AUB ScholarWorks

Metabolic implications of severe burn injuries and their management: A systematic review of the literature

Show simple item record Atiyeh B.S. Gunn S.W.A. Dibo S.A.
dc.contributor.editor Aug-2008 2017-10-05T16:07:24Z 2017-10-05T16:07:24Z 2008
dc.identifier 10.1007/s00268-008-9587-8
dc.identifier.issn 03642313
dc.description.abstract Background: Severe burn patients are some of the most challenging critically ill patients, with an extreme state of physiologic stress and an overwhelming systemic metabolic response. A major component of severe burn injury is a hypermetabolic state associated with protein losses and a significant reduction of lean body mass. The second prominent component is hyperglycemia. Reversal of the hypermetabolic response by manipulating the patient's physiologic and biochemical environment through the administration of specific nutrients, growth factors, or other agents, often in pharmacologic doses, is emerging as an essential component of the state of the art in severe burn management. The present review aims at summarizing the new treatment modalities established to reduce the catabolic burden of severe burn injuries, for which there is some evidence-based support. Methods: A systematic review of the literature was conducted. Search tools included Elsevier ScienceDirect,, Medline (OVID), MedlinePlus, and PubMed. Topics searched were Nutrition and Burns, Metabolic Response and Burns, Hypermetabolism and Burns, Hyperglycemia and Burns, and several more specific topics when indicated. With a focus on the most recently published articles, abstracts were reviewed and, when found relevant, were included as references. Full text articles, whenever available, were retrieved. Results: Many issues remain unanswered. Unfortunately, the present state of our knowledge does not allow the formulation of clear-cut guidelines. Only general trends can be outlined, and these will certainly have some practical applications but above all will dictate future research in the field. © 2008 Société Internationale de Chirurgie.
dc.format.extent Pages: (1857-1869)
dc.language English
dc.publisher NEW YORK
dc.relation.ispartof Publication Name: World Journal of Surgery; Publication Year: 2008; Volume: 32; no. 8; Pages: (1857-1869);
dc.source Scopus
dc.title Metabolic implications of severe burn injuries and their management: A systematic review of the literature
dc.type Review
dc.contributor.affiliation Atiyeh, B.S., Division Plastic and Reconstructive Surgery, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Gunn, S.W.A., WHO Collaborating Center on Burns and Fire Disasters, 1279 La Panetiere, Bogis-Bossey, Switzerland
dc.contributor.affiliation Dibo, S.A., Department of Surgery, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.authorAddress Atiyeh, B. S.; Division Plastic and Reconstructive Surgery, American University of Beirut Medical Center, Beirut, Lebanon; email:
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Surgery;
dc.contributor.authorDepartment Surgery
dc.contributor.faculty Faculty of Medicine
dc.contributor.authorInitials Atiyeh, BS
dc.contributor.authorInitials Gunn, SWA
dc.contributor.authorInitials Dibo, SA
dc.contributor.authorReprintAddress Atiyeh, BS (reprint author), Amer Univ Beirut, Med Ctr, Div Plast and Reconstruct Surg, Beirut, Lebanon.
