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Duration of post-surgical antibiotics in chronic osteomyelitis: Empiric or evidence-based?

Show simple item record Haidar R. Boghossian A.D. Atiyeh B.
dc.contributor.editor Sep-2010 2017-10-05T16:07:33Z 2017-10-05T16:07:33Z 2010
dc.identifier 10.1016/j.ijid.2010.01.005
dc.identifier.issn 12019712
dc.description.abstract Chronic osteomyelitis is a relatively common infection and is often a lifelong disease. Traditionally, osteomyelitis has been treated with 4-6 weeks of parenteral antibiotics after definitive debridement surgery. Antibiotic-impregnated cement beads have also been used as adjuvant therapy for chronic osteomyelitis. However, this time frame of antibiotic treatment has no documented superiority over other time intervals, and there is no evidence that prolonged parenteral antibiotics will penetrate the necrotic bone. There is no solid evidence in the medical literature to support the continuous use of long duration antibiotic treatment for chronic osteomyelitis. A small number of comparative trials on the treatment of chronic osteomyelitis have been published. Also, the type of surgical procedures practiced in the past in treating chronic osteomyelitis and the lack of effective muscle flap application might have contributed to the prolonged antibiotic treatment. And although the surgical approach to the treatment of chronic osteomyelitis has advanced markedly, still the same duration of antibiotic treatment is adopted. In this review we question the continuous and traditional use of long-term antibiotic treatment for chronic osteomyelitis in spite of the advances in surgical treatment using flaps. The medical literature, including studies in animals and humans, was searched for evidence to support the use of short courses of antibiotics. We hope this review will provoke the initiation of animal studies and clinical trials assessing the use of short courses of antibiotics for chronic osteomyelitis. © 2010 International Society for Infectious Diseases.
dc.language English
dc.publisher OXFORD
dc.relation.ispartof Publication Name: International Journal of Infectious Diseases; Publication Year: 2010; Volume: 14; no. 9;
dc.source Scopus
dc.title Duration of post-surgical antibiotics in chronic osteomyelitis: Empiric or evidence-based?
dc.type Review
dc.contributor.affiliation Haidar, R., Department of Surgery, American University of Beirut Medical Center, PO Box 11-0236, Riad El Solh, 1107 2020, Beirut, Lebanon
dc.contributor.affiliation Boghossian, A.D., Department of Surgery, American University of Beirut Medical Center, PO Box 11-0236, Riad El Solh, 1107 2020, Beirut, Lebanon
dc.contributor.affiliation Atiyeh, B., Department of Surgery, American University of Beirut Medical Center, PO Box 11-0236, Riad El Solh, 1107 2020, Beirut, Lebanon
dc.contributor.authorAddress Haidar, R.; Department of Surgery, American University of Beirut Medical Center, PO Box 11-0236, Riad El Solh, 1107 2020, Beirut, Lebanon; email:
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Surgery;
dc.contributor.authorDepartment Surgery
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Haidar, R
dc.contributor.authorInitials Boghossian, AD
dc.contributor.authorInitials Atiyeh, B
dc.contributor.authorReprintAddress Haidar, R (reprint author), Amer Univ Beirut, Med Ctr, Dept Surg, POB 11-0236, Beirut 11072020, Lebanon.
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedCount 17
dc.description.citedTotWOSCount 12
dc.description.citedWOSCount 8
dc.identifier.coden IJIDF
dc.identifier.pubmedID 20471296
dc.identifier.scopusID 77956617062
dc.relation.ispartOfISOAbbr Int. J. Infect. Dis.
dc.relation.ispartOfIssue 9
dc.relation.ispartofPubTitle International Journal of Infectious Diseases
dc.relation.ispartofPubTitleAbbr Int. J. Infect. Dis.
