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Quality of life after vagal nerve stimulator insertion

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dc.contributor.author Mikati M.A.
dc.contributor.author Ataya N.F.
dc.contributor.author El-Ferezli J.C.
dc.contributor.author Baghdadi T.S.
dc.contributor.author Turkmani A.H.
dc.contributor.author Comair Y.G.
dc.contributor.author Kansagra S.
dc.contributor.author Najjar M.W.
dc.contributor.editor
dc.date Mar-2009
dc.date.accessioned 2017-10-05T16:07:27Z
dc.date.available 2017-10-05T16:07:27Z
dc.date.issued 2009
dc.identifier 10.1684/epd.2009.0244
dc.identifier.isbn
dc.identifier.issn 12949361
dc.identifier.uri http://hdl.handle.net/10938/19807
dc.description.abstract Aim. Assess quality-of-life after vagal nerve stimulation and determine patient characteristics associated with improvement in quality-of-life. Methods. Sixteen patients (11 children, 5 adults) who had vagal nerve stimulation at our center were studied. Quality-of-life was assessed pre- and post-vagal nerve stimulation using the Quality-of-Life in Childhood Epilepsy questionnaire for children and the Epilepsy Surgery Inventory-55 for adults. Results. Sixteen patients who did not qualify for resective surgery were included;seven (43.75percent) were males and 9 (56.25percent) were females. Mean age at onset of seizures was 3.96 ± 4.00 years and at surgery was 15.78 ± 10.78. Follow-up time was 1.26 ± 0.92 years. Fourteen patients (87.5percent) were mentally retarded. Ten (62.5percent) had cryptogenic etiology and 6 patients (37.5percent) symptomatic etiology. Fifty percent had localization-related epilepsy. Six of 7 patients with generalized cryptogenic etiology (85.71percent) had Lennox-Gastaut syndrome. Seizures dropped from 122.31 ± 159.49 to 67.84 ± 88.22 seizures-month. Seizure reduction ( 50percent) correlated with improvement in total quality-of-life (p = 0.034). Post-vagal nerve stimulation, the total group scored significantly higher in the social domain (p = 0.039). In patients with localization-related epilepsy, significant improvements were detected in the social domain (p = 0.049) and in total quality-of-life (p = 0.042). Conclusion. Despite a diverse and small population size, we observed significant improvements in the social domain 1.26 years post-vagal nerve stimulation. In addition, there was an improvement in total quality-of-life amongst patients with partial seizures. Finally, seizure reduction was associated with quality-of-life improvement. Our results support previous studies from the West reporting improvement in quality-of-life following vagal nerve stimulation, contradict those studies that did not show such differences, and are the first coming from a developing country.
dc.format.extent
dc.format.extent Pages: (67-74)
dc.language English
dc.publisher MONTROUGE
dc.relation.ispartof Publication Name: Epileptic Disorders; Publication Year: 2009; Volume: 11; no. 1; Pages: (67-74);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Quality of life after vagal nerve stimulator insertion
dc.type Article
dc.contributor.affiliation Mikati, M.A., Department of Pediatrics and Adolescent Medicine, American University, Beirut Medical Center, Beirut, Lebanon, Adult and Pediatric Epilepsy Program, American University, Beirut Medical Center, Beirut, Lebanon, Division of Pediatric Neurology, Duke University, School of Medicine, Durham, United States, Department of Pediatrics and of Neurobiology, Duke University Medical Center, T0913 Children's Health Center, 2301 Erwin Road, Durham, NC 27710, United States
dc.contributor.affiliation Ataya, N.F., Department of Pediatrics and Adolescent Medicine, American University, Beirut Medical Center, Beirut, Lebanon, Adult and Pediatric Epilepsy Program, American University, Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation El-Ferezli, J.C., Adult and Pediatric Epilepsy Program, American University, Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Baghdadi, T.S., Department of Surgery, American University, Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Turkmani, A.H., Department of Surgery, American University, Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Comair, Y.G., Department of Surgery, American University, Beirut Medical Center, Beirut, Lebanon, Department of Neurosurgery, St. Luke's Episcopal Hospital, Baylor College of Medicine Faculty Center, TX, United States