dc.contributor.authorUniversity American University of Beirut Medical Center
dc.description.cited Aarsland A, 1996, ANN SURG, V223, P787; Aarsland A, 1996, ANN SURG, V223, P777, DOI 10.1097-00000658-199606000-00016; Arbabi S, 2004, J TRAUMA, V56, P265, DOI 10.1097-01.TA.0000109859.91202.C8; Simon RJ, 2004, J TRAUMA, V56, P269; ARNOLD L, 2000, J AM COLL SURGEONS, V190, P104; Arturson M G, 1978, World J Surg, V2, P203; Atiyeh BS, 2005, WORLD J SURG, V29, P131, DOI 10.1007-s00268-004-1082-2; Atiyeh BS, 2005, BURNS, V31, P944, DOI 10.1016-j.burns.2005.08.023; BECKER RA, 1982, CRIT CARE MED, V10, P870, DOI 10.1097-00003246-198212000-00014; Berger MM, 2007, CURR OPIN CRIT CARE, V13, P180, DOI 10.1097-MCC.0b013e3280895d47; BESSEY PQ, 1984, ANN SURG, V200, P264, DOI 10.1097-00000658-198409000-00004; Bobek S, 1996, J VET MED A, V43, P521; CALDWELL T, 1991, J BURN CARE REHABIL, V12, P385; CAMPBELL T, 1999, EUR J CLIN NUTR, V53, P143; Carlson GL, 2003, BRIT J SURG, V90, P259, DOI 10.1002-bjs.4081; Carter EA, 1996, METABOLISM, V45, P1161, DOI 10.1016-S0026-0495(96)90017-7; Chen XL, 2007, BURNS, V33, P480, DOI 10.1016-j.burns.2006.08.017; Cochran A, 2008, J BURN CARE RES, V29, P187, DOI 10.1097-BCR.0b013e318160d066; Cree MG, 2007, CRIT CARE MED, V35, pS476, DOI 10.1097-01.CCM.0000278066.05354.53; Dancey DR, 1999, INTENS CARE MED, V25, P1231, DOI 10.1007-PL00003763; Dandona P, 2001, J CLIN ENDOCR METAB, V86, P3257, DOI 10.1210-jc.86.7.3257; Davis KA, 2004, J TRAUMA, V56, P272, DOI 10.1097-01.TA.0000108995.64133.90; Dolecek R, 1985, J Burn Care Rehabil, V6, P281, DOI 10.1097-00004630-198505000-00016; DOMINIONI L, 1984, J BURN CARE REHABIL, V5, P106, DOI 10.1097-00004630-198403000-00004; DOMINIONI L, 1985, JPEN-PARENTER ENTER, V9, P269, DOI 10.1177-0148607185009003269; Garrel D, 2003, CRIT CARE MED, V31, P2444, DOI 10.1097-01.CCM.0000084848.63691.1E; Geerlings SE, 1999, FEMS IMMUNOL MED MIC, V26, P259, DOI 10.1111-j.1574-695X.1999.tb01397.x; Gore DC, 2003, J TRAUMA, V54, P555, DOI 10.1097-01.TA.0000026990.32856.58; Gore DC, 2001, J TRAUMA, V51, P540, DOI 10.1097-00005373-200109000-00021; Gore DC, 2002, CRIT CARE MED, V30, P2438, DOI 10.1097-01.CCM.0000034728.52842.EB; Gore DC, 2005, ANN SURG, V241, P334, DOI 10.1097-01.sla.0000152013.23032.dl; Gore DC, 2005, J TRAUMA, V59, P316, DOI 10.1097-01.ta.0000180387.34057.5a; Gore DC, 2002, JPEN-PARENTER ENTER, V26, P271, DOI 10.1177-0148607102026005271; Hansbrough JF, 1996, J SURG RES, V61, P17, DOI 10.1006-jsre.1996.0074; Hart DW, 2000, SURGERY, V128, P312, DOI 10.1067-msy.2000.108059; Hasselgren PO, 1999, J AM COLL SURGEONS, V188, P98, DOI 10.1016-S1072-7515(98)00297-X; Hayashi