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Transient attenuation of neuropathic manifestations in rats following lesion or reversible block of the lateral thalamic somatosensory nuclei

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dc.contributor.author Saade N.E.
dc.contributor.author Al Amin H.
dc.contributor.author Abdel Baki S.
dc.contributor.author Safieh-Garabedian B.
dc.contributor.author Atweh S.F.
dc.contributor.author Jabbur S.J.
dc.contributor.editor
dc.date Jan-2006
dc.date.accessioned 2017-10-05T16:04:45Z
dc.date.available 2017-10-05T16:04:45Z
dc.date.issued 2006
dc.identifier 10.1016/j.expneurol.2005.09.005
dc.identifier.isbn
dc.identifier.issn 00144886
dc.identifier.uri http://hdl.handle.net/10938/19676
dc.description.abstract Background and aims: Nociceptive behavior in animal models for mononeuropathy has been shown to be altered by spinal tract lesions which suggest a possible supraspinal modulation. The thalamus constitutes a chief center for the processing of nociception. We have, therefore, investigated the effects of transient or permanent blocks of the lateral somatosensory thalamic nuclei (the ventrobasal complex) on the neuropathic manifestations in rats. Methods: Different groups of rats (n = 5-6) were subjected to mononeuropathy, following the spared nerve injury model, known to produce sustained heat hyperalgesia and tactile and cold allodynia which peaked about 2 weeks after nerve injury. This was followed by stereotaxic placement of either electrolytic or chemical lesions or implantation of mini osmotic pump for slow release of lidocaine in the ventrobasal complex. Results: Chronic electrolytic and chemical lesions or reversible block of the lateral somatosensory thalamus produced transient (1-2 weeks) attenuation of neuropathic manifestations along with a persistent decrease of the hot plate latency. The most pronounced effect was observed on heat hyperalgesia, and the least significant and short-lived effect was observed on cold allodynia. Conclusion: We conclude that the lateral somatosensory thalamic complex is involved in the processing of neuropathic manifestations but cannot be considered as an obligatory or exclusive relay center for the neuropathic syndromes. © 2005 Elsevier Inc. All rights reserved.
dc.format.extent
dc.format.extent Pages: (157-166)
dc.language English
dc.publisher SAN DIEGO
dc.relation.ispartof Publication Name: Experimental Neurology; Publication Year: 2006; Volume: 197; no. 1; Pages: (157-166);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Transient attenuation of neuropathic manifestations in rats following lesion or reversible block of the lateral thalamic somatosensory nuclei
dc.type Article
dc.contributor.affiliation Saadé, N.E., Department of Human Morphology, Faculty of Medicine, American University of Beirut, Riad El Solh Beirut 1107-2020, Lebanon, Department of Physiology, Faculty of Medicine, American University of Beirut, Riad El Solh Beirut 1107-2020, Lebanon
dc.contributor.affiliation Al Amin, H., Department of Psychiatry, Faculty of Medicine, American University of Beirut, Riad El Solh Beirut 1107-2020, Lebanon
dc.contributor.affiliation Abdel Baki, S., Department of Human Morphology, Faculty of Medicine, American University of Beirut, Riad El Solh Beirut 1107-2020, Lebanon, Department of Physiology, Faculty of Medicine, American University of Beirut, Riad El Solh Beirut 1107-2020, Lebanon
dc.contributor.affiliation Safieh-Garabedian, B., Department of Biology, Faculty of Arts and Sciences, American University of Beirut, Riad El Solh Beirut 1107-2020, Lebanon
dc.contributor.affiliation Atweh, S.F., Department of Internal Medicine, Faculty of Medicine, American University of Beirut, Riad El Solh Beirut 1107-2020, Lebanon
dc.contributor.affiliation Jabbur, S.J., Department of Physiology, Faculty of Medicine, American University of Beirut, Riad El Solh Beirut 1107-2020, Lebanon
dc.contributor.authorAddress Saadé, N.E.; Department of Human Morphology, Faculty of Medicine, American University of Beirut, Riad El Solh Beirut 1107-2020, Lebanon; email: nesaade@aub.edu.lb
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Psychiatry;
dc.contributor.authorDepartment Psychiatry
dc.contributor.authorDivision
dc.contributor.authorEmail nesaade@aub.edu.lb
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Saade, NE
dc.contributor.authorInitials Al Amin, H
dc.contributor.authorInitials Baki, SA
dc.contributor.authorInitials Safieh-Garabedian, B
dc.contributor.authorInitials Atweh, SF
dc.contributor.authorInitials Jabbur, SJ
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Saade, NE (reprint author), Amer Univ Beirut, Fac Med, Dept Human Morphol, Beirut 11072020, Lebanon.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedCount 10
dc.description.citedTotWOSCount 9
dc.description.citedWOSCount 9
dc.format.extentCount 10
dc.identifier.articleNo
dc.identifier.coden EXNEA
dc.identifier.pubmedID 16214132
dc.identifier.scopusID 29144476589
dc.identifier.url
dc.publisher.address 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
dc.relation.ispartofConference
dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr Exp. Neurol.
