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Regional cerebral blood flow changes associated with focal electrically administered seizure therapy (FEAST)

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dc.contributor.author Chahine G.
dc.contributor.author Short B.
dc.contributor.author Spicer K.
dc.contributor.author Schmidt M.
dc.contributor.author Burns C.
dc.contributor.author Atoui M.
dc.contributor.author George M.S.
dc.contributor.author Sackeim H.A.
dc.contributor.author Nahas Z.
dc.contributor.editor
dc.date 2014
dc.date.accessioned 2017-10-05T16:04:45Z
dc.date.available 2017-10-05T16:04:45Z
dc.date.issued 2014
dc.identifier 10.1016/j.brs.2014.02.011
dc.identifier.isbn
dc.identifier.issn
dc.identifier.uri http://hdl.handle.net/10938/19671
dc.description.abstract Introduction Use of electroconvulsive therapy (ECT) is limited by cognitive disturbance. Focal electrically-administered seizure therapy (FEAST) is designed to initiate focal seizures in the prefrontal cortex. To date, no studies have documented the effects of FEAST on regional cerebral blood flow (rCBF). Methods A 72 year old depressed man underwent three single photon emission computed tomography (SPECT) scans to capture the onset and resolution of seizures triggered with right unilateral FEAST. We used Bioimage Suite for within-subject statistical analyses of perfusion differences ictally and post-ictally compared with the baseline scan. Results Early ictal increases in regional cerebral blood flow (rCBF) were limited to the right prefrontal cortex. Post-ictally, perfusion was reduced in bilateral frontal and occipital cortices and increased in left motor and precuneus cortex. Conclusion FEAST appears to triggers focal onsets of seizure activity in the right prefrontal cortex with subsequent generalization. Future studies are needed on a larger sample. © 2014 Elsevier Inc. All rights reserved.
dc.format.extent
dc.format.extent Pages: (483-485)
dc.language English
dc.publisher Elsevier Inc.; NEW YORK
dc.relation.ispartof Publication Name: Brain Stimulation; Publication Year: 2014; Volume: 7; no. 3; Pages: (483-485);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Regional cerebral blood flow changes associated with focal electrically administered seizure therapy (FEAST)
dc.type Article
dc.contributor.affiliation Chahine, G., American University of Beirut, Department of Psychiatry, P.O. Box 11-0236, Riad El-Solh, 1107 2020 Beirut, Lebanon
dc.contributor.affiliation Short, B., Brain Stimulation Laboratory, Psychiatry Department, Medical University of South Carolina, United States
dc.contributor.affiliation Spicer, K., Radiology Department, Medical University of South Carolina, United States
dc.contributor.affiliation Schmidt, M., Brain Stimulation Laboratory, Psychiatry Department, Medical University of South Carolina, United States, Ralph H. Johnson VA Medical Center, Charleston, SC, United States
dc.contributor.affiliation Burns, C., Brain Stimulation Laboratory, Psychiatry Department, Medical University of South Carolina, United States
dc.contributor.affiliation Atoui, M., American University of Beirut, Department of Psychiatry, P.O. Box 11-0236, Riad El-Solh, 1107 2020 Beirut, Lebanon
dc.contributor.affiliation George, M.S., Brain Stimulation Laboratory, Psychiatry Department, Medical University of South Carolina, United States, Ralph H. Johnson VA Medical Center, Charleston, SC, United States
dc.contributor.affiliation Sackeim, H.A., Department of Psychiatry, Columbia University, New York, NY, United States, Department of Radiology, Columbia University, New York, NY, United States
dc.contributor.affiliation Nahas, Z., American University of Beirut, Department of Psychiatry, P.O. Box 11-0236, Riad El-Solh, 1107 2020 Beirut, Lebanon
dc.contributor.authorAddress Nahas, Z.; American University of Beirut, Department of Psychiatry, P.O. Box 11-0236, Riad El-Solh, 1107 2020 Beirut, Lebanon; email: zn17@aub.edu.lb
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Psychiatry;
dc.contributor.authorDepartment Psychiatry
dc.contributor.authorDivision
dc.contributor.authorEmail zn17@aub.edu.lb
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Chahine, G
dc.contributor.authorInitials Short, B
dc.contributor.authorInitials Spicer, K
dc.contributor.authorInitials Schmidt, M
dc.contributor.authorInitials Burns, C
dc.contributor.authorInitials Atoui, M
dc.contributor.authorInitials George, MS
dc.contributor.authorInitials Sackeim, HA
dc.contributor.authorInitials Nahas, Z
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Nahas, Z (reprint author), Amer Univ Beirut, Dept Psychiat, POB 11-0236, Beirut 11072020, Lebanon.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.identifier.articleNo
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dc.identifier.pubmedID
dc.identifier.scopusID 84899811384
dc.identifier.url
dc.publisher.address 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
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dc.relation.ispartofConferenceDate
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dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
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dc.relation.ispartOfISOAbbr Brain Stimul.
dc.relation.ispartOfIssue 3
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Brain Stimulation
dc.relation.ispartofPubTitleAbbr Brain Stimul.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 7
dc.source.ID WOS:000335739400020
dc.type.publication Journal
dc.subject.otherAuthKeyword Brain stimulation
dc.subject.otherAuthKeyword Depression
dc.subject.otherAuthKeyword ECT
dc.subject.otherAuthKeyword Electroconvulsive therapy
dc.subject.otherAuthKeyword FEAST
dc.subject.otherAuthKeyword Focally electrically administered seizure therapy
dc.subject.otherAuthKeyword SPECT
dc.subject.otherChemCAS
dc.subject.otherIndex aged
dc.subject.otherIndex article
dc.subject.otherIndex brain blood flow
dc.subject.otherIndex case report
dc.subject.otherIndex delirium
dc.subject.otherIndex depression
dc.subject.otherIndex electroconvulsive therapy
dc.subject.otherIndex electroconvulsive therapy unit
dc.subject.otherIndex focal epilepsy
dc.subject.otherIndex Hamilton scale
dc.subject.otherIndex human
dc.subject.otherIndex inferior frontal gyrus
dc.subject.otherIndex insula
dc.subject.otherIndex male
dc.subject.otherIndex Mini Mental State Examination
dc.subject.otherIndex motor cortex
dc.subject.otherIndex named inventories, questionnaires and rating scales
dc.subject.otherIndex occipital cortex
dc.subject.otherIndex precuneus
dc.subject.otherIndex prefrontal cortex
dc.subject.otherIndex priority journal
dc.subject.otherIndex single photon emission computer tomography
dc.subject.otherIndex Suicide Scale Inventory
dc.subject.otherIndex superior frontal gyrus
dc.subject.otherKeywordPlus ELECTROCONVULSIVE-THERAPY
dc.subject.otherKeywordPlus MAJOR DEPRESSION
dc.subject.otherKeywordPlus ECT
dc.subject.otherKeywordPlus STIMULATION
dc.subject.otherKeywordPlus METABOLISM
dc.subject.otherKeywordPlus RECEPTORS
dc.subject.otherKeywordPlus DISORDER
dc.subject.otherKeywordPlus SPECT
dc.subject.otherKeywordPlus FORM
dc.subject.otherWOS Clinical Neurology
dc.subject.otherWOS Neurosciences


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