N, 1999, NUTRITION, V15, P135, DOI 10.1016-S0899-9007(98)00168-3; Herndon DN, 2004, LANCET, V363, P1895, DOI 10.1016-S0140-6736(04)16360-5; Heyland D, 2005, INTENS CARE MED, V31, P501, DOI 10.1007-s00134-005-2590-8; Hill AG, 1998, BRIT J SURG, V85, P884; Holm C, 2004, RESUSCITATION, V60, P71, DOI 10.1016-S0300-9572(03)00285-5; Ikezu T, 1997, J BIOL CHEM, V272, P25289, DOI 10.1074-jbc.272.40.25289; Ipaktchi K, 2006, CRIT CARE MED, V34, pS239, DOI 10.1097-01.CCM.0000232625.63460.D4; Jacobs DG, 2004, J TRAUMA, V57, P660, DOI 10.1097-01.TA.0000135348.48525.A0; JAHOOR F, 1988, METABOLISM, V37, P330, DOI 10.1016-0026-0495(88)90132-1; JAHOOR F, 1989, AM J PHYSIOL, V257, pE323; Jenkins Marilyn E., 1994, Journal of Burn Care and Rehabilitation, V15, P199, DOI 10.1097-00004630-199403000-00019; Jeschke MG, 2004, ANN SURG, V239, P553, DOI; JOSHI W, 1970, JAMA-J AM MED ASSOC, V211, P2130; Kahn BB, 2000, J CLIN INVEST, V106, P473, DOI 10.1172-JCI10842; Kieft H, 2005, INTENS CARE MED, V31, P524, DOI 10.1007-s00134-005-2564-x; KIMBALL R, 1997, AM J PHYSIOL, V272, pC754; Levy J, 2002, CURR OPIN GASTROEN, V18, P717, DOI 10.1097-00001574-200211000-00014; LINARES HA, 1982, BURNS, V8, P263, DOI 10.1016-0305-4179(82)90007-9; Long C, 1979, J Trauma, V19, P904; Mabuchi N, 2000, J CARDIOVASC PHARM, V36, pS87, DOI 10.1097-00005344-200000006-00019; Mangano DT, 1996, NEW ENGL J MED, V335, P1713, DOI 10.1056-NEJM199612053352301; Matthaei S, 2000, ENDOCR REV, V21, P585, DOI 10.1210-er.21.6.585; MCARDLE AH, 1984, ANN PLAS SURG, V13, P396, DOI 10.1097-00000637-198411000-00007; McCowen KC, 2000, CRIT CARE MED, V28, P3606, DOI 10.1097-00003246-200011000-00007; MOORE FA, 1992, ANN SURG, V216, P172, DOI 10.1097-00000658-199208000-00008; MOORE FD, 1953, ANN SURG, V137, P289, DOI 10.1097-00000658-195303000-00001; Morio B, 2002, ANN SURG, V236, P218, DOI 10.1097-01.SLA.0000021593.14142.36; Mowlavi A, 2000, ANN PLAS SURG, V45, P629, DOI 10.1097-00000637-200045060-00010; Murphy KD, 2003, EXPERT OPIN PHARMACO, V4, P369, DOI 10.1517-14656566.4.3.369; Neu J, 2002, CLIN PERINATOL, V29, P41, DOI 10.1016-S0095-5108(03)00064-2; NGUYEN TT, 1996, ANN SURG, V1, P14; Noordenbos J, 2000, J TRAUMA, V49, P667, DOI 10.1097-00005373-200010000-00014; Peck MD, 2004, J TRAUMA, V57, P1143, DOI 10.1097-01.TA.0000145826.84657.38; Pereira CT, 2005, J BURN CARE REHABIL, V26, P194, DOI 10.1097-01.BCR.0000162369.84374.18; Pereira Clifford T, 2005, Adv Surg, V39, P245, DOI 10.1016-j.yasu.2005.05.005; Pham TN, 2005, J TRAUMA, V59, P1148, DOI 10.1097-01.ta.0000188933.16637.68; Piccolo MTS, 1999, INFLAMMATION, V23, P371; PIDCOKE F, 2007, CRIT CARE MED, V35, pS524; PIDCOKE H, 