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Comparison of risk of radiogenic second cancer following photon and proton craniospinal irradiation for a pediatric medulloblastoma patient

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dc.contributor.author Zhang R.
dc.contributor.author Howell R.M.
dc.contributor.author Giebeler A.
dc.contributor.author Taddei P.J.
dc.contributor.author Mahajan A.
dc.contributor.author Newhauser W.D.
dc.contributor.editor
dc.date 2013
dc.date.accessioned 2017-10-05T16:05:54Z
dc.date.available 2017-10-05T16:05:54Z
dc.date.issued 2013
dc.identifier 10.1088/0031-9155/58/4/807
dc.identifier.isbn
dc.identifier.issn 00319155
dc.identifier.uri http://hdl.handle.net/10938/19697
dc.description.abstract Pediatric patients who received radiation therapy are at risk of developing side effects such as radiogenic second cancer. We compared proton and photon therapies in terms of the predicted risk of second cancers for a 4 year old medulloblastoma patient receiving craniospinal irradiation (CSI). Two CSI treatment plans with 23.4 Gy or Gy (RBE) prescribed dose were computed: a three-field 6 MV photon therapy plan and a four-field proton therapy plan. The primary doses for both plans were determined using a commercial treatment planning system. Stray radiation doses for proton therapy were determined from Monte Carlo simulations, and stray radiation doses for photon therapy were determined from measured data. Dose-risk models based on the Biological Effects of Ionization Radiation VII report were used to estimate the risk of second cancer in eight tissues-organs. Baseline predictions of the relative risk for each organ were always less for proton CSI than for photon CSI at all attained ages. The total lifetime attributable risk of the incidence of second cancer considered after proton CSI was much lower than that after photon CSI, and the ratio of lifetime risk was 0.18. Uncertainty analysis revealed that the qualitative findings of this study were insensitive to any plausible changes of dose-risk models and mean radiation weighting factor for neutrons. Proton therapy confers lower predicted risk of second cancer than photon therapy for the pediatric medulloblastoma patient. © 2013 Institute of Physics and Engineering in Medicine.
dc.format.extent
dc.format.extent Pages: (807-823)
dc.language English
dc.publisher BRISTOL
dc.relation.ispartof Publication Name: Physics in Medicine and Biology; Publication Year: 2013; Volume: 58; no. 4; Pages: (807-823);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Comparison of risk of radiogenic second cancer following photon and proton craniospinal irradiation for a pediatric medulloblastoma patient
dc.type Article
dc.contributor.affiliation Zhang, R., Graduate School of Biomedical Sciences, University of Texas at Houston, Houston, TX, United States, Department of Radiation Physics and Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, United States, Mary Bird Perkins Cancer Center, Baton Rouge, LA, United States
dc.contributor.affiliation Howell, R.M., Graduate School of Biomedical Sciences, University of Texas at Houston, Houston, TX, United States, Department of Radiation Physics and Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, United States
dc.contributor.affiliation Giebeler, A., Graduate School of Biomedical Sciences, University of Texas at Houston, Houston, TX, United States, Department of Radiation Physics and Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, United States
dc.contributor.affiliation Taddei, P.J., Graduate School of Biomedical Sciences, University of Texas at Houston, Houston, TX, United States, Department of Radiation Physics and Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, United States, Department of Radiation Oncology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon
dc.contributor.affiliation Mahajan, A., Department of Radiation Physics and Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, United States
dc.contributor.affiliation Newhauser, W.D., Graduate School of Biomedical Sciences, University of Texas at Houston, Houston, TX, United States, Department of Radiation Physics and Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, United States, Louisiana State University, Medical Physics Program, Department of Physics and Astronomy, Baton Rouge, LA, United States, Mary Bird Perkins Cancer Center, Baton Rouge, LA, United States
dc.contributor.authorAddress Newhauser, W.D.; Graduate School of Biomedical Sciences, University of Texas at Houston, Houston, TX, United States; email: newhauser@lsu.edu
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Radiation Oncology;
dc.contributor.authorDepartment Radiation Oncology
dc.contributor.authorDivision
dc.contributor.authorEmail newhauser@lsu.edu
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Zhang, R
dc.contributor.authorInitials Howell, RM
dc.contributor.authorInitials Giebeler, A
dc.contributor.authorInitials Taddei, PJ
dc.contributor.authorInitials Mahajan, A
dc.contributor.authorInitials Newhauser, WD
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Newhauser, WD (reprint author), Univ Texas Houston, Grad Sch Biomed Sci, Houston, TX 77030 USA.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedCount 9
dc.description.citedTotWOSCount 15
dc.description.citedWOSCount 14
dc.format.extentCount 17
dc.identifier.articleNo
dc.identifier.coden PHMBA
dc.identifier.pubmedID 23322160
dc.identifier.scopusID 84873635973
dc.identifier.url
dc.publisher.address TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
dc.relation.ispartofConference
dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr Phys. Med. Biol.
