AUB ScholarWorks

Postprandial metabolic and hormonal responses of obese dyslipidemic subjects with metabolic syndrome to test meals, rich in carbohydrate, fat or protein

Show simple item record

dc.contributor.author Khoury D.E.
dc.contributor.author Hwalla N.
dc.contributor.author Frochot V.
dc.contributor.author Lacorte J.-M.
dc.contributor.author Chabert M.
dc.contributor.author Kalopissis A.D.
dc.contributor.editor
dc.date 2010
dc.date.accessioned 2017-10-18T13:24:25Z
dc.date.available 2017-10-18T13:24:25Z
dc.date.issued 2010
dc.identifier 10.1016/j.atherosclerosis.2009.11.017
dc.identifier.issn 219150
dc.identifier.uri http://hdl.handle.net/10938/20269
dc.description.abstract Background: The metabolic syndrome (MS) is a cluster of heterogeneous abnormalities conferring increased risk of cardiovascular diseases. Few postprandial studies have been conducted in MS individuals. Objectives: We aimed to study MS subjects with the same abnormalities: abdominal obesity, hypertriglyceridemia and low plasma HDL. We assessed postprandial variations of metabolic parameters related to obesity, dyslipidemia and glucose homeostasis. Methods: In this randomized, double-blind, cross-over study, male MS and control subjects consumed, at separate occasions, a high carbohydrate (HC), high fat (HF) or high protein (HP) breakfast meal providing 30percent of each subject's resting energy expenditure. Results: Appetite hormones peptide YY and ghrelin did not differ between-subject groups. Interleukin-6 was two-fold higher in MS compared with control subjects, consistently with an inflammatory state. Hypertriglyceridemia of MS subjects was aggravated postprandially with the HF and HP meals and was lowest after the HC meal, arguing against increased hepatic VLDL production. HDL-cholesterol of MS subjects remained low postprandially, whereas apolipoprotein (apo) A-II was higher than in control subjects. Unexpectedly, postprandial insulin and glucose responses were higher in MS compared with control subjects, with the HP meal inducing the greater effects. Conclusions: The sustained postprandial hypertriglyceridemia of MS subjects after all meals suggests defective catabolism of triglyceride-rich lipoproteins. The greater postprandial increases in plasma insulin and glucose in MS relatively to control subjects indicate decreased insulin sensitivity, not revealed in the fasted state. © 2009.
dc.format.extent
dc.format.extent Pages: (307-313)
dc.language English
dc.publisher CLARE
dc.relation.ispartof Publication Name: Atherosclerosis; Publication Year: 2010; Volume: 210; no. 1; Pages: (307-313);
dc.source Scopus
dc.title Postprandial metabolic and hormonal responses of obese dyslipidemic subjects with metabolic syndrome to test meals, rich in carbohydrate, fat or protein
dc.type Article
dc.contributor.affiliation Khoury, D.E., INSERM, U872, Centre de Recherche des Cordeliers, Equipe 4, F-75006 Paris, France, UPMC Univ Paris 06, UMR S 872, Equipe 4, F-75006 Paris, France, Université Paris Descartes, UMR S 872, Equipe 4, F-75006 Paris, France, American University of Beirut, Faculty of Agricultural and Food Sciences, Department of Nutrition and Food Sciences, Beirut, Lebanon
dc.contributor.affiliation Hwalla, N., American University of Beirut, Faculty of Agricultural and Food Sciences, Department of Nutrition and Food Sciences, Beirut, Lebanon
dc.contributor.affiliation Frochot, V., INSERM, U872, Centre de Recherche des Cordeliers, Equipe 4, F-75006 Paris, France, UPMC Univ Paris 06, UMR S 872, Equipe 4, F-75006 Paris, France, Université Paris Descartes, UMR S 872, Equipe 4, F-75006 Paris, France, Assistance Publique-Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Biochimie Endocrinienne et Oncologique, F-75013 Paris, France
dc.contributor.affiliation Lacorte, J.-M., INSERM, U872, Centre de Recherche des Cordeliers, Equipe 4, F-75006 Paris, France, UPMC Univ Paris 06, UMR S 872, Equipe 4, F-75006 Paris, France, Université Paris Descartes, UMR S 872, Equipe 4, F-75006 Paris, France, Assistance Publique-Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Biochimie Endocrinienne et Oncologique, F-75013 Paris, France
