyword depression
dc.subject.otherAuthKeyword psychotherapy
dc.subject.otherAuthKeyword treatment
dc.subject.otherAuthKeyword treatment-resistant
dc.subject.otherChemCAS amfebutamone, 31677-93-7, 34911-55-2
dc.subject.otherChemCAS buspirone, 33386-08-2, 36505-84-7
dc.subject.otherChemCAS citalopram, 59729-33-8
dc.subject.otherChemCAS clomipramine, 17321-77-6, 303-49-1
dc.subject.otherChemCAS fluoxetine, 54910-89-3, 56296-78-7, 59333-67-4
dc.subject.otherChemCAS liothyronine, 6138-47-2, 6893-02-3
dc.subject.otherChemCAS lithium, 7439-93-2
dc.subject.otherChemCAS mirtazapine, 61337-67-5
dc.subject.otherChemCAS paroxetine, 61869-08-7
dc.subject.otherChemCAS quetiapine, 111974-72-2
dc.subject.otherChemCAS venlafaxine, 93413-69-5
dc.subject.otherChemCAS Antidepressive Agents
dc.subject.otherIndex amfebutamone
dc.subject.otherIndex buspirone
dc.subject.otherIndex citalopram
dc.subject.otherIndex clomipramine
dc.subject.otherIndex fluoxetine
dc.subject.otherIndex liothyronine
dc.subject.otherIndex lithium
dc.subject.otherIndex mirtazapine
dc.subject.otherIndex paroxetine
dc.subject.otherIndex quetiapine
dc.subject.otherIndex venlafaxine
dc.subject.otherIndex abuse
dc.subject.otherIndex acne
dc.subject.otherIndex adolescent
dc.subject.otherIndex automutilation
dc.subject.otherIndex comorbidity
dc.subject.otherIndex depression
dc.subject.otherIndex disease severity
dc.subject.otherIndex drug efficacy
dc.subject.otherIndex drug safety
dc.subject.otherIndex drug substitution
dc.subject.otherIndex electroconvulsive therapy
dc.subject.otherIndex environmental factor
dc.subject.otherIndex family conflict
dc.subject.otherIndex hopelessness
dc.subject.otherIndex human
dc.subject.otherIndex maternal disease
dc.subject.otherIndex prevalence
dc.subject.otherIndex priority journal
dc.subject.otherIndex review
dc.subject.otherIndex risk factor
dc.subject.otherIndex side effect
dc.subject.otherIndex suicidal ideation
dc.subject.otherIndex transcranial magnetic stimulation
dc.subject.otherIndex treatment indication
dc.subject.otherIndex treatment outcome
dc.subject.otherIndex vagus nerve stimulation
dc.subject.otherIndex weight gain
dc.subject.otherIndex Adolescent
dc.subject.otherIndex Antidepressive Agents
dc.subject.otherIndex Combined Modality Therapy
dc.subject.otherIndex Depressive Disorder, Treatment-Resistant
dc.subject.otherIndex Disease Management
dc.subject.otherIndex Humans
dc.subject.otherIndex Prevalence
dc.subject.otherIndex Psychotherapy
dc.subject.otherIndex Risk Factors
dc.subject.otherKeywordPlus COGNITIVE-BEHAVIORAL THERAPY
dc.subject.otherKeywordPlus STAR-ASTERISK-D
dc.subject.otherKeywordPlus RANDOMIZED CONTROLLED-TRIAL
dc.subject.otherKeywordPlus MAJOR DEPRESSION
dc.subject.otherKeywordPlus TREATMENT RESPONSE
dc.subject.otherKeywordPlus ELECTROCONVULSIVE-THERAPY
dc.subject.otherKeywordPlus ANTIDEPRESSANT TREATMENT
dc.subject.otherKeywordPlus LITHIUM AUG
dc.subject.otherWOS Psychology, Clinical
dc.subject.otherWOS Psychiatry
dc.subject.otherWOS Psychology

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