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Postprandial glycogen and lipid synthesis in prednisolone-treated rats maintained on high-protein diets with varied carbohydrate levels

Show simple item record Obeid O.A. Boukarim L.K. Al Awar R.M. Hwalla N.
dc.contributor.editor 2006 2017-10-18T13:24:13Z 2017-10-18T13:24:13Z 2006
dc.identifier 10.1016/j.nut.2005.07.014
dc.identifier.issn 8999007
dc.description.abstract Objective: The present experiment was designed to study the effect of a high-protein, high-carbohydrate diet versus a high-protein, low-carbohydrate diet on in vivo postprandial glycogen and lipid synthesis of rats treated with prednisolone. Methods: Thirty-two 6-wk-old male Sprague-Dawley rats were randomly assigned to one of four equal groups: high-protein, high-carbohydrate; high-protein, high-carbohydrate with prednisolone; high-protein, low-carbohydrate; and high-protein, low-carbohydrate with prednisolone. Rats were sham operated or subcutaneously implanted with prednisolone pellets while being maintained on their respective diets (39percent of energy from protein) for 6 wk. Food intake and body weight were monitored throughout the experiment. At the end of the feeding period, overnight-fasted rats were fed a test meal and injected with 3H2O to measure in vivo rates of glycogen and lipid synthesis. Final plasma glucose, insulin, and triacylglycerol concentrations and hepatic glycogen content were also measured. Results: Results showed that hepatic glycogen content (milligrams per gram of liver) was similar across all four experimental groups. Total hepatic glycogen synthesis and its percentage synthesis via pyruvate (indirect pathway) were higher in rats maintained on the high-protein, high-carbohydrate diet compared with those on the high-protein, low-carbohydrate diet and this was not substantially affected by prednisolone administration. Hepatic and epididymal fat pad lipid syntheses were not altered by diet or prednisolone treatments. Conclusion: Under long-term high-protein conditions, prednisolone administration does not seem to affect hepatic glycogen synthesis, which was increased with the increased carbohydrate content of the diet. © 2006 Elsevier Inc. All rights reserved.
dc.format.extent Pages: (288-294)
dc.language English
dc.publisher NEW YORK
dc.relation.ispartof Publication Name: Nutrition; Publication Year: 2006; Volume: 22; no. 3; Pages: (288-294);
dc.source Scopus
dc.title Postprandial glycogen and lipid synthesis in prednisolone-treated rats maintained on high-protein diets with varied carbohydrate levels
dc.type Article
dc.contributor.affiliation Obeid, O.A., Department of Nutrition and Food Sciences, Faculty of Agricultural and Food Sciences, American University of Beirut, Beirut, Lebanon
dc.contributor.affiliation Boukarim, L.K., Department of Nutrition and Food Sciences, Faculty of Agricultural and Food Sciences, American University of Beirut, Beirut, Lebanon
dc.contributor.affiliation Al Awar, R.M., Department of Nutrition and Food Sciences, Faculty of Agricultural and Food Sciences, American University of Beirut, Beirut, Lebanon
dc.contributor.affiliation Hwalla, N., Department of Nutrition and Food Sciences, Faculty of Agricultural and Food Sciences, American University of Beirut, Beirut, Lebanon
dc.contributor.authorAddress Obeid, O.A.; Department of Nutrition and Food Sciences, Faculty of Agricultural and Food Sciences, American University of Beirut, Beirut, Lebanon; email:
dc.contributor.authorCorporate University: American University of Beirut; Faculty: Faculty of Agricultural and Food Sciences; Department: Nutrition and Food Sciences;
dc.contributor.authorDepartment Nutrition and Food Sciences
dc.contributor.authorFaculty Faculty of Agricultural and Food Sciences
dc.contributor.authorInitials Obeid, OA
dc.contributor.authorInitials Boukarim, LK
dc.contributor.authorInitials Al Awar, RM
dc.contributor.authorInitials Hwalla, N
dc.contributor.authorReprintAddress Obeid, OA (reprint author), Amer Univ Beirut, Fac Agr and Food Sci, Dept Nutr and Food Sci, Beirut, Lebanon.
