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Nonsurgical management of hypertrophic scars: Evidence-based therapies, standard practices, and emerging methods

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dc.contributor.author Atiyeh B.S.
dc.contributor.editor
dc.date Oct-2007
dc.date.accessioned 2017-10-05T16:07:22Z
dc.date.available 2017-10-05T16:07:22Z
dc.date.issued 2007
dc.identifier 10.1007/s00266-006-0253-y
dc.identifier.isbn
dc.identifier.issn
dc.identifier.uri http://hdl.handle.net/10938/19751
dc.description.abstract Hypertrophic scars, resulting from alterations in the normal processes of cutaneous wound healing, are characterized by proliferation of dermal tissue with excessive deposition of fibroblast-derived extracellular matrix proteins, especially collagen, over long periods, and by persistent inflammation and fibrosis. Hypertrophic scars are among the most common and frustrating problems after injury. As current aesthetic surgical techniques become more standardized and results more predictable, a fine scar may be the demarcating line between acceptable and unacceptable aesthetic results. However, hypertrophic scars remain notoriously difficult to eradicate because of the high recurrence rates and the incidence of side effects associated with available treatment methods. This review explores the various treatment methods for hypertrophic scarring described in the literature including evidence-based therapies, standard practices, and emerging methods, attempting to distinguish those with clearly proven efficiency from anecdotal reports about therapies of doubtful benefits while trying to differentiate between prophylactic measures and actual treatment methods. Unfortunately, the distinction between hypertrophic scar treatments and keloid treatments is not obvious in most reports, making it difficult to assess the efficacy of hypertrophic scar treatment. © 2007 Springer Science+Business Media, LLC.
dc.format.extent
dc.format.extent Pages: (468-492)
dc.language English
dc.publisher NEW YORK
dc.relation.ispartof Publication Name: Aesthetic Plastic Surgery; Publication Year: 2007; Volume: 31; no. 5; Pages: (468-492);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Nonsurgical management of hypertrophic scars: Evidence-based therapies, standard practices, and emerging methods
dc.type Review
dc.contributor.affiliation Atiyeh, B.S., Division Plastic and Reconstructive Surgery, American University, Beirut Medical Center, Beirut, Lebanon
dc.contributor.authorAddress Atiyeh, B.S.; Division Plastic and Reconstructive Surgery, American University, Beirut Medical Center, Beirut, Lebanon; email: aata@terra.net.lb
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Surgery; Division: Plastic Surgery;
dc.contributor.authorDepartment Surgery
dc.contributor.authorDivision Plastic Surgery
dc.contributor.authorEmail aata@terra.net.lb
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Atiyeh, BS
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Atiyeh, BS (reprint author), Amer Univ Beirut, Med Ctr, Div Plast and Reconstruct Surg, Beirut, Lebanon.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.identifier.coden APSUD
dc.identifier.pubmedID 17576505
dc.identifier.scopusID 34548725086
dc.identifier.url
dc.publisher.address 233 SPRING STREET, NEW YORK, NY 10013 USA
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dc.relation.ispartOfISOAbbr Aesthet. Plast. Surg.