dc.contributor.affiliation Kansagra, S., Division of Pediatric Neurology, Duke University, School of Medicine, Durham, United States
dc.contributor.affiliation Najjar, M.W., Department of Surgery, American University, Beirut Medical Center, Beirut, Lebanon
dc.contributor.authorAddress Mikati, M. A.; Department of Pediatrics and of Neurobiology, Duke University Medical Center, T0913 Children's Health Center, 2301 Erwin Road, Durham, NC 27710, United States; email: mohamad.mikati@duke.edu
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Surgery;
dc.contributor.authorDepartment Surgery
dc.contributor.authorDivision
dc.contributor.authorEmail mohamad.mikati@duke.edu
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Mikati, MA
dc.contributor.authorInitials Ataya, NF
dc.contributor.authorInitials El-Ferezli, JC
dc.contributor.authorInitials Baghdadi, TS
dc.contributor.authorInitials Turkmani, AH
dc.contributor.authorInitials Comair, YG
dc.contributor.authorInitials Kansagra, S
dc.contributor.authorInitials Najjar, MW
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Mikati, MA (reprint author), Duke Univ, Med Ctr, Div Pediat Neurol, Childrens Hlth Ctr T0913,Sch Med, Box 3936,2301 Erwin Rd, Durham, NC 27710 USA.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedCount 14
dc.description.citedTotWOSCount 11
dc.description.citedWOSCount 11
dc.format.extentCount 8
dc.identifier.articleNo
dc.identifier.coden EPDIF
dc.identifier.pubmedID 19286494
dc.identifier.scopusID 65349156287
dc.identifier.url
dc.publisher.address 127 AVE DE LA REPUBLIQUE, 92120 MONTROUGE, FRANCE
dc.relation.ispartofConference
dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr Epileptic Disord.
dc.relation.ispartOfIssue 1
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Epileptic Disorders
dc.relation.ispartofPubTitleAbbr Epileptic Disord.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 11
dc.source.ID WOS:000265045800009
dc.type.publication Journal
dc.subject.otherAuthKeyword Drug resistance
dc.subject.otherAuthKeyword Epilepsy surgery
dc.subject.otherAuthKeyword Quality of life
dc.subject.otherAuthKeyword Vagal nerve stimulator
dc.subject.otherChemCAS
dc.subject.otherIndex adolescent
dc.subject.otherIndex adult
dc.subject.otherIndex article
dc.subject.otherIndex child
dc.subject.otherIndex clinical article
dc.subject.otherIndex clinical trial
dc.subject.otherIndex controlled clinical trial
dc.subject.otherIndex controlled study
dc.subject.otherIndex epilepsy
dc.subject.otherIndex epilepsy suregry inventory 55
dc.subject.otherIndex female
dc.subject.otherIndex follow up
dc.subject.otherIndex generalized epilepsy
dc.subject.otherIndex human
dc.subject.otherIndex Lennox Gastaut syndrome
dc.subject.otherIndex male
dc.subject.otherIndex mental deficiency
dc.subject.otherIndex named inventories, questionnaires and rating scales
dc.subject.otherIndex preschool child
dc.subject.otherIndex priority journal
dc.subject.otherIndex quality of life
dc.subject.otherIndex quality of life in childhood epilepsy questionaire
dc.subject.otherIndex questionnaire
dc.subject.otherIndex school child
dc.subject.otherIndex seizure
dc.subject.otherIndex vagus nerve stimulation
dc.subject.otherIndex Adolescent
dc.subject.otherIndex Adult
dc.subject.otherIndex Child
dc.subject.otherIndex Cognition
dc.subject.otherIndex Emotions
dc.subject.otherIndex Epilepsies, Partial
dc.subject.otherIndex Evaluation Studies as Topic
dc.subject.otherIndex Female
dc.subject.otherIndex Follow-Up Studies
dc.subject.otherIndex Humans
dc.subject.otherIndex Male
dc.subject.otherIndex Quality of Life
dc.subject.otherIndex Questionnaires
dc.subject.otherIndex Social Behavior
dc.subject.otherIndex Treatment Outcome
dc.subject.otherIndex Vagus Nerve Stimulation
dc.subject.otherIndex Young Adult
dc.subject.otherKeywordPlus REFRACTORY EPILEPSY
dc.subject.otherKeywordPlus INTRACTABLE EPILEPSY
dc.subject.otherKeywordPlus CHILDREN
dc.subject.otherKeywordPlus SURGERY
dc.subject.otherKeywordPlus THERAPY
dc.subject.otherKeywordPlus EXPERIENCE
dc.subject.otherKeywordPlus SEIZURES
dc.subject.otherKeywordPlus IMPACT
dc.subject.otherWOS Clinical Neurology


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