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Vitamin D3 dose requirement to raise 25-hydroxyvitamin D to desirable levels in adolescents: Results from a randomized controlled trial

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dc.contributor.author Al-Shaar L.
dc.contributor.author Mneimneh R.
dc.contributor.author Nabulsi M.
dc.contributor.author Maalouf J.
dc.contributor.author Fuleihan G.E.-H.
dc.contributor.editor
dc.date Oct-2014
dc.date.accessioned 2017-10-05T16:08:59Z
dc.date.available 2017-10-05T16:08:59Z
dc.date.issued 2014
dc.identifier 10.1002/jbmr.2111
dc.identifier.isbn
dc.identifier.issn 08840431
dc.identifier.uri http://hdl.handle.net/10938/20171
dc.description.abstract Several organizations issued recommendations on desirable serum 25-hydroxy vitamin D [25(OH)D] levels and doses of vitamin D needed to achieve them. Trials allowing the formulation of evidence-based recommendations in adolescents are scarce. We investigated the ability of two doses of vitamin D3 in achieving recommended vitamin D levels in this age group. Post hoc analyses on data from a 1-year double-blind trial that randomized 336 Lebanese adolescents, aged 13 ± 2 years, to placebo, vitamin D3 at 200 IU-day (low dose), or 2000 IU-day (high dose). Serum 25(OH)D level and proportions of children achieving levels ≥20 ng-mL and 30 ng-mL were determined. At baseline, mean 25(OH)D was 15 ± 7 ng-mL, 16.4 ± 7 ng-mL in boys, and 14 ± 8 ng-mL in girls, p = 0.003, with a level ≥20 ng-mL in 18percent and ≥30 ng-mL in 5percent of subjects. At 1 year, mean levels were 18.6 ± 6.6 ng-mL in the low-dose group, 17.1 ± 6 ng-mL in girls, and 20.2 ± 7 ng-mL in boys, p = 0.01, and 36.3 ± 22.3 ng-mL in the high-dose group, with no sex differences. 25(OH)D increased to ≥20 ng-mL in 34percent of children in the low-dose and 96percent in the high-dose group, being higher in boys in the low-dose arm only; it remained ≥30 ng-mL in 4percent of children in the low-dose arm but increased to 64percent in the high-dose arm. Baseline 25(OH)D level, body mass index (BMI), and vitamin D dose assigned were the most significant predictors for reaching a 25(OH)D level ≥20 ng-mL and 30 ng-mL. A daily dose of 2000 IU raised 25(OH)D level ≥20 ng-mL in 96percent of adolescents (98percent boys versus 93percent girls). Dose-response studies are needed to determine in a definitive manner the daily allowance of vitamin D for Middle Eastern adolescents with a similar profile. © 2014 American Society for Bone and Mineral Research.
dc.format.extent
dc.format.extent Pages: (944-951)
dc.language English
dc.relation.ispartof Publication Name: Journal of Bone and Mineral Research; Publication Year: 2014; Volume: 29; no. 4; Pages: (944-951);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Vitamin D3 dose requirement to raise 25-hydroxyvitamin D to desirable levels in adolescents: Results from a randomized controlled trial
dc.type Article
dc.contributor.affiliation Al-Shaar, L., Scholars in Health Research Program, American University of Beirut Medical Center, Division of Endocrinology, PO Box 11-0236, Riad El Solh, Beirut 1107 2020, Lebanon, Vascular Medicine Program, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Mneimneh, R., Department of Internal Medicine, WHO Collaborating Center for Metabolic Bone Disorder, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Nabulsi, M., Scholars in Health Research Program, American University of Beirut Medical Center, Division of Endocrinology, PO Box 11-0236, Riad El Solh, Beirut 1107 2020, Lebanon, Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Maalouf, J., Department of Internal Medicine, WHO Collaborating Center for Metabolic Bone Disorder, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Fuleihan, G.E.-H., Scholars in Health Research Program, American University of Beirut Medical Center, Division of Endocrinology, PO Box 11-0236, Riad El Solh, Beirut 1107 2020, Lebanon, Department of Internal Medicine, WHO Collaborating Center for Metabolic Bone Disorder, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.authorAddress Fuleihan, G.E.-H.; Scholars in Health Research Program, American University of Beirut Medical Center, Division of Endocrinology, PO Box 11-0236, Riad El Solh, Beirut 1107 2020, Lebanon; email: gf01@aub.edu.lb
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Vascular Medicine Program;
dc.contributor.authorDepartment Vascular Medicine Program
dc.contributor.authorDivision
dc.contributor.authorEmail
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials empty
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
dc.description.cited
dc.description.citedCount
dc.description.citedTotWOSCount
dc.description.citedWOSCount
dc.format.extentCount 8
dc.identifier.articleNo
dc.identifier.coden JBMRE
dc.identifier.pubmedID 24123134
dc.identifier.scopusID 84897831233
dc.identifier.url
dc.publisher.address
dc.relation.ispartofConference
dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr
dc.relation.ispartOfIssue 4
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Journal of Bone and Mineral Research
dc.relation.ispartofPubTitleAbbr J. Bone Miner. Res.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 29
dc.source.ID
dc.type.publication Journal
dc.subject.otherAuthKeyword ADOLESCENTS
dc.subject.otherAuthKeyword DESIRABLE LEVELS
dc.subject.otherAuthKeyword ES
dc.subject.otherAuthKeyword GUIDELINES
dc.subject.otherAuthKeyword IOM
dc.subject.otherAuthKeyword RDA
dc.subject.otherAuthKeyword VITAMIN D DOSE
dc.subject.otherChemCAS 25 hydroxyvitamin D, 64719-49-9
dc.subject.otherChemCAS alkaline phosphatase, 9001-78-9
dc.subject.otherChemCAS calcium, 14092-94-5, 7440-70-2
dc.subject.otherChemCAS colecalciferol, 1406-16-2, 67-97-0
dc.subject.otherChemCAS osteocalcin, 136461-80-8
dc.subject.otherChemCAS phosphorus, 7723-14-0
dc.subject.otherIndex 25 hydroxyvitamin D
dc.subject.otherIndex alkaline phosphatase
dc.subject.otherIndex calcium
dc.subject.otherIndex colecalciferol
dc.subject.otherIndex osteocalcin
dc.subject.otherIndex phosphorus
dc.subject.otherIndex placebo
dc.subject.otherIndex adolescent
dc.subject.otherIndex alkaline phosphatase blood level
dc.subject.otherIndex article
dc.subject.otherIndex body mass
dc.subject.otherIndex calcium blood level
dc.subject.otherIndex calcium intake
dc.subject.otherIndex controlled study
dc.subject.otherIndex dose response
dc.subject.otherIndex double blind procedure
dc.subject.otherIndex drug megadose
dc.subject.otherIndex female
dc.subject.otherIndex human
dc.subject.otherIndex low drug dose
dc.subject.otherIndex male
dc.subject.otherIndex normal human
dc.subject.otherIndex phosphate blood level
dc.subject.otherIndex physical activity
dc.subject.otherIndex post hoc analysis
dc.subject.otherIndex randomized controlled trial
dc.subject.otherIndex sun exposure
dc.subject.otherIndex treatment response
dc.subject.otherIndex vitamin blood level
dc.subject.otherIndex vitamin supplementation
dc.subject.otherKeywordPlus
dc.subject.otherWOS


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