AUB ScholarWorks

Dietary exposure to aflatoxins, ochratoxin A and deoxynivalenol from a total diet study in an adult urban Lebanese population

Show simple item record Raad F. Nasreddine L. Hilan C. Bartosik M. Parent-Massin D.
dc.contributor.editor 2014 2017-10-18T13:24:09Z 2017-10-18T13:24:09Z 2014
dc.identifier 10.1016/j.fct.2014.07.034
dc.identifier.issn 2786915
dc.description.abstract Exposure to mycotoxins may be associated with carcinogenic, immunosuppressant and estrogenic effects. In the Middle-East, studies investigating food contamination and dietary exposure to mycotoxins are particularly scarce. This study aims at evaluating the dietary exposure of an adult Lebanese urban population to four mycotoxins (AFB1, AFM1, OTA, DON) classified as priority food contaminants by the WHO. Dietary exposure assessment was performed by means of the total diet study approach. Average and excessive consumer exposure estimates (p95) were calculated and compared with appropriate toxicological reference values (TRVs). Average dietary exposure levels to OTA and DON represented 29.9percent and 156.8percent of the respective TRVs, with the p95 exposure estimates approaching or exceeding the TRVs for these mycotoxins (95.1percent and 355.8percent, respectively). Based on the mean dietary exposure level to AFB1, cancer risk was estimated at 0.0527-0.0545. cases-100,000. persons-year, while mean exposure to AFM1 was associated with a population risk of 0.0018-0.0027. cases-100,000. persons-year. The study's findings place Lebanon among countries that are highly exposed to mycotoxins through the diet and call for larger-scale studies aiming at providing a comprehensive assessment of the dietary exposure of the Lebanese population to mycotoxins as well as to other food contaminants. © 2014 The Authors.
dc.format.extent Pages: (35-43)
dc.language English
dc.publisher Elsevier Ltd; OXFORD
dc.relation.ispartof Publication Name: Food and Chemical Toxicology; Publication Year: 2014; Volume: 73; Pages: (35-43);
dc.source Scopus
dc.title Dietary exposure to aflatoxins, ochratoxin A and deoxynivalenol from a total diet study in an adult urban Lebanese population
dc.type Article
dc.contributor.affiliation Raad, F., Lebanese Agricultural Research Institute (LARI), Tel Amara Station, Bekaa, Lebanon, Laboratoire d'Evaluation du Risque Chimique pour le Consommateur (LERCCo), Université de Bretagne Occidentale (UEB-UBO), UFR Sciences et Techniques, France
dc.contributor.affiliation Nasreddine, L., Department of Nutrition and Food Science, Faculty of Agricultural and Food Sciences, American University of Beirut, Lebanon
dc.contributor.affiliation Hilan, C., Lebanese Agricultural Research Institute (LARI), Tel Amara Station, Bekaa, Lebanon
dc.contributor.affiliation Bartosik, M., ARVALIS - Institut du Végétal, PÔle Analyses et Méthodes, Station Expérimentale, 91720 Boigneville, France
dc.contributor.affiliation Parent-Massin, D., Laboratoire d'Evaluation du Risque Chimique pour le Consommateur (LERCCo), Université de Bretagne Occidentale (UEB-UBO), UFR Sciences et Techniques, France, Université Paris-Sud, Inserm UMR-S 996, 92296 Châtenay-Malabry, France
dc.contributor.authorAddress Nasreddine, L.; Department of Nutrition and Food Science, Faculty of Agricultural and Food Sciences, American University of Beirut, P.O. Box 11-0236, Riad El Solh 1107 2020 Beirut, Lebanon; email:
dc.contributor.authorCorporate University: American University of Beirut; Faculty: Faculty of Agricultural and Food Sciences; Department: Nutrition and Food Sciences;
dc.contributor.authorDepartment Nutrition and Food Sciences
dc.contributor.authorFaculty Faculty of Agricultural and Food Sciences
dc.contributor.authorInitials Raad, F
dc.contributor.authorInitials Nasreddine, L
dc.contributor.authorInitials Hilan, C
dc.contributor.authorInitials Bartosik, M
dc.contributor.authorInitials Parent-Massin, D
dc.contributor.authorReprintAddress Nasreddine, L (reprint author), Amer Univ Beirut, Fac Agr and Food Sci, Dept Nutr and Food Sci, POB 11-0236, Beirut 11072020, Lebanon.