dc.relation.ispartOfIssue 5
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Aesthetic Plastic Surgery
dc.relation.ispartofPubTitleAbbr Aesthet. Plast. Surg.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 31
dc.source.ID WOS:000249575200011
dc.type.publication Journal
dc.subject.otherAuthKeyword Hypertrophic scar
dc.subject.otherAuthKeyword Keloid
dc.subject.otherAuthKeyword Scar management
dc.subject.otherChemCAS alpha tocopherol, 1406-18-4, 1406-70-8, 52225-20-4, 58-95-7, 59-02-9
dc.subject.otherChemCAS alpha2b interferon, 99210-65-8
dc.subject.otherChemCAS asiaticoside, 16830-15-2
dc.subject.otherChemCAS betamethasone, 378-44-9
dc.subject.otherChemCAS bleomycin, 11056-06-7
dc.subject.otherChemCAS collagenase, 37288-86-1, 39433-96-0
dc.subject.otherChemCAS curcumin, 458-37-7
dc.subject.otherChemCAS cyclosporin, 79217-60-0
dc.subject.otherChemCAS epicatechin gallate, 863-03-6
dc.subject.otherChemCAS fluorouracil, 51-21-8
dc.subject.otherChemCAS hyaluronic acid, 31799-91-4, 9004-61-9, 9067-32-7
dc.subject.otherChemCAS lidocaine, 137-58-6, 24847-67-4, 56934-02-2, 73-78-9
dc.subject.otherChemCAS mitomycin C, 50-07-7, 74349-48-7
dc.subject.otherChemCAS pentoxifylline, 6493-05-6
dc.subject.otherChemCAS putrescine, 110-60-1, 333-93-7
dc.subject.otherChemCAS quercetin, 117-39-5
dc.subject.otherChemCAS retinol, 68-26-8, 82445-97-4
dc.subject.otherChemCAS scatter factor, 67256-21-7, 72980-71-3
dc.subject.otherChemCAS tocoretinate, 40516-48-1
dc.subject.otherChemCAS triamcinolone, 124-94-7
dc.subject.otherChemCAS triamcinolone acetonide, 76-25-5
dc.subject.otherChemCAS verapamil, 152-11-4, 52-53-9
dc.subject.otherChemCAS xipamide, 14293-44-8
dc.subject.otherChemCAS Anti-Infective Agents
dc.subject.otherChemCAS Glucocorticoids
dc.subject.otherChemCAS Silicone Gels
dc.subject.otherChemCAS Vitamin E, 1406-18-4
dc.subject.otherIndex alpha tocopherol
dc.subject.otherIndex alpha2b interferon
dc.subject.otherIndex asiaticoside
dc.subject.otherIndex betamethasone
dc.subject.otherIndex bleomycin
dc.subject.otherIndex butea monosperma extract
dc.subject.otherIndex collagenase
dc.subject.otherIndex contractubex
dc.subject.otherIndex corticosteroid
dc.subject.otherIndex curcumin
dc.subject.otherIndex cyclosporin
dc.subject.otherIndex epicatechin gallate
dc.subject.otherIndex fluorouracil
dc.subject.otherIndex hyaluronic acid
dc.subject.otherIndex lidocaine
dc.subject.otherIndex mitomycin C
dc.subject.otherIndex moist exposed burn ointment
dc.subject.otherIndex pentoxifylline
dc.subject.otherIndex plant extract
dc.subject.otherIndex putrescine
dc.subject.otherIndex quercetin
dc.subject.otherIndex retinol
dc.subject.otherIndex scatter factor
dc.subject.otherIndex steroid
dc.subject.otherIndex tocoretinate
dc.subject.otherIndex triamcinolone
dc.subject.otherIndex triamcinolone acetonide
dc.subject.otherIndex unclassified drug
dc.subject.otherIndex unindexed drug
dc.subject.otherIndex verapamil
dc.subject.otherIndex xipamide
dc.subject.otherIndex adjuvant therapy
dc.subject.otherIndex alopecia
dc.subject.otherIndex antineoplastic activity
dc.subject.otherIndex antioxidant activity
dc.subject.otherIndex atrophy
dc.subject.otherIndex basal cell carcinoma
dc.subject.otherIndex cancer
dc.subject.otherIndex carbon dioxide laser
dc.subject.otherIndex clinical practice
dc.subject.otherIndex clinical trial
dc.subject.otherIndex combination chemotherapy