dc.contributor.authorUniversity American University of Beirut
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dc.description.citedCount 5
dc.description.citedTotWOSCount 7
dc.description.citedWOSCount 7
dc.format.extentCount 7
dc.identifier.coden NUTRE
dc.identifier.pubmedID 16412611
dc.identifier.scopusID 32944469466
dc.publisher.address 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
dc.relation.ispartOfISOAbbr Nutrition
dc.relation.ispartOfIssue 3
dc.relation.ispartofPubTitle Nutrition
dc.relation.ispartofPubTitleAbbr Nutrition
dc.relation.ispartOfVolume 22
dc.source.ID WOS:000235898000010
dc.type.publication Journal
dc.subject.otherAuthKeyword Energy balance
dc.subject.otherAuthKeyword food intake
dc.subject.otherAuthKeyword glucocorticoids
dc.subject.otherAuthKeyword glycogen synthesis
dc.subject.otherAuthKeyword high-protein diet
dc.subject.otherAuthKeyword prednisolone
dc.subject.otherAuthKeyword rats
dc.subject.otherChemCAS Glycogen, 9005-79-2
dc.subject.otherChemCAS lipid, 66455-18-3
dc.subject.otherChemCAS prednisolone, 50-24-8
dc.subject.otherChemCAS dietary carbohydrates
dc.subject.otherChemCAS dietary proteins
dc.subject.otherChemCAS glucocorticoids
dc.subject.otherChemCAS lipids
dc.subject.otherChemCAS liver glycogen
dc.subject.otherChemCAS prednisolone, 50-24-8
dc.subject.otherChemCAS tritium oxide, 14940-65-9
dc.subject.otherChemCAS tritium, 10028-17-8
dc.subject.otherChemCAS water, 7732-18-5
dc.subject.otherIndex Glycogen
dc.subject.otherIndex lipid
dc.subject.otherIndex prednisolone
dc.subject.otherIndex animal cell
dc.subject.otherIndex animal experiment
dc.subject.otherIndex animal tissue
dc.subject.otherIndex article
dc.subject.otherIndex body weight
dc.subject.otherIndex carbohydrate intake
dc.subject.otherIndex controlled study
dc.subject.otherIndex food intake
dc.subject.otherIndex glucose blood level
dc.subject.otherIndex glycogen synthesis
dc.subject.otherIndex lipogenesis
dc.subject.otherIndex male
dc.subject.otherIndex nonhuman
dc.subject.otherIndex priority journal
dc.subject.otherIndex protein diet
dc.subject.otherIndex rat
dc.subject.otherIndex synthesis
dc.subject.otherIndex animals
dc.subject.otherIndex dietary carbohydrates
dc.subject.otherIndex dietary proteins
dc.subject.otherIndex eating
dc.subject.otherIndex energy intake
dc.subject.otherIndex glucocorticoids
dc.subject.otherIndex lipid metabolism
dc.subject.otherIndex lipids
dc.subject.otherIndex liver
dc.subject.otherIndex liver glycogen
dc.subject.otherIndex male
dc.subject.otherIndex postprandial period
dc.subject.otherIndex prednisolone
dc.subject.otherIndex random allocation
dc.subject.otherIndex rats
dc.subject.otherIndex rats, sprague-dawley
dc.subject.otherIndex tritium
dc.subject.otherIndex water
dc.subject.otherIndex weight gain
dc.subject.otherIndex animalia
dc.subject.otherKeywordPlus Glucose appearance rate
dc.subject.otherKeywordPlus high-fat diet
dc.subject.otherKeywordPlus liver-glycogen
dc.subject.otherKeywordPlus insulin-resistance
dc.subject.otherKeywordPlus weight-gain
dc.subject.otherKeywordPlus body-weight
dc.subject.otherKeywordPlus food-intake
dc.subject.otherKeywordPlus metabolism
dc.subject.otherKeywordPlus glucocorticoids
dc.subject.otherKeywordPlus gluconeogenesis
dc.subject.otherWOS Nutrition and Dietetics

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