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Hypovitaminosis D in a sunny country: Time trends, predictors, and implications for practice guidelines

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dc.contributor.author Hoteit M.
dc.contributor.author Al-Shaar L.
dc.contributor.author Yazbeck C.
dc.contributor.author Bou Sleiman M.
dc.contributor.author Ghalayini T.
dc.contributor.author El-Hajj Fuleihan G.
dc.contributor.editor
dc.date 2014
dc.date.accessioned 2017-10-05T16:08:59Z
dc.date.available 2017-10-05T16:08:59Z
dc.date.issued 2014
dc.identifier 10.1016/j.metabol.2014.04.009
dc.identifier.isbn
dc.identifier.issn 00260495
dc.identifier.uri http://hdl.handle.net/10938/20169
dc.description.abstract The aim of the current study is to investigate the prevalence of hypovitaminosis D in Lebanese subjects, its robust predictors, evaluate the relationship between 25 hydroxy vitamin D [25(OH)D] and parathyroid hormone levels, and derive desirable vitamin D levels, based on a large hospital laboratory database spanning all age groups. Data from a large representative digitized database of 9147 subjects, mostly outpatients, evaluated between 2000-2004 and 2007-2008, in whom information on age, gender, service, and time of the year, was analyzed. The PTH-25(OH)D relationship was studied in a subset of 657 adult subjects, in whom such data were available. At a 25(OH)D cut-off of 20 ng-ml, the prevalence of hypovitaminosis D ranged between 58percent and 62percent in pediatric subjects, 44percent and 60percent in adults, and 41percent and 62percent in elderly, in the 2 study periods. At a cut-off 30 ng-ml, the prevalence was above 78percent, in most sub-groups. Regardless of cut-off used, the only significant predictors of high mean 25(OH)D levels were the male gender in the pediatric group, and female gender in adults and elderly, summer-fall seasons, out-patient status, as well as study period. Curve fitting of the PTH-25(OH)D relationship, in adults and elderly, revealed a plateau at 25(OH)D levels of 17-21 ng-ml, depending on sub-study group. Hypovitaminosis D is prevalent in our sunny country, even using a conservative population-derived cut-off of 20 ng-ml, and thus the need for a public health strategy for supplementation. © 2014 Elsevier Inc.
dc.format.extent
dc.format.extent Pages: (968-978)
dc.language English
dc.publisher W.B. Saunders; PHILADELPHIA
dc.relation.ispartof Publication Name: Metabolism: Clinical and Experimental; Publication Year: 2014; Volume: 63; no. 7; Pages: (968-978);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Hypovitaminosis D in a sunny country: Time trends, predictors, and implications for practice guidelines
dc.type Article
dc.contributor.affiliation Hoteit, M., Calcium Metabolism and Osteoporosis Program, WHO Collaborating Center for Metabolic Bone Disorder, American University of Beirut Medical Center, P.O. Box: 113-6044-C8, Beirut, Lebanon
dc.contributor.affiliation Al-Shaar, L., Vascular Medicine Program, Faculty of Medicine, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Yazbeck, C., Calcium Metabolism and Osteoporosis Program, WHO Collaborating Center for Metabolic Bone Disorder, American University of Beirut Medical Center, P.O. Box: 113-6044-C8, Beirut, Lebanon
dc.contributor.affiliation Bou Sleiman, M., Calcium Metabolism and Osteoporosis Program, WHO Collaborating Center for Metabolic Bone Disorder, American University of Beirut Medical Center, P.O. Box: 113-6044-C8, Beirut, Lebanon
dc.contributor.affiliation Ghalayini, T., Calcium Metabolism and Osteoporosis Program, WHO Collaborating Center for Metabolic Bone Disorder, American University of Beirut Medical Center, P.O. Box: 113-6044-C8, Beirut, Lebanon
dc.contributor.affiliation El-Hajj Fuleihan, G., Calcium Metabolism and Osteoporosis Program, WHO Collaborating Center for Metabolic Bone Disorder, American University of Beirut Medical Center, P.O. Box: 113-6044-C8, Beirut, Lebanon
dc.contributor.authorAddress El-Hajj Fuleihan, G.; Calcium Metabolism and Osteoporosis Program, WHO Collaborating Center for Metabolic Bone Disorder, American University of Beirut Medical Center, P.O. Box: 113-6044-C8, Beirut, Lebanon; email: gf01@aub.edu.lb
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Vascular Medicine Program;
dc.contributor.authorDepartment Vascular Medicine Program
dc.contributor.authorDivision
dc.contributor.authorEmail gf01@aub.edu.lb
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Hoteit, M
dc.contributor.authorInitials A-Shaar, L
dc.contributor.authorInitials Yazbeck, C
dc.contributor.authorInitials Sleiman, MB
dc.contributor.authorInitials Ghalayini, T
dc.contributor.authorInitials Fuleihan, GE
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Fuleihan, GE (reprint author), Amer Univ Beirut, Med Ctr, Calcium Metab and Osteoporosis Program, WHO Collaborating Ctr Metab Bone Disorders, POB 113-6044-C8, Beirut, Lebanon.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedCount
dc.description.citedTotWOSCount 0
dc.description.citedWOSCount 0
dc.format.extentCount 11
dc.identifier.articleNo
dc.identifier.coden METAA
dc.identifier.pubmedID 24874590
dc.identifier.scopusID 84902535503
dc.identifier.url
dc.publisher.address 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
dc.relation.ispartofConference
dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr Metab.-Clin. Exp.