dc.contributor.affiliation Chabert, M., INSERM, U872, Centre de Recherche des Cordeliers, Equipe 4, F-75006 Paris, France, UPMC Univ Paris 06, UMR S 872, Equipe 4, F-75006 Paris, France, Université Paris Descartes, UMR S 872, Equipe 4, F-75006 Paris, France, EPHE, Laboratoire de Pharmacologie Cellulaire et Moléculaire, F-75006 Paris, France
dc.contributor.affiliation Kalopissis, A.D., INSERM, U872, Centre de Recherche des Cordeliers, Equipe 4, F-75006 Paris, France, UPMC Univ Paris 06, UMR S 872, Equipe 4, F-75006 Paris, France, Université Paris Descartes, UMR S 872, Equipe 4, F-75006 Paris, France
dc.contributor.authorAddress Kalopissis, A.D.; INSERM, U872, Centre de Recherche des Cordeliers, Rue de l'Ecole de Médecine, Equipe 4, 15, F-75006 Paris, France; email: athina.kalopissis@crc.jussieu.fr
dc.contributor.authorCorporate University: American University of Beirut; Faculty: Faculty of Agricultural and Food Sciences; Department: Nutrition and Food Sciences;
dc.contributor.authorDepartment Nutrition and Food Sciences
dc.contributor.authorDivision
dc.contributor.authorEmail athina.kalopissis@crc.jussieu.fr
dc.contributor.Faculty Faculty of Agricultural and Food Sciences
dc.contributor.authorInitials El Khoury, D
dc.contributor.authorInitials Hwalla, N
dc.contributor.authorInitials Frochot, V
dc.contributor.authorInitials Lacorte, JM
dc.contributor.authorInitials Chabert, M
dc.contributor.authorInitials Kalopissis, AD
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Kalopissis, AD (reprint author), Ctr Rech Cordeliers, INSERM, U872, Equipe 4, 15 Rue Ecole Med, F-75006 Paris, France.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut
dc.description.cited Sibai Abla-Mehio, 2008, CVD Prevention and Control, V3, DOI 10.1016-j.precon.2007.06.002; Badman MK, 2007, GASTROENTEROLOGY, V132, P2103, DOI 10.1053-j.gastro.2007.03.058; Birjmohun RS, 2007, CIRCULATION, V116, P2029, DOI 10.1161-CIRCULATIONAHA.107.704031; Bishop JR, 2007, NATURE, V446, P1030, DOI 10.1038-nature05817; Burdge GC, 2006, BRIT J NUTR, V96, P489, DOI 10.1079-BJN20061877; Considine RV, 1996, NEW ENGL J MED, V334, P292, DOI 10.1056-NEJM199602013340503; DEGASQUET P, 1977, J NUTR, V107, P199; Dugue-Pujol S, 2006, J LIPID RES, V47, P2631, DOI 10.1194-jlr.M600112-JLR200; Fain JN, 2004, ENDOCRINOLOGY, V145, P2273, DOI 10.1210-en.2003-1336; Goldberg IJ, 1996, J LIPID RES, V37, P693; GREENBERG AS, 1992, CANCER RES, V52, P4113; Haffner SM, 2006, AM J CARDIOL, V97, p3A, DOI 10.1016-j.amjcard.2005.11.010; HIRANO T, 1989, AM J PHYSIOL, V256, pE559; Huuskonen J, 2001, ATHEROSCLEROSIS, V155, P269, DOI 10.1016-S0021-9150(01)00447-6; KALOPISSIS AD, 1982, BIOCHIM BIOPHYS ACTA, V711, P33, DOI 10.1016-0005-2760(82)90006-6; KALOPISSIS AD, 1995, METABOLISM, V44, P19, DOI 10.1016-0026-0495(95)90284-8; KORO CE, 2006, AM HEART J, V151; Kugiyama K, 1999, CIRCULATION, V99, P2858; Layman DK, 2004, J NUTR, V134, p968S; Nordmann AJ, 2006, ARCH INTERN MED, V166, P285, DOI 10.1001-archinte.166.3.285; Oussadou L, 1996, AM J PHYSIOL-ENDOC M, V271, pE952; Purnell JQ, 1997, CURR OPIN LIPIDOL, V8, P17, DOI 10.1097-00041433-199702000-00005; QUARFORD.SH, 1970, J CLIN INVEST, V49, P2281, DOI 10.1172-JCI106448; Rader DJ, 2006, J CLIN INVEST, V116, P3090, DOI 10.1172-JCI30163; Reaven GM, 1997, CURR OPIN LIPIDOL, V8, P23, DOI 10.1097-00041433-199702000-00006; REAVEN GM, 1993, ANNU REV MED, V44, P121, DOI 10.1146-annurev.med.44.1.121; Tai ES, 1999, DIABETES, V48, P1088, DOI 10.2337-diabetes.48.5.1088; TALL AR, 1978, NEW ENGL J MED, V299, P1232, DOI 10.1056-NEJM197811302992207; Tilg H, 2006, NAT REV IMMUNOL, V6, P772, DOI 10.1038-nri1937; Weisberg SP, 2003, J CLIN INVEST, V112, P1796, DOI 10.1172-JCI2000319246; Williams KJ, 2008, J CLIN INVEST, V118, P3247, DOI 10.1172-JCI35206; Wren AM, 2007, GASTROENTEROLOGY, V132, P2116, DOI 10.1053-j.gastro.2007.03.048; Zimmet P, 2005, J ATHEROSCLER THROMB, V12, P295
dc.description.citedCount 27
dc.description.citedTotWOSCount 1
