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The predicted relative risk of premature ovarian failure for three radiotherapy modalities in a girl receiving craniospinal irradiation

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dc.contributor.author Perez-Andujar A.
dc.contributor.author Newhauser W.D.
dc.contributor.author Taddei P.J.
dc.contributor.author Mahajan A.
dc.contributor.author Howell R.M.
dc.contributor.editor
dc.date 2013
dc.date.accessioned 2017-10-05T16:05:54Z
dc.date.available 2017-10-05T16:05:54Z
dc.date.issued 2013
dc.identifier 10.1088/0031-9155/58/10/3107
dc.identifier.isbn
dc.identifier.issn 00319155
dc.identifier.uri http://hdl.handle.net/10938/19698
dc.description.abstract In girls and young women, irradiation of the ovaries can reduce the number of viable ovarian primordial follicles, which may lead to premature ovarian failure (POF) and subsequently to sterility. One strategy to minimize this late effect is to reduce the radiation dose to the ovaries. A primary means of reducing dose is to choose a radiotherapy technique that avoids irradiating nearby normal tissue; however, the relative risk of POF (RRPOF) due to the various therapeutic options has not been assessed. This study compared the predicted RRPOF after craniospinal proton radiotherapy, conventional photon radiotherapy (CRT) and intensity-modulated photon radiotherapy (IMRT). We calculated the equivalent dose delivered to the ovaries of an 11-year-old girl from therapeutic and stray radiation. We then predicted the percentage of ovarian primordial follicles killed by radiation and used this as a measure of the RRPOF; we also calculated the ratio of the relative risk of POF (RRRPOF) among the three radiotherapies. Proton radiotherapy had a lower RRPOF than either of the other two types. We also tested the sensitivity of the RRRPOF between photon and proton therapies to the anatomic position of the ovaries, i.e., proximity to the treatment field (2 ≤ RRRPOF ≤ 10). We found that CRT and IMRT have higher risks of POF than passive-scattering proton radiotherapy (PRT) does, regardless of uncertainties in the ovarian location. Overall, PRT represents a lower RRPOF over the two other modalities. © 2013 Institute of Physics and Engineering in Medicine.
dc.format.extent
dc.format.extent Pages: (3107-3123)
dc.language English
dc.publisher BRISTOL
dc.relation.ispartof Publication Name: Physics in Medicine and Biology; Publication Year: 2013; Volume: 58; no. 10; Pages: (3107-3123);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title The predicted relative risk of premature ovarian failure for three radiotherapy modalities in a girl receiving craniospinal irradiation
dc.type Article
dc.contributor.affiliation Pérez-Andújar, A., Department of Radiation Physics, University of Texas, MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, United States, Department of Radiation Oncology, University of California-San Francisco, 505 Parnassus Avenue, L08-D, San Francisco, CA 94143-0226, United States
dc.contributor.affiliation Newhauser, W.D., Department of Radiation Physics, University of Texas, MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, United States, Department of Physics and Astronomy, Louisiana State University, Baton Rouge, LA 70803-4001, United States
dc.contributor.affiliation Taddei, P.J., Department of Radiation Physics, University of Texas, MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, United States, Department of Radiation Oncology, American University, Beirut Medical Center, P.O.Box 11-0236, tRiad El-Solh-Beirut 1107 2020, Lebanon
dc.contributor.affiliation Mahajan, A., Department of Radiation Oncology, University of Texas, MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, United States
dc.contributor.affiliation Howell, R.M., Department of Radiation Physics, University of Texas, MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, United States
dc.contributor.authorAddress Department of Radiation Physics, University of Texas, MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, United States
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Radiation Oncology;
dc.contributor.authorDepartment Radiation Oncology
dc.contributor.authorDivision
dc.contributor.authorEmail perezandujara@radonc.ucsf.edu
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Perez-Andujar, A
dc.contributor.authorInitials Newhauser, WD
dc.contributor.authorInitials Taddei, PJ
dc.contributor.authorInitials Mahajan, A
dc.contributor.authorInitials Howell, RM
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Perez-Andujar, A (reprint author), Univ Texas MD Anderson Canc Ctr, Dept Radiat Phys, Unit 1202, 1515 Holcombe Blvd, Houston, TX 77030 USA.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedCount 2
dc.description.citedTotWOSCount 7
dc.description.citedWOSCount 7
dc.format.extentCount 17
dc.identifier.articleNo
dc.identifier.coden PHMBA
dc.identifier.pubmedID 23603657
dc.identifier.scopusID 84877609688
dc.identifier.url
dc.publisher.address TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
dc.relation.ispartofConference
dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr Phys. Med. Biol.
dc.relation.ispartOfIssue 10
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Physics in Medicine and Biology
dc.relation.ispartofPubTitleAbbr Phys. Med. Biol.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 58
dc.source.ID WOS:000318273800003
dc.type.publication Journal
dc.subject.otherAuthKeyword
dc.subject.otherChemCAS
dc.subject.otherIndex Craniospinal irradiation
dc.subject.otherIndex Equivalent dose
dc.subject.otherIndex Intensity-modulated photon radiotherapies
dc.subject.otherIndex Ovarian failures
dc.subject.otherIndex Photon radiotherapy
dc.subject.otherIndex Proton radiotherapy
dc.subject.otherIndex Proton therapy
dc.subject.otherIndex Stray radiation
dc.subject.otherIndex Irradiation
dc.subject.otherIndex Photons
dc.subject.otherIndex Physical therapy
dc.subject.otherIndex Protons
dc.subject.otherIndex Radiotherapy
dc.subject.otherIndex Tissue
dc.subject.otherIndex Chemoradiotherapy
dc.subject.otherIndex article
dc.subject.otherIndex child
dc.subject.otherIndex craniospinal irradiation
dc.subject.otherIndex female
dc.subject.otherIndex human
dc.subject.otherIndex intensity modulated radiation therapy
dc.subject.otherIndex medulloblastoma
dc.subject.otherIndex ovary
dc.subject.otherIndex premature ovarian failure
dc.subject.otherIndex proton therapy
dc.subject.otherIndex radiation dose
dc.subject.otherIndex radiation exposure
dc.subject.otherIndex risk assessment
dc.subject.otherIndex Child
dc.subject.otherIndex Craniospinal Irradiation
dc.subject.otherIndex Female
dc.subject.otherIndex Humans
dc.subject.otherIndex Medulloblastoma
dc.subject.otherIndex Ovary
dc.subject.otherIndex Primary Ovarian Insufficiency
dc.subject.otherIndex Proton Therapy
dc.subject.otherIndex Radiotherapy Dosage
dc.subject.otherIndex Radiotherapy, Intensity-Modulated
dc.subject.otherIndex Risk Assessment
dc.subject.otherKeywordPlus PASSIVELY SCATTERED PROTON
dc.subject.otherKeywordPlus MONTE-CARLO SIMULATIONS
dc.subject.otherKeywordPlus PEDIATRIC MEDULLOBLASTOMA
dc.subject.otherKeywordPlus RADIATION-THERAPY
dc.subject.otherKeywordPlus CANCER-PATIENTS
dc.subject.otherKeywordPlus 2ND CANCER
dc.subject.otherKeywordPlus FERTILITY
dc.subject.otherKeywordPlus FIELD
dc.subject.otherKeywordPlus ACCURACY
dc.subject.otherKeywordPlus PATIENT
dc.subject.otherWOS Engineering, Biomedical
dc.subject.otherWOS Radiology, Nuclear Medicine and Medical Imaging


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