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Bioavailability of vitamins e and C: Does helicobacter pylori infection play a role?

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dc.contributor.author Naja F.
dc.contributor.author Kreiger N.
dc.contributor.author McKeown Eyssen G.
dc.contributor.author Allard J.
dc.contributor.editor
dc.date 2010
dc.date.accessioned 2017-10-18T13:24:22Z
dc.date.available 2017-10-18T13:24:22Z
dc.date.issued 2010
dc.identifier 10.1159/000281819
dc.identifier.issn 2506807
dc.identifier.uri http://hdl.handle.net/10938/20267
dc.description.abstract Background: While the association between bioavailability of vitamins E and C and Helicobacter pylori infection has been extensively researched in gastritis and gastric cancer patients, little is known about this relationship in asymptomatic adults. Aim: To investigate the effect of H. pylori infection on bioavailability of vitamins E and C in asymptomatic adults. Methods: Volunteers from the University of Toronto, aged 18-45 years, were screened, for their H. pylori infection status. H. pylori-negative (n = 32) and asymptomatic H. pylori-positive (n = 27) participants received vitamin C (500 mg) and vitamin E (400 IU) supplements daily for 28 days. Plasma vitamins C, E and thiols concentrations were assessed before (baseline) and after supplementation. Results: Postsupplementation plasma levels of vitamin C and E were significantly higher than presupplementation levels in both groups. Yet, changes in plasma vitamins E and C were not significantly different between the two groups [vitamin C (μmol-l): 13.97 ± 16.86 vs. 20.87 ± 27.66, p 0.05; vitamin E (μmol-l): 15.52 ± 9.4 vs. 14.47 ± 15.77; p 0.05 for H. pylori-negative and H. pylori-positive groups, respectively]. In addition, no significant difference was found in plasma thiols levels between groups (p 0.05). Conclusion: These findings suggest that H. pylori does not influence antioxidants bioavailability in its asymptomatic stages of infection until a factor or combination of factors triggers the inflammation cascade which may lead to increased oxidative stress and possibly reduced bioavailability of vitamins E and C. © 2010 S. Karger AG, Basel.
dc.format.extent
dc.format.extent Pages: (253-259)
dc.language English
dc.publisher BASEL
dc.relation.ispartof Publication Name: Annals of Nutrition and Metabolism; Publication Year: 2010; Volume: 56; no. 4; Pages: (253-259);
dc.source Scopus
dc.title Bioavailability of vitamins e and C: Does helicobacter pylori infection play a role?
dc.type Article
dc.contributor.affiliation Naja, F., Nutrition and Food Sciences Department, American University of Beirut, Beirut, Lebanon, Population Studies, Cancer Care Ontario, Lebanon
dc.contributor.affiliation Kreiger, N., Nutrition and Food Sciences Department, American University of Beirut, Beirut, Lebanon, Population Studies, Cancer Care Ontario, Lebanon, Dalla Lana School of Public Health, Lebanon
dc.contributor.affiliation McKeown Eyssen, G., Nutrition and Food Sciences Department, American University of Beirut, Beirut, Lebanon, Dalla Lana School of Public Health, Lebanon
dc.contributor.affiliation Allard, J., Department of Medicine, Division of Gastroenterology, University of Toronto, Toronto, ON, Canada
dc.contributor.authorAddress Naja, F.; Nutrition and Food Sciences Department, American University of Beirut, Beirut, Lebanon; email: fn14@aub.edu.lb
dc.contributor.authorCorporate University: American University of Beirut; Faculty: Faculty of Agricultural and Food Sciences; Department: Nutrition and Food Sciences;
dc.contributor.authorDepartment Nutrition and Food Sciences
dc.contributor.authorDivision
dc.contributor.authorEmail fn14@aub.edu.lb
dc.contributor.authorFaculty Faculty of Agricultural and Food Sciences
dc.contributor.authorInitials Naja, F
dc.contributor.authorInitials Kreiger, N
dc.contributor.authorInitials Eyssen, GM
dc.contributor.authorInitials Allard, J
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Naja, F (reprint author), Amer Univ Beirut, Dept Food Sci and Nutr, Beirut, Lebanon.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut
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dc.description.citedCount 1
dc.description.citedTotWOSCount 2
dc.description.citedWOSCount 1
dc.format.extentCount 7
dc.identifier.articleNo
dc.identifier.coden ANUMD
dc.identifier.pubmedID 20389061
dc.identifier.scopusID 77950617187
dc.publisher.address ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
dc.relation.ispartOfISOAbbr Ann. Nutr. Metab.