dc.description.citedWOSCount 1
dc.format.extentCount 7
dc.identifier.articleNo
dc.identifier.coden ATHSB
dc.identifier.pubmedID 20031131
dc.identifier.scopusID 77952422545
dc.publisher.address ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND
dc.relation.ispartOfISOAbbr Atherosclerosis
dc.relation.ispartOfIssue 1
dc.relation.ispartofPubTitle Atherosclerosis
dc.relation.ispartofPubTitleAbbr Atherosclerosis
dc.relation.ispartOfVolume 210
dc.source.ID WOS:000277085300051
dc.type.publication Journal
dc.subject.otherAuthKeyword Hdl
dc.subject.otherAuthKeyword hypertriglyceridemia
dc.subject.otherAuthKeyword insulin sensitivity
dc.subject.otherAuthKeyword metabolic syndrome
dc.subject.otherAuthKeyword postprandial period
dc.subject.otherChemCAS Ghrelin, 258279-04-8, 304853-26-7
dc.subject.otherChemCAS glucose, 50-99-7, 84778-64-3
dc.subject.otherChemCAS insulin, 9004-10-8
dc.subject.otherChemCAS peptide yy, 81858-94-8
dc.subject.otherChemCAS apolipoprotein a-i
dc.subject.otherChemCAS blood glucose
dc.subject.otherChemCAS cholesterol, hdl
dc.subject.otherChemCAS dietary carbohydrates
dc.subject.otherChemCAS dietary fats
dc.subject.otherChemCAS dietary proteins
dc.subject.otherChemCAS ghrelin
dc.subject.otherChemCAS insulin, 11061-68-0
dc.subject.otherChemCAS interleukin-6
dc.subject.otherChemCAS peptide yy, 106388-42-5
dc.subject.otherIndex Apolipoprotein
dc.subject.otherIndex ghrelin
dc.subject.otherIndex glucose
dc.subject.otherIndex high density lipoprotein
dc.subject.otherIndex insulin
dc.subject.otherIndex interleukin 6
dc.subject.otherIndex peptide yy
dc.subject.otherIndex very low density lipoprotein
dc.subject.otherIndex abdominal obesity
dc.subject.otherIndex adult
dc.subject.otherIndex article
dc.subject.otherIndex carbohydrate intake
dc.subject.otherIndex cardiovascular risk
dc.subject.otherIndex catabolism
dc.subject.otherIndex clinical trial
dc.subject.otherIndex controlled clinical trial
dc.subject.otherIndex controlled study
dc.subject.otherIndex double blind procedure
dc.subject.otherIndex dyslipidemia
dc.subject.otherIndex energy expenditure
dc.subject.otherIndex fat intake
dc.subject.otherIndex glucose blood level
dc.subject.otherIndex glucose homeostasis
dc.subject.otherIndex human
dc.subject.otherIndex hypertriglyceridemia
dc.subject.otherIndex insulin blood level
dc.subject.otherIndex insulin sensitivity
dc.subject.otherIndex male
dc.subject.otherIndex metabolic syndrome x
dc.subject.otherIndex postprandial state
dc.subject.otherIndex priority journal
dc.subject.otherIndex protein blood level
dc.subject.otherIndex protein intake
dc.subject.otherIndex randomized controlled trial
dc.subject.otherIndex adult
dc.subject.otherIndex apolipoprotein a-i
dc.subject.otherIndex blood glucose
dc.subject.otherIndex cholesterol, hdl
dc.subject.otherIndex cross-over studies
dc.subject.otherIndex dietary carbohydrates
dc.subject.otherIndex dietary fats
dc.subject.otherIndex dietary proteins
dc.subject.otherIndex double-blind method
dc.subject.otherIndex dyslipidemias
dc.subject.otherIndex ghrelin
dc.subject.otherIndex humans
dc.subject.otherIndex hypertriglyceridemia
dc.subject.otherIndex insulin
dc.subject.otherIndex interleukin-6
dc.subject.otherIndex male
dc.subject.otherIndex metabolic syndrome x
dc.subject.otherIndex obesity, abdominal
dc.subject.otherIndex peptide yy
dc.subject.otherIndex postprandial period
dc.subject.otherKeywordPlus Density lipoprotein secretion
dc.subject.otherKeywordPlus coronary-artery-disease
dc.subject.otherKeywordPlus apolipoprotein-a-ii
dc.subject.otherKeywordPlus adipose-tissue
dc.subject.otherKeywordPlus insulin-resistance
dc.subject.otherKeywordPlus lipase activity
dc.subject.otherKeywordPlus hdl metabolism
dc.subject.otherKeywordPlus zucker rats
dc.subject.otherKeywordPlus weight-loss
dc.subject.otherKeywordPlus syndrome-x
dc.subject.otherWOS Peripheral Vascular Disease
dc.identifier.doi http://dx.doi.org/10.1016/j.atherosclerosis.2009.11.017


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search AUB ScholarWorks


Browse

My Account