dc.relation.ispartOfIssue 1
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Experimental Neurology
dc.relation.ispartofPubTitleAbbr Exp. Neurol.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 197
dc.source.ID WOS:000234534200016
dc.type.publication Journal
dc.subject.otherAuthKeyword Allodynia
dc.subject.otherAuthKeyword Central pain
dc.subject.otherAuthKeyword Hyperalgesia
dc.subject.otherAuthKeyword Pain pathways
dc.subject.otherAuthKeyword Thalamic syndrome
dc.subject.otherChemCAS lidocaine, 137-58-6, 24847-67-4, 56934-02-2, 73-78-9
dc.subject.otherChemCAS Anesthetics, Local
dc.subject.otherChemCAS Excitatory Amino Acid Agonists
dc.subject.otherChemCAS Ibotenic Acid, 2552-55-8
dc.subject.otherChemCAS Kainic Acid, 487-79-6
dc.subject.otherChemCAS Lidocaine, 137-58-6
dc.subject.otherIndex lidocaine
dc.subject.otherIndex allodynia
dc.subject.otherIndex animal model
dc.subject.otherIndex article
dc.subject.otherIndex attenuation
dc.subject.otherIndex controlled study
dc.subject.otherIndex drug release
dc.subject.otherIndex electrolysis
dc.subject.otherIndex hyperalgesia
dc.subject.otherIndex implantation
dc.subject.otherIndex latent period
dc.subject.otherIndex mononeuropathy
dc.subject.otherIndex nerve injury
dc.subject.otherIndex neuropathy
dc.subject.otherIndex nonhuman
dc.subject.otherIndex osmosis
dc.subject.otherIndex osmotic minipump
dc.subject.otherIndex priority journal
dc.subject.otherIndex rat
dc.subject.otherIndex somatosensory cortex
dc.subject.otherIndex stereotaxis
dc.subject.otherIndex thalamus lateral nucleus
dc.subject.otherIndex Anesthetics, Local
dc.subject.otherIndex Animals
dc.subject.otherIndex Behavior, Animal
dc.subject.otherIndex Cold
dc.subject.otherIndex Excitatory Amino Acid Agonists
dc.subject.otherIndex Female
dc.subject.otherIndex Heat
dc.subject.otherIndex Hyperalgesia
dc.subject.otherIndex Ibotenic Acid
dc.subject.otherIndex Kainic Acid
dc.subject.otherIndex Lateral Thalamic Nuclei
dc.subject.otherIndex Lidocaine
dc.subject.otherIndex Male
dc.subject.otherIndex Nerve Block
dc.subject.otherIndex Pain Measurement
dc.subject.otherIndex Pain Threshold
dc.subject.otherIndex Peripheral Nervous System Diseases
dc.subject.otherIndex Physical Stimulation
dc.subject.otherIndex Rats
dc.subject.otherIndex Rats, Sprague-Dawley
dc.subject.otherIndex Reaction Time
dc.subject.otherIndex Spinal Nerves
dc.subject.otherIndex Stereotaxic Techniques
dc.subject.otherKeywordPlus POSITRON-EMISSION-TOMOGRAPHY
dc.subject.otherKeywordPlus CENTRAL POSTSTROKE PAIN
dc.subject.otherKeywordPlus MECHANICAL ALLODYNIA
dc.subject.otherKeywordPlus NERVE INJURY
dc.subject.otherKeywordPlus PERIPHERAL MONONEUROPATHY
dc.subject.otherKeywordPlus BEHAVIORAL SIGNS
dc.subject.otherKeywordPlus MODEL
dc.subject.otherKeywordPlus STIMULATION
dc.subject.otherKeywordPlus NEURONS
dc.subject.otherKeywordPlus DEAFFERENTATION
dc.subject.otherWOS Neurosciences


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