2007, CRIT CARE MED, V3, pS524; PIDCOKE H, 2007, AM J SURG, V1945, P798; Prass K, 2003, J EXP MED, V198, P725, DOI 10.1084-jem.20021098; Przkora R, 2007, SHOCK, V27, P205, DOI 10.1097-01.shk.0000238069.84826.1b; Purdue GF, 2007, J BURN CARE RES, V28, P1, DOI 10.1097-BCR.0B013E31802C8995; Rassias AJ, 1999, ANESTH ANALG, V88, P1011, DOI 10.1097-00000539-199905000-00008; REISS W, 1956, J CLIN INVEST, V35, P62; Rodriguez Donna J., 1996, Journal of Burn Care and Rehabilitation, V17, P62, DOI 10.1097-00004630-199601000-00013; Rui LY, 2001, J CLIN INVEST, V107, P181, DOI 10.1172-JCI10934; SAFFLE JR, 1990, J TRAUMA, V30, P776, DOI 10.1097-00005373-199007000-00003; Sasaki J, 2003, AM J PHYSIOL-LUNG C, V284, P270; Schwacha MG, 2002, INT J MOL MED, V10, P239; SHAMOON H, 1981, J CLIN ENDOCR METAB, V52, P1235; SHANGRAW RE, 1989, METABOLISM, V38, P983, DOI 10.1016-0026-0495(89)90010-3; Sheridan R L, 1994, J Intensive Care Med, V9, P6; Sheridan RL, 2004, J AM COLL SURGEONS, V198, P243, DOI 10.1016-j.jamcollsurg.2003.11.007; Spies M, 2002, CRIT CARE MED, V30, P83, DOI 10.1097-00003246-200201000-00013; Thomas SJ, 2002, SURGERY, V132, P341, DOI 10.1067-msy.2002.126871; Van den Berghe G, 2001, NEW ENGL J MED, V345, P1359, DOI 10.1056-NEJMoa011300; Vaughan G M, 1985, J Burn Care Rehabil, V6, P275, DOI 10.1097-00004630-198505000-00015; Wallace A, 1998, ANESTHESIOLOGY, V88, P7, DOI 10.1097-00000542-199801000-00005; Wanek S, 2007, CURR OPIN CLIN NUTR, V10, P272, DOI 10.1097-MCO.0b013e3280f31b17; WILMORE DW, 1978, SURG CLIN N AM, V58, P1173; WILMORE DW, 1974, ANN SURG, V180, P653, DOI 10.1097-00000658-197410000-00031; WILMORE DW, 1971, SURG GYNECOL OBSTETR, V132, P881; Wischmeyer PE, 2001, CRIT CARE MED, V29, P2075, DOI 10.1097-00003246-200111000-00006; Wolfe RR, 2000, SURGERY, V232, P455; Wu XW, 2004, SURGERY, V135, P196, DOI 10.1016-j.surg.2003.08.018; Yu YM, 1999, JPEN-PARENTER ENTER, V23, P160, DOI 10.1177-0148607199023003160; Zhang Q, 2005, LIFE SCI, V77, P3068, DOI 10.1016-j.lfs.2005.02.034; ZHOU Y, 1999, CHUNG HUA I HSUEH TS, V79, P825; Zhou YP, 2003, JPEN-PARENTER ENTER, V27, P241, DOI 10.1177-0148607103027004241; Zick Y, 2001, TRENDS CELL BIOL, V11, P437, DOI 10.1016-S0962-8924(01)81297-6
dc.description.citedCount 24
dc.description.citedTotWOSCount 16
dc.description.citedWOSCount 13
dc.format.extentCount 13
dc.identifier.coden WJSUD
dc.identifier.pubmedID 18454355
dc.identifier.scopusID 48549106329
dc.publisher.address 233 SPRING ST, NEW YORK, NY 10013 USA
dc.relation.ispartOfISOAbbr World J.Surg.
dc.relation.ispartOfIssue 8
dc.relation.ispartofPubTitle World Journal of Surgery
dc.relation.ispartofPubTitleAbbr World J. Surg.
