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Metabolic implications of severe burn injuries and their management: A systematic review of the literature

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dc.contributor.author Atiyeh B.S.
dc.contributor.author Gunn S.W.A.
dc.contributor.author Dibo S.A.
dc.contributor.editor
dc.date Aug-2008
dc.date.accessioned 2017-10-05T16:07:24Z
dc.date.available 2017-10-05T16:07:24Z
dc.date.issued 2008
dc.identifier 10.1007/s00268-008-9587-8
dc.identifier.isbn
dc.identifier.issn 03642313
dc.identifier.uri http://hdl.handle.net/10938/19782
dc.description.abstract Background: Severe burn patients are some of the most challenging critically ill patients, with an extreme state of physiologic stress and an overwhelming systemic metabolic response. A major component of severe burn injury is a hypermetabolic state associated with protein losses and a significant reduction of lean body mass. The second prominent component is hyperglycemia. Reversal of the hypermetabolic response by manipulating the patient's physiologic and biochemical environment through the administration of specific nutrients, growth factors, or other agents, often in pharmacologic doses, is emerging as an essential component of the state of the art in severe burn management. The present review aims at summarizing the new treatment modalities established to reduce the catabolic burden of severe burn injuries, for which there is some evidence-based support. Methods: A systematic review of the literature was conducted. Search tools included Elsevier ScienceDirect, EMBASE.com, Medline (OVID), MedlinePlus, and PubMed. Topics searched were Nutrition and Burns, Metabolic Response and Burns, Hypermetabolism and Burns, Hyperglycemia and Burns, and several more specific topics when indicated. With a focus on the most recently published articles, abstracts were reviewed and, when found relevant, were included as references. Full text articles, whenever available, were retrieved. Results: Many issues remain unanswered. Unfortunately, the present state of our knowledge does not allow the formulation of clear-cut guidelines. Only general trends can be outlined, and these will certainly have some practical applications but above all will dictate future research in the field. © 2008 Société Internationale de Chirurgie.
dc.format.extent
dc.format.extent Pages: (1857-1869)
dc.language English
dc.publisher NEW YORK
dc.relation.ispartof Publication Name: World Journal of Surgery; Publication Year: 2008; Volume: 32; no. 8; Pages: (1857-1869);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Metabolic implications of severe burn injuries and their management: A systematic review of the literature
dc.type Review
dc.contributor.affiliation Atiyeh, B.S., Division Plastic and Reconstructive Surgery, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Gunn, S.W.A., WHO Collaborating Center on Burns and Fire Disasters, 1279 La Panetiere, Bogis-Bossey, Switzerland
dc.contributor.affiliation Dibo, S.A., Department of Surgery, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.authorAddress Atiyeh, B. S.; Division Plastic and Reconstructive Surgery, American University of Beirut Medical Center, Beirut, Lebanon; email: aata@terra.net.lb
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Surgery;
dc.contributor.authorDepartment Surgery
dc.contributor.authorDivision
dc.contributor.authorEmail aata@terra.net.lb
dc.contributor.faculty Faculty of Medicine
dc.contributor.authorInitials Atiyeh, BS
dc.contributor.authorInitials Gunn, SWA
dc.contributor.authorInitials Dibo, SA
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Atiyeh, BS (reprint author), Amer Univ Beirut, Med Ctr, Div Plast and Reconstruct Surg, Beirut, Lebanon.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedCount 24
dc.description.citedTotWOSCount 16
dc.description.citedWOSCount 13
dc.format.extentCount 13
dc.identifier.articleNo
dc.identifier.coden WJSUD
dc.identifier.pubmedID 18454355
dc.identifier.scopusID 48549106329
dc.identifier.url
dc.publisher.address 233 SPRING ST, NEW YORK, NY 10013 USA
dc.relation.ispartofConference
dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr World J.Surg.