dc.contributor.authorUniversity American University of Beirut
dc.description.cited Adib S.M., 2006, MINISTRY PUBLIC HLTH; AFNOR, 2003, 14132 AFNOR NF EN, P15; AFSSA, 2009, EV RISQ LIES PRES MY, P308; [Anonymous], 1994, AOAC99131; Assaf H., 2004, THESIS U PARIS 11 PA; Backer M., 2002, RISK ASSESSMENT OCHR, P1; Bennett JW, 2003, CLIN MICROBIOL REV, V16, P497, DOI 10.1128-CMR.16.3.497-516.2003; Betsy A, 2012, J APPL TOXICOL, V32, P765, DOI 10.1002-jat.2718; Coffey R., 2008, FOOD CONTROL, V20, P239; CUADRADO C, 1995, EUR J CLIN NUTR, V49, P767; Diaz D. E., 2005, MYCOTOXIN BLUE BOOK; Domijan Ana-Marija, 2005, Arhiv za Higijenu Rada i Toksikologiju, V56, P17; Dragacci S, 2001, J AOAC INT, V84, P437; EFSA, 2007, EFSA J, V73, P1; EFSA, 2006, EFSA J, V365, P1; EFSA, 2010, EFSA J, V8, P1557; EFSA FAO and WHO, 2011, EFSA J, V9, P2450; Egan SK, 2002, FOOD ADDIT CONTAM, V19, P103, DOI 10.1080-02652030110071354; European Commission, 1997, 17526 EUR EN EUR COM, P157; FAO-WHO, 2006, JOINT M FAO PAN EXP, P1; Galtier P., 2006, B ACAD VET FR, V159, P5; Gareis M., 2003, SCOOP TASK 3 2 10 CO; GEMS-Food-Euro, 1995, WORKSH FRAM GEMS FOO, P1; Gilbert J, 2001, FOOD ADDIT CONTAM, V18, P1088, DOI 10.1080-02652030110070030; Henry S., 1998, WHO FOOD ADDITIVES S, V40; ISO, 2003, 160671 ISO, P11; JECFA, 2001, WHO TECHN REP SER, V901; JECFA, 2010, 72 M ROM 16 28 FEBR; JECFA, 2002, WHO TECHN REP SER, V906; JECFA (Joint FAO-WHO Expert Committee on Food Additives), 1999, WHO TECHN REP SER; Joint FAO-WHO Expert Committee on Food Additives (JECFA), 2007, WHO TECHN REP SER, V947; Kamal S., 1995, ALEF BAA AL TABKH; Kamkar A, 2008, FOOD CHEM TOXICOL, V46, P2236, DOI 10.1016-j.fct.2008.02.028; Kew MC, 2003, LIVER INT, V23, P405, DOI 10.1111-j.1478-3231.2003.00869.x; Kroes R, 2002, FOOD CHEM TOXICOL, V40, P327, DOI 10.1016-S0278-6915(01)00113-2; KUIPERGOODMAN T, 1993, COLLOQ INSE, V231, P167; Kuiper-Goodman T, 1998, MYCOTOXINS AND PHYCOTOXINS - DEVELOPMENTS IN CHEMISTRY, TOXICOLOGY AND FOOD SAFETY, P25; Leblanc J.C., 2004, ETUDE ALIMENTATION T, P1; Leblanc JC, 2005, FOOD ADDIT CONTAM, V22, P652, DOI 10.1080-02652030500159938; Miraglia M., 2002, ASSESSMENT DIETARY I, P1; Nasreddine L, 2010, FOOD CHEM TOXICOL, V48, P1262, DOI 10.1016-j.fct.2010.02.020; Nasreddine L, 2006, PUBLIC HEALTH NUTR, V9, P194, DOI 10.1079-PHN2005855; Ormutag G.Z., 2007, FOOD CONTROL, V18, P163; Ormutag G.Z., 2003, FOOD ADDIT CONTAM, V20, P405; Park JW, 2004, FOOD ADDIT CONTAM, V21, P70, DOI 10.1080-02652030310001622782; Pitt John I., 2004, Mitteilungen aus Lebensmitteluntersuchung und Hygiene, V95, P52; Qirbi N, 2001, East Mediterr Health J, V7, P1034; Raad F., 2005, MEMOIRE DEA; Richard J.L., 2003, 139 CAST, P1; Ruprich J., 1998, 1997 TOTAL DIET STUD; SCF, 2002, OP FUS TOX 3; SCF, 1998, OP OCHR A; SCF, 1994, 35 SCF EUR COMM DG; Schothorst RC, 2005, FOOD ADDIT CONTAM, V22, P48, DOI 10.1080-02652030400019414; Shamseddine A., 2014, POPUL HEALTH METR, V12, P1; Shundo L, 2009, FOOD CONTROL, V20, P655, DOI 10.1016-j.foodcont.2008.09.019; Sirot V, 2013, FOOD CHEM TOXICOL, V52, P1, DOI 10.1016-j.fct.2012.10.036; Sizoo EA, 2005, FOOD ADDIT CONTAM, V22, P163, DOI 