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Bias to negative emotions: A depression state-dependent marker in adolescent major depressive disorder

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dc.contributor.author Maalouf F.T.
dc.contributor.author Clark L.
dc.contributor.author Tavitian L.
dc.contributor.author Sahakian B.J.
dc.contributor.author Brent D.
dc.contributor.author Phillips M.L.
dc.contributor.editor
dc.date Jun-2012
dc.date.accessioned 2017-10-05T16:04:43Z
dc.date.available 2017-10-05T16:04:43Z
dc.date.issued 2012
dc.identifier 10.1016/j.psychres.2012.01.030
dc.identifier.isbn
dc.identifier.issn 01651781
dc.identifier.uri http://hdl.handle.net/10938/19653
dc.description.abstract The aim of the current research was to examine for the first time the extent to which bias to negative emotions in an inhibitory control paradigm is a state or trait marker in major depressive disorder (MDD) in adolescents. We administered the affective go-no go task which measures the ability to switch attention to or away from positive or negative emotional stimuli to 40 adolescents with MDD (20 in acute episode (MDDa) and 20 in remission (MDDr)) and 17 healthy controls (HC). MDDa were significantly faster on the shift to negative target blocks as compared to shift to positive target blocks while HC and MDDr displayed the opposite pattern as measured by an emotional bias index (EBI = latency (shift to negative targets) - latency (shift to positive targets)). There was also a trend for an effect of group on commission errors, suggesting more impulsive responding by MDDa than both MDDr and HC independently of stimulus valence throughout the task. Negative bias was not associated with depression severity or medication status. In conclusion, bias to negative emotional stimuli appears to be present in the acute stage of MDD and absent in remission suggesting that it is a depression state-specific marker of MDD in adolescents. Latency emerges as a better proxy of negative bias than commission errors and accuracy on this inhibitory control task in adolescents with MDD. © 2012 Elsevier Ltd.
dc.format.extent
dc.format.extent Pages: (28-33)
dc.language English
dc.publisher CLARE
dc.relation.ispartof Publication Name: Psychiatry Research; Publication Year: 2012; Volume: 198; no. 1; Pages: (28-33);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Bias to negative emotions: A depression state-dependent marker in adolescent major depressive disorder
dc.type Article
dc.contributor.affiliation Maalouf, F.T., Department of Psychiatry, American University of Beirut Medical Center, Lebanon, Department of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA, United States, Department of Psychiatry, University of Cambridge, United Kingdom
dc.contributor.affiliation Clark, L., Western Psychiatric Institute and Clinic, Pittsburgh, PA, United States, Department of Experimental Psychology, University of Cambridge, United Kingdom
dc.contributor.affiliation Tavitian, L., Department of Psychiatry, American University of Beirut Medical Center, Lebanon
dc.contributor.affiliation Sahakian, B.J., Department of Experimental Psychology, University of Cambridge, United Kingdom, MRC-Wellcome Trust Behavioural and Clinical Neuroscience Institute, University of Cambridge, United Kingdom
dc.contributor.affiliation Brent, D., Department of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA, United States, Department of Psychiatry, University of Cambridge, United Kingdom
dc.contributor.affiliation Phillips, M.L., Department of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA, United States, Department of Psychiatry, University of Cambridge, United Kingdom
dc.contributor.authorAddress Maalouf, F.T.; Department of Psychiatry, American University of Beirut Medical Center, Po Box: 11-0236, Riad El Solh 11072020, Lebanon; email: fm38@aub.edu.lb
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Psychiatry;
dc.contributor.authorDepartment Psychiatry
dc.contributor.authorDivision
dc.contributor.authorEmail fm38@aub.edu.lb
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Maalouf, FT
dc.contributor.authorInitials Clark, L
dc.contributor.authorInitials Tavitian, L
dc.contributor.authorInitials Sahakian, BJ
dc.contributor.authorInitials Brent, D
dc.contributor.authorInitials Phillips, ML
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Maalouf, FT (reprint author), Amer Univ Beirut, Med Ctr, Dept Psychiat, POB 11-0236, Riad El Solh 11072020, Lebanon.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedCount 2
dc.description.citedTotWOSCount 5
dc.description.citedWOSCount 5
dc.format.extentCount 6
dc.identifier.articleNo
dc.identifier.coden PSRSD
dc.identifier.pubmedID 22460133
dc.identifier.scopusID 84867143677
dc.identifier.url
dc.publisher.address ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND
dc.relation.ispartofConference
dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr Psychiatry Res.
dc.relation.ispartOfIssue 1
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Psychiatry Research
dc.relation.ispartofPubTitleAbbr Psychiatry Res.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 198
dc.source.ID WOS:000313848200006
dc.type.publication Journal
dc.subject.otherAuthKeyword Adolescent
dc.subject.otherAuthKeyword Depression
dc.subject.otherAuthKeyword Emotion processing
dc.subject.otherChemCAS
dc.subject.otherIndex adolescent
dc.subject.otherIndex article
dc.subject.otherIndex attention
dc.subject.otherIndex bias to negative emotion
dc.subject.otherIndex clinical article
dc.subject.otherIndex cognition
dc.subject.otherIndex controlled study
dc.subject.otherIndex disease severity
dc.subject.otherIndex emotion
dc.subject.otherIndex emotional bias index
dc.subject.otherIndex error
dc.subject.otherIndex exploratory behavior
dc.subject.otherIndex female
dc.subject.otherIndex Go No Go task
dc.subject.otherIndex health status
dc.subject.otherIndex human
dc.subject.otherIndex impulsiveness
dc.subject.otherIndex latent period
dc.subject.otherIndex major depression
dc.subject.otherIndex male
dc.subject.otherIndex mental task
dc.subject.otherIndex priority journal
dc.subject.otherIndex rating scale
dc.subject.otherIndex remission
dc.subject.otherIndex Adolescent
dc.subject.otherIndex Analysis of Variance
dc.subject.otherIndex Bias (Epidemiology)
dc.subject.otherIndex Depressive Disorder, Major
dc.subject.otherIndex Emotions
dc.subject.otherIndex Female
dc.subject.otherIndex Humans
dc.subject.otherIndex Inhibition (Psychology)
dc.subject.otherIndex Male
dc.subject.otherIndex Reaction Time
dc.subject.otherIndex Statistics as Topic
dc.subject.otherKeywordPlus TREATMENT RESPONSE
dc.subject.otherKeywordPlus BIPOLAR DISORDER
dc.subject.otherKeywordPlus DECISION-MAKING
dc.subject.otherKeywordPlus FOLLOW-UP
dc.subject.otherKeywordPlus RELIABILITY
dc.subject.otherKeywordPlus PERFORMANCE
dc.subject.otherKeywordPlus CHILDREN
dc.subject.otherKeywordPlus VALIDITY
dc.subject.otherKeywordPlus VULNERABILITY
dc.subject.otherKeywordPlus INDIVIDUALS
dc.subject.otherWOS Psychiatry


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