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Analytical model for out-of-field dose in photon craniospinal irradiation

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dc.contributor.author Taddei P.J.
dc.contributor.author Jalbout W.
dc.contributor.author Howell R.M.
dc.contributor.author Khater N.
dc.contributor.author Geara F.
dc.contributor.author Homann K.
dc.contributor.author Newhauser W.D.
dc.contributor.editor
dc.date 2013
dc.date.accessioned 2017-10-05T16:05:54Z
dc.date.available 2017-10-05T16:05:54Z
dc.date.issued 2013
dc.identifier 10.1088/0031-9155/58/21/7463
dc.identifier.isbn
dc.identifier.issn 00319155
dc.identifier.uri http://hdl.handle.net/10938/19701
dc.description.abstract The prediction of late effects after radiotherapy in organs outside a treatment field requires accurate estimations of out-of-field dose. However, out-of-field dose is not calculated accurately by commercial treatment planning systems (TPSs). The purpose of this study was to develop and test an analytical model for out-of-field dose during craniospinal irradiation (CSI) from photon beams produced by a linear accelerator. In two separate evaluations of the model, we measured absorbed dose for a 6 MV CSI using thermoluminescent dosimeters placed throughout an anthropomorphic phantom and fit the measured data to an analytical model of absorbed dose versus distance outside of the composite field edge. These measurements were performed in two separate clinics - the University of Texas MD Anderson Cancer Center (MD Anderson) and the American University of Beirut Medical Center (AUBMC) - using the same phantom but different linear accelerators and TPSs commissioned for patient treatments. The measurement at AUBMC also included in-field locations. Measured dose values were compared to those predicted by TPSs and parameters were fit to the model in each setting. In each clinic, 95percent of the measured data were contained within a factor of 0.2 and one root mean square deviation of the model-based values. The root mean square deviations of the mathematical model were 0.91 cGy Gy -1 and 1.67 cGy Gy-1 in the MD Anderson and AUBMC clinics, respectively. The TPS predictions agreed poorly with measurements in regions of sharp dose gradient, e.g., near the field edge. At distances greater than 1 cm from the field edge, the TPS underestimated the dose by an average of 14percent ± 24percent and 44percent ± 19percent in the MD Anderson and AUBMC clinics, respectively. The in-field measured dose values of the measurement at AUBMC matched the dose values calculated by the TPS to within 2percent. Dose algorithms in TPSs systematically underestimated the actual out-of-field dose. Therefore, it is important to use an improved model based on measurements when estimating out-of-field dose. The model proposed in this study performed well for this purpose in two clinics and may be applicable in other clinics with similar treatment field configurations. © 2013 Institute of Physics and Engineering in Medicine.
dc.format.extent
dc.format.extent Pages: (7463-7479)
dc.language English
dc.publisher BRISTOL
dc.relation.ispartof Publication Name: Physics in Medicine and Biology; Publication Year: 2013; Volume: 58; no. 21; Pages: (7463-7479);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Analytical model for out-of-field dose in photon craniospinal irradiation
dc.type Article
dc.contributor.affiliation Taddei, P.J., Department of Radiation Physics, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, United States, Graduate School of Biomedical Sciences, University of Texas at Houston, Houston, TX 77030, United States, Department of Radiation Oncology, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Jalbout, W., Department of Radiation Oncology, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Howell, R.M., Department of Radiation Physics, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, United States, Graduate School of Biomedical Sciences, University of Texas at Houston, Houston, TX 77030, United States
dc.contributor.affiliation Khater, N., Department of Radiation Oncology, Hotel-Dieu de France University Hospital, Beirut, Lebanon
