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Attitudes of health care professionals toward pharmacogenetic testing

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dc.contributor.author Zgheib N.K.
dc.contributor.author Arawi T.
dc.contributor.author Mahfouz R.A.
dc.contributor.author Sabra R.
dc.contributor.editor
dc.date Apr-2011
dc.date.accessioned 2017-10-05T16:06:28Z
dc.date.available 2017-10-05T16:06:28Z
dc.date.issued 2011
dc.identifier 10.1007/BF03256401
dc.identifier.isbn
dc.identifier.issn 11771062
dc.identifier.uri http://hdl.handle.net/10938/19717
dc.description.abstract Background: Pharmacogenetics has emerged as a new tool for the optimization of drug therapy. Although the pharmacogenetics concept was first recognized at least 50 years ago, clinical testing to determine pharmacogenetic traits is still relatively rare, and many hurdles are markedly slowing its development. There is a lot of literature and speculation about potential ethical challenges in genetic and pharmacogenetic testing, yet few researchers have actually examined the attitudes of health care professionals regarding the clinical application of these tests. Objective: In this article, we aim to review the current literature on health care professionals' perceptions of the role of pharmacogenetic data and describe the attitudes of medical students when faced with a clinical pharmacogenetic testing scenario. Methods: A group of 59 third-year medical students from the American University of Beirut Medical Center were asked to answer a questionnaire about pharmacogenetic testing after being exposed to a clinical scenario of a patient who was diagnosed with mild Alzheimer Disease (AD) and hence was a candidate for therapy with one of the acetylcholinesterase (AChE) inhibitors. Results: The students indicated that they would respect patients' confidentiality and inform them about the test results and therapeutic plan, but they would not be as open about bad prognoses. They did not agree on the therapeutic plan that would follow a pharmacogenetic test result and were uncertain about potential patient discrimination in insurability. Conclusion: Our and others' findings demonstrate the existence and seriousness of several challenges pertaining to pharmacogenetic applications in the clinical setting. Further training and education are needed for health care professionals, since they are the ones who will most probably request these tests in the near future. © 2011 Adis Data Information BV. All rights reserved.
dc.format.extent
dc.format.extent Pages: (115-122)
dc.language English
dc.relation.ispartof Publication Name: Molecular Diagnosis and Therapy; Publication Year: 2011; Volume: 15; no. 2; Pages: (115-122);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Attitudes of health care professionals toward pharmacogenetic testing
dc.type Article
dc.contributor.affiliation Zgheib, N.K., Department of Pharmacology and Toxicology, Faculty of Medicine, American University of Beirut, PO Box 11-0236, Riad El Solh, Beirut 1107 2020, Lebanon
dc.contributor.affiliation Arawi, T., Salim-El Hoss Bioethics and Professionalism Program, Faculty of Medicine, American University of Beirut, Beirut, Lebanon
dc.contributor.affiliation Mahfouz, R.A., Department of Pathology and Laboratory Medicine, Faculty of Medicine, American University of Beirut, Beirut, Lebanon
dc.contributor.affiliation Sabra, R., Department of Pharmacology and Toxicology, Faculty of Medicine, American University of Beirut, PO Box 11-0236, Riad El Solh, Beirut 1107 2020, Lebanon
dc.contributor.authorAddress Sabra, R.; Department of Pharmacology and Toxicology, Faculty of Medicine, American University of Beirut, PO Box 11-0236, Riad El Solh, Beirut 1107 2020, Lebanon; email: rsabra@aub.edu.lb
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Salim El-Hoss Bioethics and Professionalism Program;
dc.contributor.authorDepartment Salim El-Hoss Bioethics and Professionalism Program
dc.contributor.authorDivision
dc.contributor.authorEmail
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials empty
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
dc.description.cited
dc.description.citedCount 5
dc.description.citedTotWOSCount
dc.description.citedWOSCount
dc.format.extentCount 8
dc.identifier.articleNo
dc.identifier.coden
dc.identifier.pubmedID 21623646
dc.identifier.scopusID 79957802841
dc.identifier.url
dc.publisher.address
dc.relation.ispartofConference
dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr
dc.relation.ispartOfIssue 2
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Molecular Diagnosis and Therapy
dc.relation.ispartofPubTitleAbbr Mol. Diagn. Ther.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 15
dc.source.ID
dc.type.publication Journal
dc.subject.otherAuthKeyword Diagnostic-tests
dc.subject.otherAuthKeyword Ethics
dc.subject.otherAuthKeyword Medical-education
dc.subject.otherAuthKeyword Pharmacogenetics
dc.subject.otherChemCAS tacrine, 1684-40-8, 3198-41-2, 321-64-2
dc.subject.otherIndex apolipoprotein E
dc.subject.otherIndex cholinesterase inhibitor
dc.subject.otherIndex tacrine
dc.subject.otherIndex Alzheimer disease
dc.subject.otherIndex article
dc.subject.otherIndex genetic association
dc.subject.otherIndex genetic screening
dc.subject.otherIndex health insurance
dc.subject.otherIndex health personnel attitude
dc.subject.otherIndex homozygosity
dc.subject.otherIndex human
dc.subject.otherIndex medical student
dc.subject.otherIndex outcome assessment
dc.subject.otherIndex pharmacogenetics
dc.subject.otherIndex priority journal
dc.subject.otherIndex professional secrecy
dc.subject.otherIndex questionnaire
dc.subject.otherIndex university hospital
dc.subject.otherIndex Confidentiality
dc.subject.otherIndex Health Knowledge, Attitudes, Practice
dc.subject.otherIndex Health Personnel
dc.subject.otherIndex Humans
dc.subject.otherIndex Informed Consent
dc.subject.otherIndex Pharmacogenetics
dc.subject.otherIndex Questionnaires
dc.subject.otherIndex Students, Medical
dc.subject.otherKeywordPlus
dc.subject.otherWOS


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