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Correlation of non-mass-like abnormal MR signal intensity with pathological findings surrounding pediatric osteosarcoma and Ewing's sarcoma

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dc.contributor.author Masrouha K.Z.
dc.contributor.author Musallam K.M.
dc.contributor.author Samra A.B.
dc.contributor.author Tawil A.
dc.contributor.author Haidar R.
dc.contributor.author Chakhachiro Z.
dc.contributor.author Saghieh S.
dc.contributor.author Abdallah A.
dc.contributor.author Saab R.
dc.contributor.author Muwakkit S.
dc.contributor.author Abboud M.R.
dc.contributor.author Khoury N.J.
dc.contributor.editor
dc.date Nov-2012
dc.date.accessioned 2017-10-05T16:07:40Z
dc.date.available 2017-10-05T16:07:40Z
dc.date.issued 2012
dc.identifier 10.1007/s00256-012-1383-8
dc.identifier.isbn
dc.identifier.issn 03642348
dc.identifier.uri http://hdl.handle.net/10938/19960
dc.description.abstract Objective: The aim of this work was to determine the role of MRI in interpreting abnormal signals within bones and soft tissues adjacent to tumor bulk of osteosarcoma and Ewing's sarcoma in a pediatric population by correlating MR findings with histopathology. Materials and methods: Thirty patients met the inclusion criteria, which included (1) osteosarcoma or Ewing's sarcoma, (2) MR studies no more than 2 months prior to surgery, (3) presence of abnormal MR signal surrounding the tumor bulk, (4) pathological material from resected tumor. The patients received standard neoadjuvant chemotherapy. Using grid maps on gross pathology specimens, the abnormal MR areas around the tumor were matched with the corresponding grid sections. Histopathology slides of these sections were then analyzed to determine the nature of the regions of interest. The MR-pathological correlation was evaluated using Mann-Whitney U test and Fisher's exact test. Results: Twenty-seven patients had osteosarcoma and three patients had Ewing's sarcoma. Of the studied areas, 17.4percent were positive for tumor (viable or necrotic). There was no statistically significant correlation between areas positive for tumor and age, gender, signal extent and intensity on MRI, or tissue type. There was, however, a statistically significant correlation between presence of tumor and the appearance of abnormal soft tissue signals. A feathery appearance correlated with tumor-negative areas whereas a bulky appearance correlated with tumor-positive regions. Conclusions: MR imaging is helpful in identifying the nature of abnormal signal areas surrounding bone sarcomas that are more likely to be tumor-free, particularly when the signal in the soft tissues surrounding the tumor is feathery and edema-like in appearance.© ISS 2012.
dc.format.extent
dc.format.extent Pages: (1453-1461)
dc.language English
dc.publisher NEW YORK
dc.relation.ispartof Publication Name: Skeletal Radiology; Publication Year: 2012; Volume: 41; no. 11; Pages: (1453-1461);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Correlation of non-mass-like abnormal MR signal intensity with pathological findings surrounding pediatric osteosarcoma and Ewing's sarcoma
dc.type Article
dc.contributor.affiliation Masrouha, K.Z., Department of Surgery, American University of Beirut, Medical Center, PO Box 11-0236, Riad El Solh, Beirut 1107 2020, Beirut, Lebanon
dc.contributor.affiliation Musallam, K.M., Internal Medicine Division of Hematology and Oncology, American University of Beirut, Medical Center, PO Box 11-0236, Riad El Solh, Beirut 1107 2020, Beirut, Lebanon
dc.contributor.affiliation Samra, A.B., Pathology, American University of Beirut, Medical Center, PO Box 11-0236, Riad El Solh, Beirut 1107 2020, Beirut, Lebanon
dc.contributor.affiliation Tawil, A., Pathology, American University of Beirut, Medical Center, PO Box 11-0236, Riad El Solh, Beirut 1107 2020, Beirut, Lebanon
dc.contributor.affiliation Haidar, R., Department of Surgery, American University of Beirut, Medical Center, PO Box 11-0236, Riad El Solh, Beirut 1107 2020, Beirut, Lebanon
dc.contributor.affiliation Chakhachiro, Z., Pathology, American University of Beirut, Medical Center, PO Box 11-0236, Riad El Solh, Beirut 1107 2020, Beirut, Lebanon
dc.contributor.affiliation Saghieh, S., Department of Surgery, American University of Beirut, Medical Center, PO Box 11-0236, Riad El Solh, Beirut 1107 2020, Beirut, Lebanon
dc.contributor.affiliation Abdallah, A., Diagnostic Radiology, American University of Beirut, Medical Center, PO Box 11-0236, Riad El Solh, Beirut 1107 2020, Beirut, Lebanon
dc.contributor.affiliation Saab, R., Children's Cancer Center of Lebanon, American University of Beirut, Medical Center, PO Box 11-0236, Riad El Solh, Beirut 1107 2020, Beirut, Lebanon
dc.contributor.affiliation Muwakkit, S., Children's Cancer Center of Lebanon, American University of Beirut, Medical Center, PO Box 11-0236, Riad El Solh, Beirut 1107 2020, Beirut, Lebanon
dc.contributor.affiliation Abboud, M.R., Children's Cancer Center of Lebanon, American University of Beirut, Medical Center, PO Box 11-0236, Riad El Solh, Beirut 1107 2020, Beirut, Lebanon