dc.relation.ispartOfIssue 8
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle World Journal of Surgery
dc.relation.ispartofPubTitleAbbr World J. Surg.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 32
dc.source.ID WOS:000258093900043
dc.type.publication Journal
dc.subject.otherAuthKeyword
dc.subject.otherChemCAS alpha 2 macroglobulin, 95568-41-5
dc.subject.otherChemCAS arginine, 1119-34-2, 15595-35-4, 7004-12-8, 74-79-3
dc.subject.otherChemCAS C reactive protein, 9007-41-4
dc.subject.otherChemCAS docosahexaenoic acid, 25167-62-8, 32839-18-2
dc.subject.otherChemCAS glutamine, 56-85-9, 6899-04-3
dc.subject.otherChemCAS growth hormone, 36992-73-1, 37267-05-3, 66419-50-9, 9002-72-6
dc.subject.otherChemCAS insulin, 9004-10-8
dc.subject.otherChemCAS metoprolol, 37350-58-6
dc.subject.otherChemCAS propranolol, 13013-17-7, 318-98-9, 3506-09-0, 4199-09-1, 525-66-6
dc.subject.otherChemCAS somatomedin C, 67763-96-6
dc.subject.otherChemCAS Proteins
dc.subject.otherIndex alpha 2 macroglobulin
dc.subject.otherIndex arginine
dc.subject.otherIndex beta adrenergic receptor blocking agent
dc.subject.otherIndex C reactive protein
dc.subject.otherIndex CCAAT enhancer binding protein delta
dc.subject.otherIndex chemokine
dc.subject.otherIndex cytokine
dc.subject.otherIndex docosahexaenoic acid
dc.subject.otherIndex glutamine
dc.subject.otherIndex granulocyte colony stimulating factor
dc.subject.otherIndex growth factor
dc.subject.otherIndex growth hormone
dc.subject.otherIndex insulin
dc.subject.otherIndex interleukin 10
dc.subject.otherIndex interleukin 1beta
dc.subject.otherIndex interleukin 6
dc.subject.otherIndex metoprolol
dc.subject.otherIndex omega 3 fatty acid
dc.subject.otherIndex polyunsaturated fatty acid
dc.subject.otherIndex propranolol
dc.subject.otherIndex somatomedin C
dc.subject.otherIndex STAT5 protein
dc.subject.otherIndex tumor necrosis factor
dc.subject.otherIndex burn
dc.subject.otherIndex burn patient
dc.subject.otherIndex carbohydrate intake
dc.subject.otherIndex continuous infusion
dc.subject.otherIndex critical illness
dc.subject.otherIndex drug megadose
dc.subject.otherIndex evidence based medicine
dc.subject.otherIndex human
dc.subject.otherIndex hyperglycemia
dc.subject.otherIndex hypermetabolism
dc.subject.otherIndex injury severity
dc.subject.otherIndex insulin treatment
dc.subject.otherIndex lean body weight
dc.subject.otherIndex low calory diet
dc.subject.otherIndex metabolic disorder
dc.subject.otherIndex nutrient
dc.subject.otherIndex nutritional support
dc.subject.otherIndex physiological stress
dc.subject.otherIndex protein depletion
dc.subject.otherIndex review
dc.subject.otherIndex systematic review
dc.subject.otherIndex Burns
dc.subject.otherIndex Digestive System
dc.subject.otherIndex Humans
dc.subject.otherIndex Hyperglycemia
dc.subject.otherIndex Inflammation
dc.subject.otherIndex Nutritional Physiological Phenomena
dc.subject.otherIndex Nutritional Support
dc.subject.otherIndex Proteins
dc.subject.otherKeywordPlus INDUCED INSULIN-RESISTANCE
dc.subject.otherKeywordPlus RANDOMIZED CLINICAL-TRIAL
dc.subject.otherKeywordPlus BETA-BLOCKER USE
dc.subject.otherKeywordPlus THERMAL-INJURY
dc.subject.otherKeywordPlus NEUTROPHIL ACTIVATION
dc.subject.otherKeywordPlus NUTRITIONAL SUPPORT
dc.subject.otherKeywordPlus PROTEIN CATABOLISM
dc.subject.otherKeywordPlus MUSCLE CATABOLISM
dc.subject.otherKeywordPlus ENTERAL GLUTAMINE
dc.subject.otherKeywordPlus IMPROVED OUTCOMES
dc.subject.otherWOS Surgery


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