dc.contributor.affiliation Geara, F., Department of Radiation Oncology, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Homann, K., Department of Radiation Physics, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, United States, Graduate School of Biomedical Sciences, University of Texas at Houston, Houston, TX 77030, United States
dc.contributor.affiliation Newhauser, W.D., Medical Physics Program, Department of Physics and Astronomy, Louisiana State University, Baton Rouge, LA 70803, United States, Mary Bird Perkins Cancer Center, 4950 Essen Lane, Baton Rouge, LA 70809, United States
dc.contributor.authorAddress Department of Radiation Physics, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, United States
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Radiation Oncology;
dc.contributor.authorDepartment Radiation Oncology
dc.contributor.authorDivision
dc.contributor.authorEmail pt06@aub.edu.lb
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Taddei, PJ
dc.contributor.authorInitials Jalbout, W
dc.contributor.authorInitials Howell, RM
dc.contributor.authorInitials Khater, N
dc.contributor.authorInitials Geara, F
dc.contributor.authorInitials Homann, K
dc.contributor.authorInitials Newhauser, WD
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Taddei, PJ (reprint author), Univ Texas MD Anderson Canc Ctr, Dept Radiat Phys, Houston, TX 77030 USA.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedCount
dc.description.citedTotWOSCount 2
dc.description.citedWOSCount 2
dc.format.extentCount 17
dc.identifier.articleNo
dc.identifier.coden PHMBA
dc.identifier.pubmedID 24099782
dc.identifier.scopusID 84887081838
dc.identifier.url
dc.publisher.address TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
dc.relation.ispartofConference
dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr Phys. Med. Biol.
dc.relation.ispartOfIssue 21
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Physics in Medicine and Biology
dc.relation.ispartofPubTitleAbbr Phys. Med. Biol.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 58
dc.source.ID WOS:000326377100003
dc.type.publication Journal
dc.subject.otherAuthKeyword
dc.subject.otherChemCAS
dc.subject.otherIndex Accurate estimation
dc.subject.otherIndex Anthropomorphic phantoms
dc.subject.otherIndex Composite fields
dc.subject.otherIndex Craniospinal irradiation
dc.subject.otherIndex Root mean square deviations
dc.subject.otherIndex Thermoluminescent dosimeters
dc.subject.otherIndex Treatment planning systems
dc.subject.otherIndex University of Texas
dc.subject.otherIndex Analytical models
dc.subject.otherIndex Estimation
dc.subject.otherIndex Irradiation
dc.subject.otherIndex Light weight rolling stock
dc.subject.otherIndex Linear accelerators
dc.subject.otherIndex Phase equilibria
dc.subject.otherIndex Tensors
dc.subject.otherIndex Models
dc.subject.otherIndex article
dc.subject.otherIndex biological model
dc.subject.otherIndex craniospinal irradiation
dc.subject.otherIndex equipment
dc.subject.otherIndex human
dc.subject.otherIndex image quality
dc.subject.otherIndex magnetic and electromagnetic equipment
dc.subject.otherIndex methodology
dc.subject.otherIndex photon
dc.subject.otherIndex radiation dose
dc.subject.otherIndex Craniospinal Irradiation
dc.subject.otherIndex Humans
dc.subject.otherIndex Models, Biological
dc.subject.otherIndex Particle Accelerators
dc.subject.otherIndex Phantoms, Imaging
dc.subject.otherIndex Photons
dc.subject.otherIndex Radiation Dosage
dc.subject.otherIndex Radiotherapy Dosage
dc.subject.otherKeywordPlus MODULATED RADIATION-THERAPY
dc.subject.otherKeywordPlus TREATMENT PLANNING SYSTEM
dc.subject.otherKeywordPlus MONTE-CARLO
dc.subject.otherKeywordPlus PROTON THERAPY
dc.subject.otherKeywordPlus PEDIATRIC-PATIENT
dc.subject.otherKeywordPlus MV BEAM
dc.subject.otherKeywordPlus RADIOTHERAPY MODALITIES
dc.subject.otherKeywordPlus MEDICAL ACCELERATOR
dc.subject.otherKeywordPlus HETEROGENEOUS MEDIA
dc.subject.otherKeywordPlus CONVOLUTION METHOD
dc.subject.otherWOS Engineering, Biomedical
dc.subject.otherWOS Radiology, Nuclear Medicine and Medical Imaging


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