10.1080-02652030400029439; Sommerfeld G, 2004, P WHO 3 INT WORKSH T; Soubra L, 2008, THESIS AGRO PARIS TE, P1; Soubra L, 2009, FOOD ADDIT CONTAM A, V26, P189, DOI 10.1080-02652030802366108; Taniwaki MH, 2003, INT J FOOD MICROBIOL, V82, P173, DOI 10.1016-S0168-1605(02)00310-0; Thuvander A, 2001, FOOD ADDIT CONTAM, V18, P696, DOI 10.1080-02652030110047775; TOUKAN AU, 1990, AM J EPIDEMIOL, V132, P220; Turgeon M.J., 2009, DIAGNOSTIC PREPARATI, P1; Turner NW, 2009, ANAL CHIM ACTA, V632, P168, DOI 10.1016-j.aca.2008.11.010; Van Damme P., 2004, EURO SURVEILL, V8, P47; Verger P, 2013, TOTAL DIET STUDIES, P19; Weidenborner M., 2008, MYCOTOXINS FOODSTUFF, P1, DOI 10.1007-978-0-387-73689-1_1; WHO, 2005, TOT DIET STUD REC SA; WHO, 2002, LIST PRIOR CONT COMM; WHO, 2006, 4 INT WORKSH TOT DIE; WHO IARC, 1993, WHO MON EV CARC RISK, P56; WHO (World Health Organization), 1985, WHO OFFS PUBL, V87, P1; Zinedine A, 2009, FOOD CONTROL, V20, P334, DOI 10.1016-j.foodcont.2008.07.002
dc.description.citedTotWOSCount 0
dc.description.citedWOSCount 0
dc.format.extentCount 9
dc.identifier.coden FCTOD
dc.identifier.scopusID 84906486387
dc.relation.ispartOfISOAbbr Food Chem. Toxicol.
dc.relation.ispartofPubTitle Food and Chemical Toxicology
dc.relation.ispartofPubTitleAbbr Food Chem. Toxicol.
dc.relation.ispartOfVolume 73
dc.source.ID WOS:000345491500005
dc.type.publication Journal
dc.subject.otherAuthKeyword Adults
dc.subject.otherAuthKeyword dietary exposure
dc.subject.otherAuthKeyword lebanon
dc.subject.otherAuthKeyword mycotoxins
dc.subject.otherAuthKeyword risk characterization
dc.subject.otherAuthKeyword total diet study
dc.subject.otherChemCAS Aflatoxin b1, 1162-65-8
dc.subject.otherChemCAS aflatoxin m1, 6795-23-9
dc.subject.otherChemCAS ochratoxin, 303-47-9, 37203-43-3
dc.subject.otherChemCAS vomitoxin, 51481-10-8
dc.subject.otherIndex Aflatoxin b1
dc.subject.otherIndex aflatoxin m1
dc.subject.otherIndex ochratoxin
dc.subject.otherIndex vomitoxin
dc.subject.otherIndex adult
dc.subject.otherIndex article
dc.subject.otherIndex cancer risk
dc.subject.otherIndex dietary intake
dc.subject.otherIndex food analysis
dc.subject.otherIndex food contamination
dc.subject.otherIndex human
dc.subject.otherIndex lebanese
dc.subject.otherIndex limit of detection
dc.subject.otherIndex limit of quantitation
dc.subject.otherIndex nutritional assessment
dc.subject.otherIndex nutritional health
dc.subject.otherIndex population risk
dc.subject.otherIndex reference value
dc.subject.otherIndex risk assessment
dc.subject.otherIndex toxin analysis
dc.subject.otherIndex urban population
dc.subject.otherKeywordPlus Hepatitis-b-virus
dc.subject.otherKeywordPlus french total diet
dc.subject.otherKeywordPlus food-consumption
dc.subject.otherKeywordPlus mycotoxins
dc.subject.otherKeywordPlus m-1
dc.subject.otherKeywordPlus chromatography
dc.subject.otherKeywordPlus elements
dc.subject.otherKeywordPlus children
dc.subject.otherKeywordPlus samples
dc.subject.otherKeywordPlus beirut
dc.subject.otherWOS Food Science and Technology
dc.subject.otherWOS Toxicology

Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search AUB ScholarWorks


My Account