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Postprandial acylated ghrelin status following fat and protein manipulation of meals in healthy young women

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dc.contributor.author Al Awar R.
dc.contributor.author Obeid O.
dc.contributor.author Hwalla N.
dc.contributor.author Azar S.
dc.contributor.editor
dc.date Oct-05
dc.date.accessioned 2017-10-18T13:24:03Z
dc.date.available 2017-10-18T13:24:03Z
dc.date.issued 2005
dc.identifier 10.1042/CS20050072
dc.identifier.issn 1435221
dc.identifier.uri http://hdl.handle.net/10938/20200
dc.description.abstract The aim of the present study was to investigate the postprandial effect of diet composition on circulating acylated ghrelin levels in healthy women. A randomized cross-over study of three experimental treatments was performed. A total of 11 healthy young women of normal body weight completed the study. All 11 subjects consumed three iso-energetic meals of different macro-nutrient composition, a balanced meal (50percent carbohydrates, 30percent fat and 20percent protein), a high-fat meal (45 percent carbohydrates, 45 percent fat and IO percent protein) and a high-protein meal (45 percent carbohydrates, 20percent fat and 35percent protein), for breakfast on separate days. The test meals were administered 1 month apart. Blood samples were withdrawn immediately before and at 15, 30, 60, 120 and 180 min after the test meal for measurement of plasma acylated ghrelin, as well as serum glucose, insulin and triacylglycerol (triglyceride) levels. Acylated ghrelin fell significantly after ingestion of both the balanced and high-protein meals. Ghrelin persisted at significantly lower levels than baseline for a longer duration following the high-protein meal (P 0.05 at 15, 30, 60 and 120 min) compared with the balanced meal (P 0.05 at 30 and 60 min). Moreover, acylated ghrelin levels correlated negatively with the postprandial insulin levels. In conclusion, postprandial changes in acylated plasma ghrelin depend on the macronutrient composition of the meal and are possibly influenced by insulin. © 2005 The Biochemical Society.
dc.format.extent Pages: (405-411)
dc.language English
dc.publisher LONDON
dc.relation.ispartof Publication Name: Clinical Science; Publication Year: 2005; Volume: 109; no. 4; Pages: (405-411);
dc.source Scopus
dc.title Postprandial acylated ghrelin status following fat and protein manipulation of meals in healthy young women
dc.type Article
dc.contributor.affiliation Al Awar, R., Department of Nutrition and Food Sciences, Faculty of Agricultural and Food Sciences, American University of Beirut, Beirut, Lebanon
dc.contributor.affiliation Obeid, O., Department of Nutrition and Food Sciences, Faculty of Agricultural and Food Sciences, American University of Beirut, Beirut, Lebanon
dc.contributor.affiliation Hwalla, N., Department of Nutrition and Food Sciences, Faculty of Agricultural and Food Sciences, American University of Beirut, Beirut, Lebanon
dc.contributor.affiliation Azar, S., Department of Endocrinology, American University of Beirut-Medical Center, Beirut, Lebanon
dc.contributor.authorAddress Obeid, O.; Department of Nutrition and Food Sciences, Faculty of Agricultural and Food Sciences, American University of Beirut, Beirut, Lebanon; email: omar.obeid@aub.edu.lb
dc.contributor.authorCorporate University: American University of Beirut; Faculty: Faculty of Agricultural and Food Sciences; Department: Nutrition and Food Sciences;
dc.contributor.authorDepartment Nutrition and Food Sciences
dc.contributor.authorDivision
dc.contributor.authorEmail omar.obeid@aub.edu.lb
dc.contributor.authorFaculty Faculty of Agricultural and Food Sciences
dc.contributor.authorInitials Al Awar, R
dc.contributor.authorInitials Obeid, O
dc.contributor.authorInitials Hwalla, N
dc.contributor.authorInitials Azar, S
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Obeid, O (reprint author), Amer Univ Beirut, Fac Agr and Food Sci, Dept Nutr and Food Sci, Beirut, Lebanon.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut
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dc.description.citedCount 39
dc.description.citedTotWOSCount 33
dc.description.citedWOSCount 32
dc.format.extentCount 7
dc.identifier.coden CSCIA
dc.identifier.pubmedID 15943578
dc.identifier.scopusID 26844551561
dc.publisher.address THIRD FLOOR, EAGLE HOUSE, 16 PROCTER STREET, LONDON WC1V 6 NX, ENGLAND
dc.relation.ispartOfISOAbbr Clin. Sci.
dc.relation.ispartOfIssue 4
dc.relation.ispartofPubTitle Clinical Science
dc.relation.ispartofPubTitleAbbr Clin. Sci.
dc.relation.ispartOfVolume 109
dc.source.ID WOS:000232567400007
dc.type.publication Journal
dc.subject.otherAuthKeyword Acylated ghrelin
dc.subject.otherAuthKeyword glucose
dc.subject.otherAuthKeyword insulin
dc.subject.otherAuthKeyword macronutrient
dc.subject.otherAuthKeyword meal composition
dc.subject.otherAuthKeyword protein content
dc.subject.otherAuthKeyword triacylglycerol (triglyceride)
dc.subject.otherChemCAS Ghrelin, 258279-04-8, 304853-26-7
dc.subject.otherChemCAS glucose, 50-99-7, 84778-64-3
dc.subject.otherChemCAS insulin, 9004-10-8
dc.subject.otherChemCAS blood glucose
dc.subject.otherChemCAS dietary fats
dc.subject.otherChemCAS dietary proteins
dc.subject.otherChemCAS ghrelin
dc.subject.otherChemCAS insulin, 11061-68-0
dc.subject.otherChemCAS peptide hormones
dc.subject.otherChemCAS triglycerides
dc.subject.otherIndex Ghrelin
dc.subject.otherIndex glucose
dc.subject.otherIndex insulin
dc.subject.otherIndex triacylglycerol
dc.subject.otherIndex adult
dc.subject.otherIndex article
dc.subject.otherIndex diet
dc.subject.otherIndex fat intake
dc.subject.otherIndex female
dc.subject.otherIndex glucose blood level
dc.subject.otherIndex human
dc.subject.otherIndex insulin blood level
dc.subject.otherIndex lipid diet
dc.subject.otherIndex normal human
dc.subject.otherIndex priority journal
dc.subject.otherIndex protein diet
dc.subject.otherIndex protein intake
dc.subject.otherIndex test meal
dc.subject.otherIndex triacylglycerol blood level
dc.subject.otherIndex acylation
dc.subject.otherIndex adult
dc.subject.otherIndex blood glucose
dc.subject.otherIndex blood specimen collection
dc.subject.otherIndex cross-over studies
dc.subject.otherIndex dietary fats
dc.subject.otherIndex dietary proteins
dc.subject.otherIndex fasting
dc.subject.otherIndex female
dc.subject.otherIndex humans
dc.subject.otherIndex insulin
dc.subject.otherIndex peptide hormones
dc.subject.otherIndex postprandial period
dc.subject.otherIndex triglycerides
dc.subject.otherKeywordPlus Food-intake
dc.subject.otherKeywordPlus suppress ghrelin
dc.subject.otherKeywordPlus obese humans
dc.subject.otherKeywordPlus plasma
dc.subject.otherKeywordPlus hormone
dc.subject.otherKeywordPlus insulin
dc.subject.otherKeywordPlus secretion
dc.subject.otherKeywordPlus somatostatin
dc.subject.otherKeywordPlus peptide
dc.subject.otherKeywordPlus glucose
dc.subject.otherWOS Medicine, Research and Experimental
dc.identifier.doi http://dx.doi.org/10.1042/CS20050072


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