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A comparative study on the risks of radiogenic second cancers and cardiac mortality in a set of pediatric medulloblastoma patients treated with photon or proton craniospinal irradiation

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dc.contributor.author Zhang R.
dc.contributor.author Howell R.M.
dc.contributor.author Taddei P.J.
dc.contributor.author Giebeler A.
dc.contributor.author Mahajan A.
dc.contributor.author Newhauser W.D.
dc.contributor.editor
dc.date 2014
dc.date.accessioned 2017-10-05T16:05:55Z
dc.date.available 2017-10-05T16:05:55Z
dc.date.issued 2014
dc.identifier 10.1016/j.radonc.2014.07.003
dc.identifier.isbn
dc.identifier.issn 01678140
dc.identifier.uri http://hdl.handle.net/10938/19705
dc.description.abstract Purpose: To compare the risks of radiogenic second cancers and cardiac mortality in 17 pediatric medulloblastoma patients treated with passively scattered proton or field-in-field photon craniospinal irradiation (CSI). Material-methods: Standard of care photon or proton CSI treatment plans were created for all 17 patients in a commercial treatment planning system (TPS) (Eclipse version 8.9; Varian Medical Systems, Palo Alto, CA) and prescription dose was 23.4 or 23.4 Gy (RBE) to the age specific target volume at 1.8 Gy-fraction. The therapeutic doses from proton and photon CSI plans were estimated from TPS. Stray radiation doses were determined from Monte Carlo simulations for proton CSI and from measurements and TPS for photon CSI. The Biological Effects of Ionization Radiation VII report and a linear model based on childhood cancer survivor data were used for risk predictions of second cancer and cardiac mortality, respectively. Results: The ratios of lifetime attributable risk (RLARs) (proton-photon) ranged from 0.10 to 0.22 for second cancer incidence and ranged from 0.20 to 0.53 for second cancer mortality, respectively. The ratio of relative risk (RRR) (proton-photon) of cardiac mortality ranged from 0.12 to 0.24. The RLARs of both cancer incidence and mortality decreased with patient's age at exposure (e), while the RRRs of cardiac mortality increased with e. Girls had a significantly higher RLAR of cancer mortality than boys. Conclusion: Passively scattered proton CSI provides superior predicted outcomes by conferring lower predicted risks of second cancer and cardiac mortality than field-in-field photon CSI for all medulloblastoma patients in a large clinically representative sample in the United States, but the magnitude of superiority depends strongly on the patients' anatomical development status. © 2014 Elsevier Ireland Ltd. All rights reserved.
dc.format.extent
dc.language English
dc.publisher CLARE
dc.relation.ispartof Publication Name: Radiotherapy and Oncology; Publication Year: 2014;
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title A comparative study on the risks of radiogenic second cancers and cardiac mortality in a set of pediatric medulloblastoma patients treated with photon or proton craniospinal irradiation
dc.type Article in Press
dc.contributor.affiliation Zhang, R., The University of Texas Graduate School of Biomedical Sciences at Houston, USA, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, USA
dc.contributor.affiliation Howell, R.M., The University of Texas Graduate School of Biomedical Sciences at Houston, USA, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, USA
dc.contributor.affiliation Taddei, P.J., The University of Texas Graduate School of Biomedical Sciences at Houston, USA, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, USA, Department of Radiation Oncology, American University of Beirut Medical Center, Lebanon
dc.contributor.affiliation Giebeler, A., The University of Texas Graduate School of Biomedical Sciences at Houston, USA, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, USA, Current address is: Scripps Proton Therapy Center, San Diego, CA, USA
dc.contributor.affiliation Mahajan, A., Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
dc.contributor.affiliation Newhauser, W.D., The University of Texas Graduate School of Biomedical Sciences at Houston, USA, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, USA, Medical Physics Program, Department of Physics and Astronomy, Louisiana State University, Baton Rouge, USA
dc.contributor.authorAddress Newhauser, W.D.; The University of Texas Graduate School of Biomedical Sciences at Houston, USAemail: newhauser@lsu.edu
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Radiation Oncology;
dc.contributor.authorDepartment Radiation Oncology
dc.contributor.authorDivision
dc.contributor.authorEmail newhauser@lsu.edu
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Zhang, R
dc.contributor.authorInitials Howell, RM
dc.contributor.authorInitials Taddei, PJ
dc.contributor.authorInitials Giebeler, A
dc.contributor.authorInitials Mahajan, A
dc.contributor.authorInitials Newhauser, WD
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Newhauser, WD (reprint author), Louisiana State Univ, Dept Phys and Astron, Baton Rouge, LA 70803 USA.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.format.extentCount 1
dc.identifier.articleNo
dc.identifier.coden RAOND
dc.identifier.pubmedID
dc.identifier.scopusID 84905548980
dc.identifier.url
dc.publisher.address ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND
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dc.relation.ispartofConferenceDate
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dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr Radiother. Oncol.
dc.relation.ispartOfIssue
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Radiotherapy and Oncology
dc.relation.ispartofPubTitleAbbr Radiother. Oncol.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
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dc.source.ID WOS:000347604800014
dc.type.publication Journal
dc.subject.otherAuthKeyword Cardiac mortality
dc.subject.otherAuthKeyword Craniospinal irradiation
dc.subject.otherAuthKeyword Medulloblastoma
dc.subject.otherAuthKeyword Proton therapy
dc.subject.otherAuthKeyword Second cancer
dc.subject.otherChemCAS
dc.subject.otherIndex
dc.subject.otherKeywordPlus OUT-OF-FIELD
dc.subject.otherKeywordPlus PASSIVELY SCATTERED PROTON
dc.subject.otherKeywordPlus CHILDHOOD-CANCER
dc.subject.otherKeywordPlus HELICAL TOMOTHERAPY
dc.subject.otherKeywordPlus RADIATION-THERAPY
dc.subject.otherKeywordPlus PREDICTED RISKS
dc.subject.otherKeywordPlus ADULT SURVIVORS
dc.subject.otherKeywordPlus RADIOTHERAPY
dc.subject.otherKeywordPlus TOXICITY
dc.subject.otherKeywordPlus METHODOLOGY
dc.subject.otherWOS Oncology
dc.subject.otherWOS Radiology, Nuclear Medicine and Medical Imaging


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