dc.contributor.affiliation Khoury, N.J., Diagnostic Radiology, American University of Beirut, Medical Center, PO Box 11-0236, Riad El Solh, Beirut 1107 2020, Beirut, Lebanon
dc.contributor.authorAddress Khoury, N.J.; Diagnostic Radiology, American University of Beirut, Medical Center, PO Box 11-0236, Riad El Solh, Beirut 1107 2020, Beirut, Lebanon; email: nk01@aub.edu.lb
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Surgery;
dc.contributor.authorDepartment Surgery
dc.contributor.authorDivision
dc.contributor.authorEmail km34@aub.edu.lb; kmm06@aub.edu.lb; armasoub22@hotmail.com; at04@aub.edu.lb; rh00@aub.edu.lb; z_shak@hotmail.com; ss15@aub.edu.lb; aa162@aub.edu.lb; rs88@aub.edu.lb; sm03@aub.edu.lb; ma56@aub.edu.lb; nk01@aub.edu.lb
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Masrouha, KZ
dc.contributor.authorInitials Musallam, KM
dc.contributor.authorInitials Samra, AB
dc.contributor.authorInitials Tawil, A
dc.contributor.authorInitials Haidar, R
dc.contributor.authorInitials Chakhachiro, Z
dc.contributor.authorInitials Saghieh, S
dc.contributor.authorInitials Abdallah, A
dc.contributor.authorInitials Saab, R
dc.contributor.authorInitials Muwakkit, S
dc.contributor.authorInitials Abboud, MR
dc.contributor.authorInitials Khoury, NJ
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Khoury, NJ (reprint author), Amer Univ Beirut, Dept Surg, Med Ctr, POB 11-0236, Beirut 11072020, Lebanon.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedCount 2
dc.description.citedTotWOSCount 3
dc.description.citedWOSCount 3
dc.format.extentCount 9
dc.identifier.articleNo
dc.identifier.coden SKRAD
dc.identifier.pubmedID 22406919
dc.identifier.scopusID 84866738221
dc.identifier.url
dc.publisher.address 233 SPRING ST, NEW YORK, NY 10013 USA
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dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr Skeletal Radiol.
dc.relation.ispartOfIssue 11
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Skeletal Radiology
dc.relation.ispartofPubTitleAbbr Skelet. Radiol.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 41
dc.source.ID WOS:000308952600014
dc.type.publication Journal
dc.subject.otherAuthKeyword Ewing's sarcoma
dc.subject.otherAuthKeyword Histology
dc.subject.otherAuthKeyword MRI
dc.subject.otherAuthKeyword Osteosarcoma
dc.subject.otherAuthKeyword Staging
dc.subject.otherChemCAS cisplatin, 15663-27-1, 26035-31-4, 96081-74-2
dc.subject.otherChemCAS cyclophosphamide, 50-18-0
dc.subject.otherChemCAS doxorubicin, 23214-92-8, 25316-40-9
dc.subject.otherChemCAS etoposide, 33419-42-0
dc.subject.otherChemCAS gadoterate meglumine, 92943-93-6
dc.subject.otherChemCAS ifosfamide, 3778-73-2
dc.subject.otherChemCAS methotrexate, 15475-56-6, 59-05-2, 7413-34-5
dc.subject.otherChemCAS vincristine, 57-22-7
dc.subject.otherIndex cisplatin
dc.subject.otherIndex cyclophosphamide
dc.subject.otherIndex doxorubicin
dc.subject.otherIndex etoposide
dc.subject.otherIndex gadoterate meglumine
dc.subject.otherIndex ifosfamide
dc.subject.otherIndex methotrexate
dc.subject.otherIndex vincristine
dc.subject.otherIndex adolescent
dc.subject.otherIndex adult
dc.subject.otherIndex age distribution
dc.subject.otherIndex article
dc.subject.otherIndex cancer adjuvant therapy
dc.subject.otherIndex child
dc.subject.otherIndex clinical article
dc.subject.otherIndex controlled study
dc.subject.otherIndex correlation analysis
dc.subject.otherIndex Ewing sarcoma
dc.subject.otherIndex female
dc.subject.otherIndex histopathology
dc.subject.otherIndex human
dc.subject.otherIndex human tissue
dc.subject.otherIndex image analysis
dc.subject.otherIndex male
dc.subject.otherIndex nuclear magnetic resonance imaging
dc.subject.otherIndex osteosarcoma
dc.subject.otherIndex preschool child
dc.subject.otherIndex priority journal
dc.subject.otherIndex school child
dc.subject.otherIndex sex difference
dc.subject.otherIndex signal detection
dc.subject.otherIndex soft tissue tumor
dc.subject.otherIndex tissue section
dc.subject.otherIndex tumor volume
dc.subject.otherIndex Adolescent
dc.subject.otherIndex Bone Neoplasms
dc.subject.otherIndex Child
dc.subject.otherIndex Female
dc.subject.otherIndex Humans
dc.subject.otherIndex Magnetic Resonance Imaging
dc.subject.otherIndex Male
dc.subject.otherIndex Neoadjuvant Therapy
dc.subject.otherIndex Osteosarcoma
dc.subject.otherIndex Retrospective Studies
dc.subject.otherIndex Sarcoma, Ewing
dc.subject.otherIndex Statistics, Nonparametric
dc.subject.otherIndex Young Adult
dc.subject.otherKeywordPlus MALIGNANT BONE-TUMORS
dc.subject.otherKeywordPlus LIMB-SALVAGE SURGERY
dc.subject.otherKeywordPlus MUSCULOSKELETAL NEOPLASMS
dc.subject.otherKeywordPlus EXTENT
dc.subject.otherKeywordPlus CHEMOTHERAPY
dc.subject.otherKeywordPlus CHILDHOOD
dc.subject.otherKeywordPlus ACCURACY
dc.subject.otherKeywordPlus EDEMA
dc.subject.otherWOS Radiology, Nuclear Medicine and Medical Imaging


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