dc.relation.ispartOfVolume 32
dc.source.ID WOS:000258093900043
dc.type.publication Journal
dc.subject.otherChemCAS alpha 2 macroglobulin, 95568-41-5
dc.subject.otherChemCAS arginine, 1119-34-2, 15595-35-4, 7004-12-8, 74-79-3
dc.subject.otherChemCAS C reactive protein, 9007-41-4
dc.subject.otherChemCAS docosahexaenoic acid, 25167-62-8, 32839-18-2
dc.subject.otherChemCAS glutamine, 56-85-9, 6899-04-3
dc.subject.otherChemCAS growth hormone, 36992-73-1, 37267-05-3, 66419-50-9, 9002-72-6
dc.subject.otherChemCAS insulin, 9004-10-8
dc.subject.otherChemCAS metoprolol, 37350-58-6
dc.subject.otherChemCAS propranolol, 13013-17-7, 318-98-9, 3506-09-0, 4199-09-1, 525-66-6
dc.subject.otherChemCAS somatomedin C, 67763-96-6
dc.subject.otherChemCAS Proteins
dc.subject.otherIndex alpha 2 macroglobulin
dc.subject.otherIndex arginine
dc.subject.otherIndex beta adrenergic receptor blocking agent
dc.subject.otherIndex C reactive protein
dc.subject.otherIndex CCAAT enhancer binding protein delta
dc.subject.otherIndex chemokine
dc.subject.otherIndex cytokine
dc.subject.otherIndex docosahexaenoic acid
dc.subject.otherIndex glutamine
dc.subject.otherIndex granulocyte colony stimulating factor
dc.subject.otherIndex growth factor
dc.subject.otherIndex growth hormone
dc.subject.otherIndex insulin
dc.subject.otherIndex interleukin 10
dc.subject.otherIndex interleukin 1beta
dc.subject.otherIndex interleukin 6
dc.subject.otherIndex metoprolol
dc.subject.otherIndex omega 3 fatty acid
dc.subject.otherIndex polyunsaturated fatty acid
dc.subject.otherIndex propranolol
dc.subject.otherIndex somatomedin C
dc.subject.otherIndex STAT5 protein
dc.subject.otherIndex tumor necrosis factor
dc.subject.otherIndex burn
dc.subject.otherIndex burn patient
dc.subject.otherIndex carbohydrate intake
dc.subject.otherIndex continuous infusion
dc.subject.otherIndex critical illness
dc.subject.otherIndex drug megadose
dc.subject.otherIndex evidence based medicine
dc.subject.otherIndex human
dc.subject.otherIndex hyperglycemia
dc.subject.otherIndex hypermetabolism
dc.subject.otherIndex injury severity
dc.subject.otherIndex insulin treatment
dc.subject.otherIndex lean body weight
dc.subject.otherIndex low calory diet
dc.subject.otherIndex metabolic disorder
dc.subject.otherIndex nutrient
dc.subject.otherIndex nutritional support
dc.subject.otherIndex physiological stress
dc.subject.otherIndex protein depletion
dc.subject.otherIndex review
dc.subject.otherIndex systematic review
dc.subject.otherIndex Burns
dc.subject.otherIndex Digestive System
dc.subject.otherIndex Humans
dc.subject.otherIndex Hyperglycemia
dc.subject.otherIndex Inflammation
dc.subject.otherIndex Nutritional Physiological Phenomena
dc.subject.otherIndex Nutritional Support
dc.subject.otherIndex Proteins
dc.subject.otherKeywordPlus INDUCED INSULIN-RESISTANCE
dc.subject.otherKeywordPlus RANDOMIZED CLINICAL-TRIAL
dc.subject.otherKeywordPlus BETA-BLOCKER USE
dc.subject.otherKeywordPlus THERMAL-INJURY
dc.subject.otherKeywordPlus NEUTROPHIL ACTIVATION
dc.subject.otherKeywordPlus NUTRITIONAL SUPPORT
dc.subject.otherKeywordPlus PROTEIN CATABOLISM
dc.subject.otherKeywordPlus MUSCLE CATABOLISM
dc.subject.otherKeywordPlus ENTERAL GLUTAMINE
dc.subject.otherKeywordPlus IMPROVED OUTCOMES
dc.subject.otherWOS Surgery

Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search AUB ScholarWorks


My Account