dc.subject.otherIndex compression therapy
dc.subject.otherIndex corticosteroid therapy
dc.subject.otherIndex cryotherapy
dc.subject.otherIndex dermographism
dc.subject.otherIndex diet supplementation
dc.subject.otherIndex disease association
dc.subject.otherIndex dose response
dc.subject.otherIndex drug effect
dc.subject.otherIndex drug efficacy
dc.subject.otherIndex drug mechanism
dc.subject.otherIndex drug treatment failure
dc.subject.otherIndex drug withdrawal
dc.subject.otherIndex edema
dc.subject.otherIndex elasticity
dc.subject.otherIndex electron therapy
dc.subject.otherIndex erythema
dc.subject.otherIndex evidence based practice
dc.subject.otherIndex fibrosis
dc.subject.otherIndex gangrene
dc.subject.otherIndex gel
dc.subject.otherIndex gene therapy
dc.subject.otherIndex hemangioma
dc.subject.otherIndex hidradenitis
dc.subject.otherIndex human
dc.subject.otherIndex hyperpigmentation
dc.subject.otherIndex hypertrophic scar
dc.subject.otherIndex hypopigmentation
dc.subject.otherIndex injection pain
dc.subject.otherIndex injection site blistering
dc.subject.otherIndex injection site ecchymosis
dc.subject.otherIndex injection site pain
dc.subject.otherIndex injection site reaction
dc.subject.otherIndex injection site swelling
dc.subject.otherIndex injection site ulceration
dc.subject.otherIndex keloid
dc.subject.otherIndex keratoacanthoma
dc.subject.otherIndex low level laser therapy
dc.subject.otherIndex lung fibrosis
dc.subject.otherIndex massage
dc.subject.otherIndex monotherapy
dc.subject.otherIndex nail disease
dc.subject.otherIndex onion
dc.subject.otherIndex priority journal
dc.subject.otherIndex prophylaxis
dc.subject.otherIndex pulsed dye laser
dc.subject.otherIndex radioisotope therapy
dc.subject.otherIndex Raynaud phenomenon
dc.subject.otherIndex rebound
dc.subject.otherIndex review
dc.subject.otherIndex scleroderma
dc.subject.otherIndex side effect
dc.subject.otherIndex skin atrophy
dc.subject.otherIndex skin care
dc.subject.otherIndex skin toxicity
dc.subject.otherIndex subcutaneous fat atrophy
dc.subject.otherIndex surgical technique
dc.subject.otherIndex systemic mastocytosis
dc.subject.otherIndex telangiectasia
dc.subject.otherIndex therapy effect
dc.subject.otherIndex treatment contraindication
dc.subject.otherIndex treatment planning
dc.subject.otherIndex verruca vulgaris
dc.subject.otherIndex Anti-Infective Agents
dc.subject.otherIndex Cicatrix, Hypertrophic
dc.subject.otherIndex Combined Modality Therapy
dc.subject.otherIndex Cryotherapy
dc.subject.otherIndex Evidence-Based Medicine
dc.subject.otherIndex Glucocorticoids
dc.subject.otherIndex Humans
dc.subject.otherIndex Laser Therapy
dc.subject.otherIndex Massage
dc.subject.otherIndex Practice Guidelines as Topic
dc.subject.otherIndex Silicone Gels
dc.subject.otherIndex Vitamin E
dc.subject.otherKeywordPlus PULSED-DYE-LASER
dc.subject.otherKeywordPlus CARBON-DIOXIDE LASER
dc.subject.otherKeywordPlus INTERNATIONAL CLINICAL RECOMMENDATIONS
dc.subject.otherKeywordPlus VITRO MECHANICAL COMPRESSION
dc.subject.otherKeywordPlus NONSILICONE GEL DRESSINGS
dc.subject.otherKeywordPlus GROWTH-FACTOR-BETA
dc.subject.otherKeywordPlus RABBIT EAR MODEL
dc.subject.otherKeywordPlus QUALITY-OF-LIFE
dc.subject.otherKeywordPlus SILICONE GEL
dc.subject.otherKeywordPlus PRESSURE GARMENTS
dc.subject.otherWOS Surgery


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