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Timing of caffeine ingestion alters postprandial metabolism in rats

Show simple item record Jarrar S.F. Obeid O.A.
dc.contributor.editor 2014 2017-10-18T13:24:04Z 2017-10-18T13:24:04Z 2014
dc.identifier 10.1016/j.nut.2013.07.015
dc.identifier.issn 8999007
dc.description.abstract Objective: The association between caffeine intake and the risk for chronic diseases, namely type 2diabetes, has not been consistent, and may be influenced by the timing of caffeine ingestion. The aim of this study was to investigate the acute effect of caffeine administered in different scenarios of meal ingestion on postprandial glycemic and lipidemic status, concomitant with changes in body glycogen stores. Methods: Forty overnight-fasted rats were randomly divided into five groups (meal-ingested, caffeine-administered, post-caffeine meal-ingested, co-caffeine meal-ingested, post-meal caffeine-administered), and tube-fed the appropriate intervention, then sacrificed 2 h later. Livers and gastrocnemius muscles were analyzed for glycogen content; blood samples were analyzed for glucose, insulin, triglycerides, and non-esterified fatty acid concentrations. Results: Postprandial plasma glucose concentrations were similar between groups, while significantly higher levels of insulin were witnessed following caffeine administration, irrespective of the timingof meal ingestion. Triglyceride concentrations were significantly lower in the caffeine-administered groups. Regarding glycogen status, although caffeine administration before meal ingestion reduced hepatic glycogen content, co- and post-meal caffeine administration failed toproduce such an effect. Muscle glycogen content was not significantly affected by caffeine administration. Conclusions: Caffeine administration seems to decrease insulin sensitivity as indicated by the sustenance of glucose status despite the presence of high insulin levels. The lower triglyceride levels in the presence of caffeine support the theory of retarded postprandial triglyceride absorption. Caffeine seems to play a biphasic role in glucose metabolism, as indicated by its ability to variably influence hepatic glycogen status. © 2014 Elsevier Inc.
dc.format.extent Pages: (107-111)
dc.language English
dc.publisher NEW YORK
dc.relation.ispartof Publication Name: Nutrition; Publication Year: 2014; Volume: 30; no. 1; Pages: (107-111);
dc.source Scopus
dc.title Timing of caffeine ingestion alters postprandial metabolism in rats
dc.type Article
dc.contributor.affiliation Jarrar, S.F., Department of Nutrition and Food Sciences, Faculty of Agricultural and Food Sciences, American University of Beirut, Beirut, Lebanon
dc.contributor.affiliation Obeid, O.A., Department of Nutrition and Food Sciences, Faculty of Agricultural and Food Sciences, American University of Beirut, Beirut, Lebanon
dc.contributor.authorAddress Obeid, O.A.; Department of Nutrition and Food Sciences, Faculty of Agricultural and Food Sciences, American University of Beirut, Beirut, Lebanon; email:
dc.contributor.authorCorporate University: American University of Beirut; Faculty: Faculty of Agricultural and Food Sciences; Department: Nutrition and Food Sciences;
dc.contributor.authorDepartment Nutrition and Food Sciences
dc.contributor.faculty Faculty of Agricultural and Food Sciences
dc.contributor.authorInitials Jarrar, SF
dc.contributor.authorInitials Obeid, OA
dc.contributor.authorReprintAddress Obeid, OA (reprint author), Amer Univ Beirut, Fac Agr and Food Sci, Dept Nutr and Food Sci, Beirut, Lebanon.
dc.contributor.authorUniversity American University of Beirut
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dc.description.citedTotWOSCount 0
dc.description.citedWOSCount 0
dc.format.extentCount 5
dc.identifier.coden NUTRE
dc.identifier.pubmedID 24206825
dc.identifier.scopusID 84888433183
dc.publisher.address 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
dc.relation.ispartOfISOAbbr Nutrition
dc.relation.ispartOfIssue 1
dc.relation.ispartofPubTitle Nutrition
dc.relation.ispartofPubTitleAbbr Nutrition
dc.relation.ispartOfVolume 30
dc.source.ID WOS:000329079400016
dc.type.publication Journal
dc.subject.otherAuthKeyword Caffeine
dc.subject.otherAuthKeyword fatty acids
dc.subject.otherAuthKeyword glucose
dc.subject.otherAuthKeyword glycogen
dc.subject.otherAuthKeyword insulin
dc.subject.otherAuthKeyword meal ingestion
dc.subject.otherAuthKeyword triglycerides
dc.subject.otherChemCAS Caffeine, 58-08-2
dc.subject.otherChemCAS glucose, 50-99-7, 84778-64-3
dc.subject.otherChemCAS glycogen, 9005-79-2
dc.subject.otherChemCAS insulin, 9004-10-8
dc.subject.otherIndex Caffeine
dc.subject.otherIndex fatty acid
dc.subject.otherIndex glucose
dc.subject.otherIndex glycogen
dc.subject.otherIndex insulin
dc.subject.otherIndex triacylglycerol
dc.subject.otherIndex animal experiment
dc.subject.otherIndex animal tissue
dc.subject.otherIndex article
dc.subject.otherIndex controlled study
dc.subject.otherIndex fatty acid blood level
dc.subject.otherIndex gastrocnemius muscle
dc.subject.otherIndex glucose blood level
dc.subject.otherIndex glycogen liver level
dc.subject.otherIndex glycogen muscle level
dc.subject.otherIndex insulin blood level
dc.subject.otherIndex male
dc.subject.otherIndex metabolism
dc.subject.otherIndex nonhuman
dc.subject.otherIndex postprandial state
dc.subject.otherIndex priority journal
dc.subject.otherIndex rat
dc.subject.otherIndex triacylglycerol blood level
dc.subject.otherIndex rattus
dc.subject.otherIndex caffeine
dc.subject.otherIndex fatty acids
dc.subject.otherIndex glucose
dc.subject.otherIndex glycogen
dc.subject.otherIndex insulin
dc.subject.otherIndex meal ingestion
dc.subject.otherIndex triglycerides
dc.subject.otherIndex animals
dc.subject.otherIndex blood glucose
dc.subject.otherIndex caffeine
dc.subject.otherIndex carbohydrate metabolism
dc.subject.otherIndex glycogen
dc.subject.otherIndex insulin
dc.subject.otherIndex insulin resistance
dc.subject.otherIndex male
dc.subject.otherIndex meals
dc.subject.otherIndex muscle, skeletal
dc.subject.otherIndex postprandial period
dc.subject.otherIndex rats
dc.subject.otherIndex rats, sprague-dawley
dc.subject.otherIndex time factors
dc.subject.otherIndex triglycerides
dc.subject.otherKeywordPlus Glucose-tolerance test
dc.subject.otherKeywordPlus type-2 diabetes-mellitus
dc.subject.otherKeywordPlus tumor-bearing rats
dc.subject.otherKeywordPlus double-blind
dc.subject.otherKeywordPlus green tea
dc.subject.otherKeywordPlus insulin sensitivity
dc.subject.otherKeywordPlus skeletal-muscle
dc.subject.otherKeywordPlus lipid-synthesis
dc.subject.otherKeywordPlus glycemic index
dc.subject.otherKeywordPlus fatty-acids
dc.subject.otherWOS Nutrition and Dietetics

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