dc.relation.ispartOfIssue 4
dc.relation.ispartofPubTitle Annals of Nutrition and Metabolism
dc.relation.ispartofPubTitleAbbr Ann. Nutr. Metab.
dc.relation.ispartOfVolume 56
dc.source.ID WOS:000279331000002
dc.type.publication Journal
dc.subject.otherAuthKeyword Bioavailability
dc.subject.otherAuthKeyword helicobacter pylori
dc.subject.otherAuthKeyword vitamin c
dc.subject.otherAuthKeyword vitamin e
dc.subject.otherChemCAS Alpha tocopherol, 1406-18-4, 1406-70-8, 52225-20-4, 58-95-7, 59-02-9
dc.subject.otherChemCAS ascorbic acid, 134-03-2, 15421-15-5, 50-81-7
dc.subject.otherChemCAS antioxidants
dc.subject.otherChemCAS ascorbic acid, 50-81-7
dc.subject.otherChemCAS sulfhydryl compounds
dc.subject.otherChemCAS vitamin e, 1406-18-4
dc.subject.otherIndex Alpha tocopherol
dc.subject.otherIndex ascorbic acid
dc.subject.otherIndex adult
dc.subject.otherIndex article
dc.subject.otherIndex drug bioavailability
dc.subject.otherIndex female
dc.subject.otherIndex helicobacter infection
dc.subject.otherIndex helicobacter pylori
dc.subject.otherIndex human
dc.subject.otherIndex major clinical study
dc.subject.otherIndex male
dc.subject.otherIndex marriage
dc.subject.otherIndex oxidative stress
dc.subject.otherIndex patient information
dc.subject.otherIndex patient selection
dc.subject.otherIndex priority journal
dc.subject.otherIndex screening
dc.subject.otherIndex treatment duration
dc.subject.otherIndex treatment outcome
dc.subject.otherIndex treatment response
dc.subject.otherIndex vitamin blood level
dc.subject.otherIndex adolescent
dc.subject.otherIndex adult
dc.subject.otherIndex antioxidants
dc.subject.otherIndex ascorbic acid
dc.subject.otherIndex biological availability
dc.subject.otherIndex diet
dc.subject.otherIndex dietary supplements
dc.subject.otherIndex energy intake
dc.subject.otherIndex female
dc.subject.otherIndex helicobacter infections
dc.subject.otherIndex helicobacter pylori
dc.subject.otherIndex humans
dc.subject.otherIndex male
dc.subject.otherIndex oxidative stress
dc.subject.otherIndex sulfhydryl compounds
dc.subject.otherIndex vitamin e
dc.subject.otherIndex young adult
dc.subject.otherIndex helicobacter pylori
dc.subject.otherKeywordPlus Gastric-cancer
dc.subject.otherKeywordPlus alpha-tocopherol
dc.subject.otherKeywordPlus ascorbic-acid
dc.subject.otherKeywordPlus atrophic gastritis
dc.subject.otherKeywordPlus oxidative damage
dc.subject.otherKeywordPlus dehydroascorbic acid
dc.subject.otherKeywordPlus human plasma
dc.subject.otherKeywordPlus whole-blood
dc.subject.otherKeywordPlus breath test
dc.subject.otherKeywordPlus serum
dc.subject.otherWOS Endocrinology and Metabolism
dc.subject.otherWOS Nutrition and Dietetics
dc.identifier.doi http://dx.doi.org/10.1159/000281819


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