dc.relation.ispartOfIssue 7
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Metabolism: Clinical and Experimental
dc.relation.ispartofPubTitleAbbr Metab. Clin. Exp.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 63
dc.source.ID WOS:000337715000012
dc.type.publication Journal
dc.subject.otherAuthKeyword Age
dc.subject.otherAuthKeyword Cut-offs
dc.subject.otherAuthKeyword Gender
dc.subject.otherAuthKeyword Plateau
dc.subject.otherAuthKeyword PTH
dc.subject.otherAuthKeyword Season
dc.subject.otherChemCAS parathyroid hormone, 12584-96-2, 68893-82-3, 9002-64-6
dc.subject.otherIndex parathyroid hormone
dc.subject.otherIndex vitamin D
dc.subject.otherIndex adolescent
dc.subject.otherIndex adult
dc.subject.otherIndex article
dc.subject.otherIndex child
dc.subject.otherIndex female
dc.subject.otherIndex groups by age
dc.subject.otherIndex human
dc.subject.otherIndex infant
dc.subject.otherIndex major clinical study
dc.subject.otherIndex male
dc.subject.otherIndex newborn
dc.subject.otherIndex outpatient
dc.subject.otherIndex parathyroid hormone blood level
dc.subject.otherIndex practice guideline
dc.subject.otherIndex prevalence
dc.subject.otherIndex priority journal
dc.subject.otherIndex seasonal variation
dc.subject.otherIndex sex difference
dc.subject.otherIndex vitamin blood level
dc.subject.otherIndex vitamin D deficiency
dc.subject.otherIndex Age
dc.subject.otherIndex Cut-offs
dc.subject.otherIndex Gender
dc.subject.otherIndex Plateau
dc.subject.otherIndex PTH
dc.subject.otherIndex Season
dc.subject.otherIndex 25-Hydroxyvitamin D 2
dc.subject.otherIndex Academic Medical Centers
dc.subject.otherIndex Adult
dc.subject.otherIndex Aged
dc.subject.otherIndex Calcifediol
dc.subject.otherIndex Child
dc.subject.otherIndex Climate
dc.subject.otherIndex Cross-Sectional Studies
dc.subject.otherIndex Dietary Supplements
dc.subject.otherIndex Female
dc.subject.otherIndex Health Promotion
dc.subject.otherIndex Humans
dc.subject.otherIndex Lebanon
dc.subject.otherIndex Male
dc.subject.otherIndex Nutrition Policy
dc.subject.otherIndex Parathyroid Hormone
dc.subject.otherIndex Practice Guidelines as Topic
dc.subject.otherIndex Prevalence
dc.subject.otherIndex Retrospective Studies
dc.subject.otherIndex Risk Factors
dc.subject.otherIndex Vitamin D
dc.subject.otherIndex Vitamin D Deficiency
dc.subject.otherKeywordPlus VITAMIN-D INSUFFICIENCY
dc.subject.otherKeywordPlus PARATHYROID-HORMONE
dc.subject.otherKeywordPlus 25-HYDROXYVITAMIN D
dc.subject.otherKeywordPlus D DEFICIENCY
dc.subject.otherKeywordPlus SERUM 25(OH)D
dc.subject.otherKeywordPlus PREVALENCE
dc.subject.otherKeywordPlus ADOLESCENTS
dc.subject.otherKeywordPlus POPULATION
dc.subject.otherKeywordPlus ADULTS
dc.subject.otherKeywordPlus WOMEN
dc.subject.otherWOS Endocrinology and Metabolism


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