dc.relation.ispartOfVolume 14
dc.source.ID WOS:000282101100004
dc.type.publication Journal
dc.subject.otherAuthKeyword Antibiotic treatment
dc.subject.otherAuthKeyword Chronic osteomyelitis
dc.subject.otherAuthKeyword Debridement
dc.subject.otherAuthKeyword Empiric
dc.subject.otherAuthKeyword Muscle flaps
dc.subject.otherAuthKeyword Review
dc.subject.otherChemCAS ampicillin, 69-52-3, 69-53-4, 7177-48-2, 74083-13-9, 94586-58-0
dc.subject.otherChemCAS aztreonam, 78110-38-0
dc.subject.otherChemCAS cefalexin, 15686-71-2, 23325-78-2
dc.subject.otherChemCAS cefalotin, 153-61-7, 58-71-9
dc.subject.otherChemCAS cefazolin, 25953-19-9, 27164-46-1
dc.subject.otherChemCAS cefotaxime, 63527-52-6, 64485-93-4
dc.subject.otherChemCAS cefoxitin, 33564-30-6, 35607-66-0
dc.subject.otherChemCAS cefsulodin, 52152-93-9
dc.subject.otherChemCAS cephalosporin, 11111-12-9
dc.subject.otherChemCAS ciprofloxacin, 85721-33-1
dc.subject.otherChemCAS clindamycin, 18323-44-9
dc.subject.otherChemCAS cloxacillin, 61-72-3, 642-78-4
dc.subject.otherChemCAS daptomycin, 103060-53-3
dc.subject.otherChemCAS fosfomycin, 23155-02-4
dc.subject.otherChemCAS gentamicin, 1392-48-9, 1403-66-3, 1405-41-0
dc.subject.otherChemCAS lincomycin, 154-21-2, 7179-49-9, 859-18-7
dc.subject.otherChemCAS meropenem, 96036-03-2
dc.subject.otherChemCAS ofloxacin, 82419-36-1
dc.subject.otherChemCAS pefloxacin, 70458-92-3
dc.subject.otherChemCAS penicillin G, 1406-05-9, 61-33-6
dc.subject.otherChemCAS sulbactam, 68373-14-8
dc.subject.otherChemCAS teicoplanin, 61036-62-2, 61036-64-4
dc.subject.otherChemCAS tetracycline, 23843-90-5, 60-54-8, 64-75-5, 8021-86-1
dc.subject.otherChemCAS Anti-Bacterial Agents
dc.subject.otherIndex ampicillin
dc.subject.otherIndex antibiotic agent
dc.subject.otherIndex aztreonam
dc.subject.otherIndex bone cement
dc.subject.otherIndex cefalexin
dc.subject.otherIndex cefalotin
dc.subject.otherIndex cefazolin
dc.subject.otherIndex cefotaxime
dc.subject.otherIndex cefoxitin
dc.subject.otherIndex cefsulodin
dc.subject.otherIndex cephalosporin
dc.subject.otherIndex ciprofloxacin
dc.subject.otherIndex clindamycin
dc.subject.otherIndex cloxacillin
dc.subject.otherIndex daptomycin
dc.subject.otherIndex fosfomycin
dc.subject.otherIndex gentamicin
dc.subject.otherIndex gentamicin bone cement
dc.subject.otherIndex lincomycin
dc.subject.otherIndex meropenem
dc.subject.otherIndex ofloxacin
dc.subject.otherIndex pefloxacin
dc.subject.otherIndex penicillin G
dc.subject.otherIndex sulbactam
dc.subject.otherIndex teicoplanin
dc.subject.otherIndex tetracycline
dc.subject.otherIndex antibiotic therapy
dc.subject.otherIndex chronic drug administration
dc.subject.otherIndex chronic osteomyelitis
dc.subject.otherIndex chronotherapy
dc.subject.otherIndex clinical effectiveness
dc.subject.otherIndex clinical trial
dc.subject.otherIndex debridement
dc.subject.otherIndex drug delivery system
dc.subject.otherIndex drug efficacy
dc.subject.otherIndex empiricism
dc.subject.otherIndex evidence based practice
dc.subject.otherIndex human
dc.subject.otherIndex nonhuman
dc.subject.otherIndex postoperative period
dc.subject.otherIndex review
dc.subject.otherIndex surgical approach
dc.subject.otherIndex tissue graft
dc.subject.otherIndex treatment duration
dc.subject.otherIndex Animals
dc.subject.otherIndex Anti-Bacterial Agents
dc.subject.otherIndex Chronic Disease
dc.subject.otherIndex Debridement
dc.subject.otherIndex Drug Administration Schedule
dc.subject.otherIndex Empirical Research
dc.subject.otherIndex Evidence-Based Practice
dc.subject.otherIndex Female
dc.subject.otherIndex Humans
dc.subject.otherIndex Osteomyelitis
dc.subject.otherIndex Rabbits
dc.subject.otherIndex Rats
dc.subject.otherIndex Surgical Flaps
dc.subject.otherKeywordPlus GENTAMICIN-PMMA-BEADS
dc.subject.otherKeywordPlus MUSCLE FLAP
dc.subject.otherKeywordPlus ANTIMICROBIAL TREATMENT
dc.subject.otherKeywordPlus PSEUDOMONAS-AERUGINOSA
dc.subject.otherKeywordPlus BACTERIAL-INFECTIONS
dc.subject.otherKeywordPlus JOINT INFECTIONS
dc.subject.otherKeywordPlus SOFT-TISSUE
dc.subject.otherKeywordPlus RAT MODEL
dc.subject.otherKeywordPlus BONE
dc.subject.otherWOS Infectious Diseases

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