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Bias to negative emotions: A depression state-dependent marker in adolescent major depressive disorder

Show simple item record Maalouf F.T. Clark L. Tavitian L. Sahakian B.J. Brent D. Phillips M.L.
dc.contributor.editor Jun-2012 2017-10-05T16:04:43Z 2017-10-05T16:04:43Z 2012
dc.identifier 10.1016/j.psychres.2012.01.030
dc.identifier.issn 01651781
dc.description.abstract The aim of the current research was to examine for the first time the extent to which bias to negative emotions in an inhibitory control paradigm is a state or trait marker in major depressive disorder (MDD) in adolescents. We administered the affective go-no go task which measures the ability to switch attention to or away from positive or negative emotional stimuli to 40 adolescents with MDD (20 in acute episode (MDDa) and 20 in remission (MDDr)) and 17 healthy controls (HC). MDDa were significantly faster on the shift to negative target blocks as compared to shift to positive target blocks while HC and MDDr displayed the opposite pattern as measured by an emotional bias index (EBI = latency (shift to negative targets) - latency (shift to positive targets)). There was also a trend for an effect of group on commission errors, suggesting more impulsive responding by MDDa than both MDDr and HC independently of stimulus valence throughout the task. Negative bias was not associated with depression severity or medication status. In conclusion, bias to negative emotional stimuli appears to be present in the acute stage of MDD and absent in remission suggesting that it is a depression state-specific marker of MDD in adolescents. Latency emerges as a better proxy of negative bias than commission errors and accuracy on this inhibitory control task in adolescents with MDD. © 2012 Elsevier Ltd.
dc.format.extent Pages: (28-33)
dc.language English
dc.publisher CLARE
dc.relation.ispartof Publication Name: Psychiatry Research; Publication Year: 2012; Volume: 198; no. 1; Pages: (28-33);
dc.source Scopus
dc.title Bias to negative emotions: A depression state-dependent marker in adolescent major depressive disorder
dc.type Article
dc.contributor.affiliation Maalouf, F.T., Department of Psychiatry, American University of Beirut Medical Center, Lebanon, Department of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA, United States, Department of Psychiatry, University of Cambridge, United Kingdom
dc.contributor.affiliation Clark, L., Western Psychiatric Institute and Clinic, Pittsburgh, PA, United States, Department of Experimental Psychology, University of Cambridge, United Kingdom
dc.contributor.affiliation Tavitian, L., Department of Psychiatry, American University of Beirut Medical Center, Lebanon
dc.contributor.affiliation Sahakian, B.J., Department of Experimental Psychology, University of Cambridge, United Kingdom, MRC-Wellcome Trust Behavioural and Clinical Neuroscience Institute, University of Cambridge, United Kingdom
dc.contributor.affiliation Brent, D., Department of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA, United States, Department of Psychiatry, University of Cambridge, United Kingdom
dc.contributor.affiliation Phillips, M.L., Department of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA, United States, Department of Psychiatry, University of Cambridge, United Kingdom
dc.contributor.authorAddress Maalouf, F.T.; Department of Psychiatry, American University of Beirut Medical Center, Po Box: 11-0236, Riad El Solh 11072020, Lebanon; email:
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Psychiatry;
dc.contributor.authorDepartment Psychiatry
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Maalouf, FT
dc.contributor.authorInitials Clark, L
dc.contributor.authorInitials Tavitian, L
dc.contributor.authorInitials Sahakian, BJ
dc.contributor.authorInitials Brent, D
dc.contributor.authorInitials Phillips, ML
dc.contributor.authorReprintAddress Maalouf, FT (reprint author), Amer Univ Beirut, Med Ctr, Dept Psychiat, POB 11-0236, Riad El Solh 11072020, Lebanon.
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedCount 2
dc.description.citedTotWOSCount 5
dc.description.citedWOSCount 5
dc.format.extentCount 6
dc.identifier.coden PSRSD
dc.identifier.pubmedID 22460133
dc.identifier.scopusID 84867143677
dc.relation.ispartOfISOAbbr Psychiatry Res.
dc.relation.ispartOfIssue 1
dc.relation.ispartofPubTitle Psychiatry Research
dc.relation.ispartofPubTitleAbbr Psychiatry Res.
dc.relation.ispartOfVolume 198
dc.source.ID WOS:000313848200006
dc.type.publication Journal
dc.subject.otherAuthKeyword Adolescent
dc.subject.otherAuthKeyword Depression
dc.subject.otherAuthKeyword Emotion processing
dc.subject.otherIndex adolescent
dc.subject.otherIndex article
dc.subject.otherIndex attention
dc.subject.otherIndex bias to negative emotion
dc.subject.otherIndex clinical article
dc.subject.otherIndex cognition
dc.subject.otherIndex controlled study
dc.subject.otherIndex disease severity
dc.subject.otherIndex emotion
dc.subject.otherIndex emotional bias index
dc.subject.otherIndex error
dc.subject.otherIndex exploratory behavior
dc.subject.otherIndex female
dc.subject.otherIndex Go No Go task
dc.subject.otherIndex health status
dc.subject.otherIndex human
dc.subject.otherIndex impulsiveness
dc.subject.otherIndex latent period
dc.subject.otherIndex major depression
dc.subject.otherIndex male
dc.subject.otherIndex mental task
dc.subject.otherIndex priority journal
dc.subject.otherIndex rating scale
dc.subject.otherIndex remission
dc.subject.otherIndex Adolescent
dc.subject.otherIndex Analysis of Variance
dc.subject.otherIndex Bias (Epidemiology)
dc.subject.otherIndex Depressive Disorder, Major
dc.subject.otherIndex Emotions
dc.subject.otherIndex Female
dc.subject.otherIndex Humans
dc.subject.otherIndex Inhibition (Psychology)
dc.subject.otherIndex Male
dc.subject.otherIndex Reaction Time
dc.subject.otherIndex Statistics as Topic
dc.subject.otherKeywordPlus TREATMENT RESPONSE
dc.subject.otherKeywordPlus BIPOLAR DISORDER
dc.subject.otherKeywordPlus DECISION-MAKING
dc.subject.otherKeywordPlus FOLLOW-UP
dc.subject.otherKeywordPlus RELIABILITY
dc.subject.otherKeywordPlus PERFORMANCE
dc.subject.otherKeywordPlus CHILDREN
dc.subject.otherKeywordPlus VALIDITY
dc.subject.otherKeywordPlus VULNERABILITY
dc.subject.otherKeywordPlus INDIVIDUALS
dc.subject.otherWOS Psychiatry

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