dc.relation.ispartOfIssue 4
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Physics in Medicine and Biology
dc.relation.ispartofPubTitleAbbr Phys. Med. Biol.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 58
dc.source.ID WOS:000314396800006
dc.type.publication Journal
dc.subject.otherAuthKeyword
dc.subject.otherChemCAS
dc.subject.otherIndex Attributable risks
dc.subject.otherIndex Baseline predictions
dc.subject.otherIndex Biological effects
dc.subject.otherIndex Craniospinal irradiation
dc.subject.otherIndex Medulloblastoma
dc.subject.otherIndex Monte Carlo Simulation
dc.subject.otherIndex Pediatric patients
dc.subject.otherIndex Proton therapy
dc.subject.otherIndex Radiation weighting factors
dc.subject.otherIndex Relative risks
dc.subject.otherIndex Side effect
dc.subject.otherIndex Stray radiation
dc.subject.otherIndex Treatment planning systems
dc.subject.otherIndex Treatment plans
dc.subject.otherIndex Brain
dc.subject.otherIndex Diseases
dc.subject.otherIndex Monte Carlo methods
dc.subject.otherIndex Pediatrics
dc.subject.otherIndex Photons
dc.subject.otherIndex Proton beams
dc.subject.otherIndex Protons
dc.subject.otherIndex Radiotherapy
dc.subject.otherIndex Risk assessment
dc.subject.otherIndex Risk perception
dc.subject.otherIndex Stray light
dc.subject.otherIndex Uncertainty analysis
dc.subject.otherIndex Neutron irradiation
dc.subject.otherIndex algorithm
dc.subject.otherIndex article
dc.subject.otherIndex case report
dc.subject.otherIndex central nervous system tumor
dc.subject.otherIndex comparative study
dc.subject.otherIndex computer assisted tomography
dc.subject.otherIndex craniospinal irradiation
dc.subject.otherIndex human
dc.subject.otherIndex intensity modulated radiation therapy
dc.subject.otherIndex male
dc.subject.otherIndex medulloblastoma
dc.subject.otherIndex methodology
dc.subject.otherIndex Monte Carlo method
dc.subject.otherIndex pathology
dc.subject.otherIndex preschool child
dc.subject.otherIndex proton therapy
dc.subject.otherIndex radiation induced neoplasm
dc.subject.otherIndex radiation response
dc.subject.otherIndex risk
dc.subject.otherIndex second cancer
dc.subject.otherIndex tissue distribution
dc.subject.otherIndex Algorithms
dc.subject.otherIndex Central Nervous System Neoplasms
dc.subject.otherIndex Child, Preschool
dc.subject.otherIndex Craniospinal Irradiation
dc.subject.otherIndex Dose-Response Relationship, Radiation
dc.subject.otherIndex Humans
dc.subject.otherIndex Male
dc.subject.otherIndex Medulloblastoma
dc.subject.otherIndex Monte Carlo Method
dc.subject.otherIndex Neoplasms, Radiation-Induced
dc.subject.otherIndex Neoplasms, Second Primary
dc.subject.otherIndex Proton Therapy
dc.subject.otherIndex Radiotherapy, Intensity-Modulated
dc.subject.otherIndex Risk
dc.subject.otherIndex Tissue Distribution
dc.subject.otherIndex Tomography, X-Ray Computed
dc.subject.otherKeywordPlus SECONDARY MALIGNANT NEOPLASMS
dc.subject.otherKeywordPlus RADIATION-INDUCED CANCER
dc.subject.otherKeywordPlus PRIMARY THYROID-CANCER
dc.subject.otherKeywordPlus OUT-OF-FIELD
dc.subject.otherKeywordPlus CHILDHOOD-CANCER
dc.subject.otherKeywordPlus DOSE CALCULATIONS
dc.subject.otherKeywordPlus PROSTATE-CANCER
dc.subject.otherKeywordPlus POTENTIAL ROLE
dc.subject.otherKeywordPlus IN-FIELD
dc.subject.otherKeywordPlus A-BOMB
dc.subject.otherWOS Engineering, Biomedical
dc.subject.otherWOS Radiology, Nuclear Medicine and Medical Imaging


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